Vinblastine Sulfate

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  • Identifiers

    CAS number
    143-67-9

    Molecular formula
    C46H60N4O13S

    SMILES
    CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 61.96%
    Cooling 21.98%
    Animal 19.79%
    Grape 17.86%
    Fresh 17.82%
    Milky 17.5%
    Savory 17.11%
    Nutty 16.99%
    Roasted 16.94%
    Popcorn 16.22%

     

    Flavor
    Bitter 94.3%
    Bland 25.82%
    Odorless 24.53%
    Sweet-like 21.56%
    Cedarleaf 20.58%
    Heather 18.52%
    Parsley 18.48%
    Broom 18.36%
    Nitrile 18.28%
    Lovage 18.21%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    4.88 (weak acid)

    Molecular weight
    909.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    786°C

    Melting point expt.

    • 543 to 545 °F (NTP, 1992)

    Flash point

    • 302.64 ˚C est.

    Solubility expt.

    • greater than or equal to 10 mg/mL at 76.1 °F (NTP, 1992)

  • Synonyms

    • Vinblastine sulfate
    • 143-67-9
    • Velsar
    • Alkaban-aq
    • Vinblastine sulphate
    • VLB monosulfate
    • 29060-LE
    • Vincaleucoblastine sulfate
    • Vinblastini sulfas
    • NSC-49842
    • N00W22YO2B
    • Vincaleukoblastine, sulfate (1:1) (salt)
    • 29060LE
    • 29060 LE
    • NSC 49842
    • DTXSID601017133
    • CHEBI:9984
    • Vinblast,lederle
    • Sulfate, Vinblastine
    • RefChem:56475
    • DTXCID7027831
    • 205-606-0
    • Methyl (3aR,4R,5S,5aR,10bR,13aR)-4-acetoxy-3a-ethyl-9-((5S,7R,9S)-5-ethyl-5-hydroxy-9-methoxycarbonyl-1,4,5,6,7,8,9,10-octahydro-3,7-methano-3-azacycloundecino(5,4-b)indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino(8,1-cd)carbazole-5-carboxylate monosulfate
    • NSC49842
    • Vincaleukoblastine sulfate (1:1) (salt)
    • Velban
    • Velbe
    • EXAL
    • Vinblastine (sulfate)
    • MLS000863275
    • Belvan, VLB
    • SMR000058844
    • DSSTox_CID_27831
    • DSSTox_RID_82594
    • DSSTox_GSID_47853
    • Uniblastin
    • Rozevin sulfate
    • CAS-18556-44-0
    • Vincaleukoblastine, sulfate
    • UNII-N00W22YO2B
    • CCRIS 2584
    • MFCD08706468
    • CHEMBL378544
    • NCGC00095285-01
    • Vinblastine sulfate; methyl (3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(5S,7R,9S)5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate sulfate
    • EINECS 205-606-0
    • Vinblastine sulfate [USAN:USP:JAN]
    • Vinblastine Sulfate RS
    • Vinblastine sulfate CRS
    • Opera_ID_960
    • AI3-52943
    • NCGC00181127-01
    • SCHEMBL3549
    • MLS000069550
    • MLS002153253
    • MLS002207069
    • SCHEMBL6340124
    • SCHEMBL29357903
    • VINBLASTINE SULFATE [MI]
    • VINBLASTINE SULFATE [JAN]
    • Vinblastine (sulfate) (Standard)
    • HMS2235E07
    • HMS3403N09
    • VINBLASTINE SULFATE [IARC]
    • VINBLASTINE SULFATE [USAN]
    • VINBLASTINE SULFATE [VANDF]
    • VINBLASTINE SULFATE [MART.]
    • Tox21_111498
    • Tox21_112735
    • AC-821
    • EBC-09046
    • HY-13780R
    • VINBLASTINE SULFATE [USP-RS]
    • VINBLASTINE SULFATE [WHO-DD]
    • VINBLASTINE SULFATE [WHO-IP]
    • AKOS015960580
    • Tox21_111498_1
    • Tox21_112735_1
    • CS-1365
    • NCGC00263548-01
    • NCGC00344583-01
    • VINBLASTINE SULFATE [ORANGE BOOK]
    • HY-13780
    • SY072852
    • VINBLASTINE SULFATE [EP MONOGRAPH]
    • VINBLASTINI SULFAS [WHO-IP LATIN]
    • Vinblastine Sulfate (10 mg/mL in DMSO)
    • VINBLASTINE SULFATE [USP MONOGRAPH]
    • NS00076398
    • EN300-1268144
    • Sulfuric acid--12beta-vincaleukoblastine (1/1)
    • 143V679
    • SR-01000000155
    • Vinblastine sulfate salt, powder, >=96% (HPLC)
    • SR-01000000155-7
    • Q27077057
    • Z3014322079
    • Vinblastine sulfate, European Pharmacopoeia (EP) Reference Standard
    • Vinblastine sulfate, United States Pharmacopeia (USP) Reference Standard
    • (3aR,3a1R,4R,5S,5aR,10bR)-methyl 4-acetoxy-3a-ethyl-9-((5S,7R,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-metho
    • methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0?,??.0?,??]nonadeca-4(12),5(10),6,8-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0?,?.0?,?.0??,??]nonadeca-2(7),3,5,13-tetraene-10-carboxylate; sulfuric acid
    • methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5(10),6,8-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate; sulfuric acid
    • methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
    • xy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate sulfate
    • 143-67-9

  • Applications

    Vinblastine Sulfate (CAS 143-67-9) is used primarily in laboratory-scale pharmaceutical research and development and as a reference standard. In analytical quality control, it is commonly used as a reference standard for vinca alkaloids in methods such as HPLC/LC-MS. It also serves as a lab reagent in cellular biology studies to evaluate tubulin inhibition mechanisms and effects on cell growth. Additionally, it can function as an intermediate or starting material in the synthesis and purification of related vinca alkaloids for research purposes. These applications are conducted in accordance with local regulations and the scope of a given formulation or procedure.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.51
    methanol 23.7
    isopropanol 7.94
    water 0.18
    ethyl acetate 32.9
    n-propanol 12.05
    acetone 41.55
    n-butanol 11.43
    acetonitrile 19.59
    DMF 83.5
    toluene 6.01
    isobutanol 8.21
    1,4-dioxane 22.85
    methyl acetate 42.34
    THF 48.74
    2-butanone 41.43
    n-pentanol 8.66
    sec-butanol 8.08
    n-hexane 0.22
    ethylene glycol 7.35
    NMP 169.3
    cyclohexane 0.38
    DMSO 51.43
    n-butyl acetate 14.06
    n-octanol 3.13
    chloroform 99.45
    n-propyl acetate 17.65
    acetic acid 188.17
    dichloromethane 62.79
    cyclohexanone 59.9
    propylene glycol 9.33
    isopropyl acetate 16.35
    DMAc 136.96
    2-ethoxyethanol 29.28
    isopentanol 8.82
    n-heptane 0.18
    ethyl formate 34.63
    1,2-dichloroethane 29.21
    n-hexanol 5.87
    2-methoxyethanol 49.31
    isobutyl acetate 9.45
    tetrachloromethane 12.51
    n-pentyl acetate 14.41
    transcutol 21.93
    n-heptanol 4.74
    ethylbenzene 2.13
    MIBK 12.53
    2-propoxyethanol 32.26
    tert-butanol 6.65
    MTBE 4.71
    2-butoxyethanol 22.21
    propionic acid 47.89
    o-xylene 3.02
    formic acid 78.14
    diethyl ether 6.98
    m-xylene 3.11
    p-xylene 3.08
    chlorobenzene 12.69
    dimethyl carbonate 34.66
    n-octane 0.1
    formamide 65.61
    cyclopentanone 85.99
    2-pentanone 30.46
    anisole 5.44
    cyclopentyl methyl ether 13.23
    gamma-butyrolactone 122.73
    1-methoxy-2-propanol 34.39
    pyridine 34.89
    3-pentanone 23.26
    furfural 90.66
    n-dodecane 0.09
    diethylene glycol 27.25
    diisopropyl ether 1.43
    tert-amyl alcohol 7.69
    acetylacetone 41.23
    n-hexadecane 0.11
    acetophenone 14.03
    methyl propionate 38.93
    isopentyl acetate 10.46
    trichloroethylene 99.28
    n-nonanol 3.3
    cyclohexanol 9.94
    benzyl alcohol 13.35
    2-ethylhexanol 3.19
    isooctanol 3.53
    dipropyl ether 3.2
    1,2-dichlorobenzene 12.63
    ethyl lactate 17.27
    propylene carbonate 61.26
    n-methylformamide 61.42
    2-pentanol 6.11
    n-pentane 0.3
    1-propoxy-2-propanol 16.63
    1-methoxy-2-propyl acetate 19.87
    2-(2-methoxypropoxy) propanol 13.47
    mesitylene 1.38
    ε-caprolactone 64.56
    p-cymene 1.39
    epichlorohydrin 90.08
    1,1,1-trichloroethane 31.01
    2-aminoethanol 12.63
    morpholine-4-carbaldehyde 96.83
    sulfolane 128.08
    2,2,4-trimethylpentane 0.2
    2-methyltetrahydrofuran 23.94
    n-hexyl acetate 11.89
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 16.61
    sec-butyl acetate 9.82
    tert-butyl acetate 10.28
    decalin 0.21
    glycerin 26.28
    diglyme 27.27
    acrylic acid 71.92
    isopropyl myristate 2.82
    n-butyric acid 68.26
    acetyl acetate 33.31
    di(2-ethylhexyl) phthalate 7.14
    ethyl propionate 15.42
    nitromethane 193.78
    1,2-diethoxyethane 6.92
    benzonitrile 15.52
    trioctyl phosphate 5.0
    1-bromopropane 10.44
    gamma-valerolactone 150.95
    n-decanol 2.04
    triethyl phosphate 6.27
    4-methyl-2-pentanol 3.53
    propionitrile 16.86
    vinylene carbonate 74.1
    1,1,2-trichlorotrifluoroethane 122.79
    DMS 16.44
    cumene 1.36
    2-octanol 2.65
    2-hexanone 17.5
    octyl acetate 5.43
    limonene 1.86
    1,2-dimethoxyethane 27.45
    ethyl orthosilicate 4.86
    tributyl phosphate 5.24
    diacetone alcohol 22.44
    N,N-dimethylaniline 4.11
    acrylonitrile 31.88
    aniline 12.51
    1,3-propanediol 23.44
    bromobenzene 10.67
    dibromomethane 32.72
    1,1,2,2-tetrachloroethane 64.7
    2-methyl-cyclohexyl acetate 8.83
    tetrabutyl urea 7.58
    diisobutyl methanol 1.38
    2-phenylethanol 11.84
    styrene 2.65
    dioctyl adipate 6.36
    dimethyl sulfate 61.98
    ethyl butyrate 10.22
    methyl lactate 41.39
    butyl lactate 16.56
    diethyl carbonate 7.56
    propanediol butyl ether 16.79
    triethyl orthoformate 6.64
    p-tert-butyltoluene 1.14
    methyl 4-tert-butylbenzoate 13.21
    morpholine 32.36
    tert-butylamine 2.14
    n-dodecanol 1.3
    dimethoxymethane 38.88
    ethylene carbonate 51.66
    cyrene 35.5
    2-ethoxyethyl acetate 24.34
    2-ethylhexyl acetate 8.36
    1,2,4-trichlorobenzene 20.17
    4-methylpyridine 29.87
    dibutyl ether 1.96
    2,6-dimethyl-4-heptanol 1.38
    DEF 39.3
    dimethyl isosorbide 22.83
    tetrachloroethylene 44.7
    eugenol 14.6
    triacetin 18.45
    span 80 13.82
    1,4-butanediol 11.28
    1,1-dichloroethane 29.57
    2-methyl-1-pentanol 7.62
    methyl formate 55.73
    2-methyl-1-butanol 9.3
    n-decane 0.17
    butyronitrile 14.18
    3,7-dimethyl-1-octanol 2.59
    1-chlorooctane 1.23
    1-chlorotetradecane 0.45
    n-nonane 0.13
    undecane 0.12
    tert-butylcyclohexane 0.15
    cyclooctane 0.13
    cyclopentanol 16.84
    tetrahydropyran 15.0
    tert-amyl methyl ether 4.96
    2,5,8-trioxanonane 16.49
    1-hexene 1.29
    2-isopropoxyethanol 16.81
    2,2,2-trifluoroethanol 81.15
    methyl butyrate 21.93

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction