Validamycin A

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  • Identifiers

    CAS number
    37248-47-8

    Molecular formula
    C20H35NO13

    SMILES
    C1[C@@H]([C@H]([C@@H]([C@H]([C@H]1N[C@H]2C=C([C@H]([C@@H]([C@H]2O)O)O)CO)O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 74.06%
    Sweet 41.11%
    Alcoholic 21.66%
    Savory 17.83%
    Cooling 17.64%
    Fishy 16.61%
    Woody 16.32%
    Caramellic 16.14%
    Bitter 16.06%
    Vanilla 15.7%

     

    Flavor
    Sweet 65.68%
    Odorless 52.69%
    Bitter 51.01%
    Sweet-like 31.96%
    Cauliflower 21.43%
    Very slight 21.38%
    Fatty 21.04%
    Bland 20.97%
    Alkaline 20.54%
    Very mild 20.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -6.3

    pKa est.
    5.06 (weak acid)

    Molecular weight
    497.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    3906°C

    Melting point expt.

    • 130-135 °C (with decomp)

    Flash point

    • 312.97 ˚C est.

    Solubility expt.

    • Solubility: very soluble in water; soluble in dimethylformamide, dimethyl sulphoxide, methanol; sparingly soluble in acetone, ethanol.
    • Sparingly soluble in diethyl ether and ethyl acetate.

  • Synonyms

    • Validamycin
    • VALIDAMYCIN A
    • 37248-47-8
    • Validacin
    • Valimon
    • UNII-313E9620QS
    • CHEBI:29703
    • HSDB 6745
    • 313E9620QS
    • T-7545-A
    • VALIDAMYCIN A [HSDB]
    • (2R,3R,4S,5S,6R)-2-[(1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
    • DTXSID4058073
    • VALIDAMYCINS VALIDAMYCIN A [MI]
    • (1S-(1a,4a,5B,6a))-1,5,6-Trideoxy-3-O-B-D-glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-d-chiro-inositol
    • (1S-(1alpha,4alpha,5beta,6alpha))-1,5,6-trideoxy-4-O-beta-D-glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-D-chiro-inositol
    • 1L-(1,3,4/2,6)-2,3-Dihydroxy-6-hydromethyl-4-((1S,4R,5S,6S)-4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-enylamino)cyclohexyl beta-D-glucopyranoside
    • 1L-(1,3,4/2,6)-2,3-Dihydroxy-6-hydroxymethyl-4-((1S,4R,5S,6S)-4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-enylamino)cyclohexyl beta-D-glucopyranoside
    • D-1,5,6-Trideoxy-3-O-beta-D-glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-D-chiroinositol
    • (1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}cyclohexyl beta-D-glucopyranoside
    • (2R,3R,4S,5S,6R)-2-[(1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]cyclohexoxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • D-chiro-Inositol, 1,5,6-trideoxy-3-O-beta-D-glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-, (1S-(1-alpha,4-alpha,5-beta,6-alpha))-
    • D-CHIRO-INOSITOL, 1,5,6-TRIDEOXY-4-O-.BETA.-D-GLUCOPYRANOSYL-5-(HYDROXYMETHYL)-1-(((1S,4R,5S,6S)-4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-2-CYCLOHEXEN-1-YL)AMINO)-
    • D-CHIRO-INOSITOL, 1,5,6-TRIDEOXY-4-O-.BETA.-D-GLUCOPYRANOSYL-5-(HYDROXYMETHYL)-1-((4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-2-CYCLOHEXEN-1-YL)AMINO)-, (1S-(1.ALPHA.,4.ALPHA.,5.BETA.,6.ALPHA.))-
    • Validamycin A (>70%) Hydrochloride Salt
    • Cepex 10SL; Validacin
    • Validamycin A Sulfate salt (Technical grade)
    • jinganmycin A
    • (1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)amino)cyclohexyl beta-D-glucopyranoside
    • (2R,3R,4S,5S,6R)-2-((1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)amino)cyclohexoxy)-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • (2R,5S)-2-((1R,2R,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)amino)cyclohexyl)oxy-6-(hydroxymethyl)oxane-3,4,5-triol
    • (2R,5S)-2-[(1R,2R,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
    • 1,5,6-Trideoxy-4-O-b-D-glucopyranosyl-5-(hydroxymethyl)-1-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-D-chiro-inositol
    • 1,5,6-Trideoxy-4-O-b-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol
    • 1,5,6-Trideoxy-4-O-I2-D-glucopyranosyl-5-(hydroxymethyl)-1-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-D-chiro-inositol
    • 1,5,6-Trideoxy-4-O-I2-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol
    • D-chiro-Inositol, 1,5,6-trideoxy-4-O-.beta.-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-
    • D-CHIRO-INOSITOL, 1,5,6-TRIDEOXY-4-O-BETA-D-GLUCOPYRANOSYL-5-(HYDROXYMETHYL)-1-(((1S,4R,5S,6S)-4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-2-CYCLOHEXEN-1-YL)AMINO)-
    • D-chiro-Inositol, 1,5,6-trideoxy-4-O-beta-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-
    • MFCD09028089
    • (+)-validamycin A
    • Validamycin A (Standard)
    • SCHEMBL3121491
    • CHEMBL1923413
    • DTXCID0031841
    • HY-B0856R
    • VALIDAMYCINS VALIDAMYCIN A
    • JARYYMUOCXVXNK-CSLFJTBJSA-N
    • HY-B0856
    • T7545A
    • AKOS016012982
    • AG-F-30599
    • AV59477
    • AC-32607
    • AS-15281
    • CS-0012869
    • Validamycin A, PESTANAL(R), analytical standard
    • Validamycin; CE30; JARYYMUOCXVXNK-CSLFJTBJSA-N
    • D-Chiro-inositol,1,5,6-trideoxy-3-O-beta-D-glucopyranosyl-
    • (1S(1a,4a,5b,6a))1,5,6Trideoxy3ObDglucopyranosyl5(hydroxymethyl)1((4,5,6trihydroxy3(hydroxymethyl)2cyclohexen1yl)amino)Dchiroinositol
    • (1S(1alpha,4alpha,5beta,6alpha))1,5,6trideoxy4ObetaDglucopyranosyl5(hydroxymethyl)1((4,5,6trihydroxy3(hydroxymethyl)2cyclohexen1yl)amino)Dchiroinositol
    • (1S-(1 alpha, 4 alpha, 5 beta, 6 alpha))-1,5,6-trideoxy-4-O-beta-D-glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-D-chiro-inositol
    • (1S-(1.ALPHA.,4.ALPHA.,5.BETA.,6.ALPHA.))-1,5,6-TRIDEOXY-4-O-.BETA.-D- GLUCOPYRANOSYL-5-(HYDROXYMETHYL)-1-((4,5,6-TRIHYDROXY-3- (HYDROXYMETHYL)-2-CYCLOHEXEN-1-YL)AMINO)-D-CHIRO-INOSITOL
    • (1S-(1A,4A,5B,6A))-1,5,6-TRIDEOXY-3-O-B-D-GLUCOPYRANOSYL-5- (HYDROXYMETHYL)-1-((4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-2- CYCLOHEXEN-1-YL)AMINO)-D-CHIRO-INOSITOL
    • (1S-(1a,4a,5B,6a))-1,5,6-trideoxy-3-O-B-D-glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-=2-cyclohexen-1-yl)amino)-d-chiro-inositol
    • (1S-(1a,4a,5b,6a))-1,5,6-Trideoxy-4-O-b-D-glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-D-chiro-inositol
    • (2R,3R,4S,5S,6R)-2-(((1R,2R,3S,4S,6R)-2,3-Dihydroxy-6-(hydroxymethyl)-4-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)amino)cyclohexyl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
    • 1,5,6-trideoxy-4-O-beta-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol
    • 1L(1,3,4/2,6)2,3Dihydroxy6hydromethyl4((1S,4R,5S,6S)4,5,6trihydroxy3hydroxymethylcyclohex2enylamino)cyclohexyl betaDglucopyranoside
    • 1L(1,3,4/2,6)2,3Dihydroxy6hydroxymethyl4((1S,4R,5S,6S)4,5,6trihydroxy3hydroxymethylcyclohex2enylamino)cyclohexyl betaDglucopyranoside
    • 1L-(1,3,4/2,6)-2,3-DIHYDROXY-6-HYDROMETHYL-4-((1S,4R,5S,6S)- 4,5,6-TRIHYDROXY-3-HYDROXYMETHYLCYCLOHEX-2- ENYLAMINO)CYCLOHEXYL .BETA.-D-GLUCOPYRANOSIDE
    • 1L-(1,3,4/2,6)-2,3-dihydroxy-6-hydromethyl-4-((1S,4R,5S,6S)-4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-enylamino) cyclohexyl beta-D-glucopyranoside
    • 1L-(1,3,4/2,6)-2,3-DIHYDROXY-6-HYDROMETHYL-4-((1S,4R,5S,6S)-4,5,6-TRIHYDROXY-3-HYDROXYMETHYLCYCLOHEX-2-ENYLAMINO)CYCLOHEXYL .BETA.-D-GLUCOPYRANOSIDE
    • 1L-(1,3,4/2,6)-2,3-DIHYDROXY-6-HYDROXYMETHYL-4- ((1S,4R,5S,6S)-4,5,6-TRIHYDROXY-3-HYDROXYMETHYLCYCLOHEX-2- ENYLAMINO)CYCLOHEXYL .BETA.-D-GLUCOPYRANOSIDE
    • 1l-(1,3,4/2,6)-2,3-dihydroxy-6-hydroxymethyl-4-((1S,4R,5S,6S)-4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-enylamino)cyclohexyl I2-D-glucopyranoside
    • 58194-43-7
    • 609-372-4
    • D-1,5,6-TRIDEOXY-3-O-.BETA.-D-GLUCOPYRANOSYL-5- (HYDROXYMETHYL)-1-((4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-2- CYCLOHEXEN-1-YL)AMINO)-D-CHIROINOSITOL
    • D-1,5,6-Trideoxy-3-O-b-D-glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-D-chiroinositol
    • D-1,5,6-Trideoxy-3-O-I2-D-glucopyranosyl-5-(hydroxymethyl)-1-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-D-chiroinositol
    • D-CHIRO-INOSITOL, 1,5,6-TRIDEOXY-3-O-.BETA.-D-GLUCOPYRANOSYL- 5-(HYDROXYMETHYL)-1-((4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-2- CYCLOHEXEN-1-YL)AMINO)-, (1S-(1-.ALPHA.,4-.ALPHA.,5-.BETA.,6- .ALPHA.))-
    • D-CHIRO-INOSITOL, 1,5,6-TRIDEOXY-3-O-.BETA.-D-GLUCOPYRANOSYL-5-(HYDROXYMETHYL)-1-((4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-2-CYCLOHEXEN-1-YL)AMINO)-, (1S-(1-.ALPHA.,4-.ALPHA.,5-.BETA.,6-.ALPHA.))-
    • D-CHIRO-INOSITOL, 1,5,6-TRIDEOXY-4-O-BETA-D-GLUCOPYRANOSYL-5-(HYDROXYMETHYL)-1-((4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)-2-CYCLOHEXEN-1-YL)AMINO)-, (1S-(1ALPHA,4ALPHA,5BETA,6ALPHA))-
    • D1,5,6Trideoxy3ObetaDglucopyranosyl5(hydroxymethyl)1((4,5,6trihydroxy3(hydroxymethyl)2cyclohexen1yl)amino)Dchiroinositol

  • Applications

    Validamycin A (CAS 37248-47-8) is primarily used as a fungicidal antibiotic in agriculture to protect crops from fungal diseases, notably rice sheath blight caused by Rhizoctonia solani, by acting as a fungal trehalase inhibitor that disrupts energy metabolism. In practice, it is applied as a crop protection fungicide, often included in integrated pest management programs, with considerations for formulation and local regulatory limits. It is also studied as a post-harvest and grain-disease control option under evaluation for stored-product protection. In research settings, it serves as a tool compound to study fungal trehalase and fungal physiology, and may be explored as a lead compound in antifungal development. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.41
    methanol 4.1
    isopropanol 0.25
    water 44.19
    ethyl acetate 0.13
    n-propanol 0.44
    acetone 0.4
    n-butanol 0.3
    acetonitrile 0.15
    DMF 7.1
    toluene 0.08
    isobutanol 0.12
    1,4-dioxane 0.92
    methyl acetate 0.11
    THF 0.9
    2-butanone 0.21
    n-pentanol 0.12
    sec-butanol 0.16
    n-hexane 0.01
    ethylene glycol 11.93
    NMP 12.02
    cyclohexane 0.05
    DMSO 41.08
    n-butyl acetate 0.05
    n-octanol 0.14
    chloroform 0.04
    n-propyl acetate 0.04
    acetic acid 7.67
    dichloromethane 0.05
    cyclohexanone 0.55
    propylene glycol 4.93
    isopropyl acetate 0.08
    DMAc 6.28
    2-ethoxyethanol 2.2
    isopentanol 0.11
    n-heptane 0.04
    ethyl formate 0.22
    1,2-dichloroethane 0.06
    n-hexanol 0.15
    2-methoxyethanol 9.36
    isobutyl acetate 0.02
    tetrachloromethane 0.02
    n-pentyl acetate 0.1
    transcutol 3.82
    n-heptanol 0.23
    ethylbenzene 0.03
    MIBK 0.09
    2-propoxyethanol 1.61
    tert-butanol 0.11
    MTBE 0.04
    2-butoxyethanol 1.33
    propionic acid 0.73
    o-xylene 0.08
    formic acid 68.14
    diethyl ether 0.13
    m-xylene 0.07
    p-xylene 0.02
    chlorobenzene 0.02
    dimethyl carbonate 0.61
    n-octane 0.02
    formamide 38.71
    cyclopentanone 0.91
    2-pentanone 0.22
    anisole 0.06
    cyclopentyl methyl ether 0.39
    gamma-butyrolactone 1.09
    1-methoxy-2-propanol 3.54
    pyridine 0.49
    3-pentanone 0.19
    furfural 1.96
    n-dodecane 0.01
    diethylene glycol 6.1
    diisopropyl ether 0.03
    tert-amyl alcohol 0.11
    acetylacetone 0.52
    n-hexadecane 0.01
    acetophenone 0.14
    methyl propionate 0.32
    isopentyl acetate 0.03
    trichloroethylene 0.09
    n-nonanol 0.15
    cyclohexanol 0.34
    benzyl alcohol 0.22
    2-ethylhexanol 0.06
    isooctanol 0.11
    dipropyl ether 0.13
    1,2-dichlorobenzene 0.02
    ethyl lactate 0.31
    propylene carbonate 0.31
    n-methylformamide 3.99
    2-pentanol 0.13
    n-pentane 0.02
    1-propoxy-2-propanol 0.74
    1-methoxy-2-propyl acetate 0.32
    2-(2-methoxypropoxy) propanol 0.75
    mesitylene 0.04
    ε-caprolactone 0.54
    p-cymene 0.03
    epichlorohydrin 0.54
    1,1,1-trichloroethane 0.01
    2-aminoethanol 7.11
    morpholine-4-carbaldehyde 9.11
    sulfolane 6.24
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.26
    n-hexyl acetate 0.1
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 1.66
    sec-butyl acetate 0.03
    tert-butyl acetate 0.08
    decalin 0.01
    glycerin 27.8
    diglyme 2.4
    acrylic acid 1.93
    isopropyl myristate 0.03
    n-butyric acid 0.56
    acetyl acetate 0.15
    di(2-ethylhexyl) phthalate 0.08
    ethyl propionate 0.07
    nitromethane 3.95
    1,2-diethoxyethane 0.23
    benzonitrile 0.06
    trioctyl phosphate 0.07
    1-bromopropane 0.03
    gamma-valerolactone 3.63
    n-decanol 0.1
    triethyl phosphate 0.07
    4-methyl-2-pentanol 0.05
    propionitrile 0.06
    vinylene carbonate 0.35
    1,1,2-trichlorotrifluoroethane 3.51
    DMS 0.16
    cumene 0.02
    2-octanol 0.1
    2-hexanone 0.06
    octyl acetate 0.07
    limonene 0.05
    1,2-dimethoxyethane 0.88
    ethyl orthosilicate 0.07
    tributyl phosphate 0.05
    diacetone alcohol 0.59
    N,N-dimethylaniline 0.1
    acrylonitrile 0.17
    aniline 0.27
    1,3-propanediol 4.75
    bromobenzene 0.01
    dibromomethane 0.03
    1,1,2,2-tetrachloroethane 0.1
    2-methyl-cyclohexyl acetate 0.05
    tetrabutyl urea 0.14
    diisobutyl methanol 0.04
    2-phenylethanol 0.17
    styrene 0.03
    dioctyl adipate 0.07
    dimethyl sulfate 2.08
    ethyl butyrate 0.06
    methyl lactate 2.21
    butyl lactate 0.3
    diethyl carbonate 0.04
    propanediol butyl ether 1.83
    triethyl orthoformate 0.09
    p-tert-butyltoluene 0.03
    methyl 4-tert-butylbenzoate 0.34
    morpholine 1.67
    tert-butylamine 0.04
    n-dodecanol 0.07
    dimethoxymethane 2.28
    ethylene carbonate 0.23
    cyrene 2.07
    2-ethoxyethyl acetate 0.27
    2-ethylhexyl acetate 0.03
    1,2,4-trichlorobenzene 0.03
    4-methylpyridine 0.2
    dibutyl ether 0.06
    2,6-dimethyl-4-heptanol 0.04
    DEF 0.91
    dimethyl isosorbide 1.12
    tetrachloroethylene 0.14
    eugenol 0.48
    triacetin 0.27
    span 80 0.96
    1,4-butanediol 1.13
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.06
    methyl formate 2.02
    2-methyl-1-butanol 0.13
    n-decane 0.02
    butyronitrile 0.06
    3,7-dimethyl-1-octanol 0.05
    1-chlorooctane 0.04
    1-chlorotetradecane 0.01
    n-nonane 0.02
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.04
    cyclopentanol 0.43
    tetrahydropyran 0.3
    tert-amyl methyl ether 0.07
    2,5,8-trioxanonane 2.0
    1-hexene 0.02
    2-isopropoxyethanol 0.62
    2,2,2-trifluoroethanol 4.18
    methyl butyrate 0.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction