Wogonin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    632-85-9

    Molecular formula
    C16H12O5

    SMILES
    COC1=C(C=C(C2=C1OC(=CC2=O)C3=CC=CC=C3)O)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 54.53%
    Odorless 40.79%
    Burnt 34.52%
    Spicy 30.55%
    Smoky 27.53%
    Fruity 26.44%
    Balsamic 25.89%
    Vanilla 25.46%
    Medicinal 25.04%
    Sweet 24.05%

     

    Flavor
    Bitter 90.16%
    Parsley 20.57%
    Lovage 20.46%
    Cedarleaf 20.42%
    Eugenol 20.13%
    Very strong 19.9%
    Curry 19.83%
    Sweet-like 19.82%
    Indole 19.79%
    Ethyl benzoate 19.64%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    8.9 (weak base)

    Molecular weight
    284.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    719°C

    Flash point

    • 192.95 ˚C est.

  • Synonyms

    • Wogonin
    • 632-85-9
    • 5,7-Dihydroxy-8-methoxyflavone
    • Vogonin
    • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-
    • 5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one
    • Norwogonin 8-methyl ether
    • 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one
    • FLAVONE, 5,7-DIHYDROXY-8-METHOXY-
    • POK93PO28W
    • DTXSID70212557
    • CHEBI:10043
    • RefChem:194946
    • DTXCID00135048
    • 5,7-dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one
    • MFCD00017736
    • 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one
    • CHEMBL16171
    • ST077088
    • UNII-POK93PO28W
    • BRN 0287152
    • wagonin
    • Wogonin hydrate
    • Wogonin?
    • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-; Flavone, 5,7-dihydroxy-8-methoxy- (7CI,8CI); Wogonin (6CI); 5,7-Dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one; 5,7-Dihydroxy-8-methoxyflavone
    • Wogonin (Standard)
    • Wogonin, S. baicalensis
    • MLS002473006
    • SCHEMBL139083
    • orb1304829
    • SCHEMBL29632729
    • HY-N0400R
    • 5,7-dihydroxy-8-methoxy flavone
    • GLXC-03816
    • HMS2270G08
    • HY-N0400
    • BDBM50140257
    • HB4126
    • LMPK12111330
    • MFCD12828871
    • MSK158723
    • NSC717845
    • s4743
    • AKOS015917860
    • CCG-208499
    • CS-3959
    • EBC-224037
    • FW09374
    • NSC-717845
    • NCGC00247464-01
    • NCGC00247464-08
    • AC-20338
    • AC-32550
    • AS-70103
    • NCI60_040649
    • SMR001397111
    • DB-054448
    • NS00018017
    • W0010
    • 632W859
    • Q409606
    • SR-05000002216
    • SR-05000002216-2
    • 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one(Wogonin)
    • WogoninVogonin; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-; Norwogonin 8-methyl ether
    • 632-85-9

  • Applications

    Wogonin (CAS 632-85-9), a flavone from Scutellaria baicalensis, is primarily used as a natural product in pharmaceutical research and development. It serves as a lead compound and a pharmacological probe in chemical biology studies, is used as a reference material for quality control of botanical extracts containing Scutellaria, and is an intermediate or starting material for the synthesis of related flavones for research and development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.22
    methanol 0.93
    isopropanol 1.1
    water 0.0
    ethyl acetate 2.42
    n-propanol 1.48
    acetone 2.33
    n-butanol 1.37
    acetonitrile 1.37
    DMF 34.04
    toluene 0.4
    isobutanol 1.29
    1,4-dioxane 5.09
    methyl acetate 3.63
    THF 38.93
    2-butanone 4.2
    n-pentanol 1.24
    sec-butanol 1.38
    n-hexane 0.01
    ethylene glycol 3.59
    NMP 66.23
    cyclohexane 0.01
    DMSO 156.07
    n-butyl acetate 3.43
    n-octanol 0.92
    chloroform 0.58
    n-propyl acetate 3.14
    acetic acid 7.62
    dichloromethane 1.29
    cyclohexanone 10.03
    propylene glycol 3.93
    isopropyl acetate 2.34
    DMAc 48.68
    2-ethoxyethanol 9.28
    isopentanol 1.99
    n-heptane 0.03
    ethyl formate 2.07
    1,2-dichloroethane 2.39
    n-hexanol 1.27
    2-methoxyethanol 27.59
    isobutyl acetate 2.21
    tetrachloromethane 0.07
    n-pentyl acetate 2.47
    transcutol 67.37
    n-heptanol 1.25
    ethylbenzene 0.3
    MIBK 2.8
    2-propoxyethanol 13.67
    tert-butanol 2.27
    MTBE 1.05
    2-butoxyethanol 7.12
    propionic acid 4.78
    o-xylene 0.47
    formic acid 4.67
    diethyl ether 0.5
    m-xylene 0.42
    p-xylene 0.41
    chlorobenzene 0.79
    dimethyl carbonate 6.38
    n-octane 0.01
    formamide 11.63
    cyclopentanone 23.78
    2-pentanone 2.75
    anisole 2.05
    cyclopentyl methyl ether 5.89
    gamma-butyrolactone 36.54
    1-methoxy-2-propanol 19.85
    pyridine 6.51
    3-pentanone 2.09
    furfural 27.86
    n-dodecane 0.03
    diethylene glycol 20.3
    diisopropyl ether 0.27
    tert-amyl alcohol 2.23
    acetylacetone 8.68
    n-hexadecane 0.04
    acetophenone 4.49
    methyl propionate 5.19
    isopentyl acetate 4.16
    trichloroethylene 6.0
    n-nonanol 1.13
    cyclohexanol 2.38
    benzyl alcohol 3.66
    2-ethylhexanol 1.4
    isooctanol 1.33
    dipropyl ether 1.38
    1,2-dichlorobenzene 1.15
    ethyl lactate 5.23
    propylene carbonate 10.97
    n-methylformamide 8.96
    2-pentanol 0.94
    n-pentane 0.01
    1-propoxy-2-propanol 9.92
    1-methoxy-2-propyl acetate 11.24
    2-(2-methoxypropoxy) propanol 13.36
    mesitylene 0.28
    ε-caprolactone 12.47
    p-cymene 0.77
    epichlorohydrin 42.36
    1,1,1-trichloroethane 0.64
    2-aminoethanol 4.39
    morpholine-4-carbaldehyde 45.2
    sulfolane 101.75
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 9.02
    n-hexyl acetate 3.28
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 16.1
    sec-butyl acetate 2.23
    tert-butyl acetate 4.35
    decalin 0.04
    glycerin 19.44
    diglyme 34.0
    acrylic acid 7.73
    isopropyl myristate 1.66
    n-butyric acid 4.39
    acetyl acetate 2.71
    di(2-ethylhexyl) phthalate 3.18
    ethyl propionate 3.07
    nitromethane 20.27
    1,2-diethoxyethane 6.05
    benzonitrile 2.91
    trioctyl phosphate 2.02
    1-bromopropane 0.43
    gamma-valerolactone 44.22
    n-decanol 0.89
    triethyl phosphate 3.81
    4-methyl-2-pentanol 1.03
    propionitrile 1.71
    vinylene carbonate 8.74
    1,1,2-trichlorotrifluoroethane 40.57
    DMS 7.98
    cumene 0.33
    2-octanol 0.71
    2-hexanone 2.88
    octyl acetate 2.13
    limonene 1.04
    1,2-dimethoxyethane 15.65
    ethyl orthosilicate 3.21
    tributyl phosphate 2.65
    diacetone alcohol 13.52
    N,N-dimethylaniline 2.11
    acrylonitrile 4.2
    aniline 2.54
    1,3-propanediol 7.49
    bromobenzene 0.58
    dibromomethane 0.46
    1,1,2,2-tetrachloroethane 4.83
    2-methyl-cyclohexyl acetate 4.21
    tetrabutyl urea 4.41
    diisobutyl methanol 1.27
    2-phenylethanol 4.09
    styrene 0.32
    dioctyl adipate 4.14
    dimethyl sulfate 23.95
    ethyl butyrate 3.51
    methyl lactate 11.86
    butyl lactate 5.11
    diethyl carbonate 3.01
    propanediol butyl ether 7.92
    triethyl orthoformate 4.11
    p-tert-butyltoluene 0.77
    methyl 4-tert-butylbenzoate 7.73
    morpholine 13.18
    tert-butylamine 0.71
    n-dodecanol 0.69
    dimethoxymethane 15.22
    ethylene carbonate 5.67
    cyrene 18.2
    2-ethoxyethyl acetate 6.69
    2-ethylhexyl acetate 3.07
    1,2,4-trichlorobenzene 2.39
    4-methylpyridine 4.63
    dibutyl ether 1.27
    2,6-dimethyl-4-heptanol 1.27
    DEF 7.97
    dimethyl isosorbide 29.43
    tetrachloroethylene 1.94
    eugenol 8.4
    triacetin 8.72
    span 80 8.6
    1,4-butanediol 2.04
    1,1-dichloroethane 0.52
    2-methyl-1-pentanol 1.89
    methyl formate 6.59
    2-methyl-1-butanol 1.87
    n-decane 0.04
    butyronitrile 1.3
    3,7-dimethyl-1-octanol 1.48
    1-chlorooctane 0.35
    1-chlorotetradecane 0.2
    n-nonane 0.03
    undecane 0.04
    tert-butylcyclohexane 0.04
    cyclooctane 0.01
    cyclopentanol 4.38
    tetrahydropyran 2.63
    tert-amyl methyl ether 1.48
    2,5,8-trioxanonane 25.25
    1-hexene 0.06
    2-isopropoxyethanol 6.17
    2,2,2-trifluoroethanol 3.68
    methyl butyrate 4.17

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction