Urolithin A

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  • Identifiers

    CAS number
    1143-70-0

    Molecular formula
    C13H8O4

    SMILES
    C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 65.31%
    Odorless 42.14%
    Burnt 35.09%
    Medicinal 30.68%
    Nutty 27.54%
    Animal 24.85%
    Bitter 24.27%
    Balsamic 23.27%
    Smoky 23.14%
    Vanilla 22.51%

     

    Flavor
    Bitter 96.0%
    Very strong 20.54%
    Odorless 20.13%
    Indole 20.08%
    Nitrile 19.77%
    Cedarleaf 19.27%
    Rotten 19.12%
    Sweet-like 19.02%
    Moth ball 18.98%
    Lovage 18.88%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    8.83 (weak base)

    Molecular weight
    228.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    505°C

    Flash point

    • 230.18 ˚C est.

  • Synonyms

    • urolithin A
    • 1143-70-0
    • 3,8-dihydroxy-6H-benzo[c]chromen-6-one
    • 3,8-Dihydroxyurolithin
    • 6H-Dibenzo[b,d]pyran-6-one, 3,8-dihydroxy-
    • 3,8-dihydroxybenzo[c]chromen-6-one
    • 3,8-Hydroxydibenzo-alpha-pyrone
    • Mitopure
    • ILJ8NEF6DT
    • DTXSID40150694
    • 6H-Dibenzo(b,d)pyran-6-one, 3,8-dihydroxy-
    • 3,8-DIHYDROXYBENZO(C)CHROMEN-6-ONE
    • 3,8-dihydroxy-6H-benzo(c)chromen-6-one
    • RefChem:193319
    • DTXCID3073185
    • 881-478-5
    • 3,8-Dihydroxy-6H-dibenzo(b,d)pyran-6-one
    • MFCD20275235
    • 3,8-dihydroxy-6h-dibenzo[b,d]pyran-6-one
    • urolithin-A
    • Urolithin A?
    • Uro-A
    • UNII-ILJ8NEF6DT
    • 3,8-dihydroxy-urolithin
    • Urolithin A [WHO-DD]
    • SCHEMBL803408
    • orb1300010
    • CHEMBL1836264
    • SCHEMBL29368885
    • SCHEMBL29401099
    • CHEBI:168442
    • HMS6018O08
    • Urolithin A, >=97% (HPLC)
    • EX-A4345
    • s5312
    • AKOS028108778
    • 3,8-Dihydroxybenzo[c]chromen-6-oneEE
    • CCG-266776
    • CS-6305
    • DB15464
    • EBC-252133
    • MSK183729-100M
    • AC-31959
    • DS-19328
    • FD171109
    • SY070232
    • DB-122496
    • HY-100599
    • Urolithin A Solution in Methanol, 100ug/mL
    • C22595
    • Y10574
    • EN300-7415486
    • F054025
    • Q15634120
    • 2-Biphenylcarboxylic acid, 2',4,4'-trihydroxy-, delta-lactone
    • 1143-70-0

  • Applications

    Chemical name: Urolithin A; CAS number: 1143-70-0. Urolithin A is a polyphenol metabolite derived from ellagitannins via gut microbiota. In real-world industry, its primary applications are as a research chemical and as a potential functional ingredient for nutraceuticals and cosmetics; it is evaluated as a bioactive compound with antioxidant potential in cosmetic formulations and as a reference standard for analytical methods (for example, HPLC/LC-MS) to quantify polyphenols. It is also used as a subject of study in gut microbiome and nutrition research, and may serve as a building block or library reference in polyphenol research. Local regulations and formulation limits apply.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.02
    methanol 5.68
    isopropanol 3.81
    water 0.07
    ethyl acetate 5.51
    n-propanol 3.72
    acetone 3.87
    n-butanol 4.23
    acetonitrile 1.65
    DMF 41.15
    toluene 0.41
    isobutanol 2.56
    1,4-dioxane 11.45
    methyl acetate 7.52
    THF 44.06
    2-butanone 11.04
    n-pentanol 2.25
    sec-butanol 4.52
    n-hexane 0.0
    ethylene glycol 8.01
    NMP 42.47
    cyclohexane 0.01
    DMSO 83.65
    n-butyl acetate 7.97
    n-octanol 2.1
    chloroform 0.0
    n-propyl acetate 5.71
    acetic acid 5.48
    dichloromethane 0.02
    cyclohexanone 8.06
    propylene glycol 5.24
    isopropyl acetate 6.1
    DMAc 96.12
    2-ethoxyethanol 24.96
    isopentanol 5.59
    n-heptane 0.03
    ethyl formate 2.74
    1,2-dichloroethane 0.14
    n-hexanol 3.14
    2-methoxyethanol 61.18
    isobutyl acetate 2.49
    tetrachloromethane 0.02
    n-pentyl acetate 5.55
    transcutol 80.63
    n-heptanol 3.01
    ethylbenzene 0.56
    MIBK 6.03
    2-propoxyethanol 32.68
    tert-butanol 7.94
    MTBE 3.85
    2-butoxyethanol 16.29
    propionic acid 5.75
    o-xylene 0.92
    formic acid 7.73
    diethyl ether 1.54
    m-xylene 0.56
    p-xylene 0.58
    chlorobenzene 0.19
    dimethyl carbonate 9.14
    n-octane 0.02
    formamide 27.87
    cyclopentanone 16.65
    2-pentanone 6.11
    anisole 6.62
    cyclopentyl methyl ether 6.45
    gamma-butyrolactone 22.26
    1-methoxy-2-propanol 40.31
    pyridine 5.12
    3-pentanone 4.19
    furfural 17.76
    n-dodecane 0.05
    diethylene glycol 38.02
    diisopropyl ether 0.75
    tert-amyl alcohol 8.87
    acetylacetone 12.13
    n-hexadecane 0.05
    acetophenone 9.49
    methyl propionate 8.9
    isopentyl acetate 8.6
    trichloroethylene 0.24
    n-nonanol 2.5
    cyclohexanol 3.1
    benzyl alcohol 6.41
    2-ethylhexanol 2.97
    isooctanol 2.76
    dipropyl ether 2.79
    1,2-dichlorobenzene 0.55
    ethyl lactate 9.94
    propylene carbonate 8.46
    n-methylformamide 13.8
    2-pentanol 2.97
    n-pentane 0.0
    1-propoxy-2-propanol 21.16
    1-methoxy-2-propyl acetate 22.15
    2-(2-methoxypropoxy) propanol 25.14
    mesitylene 0.48
    ε-caprolactone 13.61
    p-cymene 1.41
    epichlorohydrin 19.94
    1,1,1-trichloroethane 0.07
    2-aminoethanol 10.54
    morpholine-4-carbaldehyde 44.76
    sulfolane 41.31
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 14.34
    n-hexyl acetate 6.41
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 28.44
    sec-butyl acetate 5.13
    tert-butyl acetate 10.49
    decalin 0.04
    glycerin 21.75
    diglyme 51.13
    acrylic acid 6.45
    isopropyl myristate 3.47
    n-butyric acid 6.2
    acetyl acetate 3.61
    di(2-ethylhexyl) phthalate 5.26
    ethyl propionate 7.57
    nitromethane 12.84
    1,2-diethoxyethane 13.59
    benzonitrile 3.42
    trioctyl phosphate 3.73
    1-bromopropane 0.06
    gamma-valerolactone 32.74
    n-decanol 1.97
    triethyl phosphate 7.58
    4-methyl-2-pentanol 2.61
    propionitrile 2.49
    vinylene carbonate 5.9
    1,1,2-trichlorotrifluoroethane 17.46
    DMS 10.94
    cumene 0.7
    2-octanol 1.66
    2-hexanone 5.45
    octyl acetate 4.42
    limonene 1.45
    1,2-dimethoxyethane 35.82
    ethyl orthosilicate 6.66
    tributyl phosphate 4.4
    diacetone alcohol 27.63
    N,N-dimethylaniline 5.48
    acrylonitrile 4.54
    aniline 3.36
    1,3-propanediol 19.18
    bromobenzene 0.11
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.34
    2-methyl-cyclohexyl acetate 7.71
    tetrabutyl urea 7.38
    diisobutyl methanol 2.54
    2-phenylethanol 8.19
    styrene 0.5
    dioctyl adipate 6.6
    dimethyl sulfate 22.17
    ethyl butyrate 6.8
    methyl lactate 16.97
    butyl lactate 8.77
    diethyl carbonate 6.27
    propanediol butyl ether 14.54
    triethyl orthoformate 7.9
    p-tert-butyltoluene 1.34
    methyl 4-tert-butylbenzoate 13.19
    morpholine 24.05
    tert-butylamine 1.76
    n-dodecanol 1.48
    dimethoxymethane 28.57
    ethylene carbonate 5.06
    cyrene 20.49
    2-ethoxyethyl acetate 13.21
    2-ethylhexyl acetate 6.56
    1,2,4-trichlorobenzene 1.25
    4-methylpyridine 5.05
    dibutyl ether 2.46
    2,6-dimethyl-4-heptanol 2.54
    DEF 16.62
    dimethyl isosorbide 34.18
    tetrachloroethylene 0.29
    eugenol 14.93
    triacetin 11.95
    span 80 12.36
    1,4-butanediol 4.78
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 3.95
    methyl formate 6.45
    2-methyl-1-butanol 5.08
    n-decane 0.06
    butyronitrile 2.0
    3,7-dimethyl-1-octanol 2.9
    1-chlorooctane 0.42
    1-chlorotetradecane 0.27
    n-nonane 0.03
    undecane 0.05
    tert-butylcyclohexane 0.05
    cyclooctane 0.01
    cyclopentanol 3.91
    tetrahydropyran 3.44
    tert-amyl methyl ether 5.71
    2,5,8-trioxanonane 38.64
    1-hexene 0.04
    2-isopropoxyethanol 16.51
    2,2,2-trifluoroethanol 4.21
    methyl butyrate 7.64

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction