Tween 20

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  • Identifiers

    CAS number
    1052273-76-3

    Molecular formula
    C26H50O10

    SMILES
    CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO

  • Odor profile

    Fragrance
    Odorless 48.49%
    Alcoholic 35.25%
    Oily 30.85%
    Waxy 24.33%
    Fresh 22.42%
    Fatty 21.41%
    Sweet 20.99%
    Buttery 20.44%
    Lactonic 18.15%
    Fruity 17.98%

     

    Flavor
    Fatty 42.54%
    Waxy 42.17%
    Odorless 35.64%
    Sweet 34.6%
    Oily 32.27%
    Mild 30.78%
    Creamy 28.46%
    Fruity 27.63%
    Sweet-like 26.78%
    Mushroom 26.61%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    4.87 (weak acid)

    Molecular weight
    522.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1256°C

    Flash point

    • 235.75 ˚C est.

  • Synonyms

    • Tween 20
    • 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
    • Tween 40
    • 1052273-76-3
    • PEG-80 Sorbitan laurate
    • Sorbimacrogol laurate 300
    • 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate
    • 2-(2-(3,4-Bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate
    • 2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
    • Alkest TW 20
    • tween (R) 20
    • Tween 20 (TN)
    • Tween 40 (TN)
    • Tween 60 (TN)
    • TWEEN? 20
    • SCHEMBL118527
    • POE (6) sorbitol monolaurate
    • POE(20) sorbitan monolaurate
    • CHEMBL371631
    • POE (20) sorbitan monolaurate
    • DTXSID60922815
    • HMFKFHLTUCJZJO-UHFFFAOYSA-N
    • MFCD00165986
    • FP44979
    • FT47116
    • E432
    • NS00013950
    • D05565
    • D05566
    • D05567
    • Polyethylene glycol sorbitan monolaurate;Tween 20
    • Polysorbate 4;Polyoxyethylene glycol sorbitan Monopalmitate
    • 2-(2-(3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyldodecanoate
    • 2-{2-[3,4-Bis(2-hydroxyethoxy)tetrahydro-2-furanyl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate

  • Applications

    Tween 20 (Polysorbate 20) is a nonionic surfactant broadly used as an emulsifier, stabilizer, and wetting agent in a range of industrial and consumer formulations. In cosmetics and personal care, it helps form and stabilize emulsions and improves cleansing performance. In food processing, it serves as an emulsifier and solubilizing aid for hydrophobic ingredients. In household cleaning products, it acts as a surfactant to improve wetting, dispersion, and cleaning efficacy. In pharmaceuticals, it is commonly used as a solubilizer and formulation aid. In coatings, inks, and paints, it provides wetting and pigment dispersion. In agricultural formulations, it may be used as an adjuvant to improve spray coverage and formulation compatibility.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 23.34
    methanol 77.58
    isopropanol 10.74
    water 24.55
    ethyl acetate 57.81
    n-propanol 25.34
    acetone 64.49
    n-butanol 17.73
    acetonitrile 30.63
    DMF 216.5
    toluene 17.17
    isobutanol 15.97
    1,4-dioxane 61.35
    methyl acetate 57.19
    THF 92.22
    2-butanone 54.48
    n-pentanol 16.38
    sec-butanol 15.93
    n-hexane 0.86
    ethylene glycol 25.42
    NMP 545.46
    cyclohexane 3.76
    DMSO 395.5
    n-butyl acetate 26.6
    n-octanol 15.74
    chloroform 112.95
    n-propyl acetate 34.6
    acetic acid 281.55
    dichloromethane 149.37
    cyclohexanone 143.43
    propylene glycol 26.82
    isopropyl acetate 36.91
    DMAc 385.86
    2-ethoxyethanol 73.11
    isopentanol 14.31
    n-heptane 1.39
    ethyl formate 55.4
    1,2-dichloroethane 83.09
    n-hexanol 10.26
    2-methoxyethanol 104.47
    isobutyl acetate 19.66
    tetrachloromethane 21.93
    n-pentyl acetate 49.2
    transcutol 173.35
    n-heptanol 16.59
    ethylbenzene 8.49
    MIBK 24.07
    2-propoxyethanol 49.34
    tert-butanol 13.27
    MTBE 11.82
    2-butoxyethanol 63.45
    propionic acid 106.62
    o-xylene 17.63
    formic acid 239.63
    diethyl ether 13.55
    m-xylene 13.18
    p-xylene 10.79
    chlorobenzene 28.74
    dimethyl carbonate 72.77
    n-octane 0.97
    formamide 252.85
    cyclopentanone 165.46
    2-pentanone 42.6
    anisole 20.49
    cyclopentyl methyl ether 54.82
    gamma-butyrolactone 270.68
    1-methoxy-2-propanol 67.22
    pyridine 79.1
    3-pentanone 49.64
    furfural 236.45
    n-dodecane 0.83
    diethylene glycol 51.28
    diisopropyl ether 5.11
    tert-amyl alcohol 18.95
    acetylacetone 106.6
    n-hexadecane 0.94
    acetophenone 53.46
    methyl propionate 74.35
    isopentyl acetate 24.75
    trichloroethylene 206.04
    n-nonanol 16.15
    cyclohexanol 35.32
    benzyl alcohol 35.4
    2-ethylhexanol 9.01
    isooctanol 13.82
    dipropyl ether 11.96
    1,2-dichlorobenzene 42.69
    ethyl lactate 49.22
    propylene carbonate 143.86
    n-methylformamide 134.13
    2-pentanol 10.54
    n-pentane 0.93
    1-propoxy-2-propanol 37.14
    1-methoxy-2-propyl acetate 54.19
    2-(2-methoxypropoxy) propanol 52.86
    mesitylene 8.11
    ε-caprolactone 169.97
    p-cymene 7.82
    epichlorohydrin 177.52
    1,1,1-trichloroethane 57.28
    2-aminoethanol 45.47
    morpholine-4-carbaldehyde 263.85
    sulfolane 554.32
    2,2,4-trimethylpentane 1.27
    2-methyltetrahydrofuran 60.86
    n-hexyl acetate 43.49
    isooctane 0.48
    2-(2-butoxyethoxy)ethanol 66.19
    sec-butyl acetate 24.47
    tert-butyl acetate 38.36
    decalin 2.32
    glycerin 72.55
    diglyme 149.92
    acrylic acid 139.69
    isopropyl myristate 13.23
    n-butyric acid 107.15
    acetyl acetate 79.76
    di(2-ethylhexyl) phthalate 22.53
    ethyl propionate 36.14
    nitromethane 402.52
    1,2-diethoxyethane 34.45
    benzonitrile 36.54
    trioctyl phosphate 17.1
    1-bromopropane 20.98
    gamma-valerolactone 286.38
    n-decanol 9.87
    triethyl phosphate 32.71
    4-methyl-2-pentanol 6.83
    propionitrile 21.39
    vinylene carbonate 155.17
    1,1,2-trichlorotrifluoroethane 287.59
    DMS 58.07
    cumene 6.81
    2-octanol 10.7
    2-hexanone 26.23
    octyl acetate 21.82
    limonene 11.78
    1,2-dimethoxyethane 71.2
    ethyl orthosilicate 26.96
    tributyl phosphate 20.75
    diacetone alcohol 58.92
    N,N-dimethylaniline 21.7
    acrylonitrile 43.9
    aniline 33.03
    1,3-propanediol 44.87
    bromobenzene 28.72
    dibromomethane 60.59
    1,1,2,2-tetrachloroethane 161.26
    2-methyl-cyclohexyl acetate 31.1
    tetrabutyl urea 31.18
    diisobutyl methanol 5.3
    2-phenylethanol 21.33
    styrene 9.55
    dioctyl adipate 31.45
    dimethyl sulfate 213.15
    ethyl butyrate 30.26
    methyl lactate 85.1
    butyl lactate 56.47
    diethyl carbonate 24.33
    propanediol butyl ether 54.78
    triethyl orthoformate 31.0
    p-tert-butyltoluene 7.15
    methyl 4-tert-butylbenzoate 66.91
    morpholine 91.36
    tert-butylamine 5.74
    n-dodecanol 6.5
    dimethoxymethane 81.63
    ethylene carbonate 122.41
    cyrene 104.94
    2-ethoxyethyl acetate 81.5
    2-ethylhexyl acetate 21.17
    1,2,4-trichlorobenzene 63.55
    4-methylpyridine 56.48
    dibutyl ether 12.33
    2,6-dimethyl-4-heptanol 5.3
    DEF 107.32
    dimethyl isosorbide 93.73
    tetrachloroethylene 112.88
    eugenol 57.37
    triacetin 107.44
    span 80 47.68
    1,4-butanediol 25.35
    1,1-dichloroethane 42.25
    2-methyl-1-pentanol 15.24
    methyl formate 109.72
    2-methyl-1-butanol 18.55
    n-decane 1.61
    butyronitrile 16.54
    3,7-dimethyl-1-octanol 11.64
    1-chlorooctane 9.03
    1-chlorotetradecane 3.07
    n-nonane 1.35
    undecane 1.1
    tert-butylcyclohexane 1.32
    cyclooctane 1.69
    cyclopentanol 43.78
    tetrahydropyran 42.02
    tert-amyl methyl ether 17.39
    2,5,8-trioxanonane 93.87
    1-hexene 3.14
    2-isopropoxyethanol 42.02
    2,2,2-trifluoroethanol 196.36
    methyl butyrate 50.39

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction