Vincristine Sulfate

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  • Identifiers

    CAS number
    2068-78-2

    Molecular formula
    C46H58N4O14S

    SMILES
    CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 65.52%
    Cooling 21.13%
    Popcorn 18.27%
    Roasted 18.11%
    Animal 17.68%
    Savory 17.39%
    Nutty 17.36%
    Milky 17.23%
    Grape 16.65%
    Fresh 16.18%

     

    Flavor
    Bitter 94.96%
    Bland 25.58%
    Odorless 25.24%
    Sweet-like 21.12%
    Cedarleaf 20.26%
    Heather 18.36%
    Parsley 18.23%
    Nitrile 18.21%
    Broom 18.2%
    Lovage 18.14%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    5.33 (weak acid)

    Molecular weight
    923.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    1428°C

    Melting point expt.

    • 531 °F approximately (NTP, 1992)

    Flash point

    • 309.62 ˚C est.

    Solubility expt.

    • greater than or equal to 10 mg/mL at 75 °F (NTP, 1992)

  • Synonyms

    • Vincristine sulfate
    • 2068-78-2
    • Vincrisul
    • Onkovin
    • Vincristine sulphate
    • VCR sulfate
    • Kyocristine
    • Lilly 37231
    • Novopharm
    • Leurocristine sulfate
    • Vincristini sulfas
    • NSC 67574
    • Vincrex
    • Leurocristine, sulfate (1:1) (salt)
    • Vincristine, sulfate
    • Leurocristine, sulfate
    • Vincasar PFS
    • NSC67574
    • Vincristine Sulfate PFS
    • Marqibo Kit
    • DTXSID8044331
    • LILLY-37231
    • Leurocristine sulfate (1:1) (salt)
    • Vincasar
    • Vincaleukoblastine, 22-oxo-, sulfate (1:1) (salt)
    • CHEBI:79401
    • Vincosid
    • PFS, Vincasar
    • Sulfate, Vincristine
    • RefChem:56476
    • DTXCID6024331
    • 22-OXOVINCALEUKOBLASTINE SULFATE (1:1) (SALT)
    • 218-190-0
    • Methyl (3aR,4R,5S,5aR,10bR,13aR)-4-acetoxy-3a-ethyl-9-((5S,7R,9S)-5-ethyl-5-hydroxy-9-methoxycarbonyl-1,4,5,6,7,8,9,10-octahydro-3,7-methano-3-azacycloundecino(5,4-b)indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino(8,1-cd)carbazole-5-carboxylate monosulfate
    • T5IRO3534A
    • Oncovin
    • Vincaleukoblastine, 22-oxo-, sulfate (1:1)
    • Marqibo
    • rel-Vincristine Sulfate
    • C46H58N4O14S
    • MFCD08706469
    • Vincristine (sulfate)
    • 1217704-93-2
    • MLS002702994
    • 22-oxovincaleukoblastine sulfate
    • Oncovin (Lilly)
    • Vincasar (TN)
    • Marqibo (TN)
    • Oncovin (TN)
    • Vincrex (TN)
    • Vincristine sulphate Salt
    • Vincristine sulfate liposome
    • SCHEMBL3710
    • SCHEMBL3998
    • Leurocristine sulfate (1:1)
    • CHEMBL501867
    • orb1309169
    • SCHEMBL29895946
    • HY-N0488R
    • Leurocristine (sulfate);NSC-67574 (sulfate);22-Oxovincaleukoblastine (sulfate)
    • Vincristine (sulfate) (Standard)
    • Vincristine sulfate (JP18/USP)
    • HMS3414L13
    • HMS3678L11
    • MFCD27980578
    • 22-Oxovincaleukoblastine sulfate salt
    • AKOS015895862
    • EBC-609587
    • FV28696
    • NS00076429
    • V0129
    • LCR
    • VCR
    • D02197
    • Sulfuric acid--22-oxovincaleukoblastine (1/1)
    • 068V782
    • (2ALPHA,2'BETA,3ALPHA,4ALPHA,5BETA,19BETA)-22-OXOVINCALEUKOBLASTINE SULFATE (1:1)
    • methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5(10),6,8-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate; sulfuric acid
    • methyl (1R,9R,10S,11R,12R,19R)-11-acetoxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
    • methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
    • methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate sulfate
    • 2068-78-2

  • Applications

    Vincristine Sulfate (CAS 2068-78-2), a vinca alkaloid, is commonly regarded as a research tool and analytical reference in pharmaceutical chemistry and molecular biology. In pharmaceutical research and development, it is evaluated for drug discovery and formulation studies. As a cytotoxic agent used in laboratory experiments, it helps elucidate mechanisms of cell division inhibition and the impact on microtubules in mechanistic studies. In analytical chemistry, vincristine sulfate serves as a reference standard and quantification anchor for methods such as HPLC or LC-MS, supporting quality control and method validation. It is also used as an educational reagent in bioscience and pharmaceutical training to illustrate mechanism and analytical techniques. Handling and use are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.61
    methanol 31.55
    isopropanol 5.96
    water 0.27
    ethyl acetate 28.82
    n-propanol 8.77
    acetone 33.38
    n-butanol 8.17
    acetonitrile 20.19
    DMF 102.88
    toluene 3.34
    isobutanol 5.4
    1,4-dioxane 17.01
    methyl acetate 39.86
    THF 37.97
    2-butanone 31.68
    n-pentanol 5.35
    sec-butanol 5.51
    n-hexane 0.11
    ethylene glycol 8.87
    NMP 192.66
    cyclohexane 0.17
    DMSO 54.57
    n-butyl acetate 10.64
    n-octanol 1.81
    chloroform 95.74
    n-propyl acetate 14.12
    acetic acid 247.04
    dichloromethane 68.28
    cyclohexanone 42.27
    propylene glycol 10.73
    isopropyl acetate 12.29
    DMAc 143.92
    2-ethoxyethanol 25.41
    isopentanol 5.65
    n-heptane 0.09
    ethyl formate 36.45
    1,2-dichloroethane 24.92
    n-hexanol 3.43
    2-methoxyethanol 54.84
    isobutyl acetate 6.27
    tetrachloromethane 9.14
    n-pentyl acetate 9.88
    transcutol 17.41
    n-heptanol 2.76
    ethylbenzene 1.18
    MIBK 8.24
    2-propoxyethanol 26.17
    tert-butanol 4.17
    MTBE 2.75
    2-butoxyethanol 16.99
    propionic acid 49.6
    o-xylene 1.72
    formic acid 126.71
    diethyl ether 4.48
    m-xylene 1.74
    p-xylene 1.7
    chlorobenzene 9.16
    dimethyl carbonate 41.4
    n-octane 0.05
    formamide 100.98
    cyclopentanone 73.39
    2-pentanone 22.64
    anisole 3.87
    cyclopentyl methyl ether 9.03
    gamma-butyrolactone 134.81
    1-methoxy-2-propanol 33.3
    pyridine 29.15
    3-pentanone 16.68
    furfural 107.98
    n-dodecane 0.05
    diethylene glycol 27.31
    diisopropyl ether 0.77
    tert-amyl alcohol 4.65
    acetylacetone 36.25
    n-hexadecane 0.05
    acetophenone 10.91
    methyl propionate 37.35
    isopentyl acetate 6.92
    trichloroethylene 105.53
    n-nonanol 1.87
    cyclohexanol 6.21
    benzyl alcohol 9.94
    2-ethylhexanol 1.73
    isooctanol 1.94
    dipropyl ether 2.0
    1,2-dichlorobenzene 9.77
    ethyl lactate 17.03
    propylene carbonate 69.62
    n-methylformamide 84.81
    2-pentanol 3.84
    n-pentane 0.15
    1-propoxy-2-propanol 13.21
    1-methoxy-2-propyl acetate 17.34
    2-(2-methoxypropoxy) propanol 10.14
    mesitylene 0.74
    ε-caprolactone 53.62
    p-cymene 0.75
    epichlorohydrin 89.28
    1,1,1-trichloroethane 24.79
    2-aminoethanol 13.22
    morpholine-4-carbaldehyde 105.38
    sulfolane 141.69
    2,2,4-trimethylpentane 0.1
    2-methyltetrahydrofuran 16.13
    n-hexyl acetate 7.81
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 12.27
    sec-butyl acetate 7.01
    tert-butyl acetate 7.07
    decalin 0.1
    glycerin 34.0
    diglyme 22.24
    acrylic acid 88.2
    isopropyl myristate 1.7
    n-butyric acid 61.35
    acetyl acetate 32.8
    di(2-ethylhexyl) phthalate 4.71
    ethyl propionate 12.61
    nitromethane 277.69
    1,2-diethoxyethane 4.61
    benzonitrile 12.72
    trioctyl phosphate 3.13
    1-bromopropane 7.0
    gamma-valerolactone 153.3
    n-decanol 1.15
    triethyl phosphate 4.92
    4-methyl-2-pentanol 2.02
    propionitrile 14.3
    vinylene carbonate 88.8
    1,1,2-trichlorotrifluoroethane 148.97
    DMS 14.23
    cumene 0.73
    2-octanol 1.44
    2-hexanone 11.62
    octyl acetate 3.46
    limonene 1.0
    1,2-dimethoxyethane 22.57
    ethyl orthosilicate 3.59
    tributyl phosphate 3.55
    diacetone alcohol 17.72
    N,N-dimethylaniline 2.81
    acrylonitrile 33.51
    aniline 9.01
    1,3-propanediol 23.55
    bromobenzene 7.44
    dibromomethane 27.62
    1,1,2,2-tetrachloroethane 60.64
    2-methyl-cyclohexyl acetate 5.92
    tetrabutyl urea 5.01
    diisobutyl methanol 0.73
    2-phenylethanol 8.27
    styrene 1.6
    dioctyl adipate 4.23
    dimethyl sulfate 76.16
    ethyl butyrate 7.86
    methyl lactate 48.71
    butyl lactate 13.5
    diethyl carbonate 6.42
    propanediol butyl ether 13.8
    triethyl orthoformate 4.97
    p-tert-butyltoluene 0.61
    methyl 4-tert-butylbenzoate 9.67
    morpholine 25.73
    tert-butylamine 1.22
    n-dodecanol 0.72
    dimethoxymethane 39.09
    ethylene carbonate 55.24
    cyrene 31.47
    2-ethoxyethyl acetate 19.23
    2-ethylhexyl acetate 5.43
    1,2,4-trichlorobenzene 15.95
    4-methylpyridine 24.13
    dibutyl ether 1.14
    2,6-dimethyl-4-heptanol 0.73
    DEF 33.52
    dimethyl isosorbide 18.67
    tetrachloroethylene 39.44
    eugenol 11.66
    triacetin 15.32
    span 80 10.15
    1,4-butanediol 9.44
    1,1-dichloroethane 24.34
    2-methyl-1-pentanol 4.16
    methyl formate 79.18
    2-methyl-1-butanol 6.0
    n-decane 0.08
    butyronitrile 11.36
    3,7-dimethyl-1-octanol 1.42
    1-chlorooctane 0.66
    1-chlorotetradecane 0.23
    n-nonane 0.07
    undecane 0.06
    tert-butylcyclohexane 0.07
    cyclooctane 0.06
    cyclopentanol 11.31
    tetrahydropyran 9.25
    tert-amyl methyl ether 3.01
    2,5,8-trioxanonane 12.66
    1-hexene 0.69
    2-isopropoxyethanol 12.53
    2,2,2-trifluoroethanol 114.41
    methyl butyrate 18.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction