Ubiquinone-5

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  • Identifiers

    CAS number
    4370-61-0

    Molecular formula
    C34H50O4

    SMILES
    CC1=C(C(=O)C(=C(C1=O)OC)OC)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C

    Safety labels

  • Odor profile

    Fragrance
    Floral 68.29%
    Fruity 53.56%
    Sweet 49.29%
    Woody 47.14%
    Waxy 44.3%
    Balsamic 36.45%
    Rose 34.89%
    Powdery 34.55%
    Oily 33.64%
    Tropical 31.23%

     

    Flavor
    Herbal 39.56%
    Spicy 32.36%
    Woody 31.93%
    Balsam 29.95%
    Floral 29.66%
    Wood 26.96%
    Balsamic 25.13%
    Jasmin 23.98%
    Diterpene 22.68%
    Low 22.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    10.1

    pKa est.
    4.23 (weak acid)

    Molecular weight
    522.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    562°C

    Flash point

    • 195.37 ˚C est.

  • Synonyms

    • ubiquinone 25
    • CHEBI:46331
    • 2,3-dimethoxy-5-methyl-6-[(2E,6E,10E,14E)-3,7,11,15,19-pentamethylicosa-2,6,10,14,18-pentaen-1-yl]cyclohexa-2,5-diene-1,4-dione
    • 2,3-dimethoxy-5-methyl-6-[(2E,6E,10E,14E)-3,7,11,15,19-pentamethylicosa-2,6,10,14,18-pentaenyl]cyclohexa-2,5-diene-1,4-dione
    • 2,3-dimethoxy-5-methyl-6-pentaprenyl-1,4-benzoquinone
    • 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
    • 2,5-Cyclohexadiene-1,4-dione, 2,3-dimethoxy-5-methyl-6-(3,7,11,15,19-pentamethyl-2,6,10,14,18-eicosapentaenyl)-, (all-E)-
    • (all-E)-2,3-dimethoxy-5-methyl-6-(3,7,11,15,19-pentamethyl-2,6,10,14,18-eicosapentaenyl)-2,5-cyclohexadiene-1,4-dione
    • 2,3-dimethoxy-5-methyl-6-[(2E,6E,10E,14E)-3,7,11,15,19-pentamethylicosa-2,6,10,14,18-pentaen-1-yl]-1,4-benzoquinone
    • 2,3-dimethoxy-5-methyl-6-((2E,6E,10E,14E)-3,7,11,15,19-pentamethylicosa-2,6,10,14,18-pentaen-1-yl)-1,4-benzoquinone
    • 2,3-dimethoxy-5-methyl-6-((2E,6E,10E,14E)-3,7,11,15,19-pentamethylicosa-2,6,10,14,18-pentaen-1-yl)cyclohexa-2,5-diene-1,4-dione
    • 2,3-dimethoxy-5-methyl-6-((2E,6E,10E,14E)-3,7,11,15,19-pentamethylicosa-2,6,10,14,18-pentaenyl)cyclohexa-2,5-diene-1,4-dione
    • 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-(1,4)BENZOQUINONE
    • RefChem:192858
    • Ubiquinone 5
    • Ubiquinone-5
    • CoQ5
    • 4370-61-0
    • SCHEMBL29402769
    • Q27104564
    • 4370-61-0

  • Applications

    Ubiquinone-5 (CAS 4370-61-0) is used primarily as an antioxidant in cosmetics and personal care formulations, helping to stabilize products and mitigate oxidative degradation. It also serves as a stabilizer and radical-scavenging additive for polymers, plastics, and coatings/inks, improving UV and thermal stability during processing and service. In food processing and nutraceutical contexts, ubiquinone-5 is evaluated as a dietary supplement ingredient with potential as a nutraceutical additive in certain markets. In pharmaceutical research, it is employed as a biochemical reference standard and as a reagent in synthetic routes to ubiquinone and related analogs. Additionally, ubiquinone-5 can function as an intermediate in the preparation of ubiquinone derivatives for research and development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.1
    methanol 1.24
    isopropanol 2.29
    water 0.0
    ethyl acetate 36.46
    n-propanol 5.93
    acetone 17.29
    n-butanol 6.54
    acetonitrile 3.56
    DMF 16.02
    toluene 35.1
    isobutanol 4.98
    1,4-dioxane 34.37
    methyl acetate 19.47
    THF 104.35
    2-butanone 41.49
    n-pentanol 11.84
    sec-butanol 8.48
    n-hexane 9.46
    ethylene glycol 0.09
    NMP 86.87
    cyclohexane 8.33
    DMSO 13.15
    n-butyl acetate 26.65
    n-octanol 6.67
    chloroform 120.91
    n-propyl acetate 30.14
    acetic acid 7.44
    dichloromethane 103.35
    cyclohexanone 86.12
    propylene glycol 0.48
    isopropyl acetate 24.98
    DMAc 68.87
    2-ethoxyethanol 13.68
    isopentanol 7.5
    n-heptane 4.14
    ethyl formate 8.89
    1,2-dichloroethane 58.82
    n-hexanol 8.39
    2-methoxyethanol 6.1
    isobutyl acetate 21.1
    tetrachloromethane 19.69
    n-pentyl acetate 36.77
    transcutol 46.41
    n-heptanol 9.01
    ethylbenzene 28.45
    MIBK 22.35
    2-propoxyethanol 15.56
    tert-butanol 4.53
    MTBE 23.65
    2-butoxyethanol 20.61
    propionic acid 7.13
    o-xylene 24.68
    formic acid 0.84
    diethyl ether 29.59
    m-xylene 21.14
    p-xylene 32.73
    chlorobenzene 45.6
    dimethyl carbonate 7.98
    n-octane 2.04
    formamide 1.87
    cyclopentanone 77.05
    2-pentanone 36.41
    anisole 39.08
    cyclopentyl methyl ether 59.58
    gamma-butyrolactone 58.45
    1-methoxy-2-propanol 8.52
    pyridine 55.26
    3-pentanone 42.21
    furfural 38.4
    n-dodecane 0.81
    diethylene glycol 2.46
    diisopropyl ether 10.06
    tert-amyl alcohol 13.03
    acetylacetone 35.05
    n-hexadecane 1.0
    acetophenone 41.79
    methyl propionate 25.37
    isopentyl acetate 27.74
    trichloroethylene 135.22
    n-nonanol 8.67
    cyclohexanol 14.62
    benzyl alcohol 17.1
    2-ethylhexanol 10.94
    isooctanol 9.91
    dipropyl ether 21.8
    1,2-dichlorobenzene 46.06
    ethyl lactate 7.77
    propylene carbonate 27.41
    n-methylformamide 4.6
    2-pentanol 7.21
    n-pentane 4.11
    1-propoxy-2-propanol 15.23
    1-methoxy-2-propyl acetate 28.29
    2-(2-methoxypropoxy) propanol 20.98
    mesitylene 12.23
    ε-caprolactone 77.0
    p-cymene 11.25
    epichlorohydrin 93.09
    1,1,1-trichloroethane 77.3
    2-aminoethanol 0.67
    morpholine-4-carbaldehyde 40.16
    sulfolane 75.73
    2,2,4-trimethylpentane 4.0
    2-methyltetrahydrofuran 92.7
    n-hexyl acetate 32.31
    isooctane 1.52
    2-(2-butoxyethoxy)ethanol 23.48
    sec-butyl acetate 30.5
    tert-butyl acetate 31.72
    decalin 7.59
    glycerin 0.72
    diglyme 51.61
    acrylic acid 5.05
    isopropyl myristate 10.69
    n-butyric acid 16.0
    acetyl acetate 19.48
    di(2-ethylhexyl) phthalate 11.57
    ethyl propionate 31.9
    nitromethane 15.31
    1,2-diethoxyethane 33.19
    benzonitrile 14.17
    trioctyl phosphate 7.0
    1-bromopropane 51.97
    gamma-valerolactone 84.72
    n-decanol 5.36
    triethyl phosphate 15.58
    4-methyl-2-pentanol 5.33
    propionitrile 7.1
    vinylene carbonate 21.59
    1,1,2-trichlorotrifluoroethane 35.19
    DMS 17.69
    cumene 17.91
    2-octanol 7.38
    2-hexanone 41.37
    octyl acetate 13.76
    limonene 17.33
    1,2-dimethoxyethane 37.69
    ethyl orthosilicate 18.48
    tributyl phosphate 8.09
    diacetone alcohol 20.56
    N,N-dimethylaniline 31.32
    acrylonitrile 6.34
    aniline 20.37
    1,3-propanediol 1.6
    bromobenzene 59.53
    dibromomethane 70.98
    1,1,2,2-tetrachloroethane 117.43
    2-methyl-cyclohexyl acetate 33.29
    tetrabutyl urea 13.34
    diisobutyl methanol 6.14
    2-phenylethanol 16.55
    styrene 27.21
    dioctyl adipate 18.66
    dimethyl sulfate 17.33
    ethyl butyrate 28.55
    methyl lactate 5.27
    butyl lactate 15.3
    diethyl carbonate 14.72
    propanediol butyl ether 8.17
    triethyl orthoformate 25.39
    p-tert-butyltoluene 10.42
    methyl 4-tert-butylbenzoate 35.68
    morpholine 40.79
    tert-butylamine 3.81
    n-dodecanol 3.51
    dimethoxymethane 16.16
    ethylene carbonate 18.0
    cyrene 30.58
    2-ethoxyethyl acetate 44.22
    2-ethylhexyl acetate 28.82
    1,2,4-trichlorobenzene 62.93
    4-methylpyridine 52.09
    dibutyl ether 16.41
    2,6-dimethyl-4-heptanol 6.14
    DEF 42.27
    dimethyl isosorbide 52.85
    tetrachloroethylene 62.82
    eugenol 25.21
    triacetin 30.14
    span 80 18.68
    1,4-butanediol 1.3
    1,1-dichloroethane 48.57
    2-methyl-1-pentanol 17.92
    methyl formate 4.19
    2-methyl-1-butanol 10.58
    n-decane 2.25
    butyronitrile 9.0
    3,7-dimethyl-1-octanol 7.83
    1-chlorooctane 11.04
    1-chlorotetradecane 2.97
    n-nonane 2.0
    undecane 1.24
    tert-butylcyclohexane 5.91
    cyclooctane 4.02
    cyclopentanol 13.05
    tetrahydropyran 67.01
    tert-amyl methyl ether 33.7
    2,5,8-trioxanonane 30.45
    1-hexene 23.82
    2-isopropoxyethanol 15.35
    2,2,2-trifluoroethanol 2.99
    methyl butyrate 37.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction