Uridine

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  • Identifiers

    CAS number
    58-96-8

    Molecular formula
    C9H12N2O6

    SMILES
    C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 85.74%
    Bitter 20.16%
    Burnt 18.21%
    Savory 18.04%
    Caramellic 15.86%
    Cooked 13.87%
    Milky 13.29%
    Popcorn 12.9%
    Roasted 12.48%
    Nutty 12.32%

     

    Flavor
    Bitter 78.72%
    Odorless 38.9%
    Sweet-like 23.51%
    Bland 23.03%
    Very mild 21.04%
    Cedarleaf 19.46%
    Nitrile 19.2%
    Bread crust 18.9%
    Formyl 18.73%
    Cardboard 18.69%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.0

    pKa est.
    6.25 (neutral)

    Molecular weight
    244.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1488°C

    Melting point expt.

    • 165 °C
    • 163 °C

    Flash point

    • 282.32 ˚C est.

    Solubility expt.

    • 34.9 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • uridine
    • 58-96-8
    • Uridin
    • Uracil riboside
    • 1-beta-D-Ribofuranosyluracil
    • CHEBI:16704
    • WHI7HQ7H85
    • DTXSID40891555
    • NSC-20256
    • NSC20256
    • 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione
    • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
    • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
    • Allo Uridine
    • Allo-Uridine
    • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)pyrimidine-2,4-dione
    • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
    • RefChem:6340
    • DTXCID001030648
    • 200-407-5
    • MFCD00006526
    • Uracil, 1-beta-D-ribofuranosyl-
    • beta-Uridine
    • 1-.beta.-D-Ribofuranosyluracil
    • d-uridine
    • NSC 20256
    • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
    • Urd
    • AI3-52690
    • C9H12N2O6
    • MLS000069625
    • 92487-68-8
    • Uridine-15N2
    • SMR000058222
    • 69-75-0
    • Uracil-1-beta-d-ribofuranoside
    • 1-beta-D-Ribofuranosylpyrimidine-2,4(1H,3H)-dione (Uridine)
    • b-Uridine
    • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
    • 1-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-dihydropyrimi dine-2,4-dione
    • EINECS 200-407-5
    • UNII-WHI7HQ7H85
    • araU
    • d-Ribosyl uracil
    • .beta.-Uridine
    • Uridine (Standard)
    • Adenosine Impurity 8
    • 1af2
    • 4jx9
    • 4pd6
    • Opera_ID_118
    • Uridine, >=99%
    • URIDINE [MI]
    • URIDINE [MART.]
    • 1-b-D-Ribofuranosyluracil
    • URIDINE [USP-RS]
    • URIDINE [WHO-DD]
    • 1-A-D-Ribofuranosyluracil
    • bmse000158
    • bmse000816
    • bmse000864
    • Epitope ID:149164
    • 1-.beta.-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
    • beta-D-ribofuranosyl-uridine
    • SCHEMBL20667
    • Uracil-1-A-D-ribofuranoside
    • rg2417
    • Uridine, BioUltra, >=99%
    • URIDINE [USP IMPURITY]
    • CHEMBL100259
    • GTPL4566
    • SCHEMBL3370976
    • SCHEMBL8600376
    • SCHEMBL9177985
    • SCHEMBL9179675
    • 1-beta-delta-Ribofuranosyluracil
    • HY-B1449R
    • MSK6806
    • Uracil-1-.beta.-d-ribofuranoside
    • HMS2230P13
    • HMS3884M20
    • BB_NC-03354
    • HY-B1449
    • BDBM50088517
    • EBC-08618
    • s2029
    • SBB000838
    • AKOS015896922
    • CCG-214447
    • CS-5153
    • DB02745
    • NU06309
    • SMP1_000029
    • NCGC00017312-02
    • NCGC00017312-04
    • NCGC00017312-05
    • NCGC00142368-01
    • BP-58653
    • DS-14345
    • SRI-10895_12
    • ST023512
    • SY005419
    • Uridine, Vetec(TM) reagent grade, 99%
    • ADENOSINE IMPURITY F [EP IMPURITY]
    • DB-030519
    • NS00014580
    • U0020
    • C00299
    • EN300-221746
    • 1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
    • b-D-Ribofuranoside 2,4(1H,3H)-pyrimidinedione-1
    • F078878
    • Q422573
    • BRD-K13050303-001-17-3
    • BRD-K13050303-001-18-1
    • Uridine, powder, BioReagent, suitable for cell culture
    • .beta.-D-Ribofuranoside, 2,4(1H,3H)-pyrimidinedione-1
    • 1-beta-delta-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
    • 6B6FA3F8-70A2-44EA-B99C-D35D0A9237AA
    • beta-delta-Ribofuranoside 2,4(1H,3H)-pyrimidinedione-1
    • Z1741976658
    • Uridine; Adenosine EP Impurity F; Cytarabine EP Impurity B
    • 1-.BETA.-D-RIBOFURANOSYLPYRIMIDINE-2,4(1H,3H)-DIONE
    • 1-beta-D-Ribofuranosyluracil, Uracil-1-beta-D-ribofuranoside
    • Uridine, United States Pharmacopeia (USP) Reference Standard
    • 58-96-8

  • Applications

    Uridine (CAS 58-96-8) is primarily used as a building block and intermediate in the synthesis of nucleotides and nucleotide derivatives for pharmaceutical manufacturing; as a cell culture media supplement to support RNA synthesis and cell growth; as a biochemical reagent in molecular biology and enzymology studies, for example as a substrate or reference material in nucleoside assays; serving as an analytical standard for quantifying nucleosides by HPLC/LC-MS; and may be used as or regarded as a precursor in the industrial production of nucleotides or nucleotide derivatives for various applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.75
    methanol 12.66
    isopropanol 2.09
    water 273.41
    ethyl acetate 0.17
    n-propanol 1.81
    acetone 0.88
    n-butanol 1.63
    acetonitrile 0.81
    DMF 360.0
    toluene 0.1
    isobutanol 0.91
    1,4-dioxane 1.86
    methyl acetate 0.34
    THF 3.32
    2-butanone 0.71
    n-pentanol 0.72
    sec-butanol 1.31
    n-hexane 0.05
    ethylene glycol 40.28
    NMP 175.37
    cyclohexane 0.11
    DMSO 426.53
    n-butyl acetate 0.39
    n-octanol 0.45
    chloroform 0.09
    n-propyl acetate 0.27
    acetic acid 13.04
    dichloromethane 0.14
    cyclohexanone 3.43
    propylene glycol 19.53
    isopropyl acetate 0.16
    DMAc 126.41
    2-ethoxyethanol 11.33
    isopentanol 1.11
    n-heptane 0.14
    ethyl formate 1.0
    1,2-dichloroethane 0.2
    n-hexanol 0.85
    2-methoxyethanol 38.41
    isobutyl acetate 0.11
    tetrachloromethane 0.09
    n-pentyl acetate 0.3
    transcutol 6.4
    n-heptanol 0.76
    ethylbenzene 0.09
    MIBK 0.51
    2-propoxyethanol 6.89
    tert-butanol 1.77
    MTBE 0.19
    2-butoxyethanol 3.87
    propionic acid 2.66
    o-xylene 0.21
    formic acid 236.52
    diethyl ether 0.28
    m-xylene 0.14
    p-xylene 0.14
    chlorobenzene 0.05
    dimethyl carbonate 1.66
    n-octane 0.06
    formamide 227.79
    cyclopentanone 4.79
    2-pentanone 0.62
    anisole 0.26
    cyclopentyl methyl ether 1.21
    gamma-butyrolactone 7.2
    1-methoxy-2-propanol 16.45
    pyridine 1.44
    3-pentanone 0.58
    furfural 11.48
    n-dodecane 0.03
    diethylene glycol 20.53
    diisopropyl ether 0.09
    tert-amyl alcohol 1.38
    acetylacetone 0.94
    n-hexadecane 0.04
    acetophenone 0.75
    methyl propionate 0.85
    isopentyl acetate 0.41
    trichloroethylene 0.27
    n-nonanol 0.47
    cyclohexanol 1.81
    benzyl alcohol 0.95
    2-ethylhexanol 0.51
    isooctanol 0.51
    dipropyl ether 0.64
    1,2-dichlorobenzene 0.09
    ethyl lactate 2.3
    propylene carbonate 2.25
    n-methylformamide 73.34
    2-pentanol 0.76
    n-pentane 0.06
    1-propoxy-2-propanol 3.91
    1-methoxy-2-propyl acetate 1.29
    2-(2-methoxypropoxy) propanol 3.9
    mesitylene 0.14
    ε-caprolactone 3.09
    p-cymene 0.21
    epichlorohydrin 2.28
    1,1,1-trichloroethane 0.06
    2-aminoethanol 25.03
    morpholine-4-carbaldehyde 62.36
    sulfolane 50.66
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 1.04
    n-hexyl acetate 0.35
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 4.46
    sec-butyl acetate 0.14
    tert-butyl acetate 0.31
    decalin 0.04
    glycerin 79.17
    diglyme 8.49
    acrylic acid 6.47
    isopropyl myristate 0.19
    n-butyric acid 1.92
    acetyl acetate 0.17
    di(2-ethylhexyl) phthalate 0.5
    ethyl propionate 0.34
    nitromethane 17.1
    1,2-diethoxyethane 0.56
    benzonitrile 0.54
    trioctyl phosphate 0.47
    1-bromopropane 0.11
    gamma-valerolactone 18.89
    n-decanol 0.36
    triethyl phosphate 0.73
    4-methyl-2-pentanol 0.42
    propionitrile 0.59
    vinylene carbonate 2.25
    1,1,2-trichlorotrifluoroethane 17.32
    DMS 0.49
    cumene 0.09
    2-octanol 0.37
    2-hexanone 0.4
    octyl acetate 0.29
    limonene 0.3
    1,2-dimethoxyethane 7.87
    ethyl orthosilicate 0.58
    tributyl phosphate 0.47
    diacetone alcohol 3.16
    N,N-dimethylaniline 0.56
    acrylonitrile 1.56
    aniline 0.57
    1,3-propanediol 17.02
    bromobenzene 0.03
    dibromomethane 0.08
    1,1,2,2-tetrachloroethane 0.37
    2-methyl-cyclohexyl acetate 0.58
    tetrabutyl urea 1.33
    diisobutyl methanol 0.35
    2-phenylethanol 0.89
    styrene 0.07
    dioctyl adipate 0.44
    dimethyl sulfate 9.94
    ethyl butyrate 0.54
    methyl lactate 8.1
    butyl lactate 1.47
    diethyl carbonate 0.4
    propanediol butyl ether 4.45
    triethyl orthoformate 0.71
    p-tert-butyltoluene 0.19
    methyl 4-tert-butylbenzoate 1.51
    morpholine 5.95
    tert-butylamine 0.5
    n-dodecanol 0.26
    dimethoxymethane 11.31
    ethylene carbonate 1.43
    cyrene 10.86
    2-ethoxyethyl acetate 0.47
    2-ethylhexyl acetate 0.31
    1,2,4-trichlorobenzene 0.15
    4-methylpyridine 1.01
    dibutyl ether 0.27
    2,6-dimethyl-4-heptanol 0.35
    DEF 7.19
    dimethyl isosorbide 5.9
    tetrachloroethylene 0.37
    eugenol 2.32
    triacetin 0.77
    span 80 2.75
    1,4-butanediol 7.35
    1,1-dichloroethane 0.06
    2-methyl-1-pentanol 0.52
    methyl formate 20.46
    2-methyl-1-butanol 1.03
    n-decane 0.06
    butyronitrile 0.53
    3,7-dimethyl-1-octanol 0.35
    1-chlorooctane 0.11
    1-chlorotetradecane 0.05
    n-nonane 0.06
    undecane 0.04
    tert-butylcyclohexane 0.02
    cyclooctane 0.06
    cyclopentanol 2.6
    tetrahydropyran 0.9
    tert-amyl methyl ether 0.36
    2,5,8-trioxanonane 6.73
    1-hexene 0.1
    2-isopropoxyethanol 3.09
    2,2,2-trifluoroethanol 14.96
    methyl butyrate 0.7

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction