Verbascoside

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  • Identifiers

    CAS number
    61276-17-3

    Molecular formula
    C29H36O15

    SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H](O[C@@H]([C@H]2OC(=O)/C=C/C3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 78.07%
    Vanilla 29.44%
    Savory 24.98%
    Milky 22.58%
    Sweet 18.78%
    Spicy 17.52%
    Phenolic 17.51%
    Burnt 17.5%
    Balsamic 16.99%
    Bitter 16.75%

     

    Flavor
    Bitter 73.44%
    Odorless 39.82%
    Bland 34.09%
    Sweet-like 27.97%
    Very mild 21.89%
    Cedarleaf 20.01%
    Mild 19.54%
    Parsley 19.43%
    Eugenol 19.17%
    Very slight 19.13%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.5

    pKa est.
    7.35 (neutral)

    Molecular weight
    624.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    4041°C

    Flash point

    • 254.31 ˚C est.

  • Synonyms

    • Verbascoside
    • Acteoside
    • 61276-17-3
    • Kusaginin
    • TJC 160
    • TJC-160
    • 3TGX09BD5B
    • DTXSID701021953
    • CHEBI:132853
    • NSC-603831
    • [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-tetrahydropyran-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    • [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    • beta-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
    • ((2R,3R,4R,5R,6R)-6-(2-(3,4-dihydroxyphenyl)ethoxy)-5-hydroxy-2-(hydroxymethyl)-4-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxy-tetrahydropyran-3-yl) (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    • ((2R,3R,4R,5R,6R)-6-(2-(3,4-dihydroxyphenyl)ethoxy)-5-hydroxy-2-(hydroxymethyl)-4-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-3-yl) (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    • beta-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-, 4-((2E)-3-(3,4-dihydroxyphenyl)-2-propenoate)
    • RefChem:51015
    • DTXCID101506860
    • 6-(2-(3,4-dihydroxyphenyl)ethoxy)-5-hydroxy-2-(hydroxymethyl)-4-((3,4,5-trihydroxy-6-methyloxan-2-yl)oxy)oxan-3-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    • 612-110-1
    • Verbacoside
    • acetoside
    • MFCD00221751
    • NSC 603831
    • C29H36O15
    • (2R,3R,4R,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-5-hydroxy-2-(hydroxymethyl)-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate
    • UNII-3TGX09BD5B
    • Reh-acteoside
    • .BETA.-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-, 4-((2E)-3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE)
    • .beta.-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-.alpha.-L-mannopyranosyl)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
    • RUSSETINOL
    • STEREOSPERMIN
    • Acteoside; Verbascoside
    • Verbascoside (Standard)
    • Acetoside (Verbascoside)
    • Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-, 4-(3-(3,4-dihydroxyphenyl)-2-propenoate), (E)-beta-D-
    • MLS002473233
    • SCHEMBL657970
    • VERBASCOSIDE [USP-RS]
    • CHEMBL231853
    • CHEMBL444478
    • orb1304265
    • SCHEMBL29485048
    • SCHEMBL29499087
    • SCHEMBL29626822
    • cid_5281800
    • GTPL12550
    • HY-N0021R
    • Verbascoside, >=99% (HPLC)
    • cid_24978601
    • GLXC-07496
    • HMS2205K11
    • HY-N0021
    • BDBM50241867
    • MSK000876
    • s5458
    • AKOS015897165
    • CCG-270269
    • DB12996
    • EBC-224027
    • OV08034
    • NCGC00378687-03
    • (2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-3-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    • AS-75167
    • SMR001397320
    • NS00070422
    • 276A173
    • B864379
    • Q411426
    • BRD-K36201510-001-06-7
    • Verbascoside, primary pharmaceutical reference standard
    • Verbascoside, United States Pharmacopeia (USP) Reference Standard
    • ((2R,3R,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-5-hydroxy-2-(hydroxymethyl)-4-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)tetrahydro-2H-pyran-3-yl) 3-(3,4-dihydroxyphenyl)acrylate
    • ((2R,3R,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-5-hydroxy-2-(hydroxymethyl)-4-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)tetrahydro-2H-pyran-3-yl)3-(3,4-dihydroxyphenyl)acrylate
    • (3,4-Dihydroxyphenyl)ethyl O-.alpha.-rhamnopyranosyl(1->3)-4-O-caffeoyl-.beta.-D glucopyranoside
    • (E)-(2R,3R,4R,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-5-hydroxy-2-(hydroxymethyl)-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl 3-(3,4-dihydroxyphenyl)acrylate
    • .beta.-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl3-O-(6-deoxy-.alpha.-L-mannopyranosyl)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
    • |A-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-|A-L-mannopyranosyl)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
    • 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside
    • 2-(3,4-dihydroxyphenyl)ethyl 3-O-(alpha-L-rhamnopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside
    • Verbascoside; (2R,3R,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-5-hydroxy-2-(hydroxymethyl)-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate
    • 61276-17-3

  • Applications

    Verbascoside is commonly used in cosmetics and personal care as a natural antioxidant and stabilizer, helping to protect formulations from oxidative degradation and supporting color and fragrance stability. It is also evaluated as a functional antioxidant additive in polymer coatings, inks, and other plastic formulations to improve oxidative stability. In pharmaceutical and nutraceutical contexts, verbascoside is considered a botanical constituent with potential bioactive properties and is routinely evaluated in plant extracts used for health-oriented products. In household products, verbascoside may be employed as a natural antioxidant/stabilizer in cleaning and consumer formulations to enhance stability and shelf life. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 31.5
    methanol 67.42
    isopropanol 11.43
    water 1.88
    ethyl acetate 7.96
    n-propanol 18.2
    acetone 37.44
    n-butanol 10.48
    acetonitrile 5.81
    DMF 107.38
    toluene 1.05
    isobutanol 4.84
    1,4-dioxane 40.15
    methyl acetate 11.1
    THF 100.76
    2-butanone 16.93
    n-pentanol 4.17
    sec-butanol 7.84
    n-hexane 0.05
    ethylene glycol 49.18
    NMP 76.41
    cyclohexane 0.17
    DMSO 455.68
    n-butyl acetate 0.87
    n-octanol 2.91
    chloroform 2.14
    n-propyl acetate 1.56
    acetic acid 98.51
    dichloromethane 3.13
    cyclohexanone 17.01
    propylene glycol 47.74
    isopropyl acetate 3.23
    DMAc 105.13
    2-ethoxyethanol 49.88
    isopentanol 3.47
    n-heptane 0.15
    ethyl formate 9.47
    1,2-dichloroethane 2.95
    n-hexanol 1.58
    2-methoxyethanol 150.65
    isobutyl acetate 0.43
    tetrachloromethane 0.36
    n-pentyl acetate 2.57
    transcutol 42.95
    n-heptanol 2.77
    ethylbenzene 0.26
    MIBK 2.77
    2-propoxyethanol 18.25
    tert-butanol 5.11
    MTBE 2.44
    2-butoxyethanol 12.34
    propionic acid 18.21
    o-xylene 0.62
    formic acid 116.35
    diethyl ether 6.12
    m-xylene 0.5
    p-xylene 0.23
    chlorobenzene 0.49
    dimethyl carbonate 13.53
    n-octane 0.12
    formamide 109.21
    cyclopentanone 41.2
    2-pentanone 12.34
    anisole 1.78
    cyclopentyl methyl ether 8.71
    gamma-butyrolactone 42.63
    1-methoxy-2-propanol 69.43
    pyridine 12.84
    3-pentanone 6.84
    furfural 27.8
    n-dodecane 0.08
    diethylene glycol 31.77
    diisopropyl ether 0.53
    tert-amyl alcohol 4.31
    acetylacetone 23.29
    n-hexadecane 0.09
    acetophenone 2.28
    methyl propionate 13.12
    isopentyl acetate 0.58
    trichloroethylene 4.61
    n-nonanol 2.85
    cyclohexanol 5.87
    benzyl alcohol 4.0
    2-ethylhexanol 0.57
    isooctanol 1.39
    dipropyl ether 1.8
    1,2-dichlorobenzene 0.38
    ethyl lactate 4.09
    propylene carbonate 6.87
    n-methylformamide 61.68
    2-pentanol 3.95
    n-pentane 0.13
    1-propoxy-2-propanol 8.97
    1-methoxy-2-propyl acetate 4.03
    2-(2-methoxypropoxy) propanol 8.73
    mesitylene 0.24
    ε-caprolactone 13.59
    p-cymene 0.17
    epichlorohydrin 31.79
    1,1,1-trichloroethane 0.73
    2-aminoethanol 47.37
    morpholine-4-carbaldehyde 83.58
    sulfolane 87.99
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 14.93
    n-hexyl acetate 3.03
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 16.84
    sec-butyl acetate 0.76
    tert-butyl acetate 2.53
    decalin 0.04
    glycerin 102.27
    diglyme 28.26
    acrylic acid 27.58
    isopropyl myristate 0.99
    n-butyric acid 15.77
    acetyl acetate 5.08
    di(2-ethylhexyl) phthalate 1.29
    ethyl propionate 1.92
    nitromethane 108.85
    1,2-diethoxyethane 6.04
    benzonitrile 1.24
    trioctyl phosphate 1.27
    1-bromopropane 1.08
    gamma-valerolactone 86.42
    n-decanol 1.88
    triethyl phosphate 0.73
    4-methyl-2-pentanol 1.01
    propionitrile 3.28
    vinylene carbonate 7.02
    1,1,2-trichlorotrifluoroethane 41.4
    DMS 3.01
    cumene 0.13
    2-octanol 1.65
    2-hexanone 2.37
    octyl acetate 2.04
    limonene 0.34
    1,2-dimethoxyethane 30.71
    ethyl orthosilicate 0.71
    tributyl phosphate 0.95
    diacetone alcohol 12.13
    N,N-dimethylaniline 1.26
    acrylonitrile 6.33
    aniline 4.02
    1,3-propanediol 57.39
    bromobenzene 0.3
    dibromomethane 1.26
    1,1,2,2-tetrachloroethane 4.36
    2-methyl-cyclohexyl acetate 0.69
    tetrabutyl urea 2.08
    diisobutyl methanol 0.35
    2-phenylethanol 1.73
    styrene 0.33
    dioctyl adipate 2.09
    dimethyl sulfate 27.88
    ethyl butyrate 1.06
    methyl lactate 25.42
    butyl lactate 4.26
    diethyl carbonate 0.64
    propanediol butyl ether 17.88
    triethyl orthoformate 1.16
    p-tert-butyltoluene 0.18
    methyl 4-tert-butylbenzoate 4.1
    morpholine 55.63
    tert-butylamine 1.09
    n-dodecanol 1.21
    dimethoxymethane 70.26
    ethylene carbonate 5.51
    cyrene 15.72
    2-ethoxyethyl acetate 6.87
    2-ethylhexyl acetate 0.4
    1,2,4-trichlorobenzene 0.71
    4-methylpyridine 5.55
    dibutyl ether 1.63
    2,6-dimethyl-4-heptanol 0.35
    DEF 17.78
    dimethyl isosorbide 9.29
    tetrachloroethylene 2.86
    eugenol 4.41
    triacetin 5.46
    span 80 9.56
    1,4-butanediol 15.79
    1,1-dichloroethane 1.38
    2-methyl-1-pentanol 1.66
    methyl formate 47.79
    2-methyl-1-butanol 3.94
    n-decane 0.18
    butyronitrile 2.74
    3,7-dimethyl-1-octanol 1.02
    1-chlorooctane 0.64
    1-chlorotetradecane 0.22
    n-nonane 0.16
    undecane 0.12
    tert-butylcyclohexane 0.02
    cyclooctane 0.09
    cyclopentanol 11.88
    tetrahydropyran 14.23
    tert-amyl methyl ether 2.58
    2,5,8-trioxanonane 20.4
    1-hexene 0.22
    2-isopropoxyethanol 13.86
    2,2,2-trifluoroethanol 30.19
    methyl butyrate 2.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction