Vasoxyl

Overview IFRA Request a quote

  • Identifiers

    CAS number
    390-28-3

    Molecular formula
    C11H17NO3

    SMILES
    CC(C(C1=C(C=CC(=C1)OC)OC)O)N

  • Odor profile

    Fragrance
    Odorless 45.23%
    Sweet 41.44%
    Vanilla 33.94%
    Cooling 25.8%
    Milky 23.0%
    Bitter 22.52%
    Creamy 21.87%
    Savory 21.77%
    Mint 21.53%
    Chocolate 18.69%

     

    Flavor
    Bitter 44.79%
    Odorless 34.19%
    Mild 28.76%
    Bland 27.63%
    Sweet-like 23.03%
    Parsley 19.62%
    Eugenol 19.45%
    Cedarleaf 19.35%
    Orange flower 19.25%
    Fruity 19.22%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    6.19 (neutral)

    Molecular weight
    211.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    356°C

    Flash point

    • 150.37 ˚C est.

    Solubility expt.

    • 9.21e+00 g/L

  • Synonyms

    • methoxamine
    • 390-28-3
    • 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
    • Methoxamin
    • Pseudomethoxamine
    • Vasoxyl
    • 2,5-Dimethoxynorephedrine
    • CHEMBL524
    • CHEBI:6839
    • Methoxamine (BAN)
    • Benzenemethanol, alpha-(1-aminoethyl)-2,5-dimethoxy-
    • Benzenemethanol, .alpha.-(1-aminoethyl)-2,5-dimethoxy-
    • Benzyl alcohol, .alpha.-(1-aminoethyl)-2,5-dimethoxy-
    • DTXSID0023290
    • Spectrum_001021
    • Prestwick0_000535
    • Prestwick1_000535
    • Prestwick2_000535
    • Prestwick3_000535
    • Spectrum2_000776
    • Spectrum3_000498
    • Spectrum4_000051
    • Spectrum5_001821
    • (1R,2S)-2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
    • Lopac0_000769
    • SCHEMBL34158
    • BSPBio_000549
    • BSPBio_001995
    • GTPL483
    • KBioGR_000541
    • KBioSS_001501
    • 2-amino-1-[2,5-bis(methyloxy)phenyl]propan-1-ol
    • SPBio_000852
    • SPBio_002470
    • BPBio1_000605
    • KBio2_001501
    • KBio2_004069
    • KBio2_006637
    • KBio3_001495
    • BDBM50026777
    • MFCD00242998
    • AKOS009208855
    • CCG-204854
    • DB00723
    • SDCCGSBI-0050747.P004
    • NCGC00015692-03
    • NCGC00015692-04
    • NCGC00015692-06
    • NCGC00015692-08
    • NCGC00015692-13
    • NCGC00089793-02
    • SBI-0050747.P003
    • AB00053731
    • NS00007655
    • C07513
    • D08201
    • EN300-365687
    • 2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol
    • 2-Amino-1-(2,5-dimethoxyphenyl)-1-propanol #
    • AB00053731_12
    • AB00053731_13
    • L000757
    • Q685119
    • BRD-A39189014-003-14-4
    • BRD-A39189014-003-21-9
    • BRD-A39189014-003-22-7
    • (.+/-.)-.alpha.-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol
    • 2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol (methoxamine)
    • 2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol(Methoxamine)

  • Applications

    Vasoxyl (CAS 390-28-3) is primarily used as a fragrance ingredient and fixation agent in perfumery and cosmetic formulations; it may serve as a fragrance component in personal care products. It is also evaluated for use in household and cleaning products to impart and stabilize scent. In materials applications, Vasoxyl can be employed as a fragrance additive or release agent in polymers and plastics to control fragrance release in coatings and inks. The use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 55.93
    methanol 131.34
    isopropanol 21.02
    water 26.09
    ethyl acetate 15.84
    n-propanol 32.31
    acetone 17.96
    n-butanol 21.97
    acetonitrile 21.19
    DMF 157.45
    toluene 4.24
    isobutanol 17.95
    1,4-dioxane 92.88
    methyl acetate 19.96
    THF 84.79
    2-butanone 11.52
    n-pentanol 16.79
    sec-butanol 12.51
    n-hexane 0.2
    ethylene glycol 120.61
    NMP 130.63
    cyclohexane 1.45
    DMSO 278.21
    n-butyl acetate 10.34
    n-octanol 7.64
    chloroform 45.49
    n-propyl acetate 13.06
    acetic acid 244.72
    dichloromethane 60.62
    cyclohexanone 51.02
    propylene glycol 63.44
    isopropyl acetate 8.39
    DMAc 136.54
    2-ethoxyethanol 101.54
    isopentanol 16.44
    n-heptane 0.55
    ethyl formate 46.12
    1,2-dichloroethane 29.76
    n-hexanol 14.16
    2-methoxyethanol 197.59
    isobutyl acetate 9.39
    tetrachloromethane 7.08
    n-pentyl acetate 7.18
    transcutol 79.81
    n-heptanol 10.8
    ethylbenzene 4.17
    MIBK 6.99
    2-propoxyethanol 60.82
    tert-butanol 30.97
    MTBE 7.31
    2-butoxyethanol 38.08
    propionic acid 51.85
    o-xylene 6.56
    formic acid 325.76
    diethyl ether 4.61
    m-xylene 4.72
    p-xylene 6.23
    chlorobenzene 13.89
    dimethyl carbonate 19.32
    n-octane 0.38
    formamide 266.25
    cyclopentanone 61.68
    2-pentanone 7.77
    anisole 16.82
    cyclopentyl methyl ether 16.64
    gamma-butyrolactone 111.66
    1-methoxy-2-propanol 68.0
    pyridine 47.02
    3-pentanone 6.98
    furfural 163.87
    n-dodecane 0.4
    diethylene glycol 117.69
    diisopropyl ether 1.49
    tert-amyl alcohol 18.62
    acetylacetone 25.98
    n-hexadecane 0.45
    acetophenone 26.25
    methyl propionate 16.71
    isopentyl acetate 10.87
    trichloroethylene 66.82
    n-nonanol 7.82
    cyclohexanol 23.67
    benzyl alcohol 33.04
    2-ethylhexanol 8.47
    isooctanol 9.16
    dipropyl ether 5.21
    1,2-dichlorobenzene 17.16
    ethyl lactate 22.69
    propylene carbonate 70.36
    n-methylformamide 112.44
    2-pentanol 6.21
    n-pentane 0.26
    1-propoxy-2-propanol 27.11
    1-methoxy-2-propyl acetate 20.45
    2-(2-methoxypropoxy) propanol 28.36
    mesitylene 3.51
    ε-caprolactone 52.52
    p-cymene 4.5
    epichlorohydrin 93.77
    1,1,1-trichloroethane 15.03
    2-aminoethanol 111.08
    morpholine-4-carbaldehyde 142.83
    sulfolane 153.81
    2,2,4-trimethylpentane 0.45
    2-methyltetrahydrofuran 34.2
    n-hexyl acetate 10.0
    isooctane 0.24
    2-(2-butoxyethoxy)ethanol 38.68
    sec-butyl acetate 7.23
    tert-butyl acetate 10.42
    decalin 0.93
    glycerin 169.32
    diglyme 74.75
    acrylic acid 77.67
    isopropyl myristate 4.22
    n-butyric acid 64.39
    acetyl acetate 22.86
    di(2-ethylhexyl) phthalate 12.2
    ethyl propionate 10.45
    nitromethane 210.69
    1,2-diethoxyethane 13.05
    benzonitrile 25.03
    trioctyl phosphate 8.07
    1-bromopropane 5.45
    gamma-valerolactone 127.34
    n-decanol 5.82
    triethyl phosphate 13.25
    4-methyl-2-pentanol 4.9
    propionitrile 13.49
    vinylene carbonate 76.99
    1,1,2-trichlorotrifluoroethane 161.17
    DMS 15.55
    cumene 4.18
    2-octanol 4.85
    2-hexanone 9.67
    octyl acetate 6.7
    limonene 5.87
    1,2-dimethoxyethane 88.24
    ethyl orthosilicate 12.3
    tributyl phosphate 8.07
    diacetone alcohol 26.98
    N,N-dimethylaniline 15.49
    acrylonitrile 29.8
    aniline 23.41
    1,3-propanediol 121.46
    bromobenzene 10.44
    dibromomethane 23.19
    1,1,2,2-tetrachloroethane 50.2
    2-methyl-cyclohexyl acetate 16.13
    tetrabutyl urea 11.85
    diisobutyl methanol 4.82
    2-phenylethanol 24.62
    styrene 5.05
    dioctyl adipate 11.03
    dimethyl sulfate 50.19
    ethyl butyrate 11.22
    methyl lactate 39.18
    butyl lactate 13.55
    diethyl carbonate 11.93
    propanediol butyl ether 30.36
    triethyl orthoformate 12.3
    p-tert-butyltoluene 4.23
    methyl 4-tert-butylbenzoate 24.6
    morpholine 104.23
    tert-butylamine 9.7
    n-dodecanol 4.36
    dimethoxymethane 48.01
    ethylene carbonate 58.59
    cyrene 58.18
    2-ethoxyethyl acetate 15.85
    2-ethylhexyl acetate 8.14
    1,2,4-trichlorobenzene 24.8
    4-methylpyridine 32.16
    dibutyl ether 4.13
    2,6-dimethyl-4-heptanol 4.82
    DEF 30.63
    dimethyl isosorbide 50.91
    tetrachloroethylene 39.75
    eugenol 29.29
    triacetin 21.42
    span 80 26.74
    1,4-butanediol 53.31
    1,1-dichloroethane 12.31
    2-methyl-1-pentanol 14.75
    methyl formate 103.47
    2-methyl-1-butanol 15.96
    n-decane 0.58
    butyronitrile 13.5
    3,7-dimethyl-1-octanol 6.33
    1-chlorooctane 2.53
    1-chlorotetradecane 1.23
    n-nonane 0.47
    undecane 0.46
    tert-butylcyclohexane 0.71
    cyclooctane 0.58
    cyclopentanol 33.21
    tetrahydropyran 27.13
    tert-amyl methyl ether 6.75
    2,5,8-trioxanonane 56.98
    1-hexene 0.92
    2-isopropoxyethanol 44.12
    2,2,2-trifluoroethanol 121.57
    methyl butyrate 18.72

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction