Xylidine

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  • Identifiers

    CAS number
    1300-73-8

    Molecular formula
    C48H66N6

    SMILES
    CC1=CC(=C(C=C1)N)C.CC1=CC(=C(C=C1)C)N.CC1=C(C(=CC=C1)N)C.CC1=C(C(=CC=C1)C)N.CC1=C(C=C(C=C1)N)C.CC1=CC(=CC(=C1)N)C

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Animal 46.01%
    Phenolic 44.24%
    Sweet 38.44%
    Leathery 36.59%
    Floral 34.93%
    Smoky 33.24%
    Musty 31.74%
    Woody 30.46%
    Burnt 29.9%
    Medicinal 26.74%

     

    Flavor
    Phenolic 46.02%
    Medicinal 38.36%
    Meaty 29.92%
    Plastic 28.41%
    Smoke 24.75%
    Naphthyl 24.17%
    Woody 23.94%
    Smoky 23.73%
    Roasted 23.72%
    Guaiacol 23.69%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 0.005 [ppm]. Odor threshold from CHEMINFO
    • Odor threshold in air= 1.00X10+12 molecules/cc.
    • Threshold for xylidine is 0.0240 mg/cu m

  • Properties

    pKa est.
    5.05 (weak acid)

    Molecular weight
    727.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Melting point expt.

    • -33 °F (NIOSH, 2024)
    • -36 °C
    • -33 °F

    Boiling point

    • 415 to 439 °F at 760 mmHg (NIOSH, 2024)
    • 213-226 °C
    • 216-228 °C
    • 415-439 °F

    Flash point

    • 93.6 ˚C est.
    • 206 °F (2,3-) (NIOSH, 2024)
    • 206 °F
    • 90-98 °C c.c.
    • 206 °F (2,3-)

    Solubility expt.

    • Slight (NIOSH, 2024)
    • Slightly sol in water; sol in alcohol
    • Sparingly soluble in water, soluble in alcohol.
    • Soluble in ether.
    • Solubility in water: poor
    • Slight

  • Synonyms

    • 1300-73-8
    • XYLIDINE
    • aminoxylene
    • Xilidine
    • Xylidinen
    • Xylidines
    • Xylidine isomers
    • Aminodimethylbenzene
    • RefChem:53412
    • UNII-0V872Q19HT
    • HSDB 6464
    • 0V872Q19HT
    • EINECS 215-091-4
    • AI3-24178-X (USDA)
    • Xylidine mixed ortho-meta-para isomers
    • EC 215-091-4
    • Dimethylaminobenzene
    • MFCD00167021
    • 2,3-dimethylaniline;2,4-dimethylaniline;2,5-dimethylaniline;2,6-dimethylaniline;3,4-dimethylaniline;3,5-dimethylaniline
    • CDULGHZNHURECF-UHFFFAOYSA-N
    • C48H66N6
    • AKOS015914121
    • 1300-73-8

  • Applications

    Xylidine (CAS 1300-73-8) is primarily used as an intermediate in the synthesis of dyes and pigments, particularly azo dyes and colorants; it also serves as a precursor for chemicals used in the rubber industry, including accelerators and vulcanization systems; it is a precursor for certain pharmaceutical and agrochemical intermediates; in addition, xylidine is employed in coatings and inks as a color precursor for decorative and functional formulations; it may also be used in the synthesis of polymer and plastics additives under appropriate regulatory controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 588.91
    methanol 703.11
    isopropanol 354.5
    water 6.08
    ethyl acetate 631.03
    n-propanol 440.66
    acetone 739.55
    n-butanol 365.1
    acetonitrile 808.5
    DMF 544.57
    toluene 117.93
    isobutanol 238.86
    1,4-dioxane 910.81
    methyl acetate 611.23
    THF 1392.24
    2-butanone 583.48
    n-pentanol 232.55
    sec-butanol 246.11
    n-hexane 37.3
    ethylene glycol 67.09
    NMP 307.48
    cyclohexane 19.77
    DMSO 502.4
    n-butyl acetate 520.74
    n-octanol 129.53
    chloroform 659.12
    n-propyl acetate 273.2
    acetic acid 367.2
    dichloromethane 534.13
    cyclohexanone 462.34
    propylene glycol 81.35
    isopropyl acetate 278.35
    DMAc 350.28
    2-ethoxyethanol 342.01
    isopentanol 248.25
    n-heptane 46.06
    ethyl formate 480.64
    1,2-dichloroethane 363.68
    n-hexanol 451.27
    2-methoxyethanol 533.77
    isobutyl acetate 151.26
    tetrachloromethane 170.09
    n-pentyl acetate 168.52
    transcutol 406.85
    n-heptanol 196.05
    ethylbenzene 59.2
    MIBK 229.53
    2-propoxyethanol 675.99
    tert-butanol 391.54
    MTBE 441.95
    2-butoxyethanol 296.33
    propionic acid 289.61
    o-xylene 66.28
    formic acid 185.51
    diethyl ether 531.85
    m-xylene 86.84
    p-xylene 71.2
    chlorobenzene 182.65
    dimethyl carbonate 182.77
    n-octane 19.06
    formamide 290.47
    cyclopentanone 728.84
    2-pentanone 500.26
    anisole 168.73
    cyclopentyl methyl ether 428.91
    gamma-butyrolactone 792.9
    1-methoxy-2-propanol 367.91
    pyridine 397.54
    3-pentanone 326.98
    furfural 449.84
    n-dodecane 12.84
    diethylene glycol 295.5
    diisopropyl ether 116.63
    tert-amyl alcohol 269.47
    acetylacetone 370.59
    n-hexadecane 14.24
    acetophenone 117.27
    methyl propionate 401.52
    isopentyl acetate 321.5
    trichloroethylene 571.72
    n-nonanol 110.01
    cyclohexanol 152.78
    benzyl alcohol 110.21
    2-ethylhexanol 204.11
    isooctanol 138.53
    dipropyl ether 333.76
    1,2-dichlorobenzene 139.7
    ethyl lactate 83.6
    propylene carbonate 332.11
    n-methylformamide 479.15
    2-pentanol 206.61
    n-pentane 31.51
    1-propoxy-2-propanol 395.42
    1-methoxy-2-propyl acetate 298.21
    2-(2-methoxypropoxy) propanol 134.42
    mesitylene 55.69
    ε-caprolactone 347.73
    p-cymene 56.6
    epichlorohydrin 781.79
    1,1,1-trichloroethane 434.67
    2-aminoethanol 157.56
    morpholine-4-carbaldehyde 413.84
    sulfolane 488.43
    2,2,4-trimethylpentane 20.68
    2-methyltetrahydrofuran 715.97
    n-hexyl acetate 194.62
    isooctane 20.65
    2-(2-butoxyethoxy)ethanol 226.99
    sec-butyl acetate 142.67
    tert-butyl acetate 264.63
    decalin 17.28
    glycerin 116.39
    diglyme 425.61
    acrylic acid 187.74
    isopropyl myristate 72.35
    n-butyric acid 500.65
    acetyl acetate 262.27
    di(2-ethylhexyl) phthalate 59.22
    ethyl propionate 212.03
    nitromethane 958.01
    1,2-diethoxyethane 308.47
    benzonitrile 167.48
    trioctyl phosphate 57.66
    1-bromopropane 236.92
    gamma-valerolactone 750.75
    n-decanol 84.47
    triethyl phosphate 78.59
    4-methyl-2-pentanol 121.03
    propionitrile 504.21
    vinylene carbonate 292.01
    1,1,2-trichlorotrifluoroethane 289.58
    DMS 115.95
    cumene 47.35
    2-octanol 108.31
    2-hexanone 292.75
    octyl acetate 102.8
    limonene 90.1
    1,2-dimethoxyethane 583.49
    ethyl orthosilicate 83.91
    tributyl phosphate 62.95
    diacetone alcohol 242.8
    N,N-dimethylaniline 98.11
    acrylonitrile 474.95
    aniline 165.81
    1,3-propanediol 279.63
    bromobenzene 173.1
    dibromomethane 355.13
    1,1,2,2-tetrachloroethane 409.79
    2-methyl-cyclohexyl acetate 129.95
    tetrabutyl urea 76.21
    diisobutyl methanol 104.69
    2-phenylethanol 182.4
    styrene 68.68
    dioctyl adipate 75.06
    dimethyl sulfate 199.05
    ethyl butyrate 252.76
    methyl lactate 127.84
    butyl lactate 103.31
    diethyl carbonate 131.44
    propanediol butyl ether 127.73
    triethyl orthoformate 149.05
    p-tert-butyltoluene 61.0
    methyl 4-tert-butylbenzoate 121.62
    morpholine 760.58
    tert-butylamine 227.45
    n-dodecanol 64.27
    dimethoxymethane 521.92
    ethylene carbonate 281.46
    cyrene 119.14
    2-ethoxyethyl acetate 218.68
    2-ethylhexyl acetate 232.4
    1,2,4-trichlorobenzene 141.87
    4-methylpyridine 376.02
    dibutyl ether 148.28
    2,6-dimethyl-4-heptanol 104.69
    DEF 354.01
    dimethyl isosorbide 242.28
    tetrachloroethylene 282.06
    eugenol 120.93
    triacetin 104.6
    span 80 127.65
    1,4-butanediol 94.03
    1,1-dichloroethane 469.37
    2-methyl-1-pentanol 171.02
    methyl formate 409.36
    2-methyl-1-butanol 219.5
    n-decane 24.02
    butyronitrile 546.12
    3,7-dimethyl-1-octanol 109.06
    1-chlorooctane 87.57
    1-chlorotetradecane 31.53
    n-nonane 23.31
    undecane 16.84
    tert-butylcyclohexane 25.36
    cyclooctane 10.55
    cyclopentanol 214.85
    tetrahydropyran 639.99
    tert-amyl methyl ether 240.25
    2,5,8-trioxanonane 227.39
    1-hexene 140.05
    2-isopropoxyethanol 221.97
    2,2,2-trifluoroethanol 150.33
    methyl butyrate 280.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction