Zinc Gluconate

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  • Identifiers

    CAS number
    4468-02-4

    Molecular formula
    C12H22O14Zn

    SMILES
    C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Zn+2]

    Safety labels

    Corrosive
    Corrosive

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 72.18%
    Sweet 48.12%
    Caramellic 26.01%
    Buttery 21.5%
    Milky 17.36%
    Clean 17.28%
    Savory 16.84%
    Bitter 15.85%
    Alcoholic 15.73%
    Sharp 14.68%

     

    Flavor
    Odorless 71.97%
    Sweet 33.74%
    Sweet-like 30.88%
    Very mild 30.55%
    Bland 24.22%
    Mild 21.49%
    Very slight 20.22%
    Yeast 19.74%
    Caramellic 19.02%
    Acetoin 18.45%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    1.43 (strong acid)

    Molecular weight
    455.7 g/mol

    Flash point

    • 228.83 ˚C est.

    Solubility expt.

    • moderately soluble

  • Synonyms

    • ZINC GLUCONATE
    • 4468-02-4
    • Zincum gluconicum
    • Zinc D-gluconate (1:2)
    • Bis(D-gluconato-O1,O2) zinc
    • Zinc gluconate (USP)
    • U6WSN5SQ1Z
    • DTXSID20894125
    • Zinkgluconaat
    • Rubozine
    • Zinc, bis(D-gluconato-kappaO1,kappaO2)-, (T-4)-
    • Zeuterin
    • MaxiGuard
    • OticClrandClnz
    • PlaqClnz
    • Blue Scorpion
    • Clunia EasyDent
    • OraZn
    • Big Richard
    • Medique ColdEeze
    • Zinc Cold Remedy
    • The Bee
    • CLX Wipes
    • Medique Cold Eeze
    • Zinc Cold Therapy
    • NBE Cool Mint
    • PlaqClnz Ez Wipes
    • CutisClr7.0
    • Meijer Cold Therapy
    • Pegasus-Fire Desire
    • Zn7 Derm
    • ERMIDRA
    • Zincum Gluconicum 2x
    • Walgreen Cold Therapy
    • Zn4.5Otic
    • RHINO AFRODITA
    • ANGELS EYES
    • COLD EEZE
    • ZINC OTIC
    • Abelia Small Pet Otic
    • Pegasus 21000
    • RefChem:6362
    • Zn4.5 Otic
    • Cold-EEZE Cold Remedy
    • Mega Rhino 82000
    • Rhino Love 97000
    • Rhino Time 78000
    • Rhino Time 94000
    • Black Spider-Libi Sting
    • CVS Health Cold Remedy
    • Horny Rhino 66000
    • Horny Rhino 69000
    • Ultra Zinc Cold Therapy
    • RHINO DOUBLE HORN
    • Target Zinc Cold Therapy
    • TopCare Zinc Cold Remedy
    • ZEBRA FANTASY RIDE
    • Thank you for Last Night
    • Walgreen Zinc Cold Therapy
    • TopCare Health Cold Remedy
    • Rite Aid Zinc Cold Therapy
    • PV Ultra Zinc Cold Therapy
    • Pegasus Male Sexual Enhancer
    • Zinc cold Remedy Non Drowsy
    • Maxi/Guard Oral Cleansing Gel
    • GoodSense Cherry Zinc Lozenges
    • SEXY MATADOR 17000
    • MaxiGuard oral cleansing formula
    • Maxi/Guard Oral Cleansing Wipes
    • Premier Value Zinc Cold Therapy
    • Zinc Cold Therapy Citrus Flavor
    • Libi Xplode Male Sexual Enhancer
    • RHINO DOUBLE HORN LIBI XX
    • Blue Monster Male Sexual Enhancer
    • Maxi/Guard Dental Cleansing Wipes
    • Meijer Cold Therapy Citrus Flavor
    • Rite Aid Ultra Zinc Cold Therapy
    • DTXCID501324165
    • Cold-EEZE Cold Remedy honey lemon
    • CVS Cherry Zinc Cold Relief 25ct
    • Walgreen Cold Therapy Cherry Flavor
    • CVS Health Cold Remedy Lemon Flavor
    • ADVANCED HOMEOPATHIC COLD-EEZE
    • CVS Health Cold Remedy Cherry Flavor
    • CVS Health Cold Remedy Citrus Flavor
    • Target Zinc Cold Therapy Citrus Flavor
    • TopCare Zinc Cold Remedy Citrus Flavor
    • Cold-EEZE Cold Remedy UltraMELT Chews
    • Zinc Gluconate, Valerian, and Chamomile
    • First Aid Direct Cold-EEZE Cold Remedy
    • NBE Cool Mint Cold Remedy Fast Melting
    • Walgreen Zinc Cold Therapy Citrus Flavor
    • TopCare Health Cold Remedy Cherry Flavor
    • CVS Honey Lemon Zinc Cold Relief Lozenges
    • Cold-EEZE Daytime and Nighttime QuickMelts
    • CVS Health Cold Remedy Orange Cream Flavor
    • Premier Value Zinc Cold Therapy Citrus Flavor
    • 224-736-9
    • Zincgluconate
    • Zinc(II) (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
    • Zinc gluconate hydrate
    • Gluconic Acid Zinc(II) Salt
    • Zinc;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
    • C12H22O14Zn
    • zinc (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
    • D-Gluconic acid zinc (II) salt
    • Zinc(II) Gluconate
    • Zinc di(D-gluconate)
    • SCHEMBL21280
    • ZINC GLUCONATE [FCC]
    • ZINC GLUCONATE [HSDB]
    • ZINC GLUCONATE [VANDF]
    • ZINC GLUCONATE [MART.]
    • CHEMBL3833377
    • ZINC GLUCONATE [WHO-DD]
    • ZINCUM GLUCONICUM [HPUS]
    • CHEBI:29708
    • ZINC GLUCONATE [GREEN BOOK]
    • EBC-27145
    • ZINC GLUCONATE [EP IMPURITY]
    • Gluconic Acid Zinc(II) Salt Hydrate
    • ZINC GLUCONATE [EP MONOGRAPH]
    • AKOS015951235
    • ZINC GLUCONATE [USP MONOGRAPH]
    • DB11248
    • MG07607
    • G0277
    • 4468-02-4

  • Applications

    Zinc Gluconate (CAS 4468-02-4) is commonly used as a stable zinc source in nutritional supplements and animal feeds; in cosmetics and personal care, it serves as a zinc ion donor in topical formulations; in cleaning and industrial formulations it can function as a chelating agent to bind trace metals and improve stability; it is often evaluated for micronutrient fortification in agricultural applications; and in certain polymer or coating systems it may act as a stabilizing salt or zinc source depending on the formulation.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.11
    methanol 40.94
    isopropanol 2.81
    water 1208.44
    ethyl acetate 0.9
    n-propanol 3.53
    acetone 3.72
    n-butanol 1.65
    acetonitrile 0.94
    DMF 145.44
    toluene 0.29
    isobutanol 1.55
    1,4-dioxane 4.15
    methyl acetate 0.96
    THF 3.76
    2-butanone 1.46
    n-pentanol 0.66
    sec-butanol 2.23
    n-hexane 0.07
    ethylene glycol 250.97
    NMP 142.13
    cyclohexane 0.54
    DMSO 701.99
    n-butyl acetate 0.47
    n-octanol 0.65
    chloroform 0.07
    n-propyl acetate 0.31
    acetic acid 22.2
    dichloromethane 0.18
    cyclohexanone 2.5
    propylene glycol 72.85
    isopropyl acetate 0.62
    DMAc 73.62
    2-ethoxyethanol 16.13
    isopentanol 1.2
    n-heptane 0.4
    ethyl formate 1.26
    1,2-dichloroethane 0.39
    n-hexanol 1.38
    2-methoxyethanol 72.59
    isobutyl acetate 0.08
    tetrachloromethane 0.15
    n-pentyl acetate 0.32
    transcutol 13.34
    n-heptanol 1.09
    ethylbenzene 0.16
    MIBK 0.94
    2-propoxyethanol 10.44
    tert-butanol 4.66
    MTBE 0.8
    2-butoxyethanol 4.42
    propionic acid 7.46
    o-xylene 0.7
    formic acid 404.26
    diethyl ether 0.75
    m-xylene 0.46
    p-xylene 0.15
    chlorobenzene 0.07
    dimethyl carbonate 4.25
    n-octane 0.13
    formamide 311.53
    cyclopentanone 4.13
    2-pentanone 1.56
    anisole 0.46
    cyclopentyl methyl ether 2.72
    gamma-butyrolactone 6.45
    1-methoxy-2-propanol 30.47
    pyridine 1.19
    3-pentanone 1.45
    furfural 7.69
    n-dodecane 0.07
    diethylene glycol 49.83
    diisopropyl ether 0.39
    tert-amyl alcohol 3.79
    acetylacetone 4.08
    n-hexadecane 0.07
    acetophenone 0.83
    methyl propionate 2.68
    isopentyl acetate 0.34
    trichloroethylene 0.34
    n-nonanol 0.61
    cyclohexanol 2.93
    benzyl alcohol 1.14
    2-ethylhexanol 0.72
    isooctanol 0.67
    dipropyl ether 0.98
    1,2-dichlorobenzene 0.12
    ethyl lactate 2.4
    propylene carbonate 1.75
    n-methylformamide 58.1
    2-pentanol 1.32
    n-pentane 0.17
    1-propoxy-2-propanol 6.06
    1-methoxy-2-propyl acetate 2.29
    2-(2-methoxypropoxy) propanol 4.38
    mesitylene 0.49
    ε-caprolactone 2.63
    p-cymene 0.38
    epichlorohydrin 1.94
    1,1,1-trichloroethane 0.09
    2-aminoethanol 99.1
    morpholine-4-carbaldehyde 67.42
    sulfolane 60.31
    2,2,4-trimethylpentane 0.12
    2-methyltetrahydrofuran 1.81
    n-hexyl acetate 0.41
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 5.82
    sec-butyl acetate 0.19
    tert-butyl acetate 1.13
    decalin 0.12
    glycerin 297.71
    diglyme 12.18
    acrylic acid 15.25
    isopropyl myristate 0.2
    n-butyric acid 2.89
    acetyl acetate 0.82
    di(2-ethylhexyl) phthalate 0.34
    ethyl propionate 0.54
    nitromethane 20.57
    1,2-diethoxyethane 0.87
    benzonitrile 0.22
    trioctyl phosphate 0.4
    1-bromopropane 0.11
    gamma-valerolactone 12.22
    n-decanol 0.48
    triethyl phosphate 0.78
    4-methyl-2-pentanol 0.73
    propionitrile 0.44
    vinylene carbonate 1.35
    1,1,2-trichlorotrifluoroethane 17.2
    DMS 0.93
    cumene 0.15
    2-octanol 0.52
    2-hexanone 0.35
    octyl acetate 0.31
    limonene 0.7
    1,2-dimethoxyethane 6.74
    ethyl orthosilicate 0.66
    tributyl phosphate 0.31
    diacetone alcohol 8.52
    N,N-dimethylaniline 1.0
    acrylonitrile 1.13
    aniline 1.07
    1,3-propanediol 44.97
    bromobenzene 0.05
    dibromomethane 0.11
    1,1,2,2-tetrachloroethane 0.5
    2-methyl-cyclohexyl acetate 0.46
    tetrabutyl urea 0.91
    diisobutyl methanol 0.64
    2-phenylethanol 1.11
    styrene 0.12
    dioctyl adipate 0.37
    dimethyl sulfate 22.21
    ethyl butyrate 0.58
    methyl lactate 18.02
    butyl lactate 1.19
    diethyl carbonate 0.36
    propanediol butyl ether 5.97
    triethyl orthoformate 0.72
    p-tert-butyltoluene 0.45
    methyl 4-tert-butylbenzoate 2.03
    morpholine 8.1
    tert-butylamine 1.51
    n-dodecanol 0.38
    dimethoxymethane 20.21
    ethylene carbonate 1.03
    cyrene 12.22
    2-ethoxyethyl acetate 0.7
    2-ethylhexyl acetate 0.26
    1,2,4-trichlorobenzene 0.17
    4-methylpyridine 0.79
    dibutyl ether 0.26
    2,6-dimethyl-4-heptanol 0.64
    DEF 9.24
    dimethyl isosorbide 6.43
    tetrachloroethylene 0.73
    eugenol 2.17
    triacetin 1.06
    span 80 3.77
    1,4-butanediol 12.22
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 0.5
    methyl formate 21.33
    2-methyl-1-butanol 1.41
    n-decane 0.11
    butyronitrile 0.26
    3,7-dimethyl-1-octanol 0.41
    1-chlorooctane 0.15
    1-chlorotetradecane 0.08
    n-nonane 0.11
    undecane 0.08
    tert-butylcyclohexane 0.06
    cyclooctane 0.38
    cyclopentanol 4.18
    tetrahydropyran 1.16
    tert-amyl methyl ether 1.24
    2,5,8-trioxanonane 10.11
    1-hexene 0.08
    2-isopropoxyethanol 4.76
    2,2,2-trifluoroethanol 24.9
    methyl butyrate 0.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction