Tryptophol

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  • Identifiers

    CAS number
    526-55-6

    Molecular formula
    C10H11NO

    SMILES
    C1=CC=C2C(=C1)C(=CN2)CCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 62.42%
    Grape 41.78%
    Fruity 41.59%
    Sweet 40.07%
    Animal 39.08%
    Honey 33.39%
    Rose 31.69%
    Neroli 29.39%
    Powdery 26.52%
    Orange 26.12%

     

    Flavor
    Sweet 62.06%
    Fruity 56.8%
    Bitter 56.63%
    Floral 52.54%
    Mild 37.22%
    Honey 30.3%
    Powdery 29.5%
    Rose 29.33%
    Grape 26.64%
    Balsam 26.54%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    7.0 (neutral)

    Molecular weight
    161.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    383°C

    Melting point expt.

    • 59 °C

    Flash point

    • 184.78 ˚C est.

  • Synonyms

    • Tryptophol
    • 526-55-6
    • Indole-3-ethanol
    • 3-(2-Hydroxyethyl)indole
    • 1H-Indole-3-ethanol
    • 2-(1H-Indol-3-yl)ethanol
    • 3-Indolylethanol
    • Indoleethanol
    • Indole ethanol
    • DTXSID2060173
    • 5809LZ7G1U
    • NSC-3884
    • CHEBI:17890
    • RefChem:900693
    • DTXCID1041219
    • 208-393-2
    • 3-Indoleethanol
    • 2-(3-Indolyl)ethanol
    • Ethanol, 2-indol-3-yl-
    • 3-(beta-Hydroxyethyl)indole
    • ETHANOL, 3-INDOLYL-
    • 1H-Indolyl-3-ethanol
    • beta-Indol-3-ylethanol
    • MFCD00005659
    • 2-(1H-Indol-3-yl)-ethanol
    • NSC 3884
    • IEA
    • 2-(indol-3-yl)ethanol
    • Maybridge1_002422
    • .beta.-(3-Indole)ethanol
    • 3-(.beta.-Hydroxyethyl)indole
    • 2-indol-3-ylethan-1-ol
    • EINECS 208-393-2
    • BRN 0125553
    • 2-(3-INDOLE)ETHANOL
    • UNII-5809LZ7G1U
    • 3-indolethanol
    • Tryptaphol, 6
    • ZCW
    • (indol-3-yl)ethanol
    • 2-(3-Indolylethanol
    • b-(3-Indole)ethanol
    • TRYPTOPHOL [MI]
    • beta-(3-Indole)ethanol
    • 2-(3-Indolyl)ethanol;
    • 3-(b-Hydroxyethyl)indole
    • 2-(indol-3-yl)-ethanol
    • bmse000473
    • 3-(2-Hydroxyethyl) Indole
    • 5-21-03-00061 (Beilstein Handbook Reference)
    • MLS001250154
    • DivK1c_001174
    • SCHEMBL196126
    • WLN: T56 BMJ D2Q
    • 2-INDOLYL(3)-ETHANOL
    • CHEMBL226545
    • ISUPSL100239
    • orb1302489
    • SCHEMBL2432999
    • SCHEMBL5513682
    • SCHEMBL5846319
    • SCHEMBL15515563
    • SCHEMBL27631244
    • SCHEMBL29364545
    • BDBM92686
    • HMS548G02
    • MBBOMCVGYCRMEA-UHFFFAOYSA-
    • 2-(1H-Indol-3-yl)ethanol #
    • NSC3884
    • 3-(2-Hydroxy-ethyl)-1H-indole
    • 3-(2-Hydroxyethyl)indole, 97%
    • HMS2270O23
    • .BETA.-INDOLYLETHYL ALCOHOL
    • 3-.BETA.-HYDROXYETHYLINDOLE
    • BB_NC-01188
    • 2-(3-INDOLYL)ETHYL ALCOHOL
    • 3-.OMEGA.-HYDROXYETHYLINDOLE
    • BBL027534
    • EBC-47210
    • s4858
    • SBB003950
    • STL382051
    • AKOS002666320
    • AC-3286
    • CCG-266289
    • CS-W010871
    • HY-W010155
    • MSK170045-100M
    • SB14961
    • CDS1_000134
    • NCGC00247328-01
    • 930395-07-6
    • AS-15780
    • SMR000686021
    • SY004666
    • DB-007578
    • DB-345928
    • Tryptophol Solution in Methanol, 100ug/mL
    • I0030
    • NS00014703
    • ST45023864
    • EN300-70080
    • C00955
    • T-8500
    • 526T556
    • AE-508/40182784
    • F791072
    • Q5479351
    • F2113-0945
    • Z1123806416
    • 3-(2-Hydroxyethyl)indole, Vetec(TM) reagent grade, 97%
    • 08DD2DF3-02E7-44DC-9714-864651873577
    • InChI=1/C10H11NO/c12-6-5-8-7-11-10-4-2-1-3-9(8)10/h1-4,7,11-12H,5-6H2
    • 526-55-6

  • Applications

    Tryptophol (CAS 526-55-6) is primarily used as a synthetic intermediate for indole-based compounds, supporting the production of pharmaceuticals and agrochemicals; acts as a precursor for indole-containing aromatics and related derivatives; its hydroxyl group can be functionalized (esterification or etherification) to enable material and coating applications; it is also considered as a candidate in fragrance and perfume development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 54.36
    methanol 114.73
    isopropanol 30.98
    water 2.76
    ethyl acetate 27.99
    n-propanol 50.45
    acetone 47.25
    n-butanol 39.66
    acetonitrile 16.49
    DMF 114.66
    toluene 1.73
    isobutanol 42.73
    1,4-dioxane 35.46
    methyl acetate 33.3
    THF 134.47
    2-butanone 42.91
    n-pentanol 46.39
    sec-butanol 35.19
    n-hexane 0.55
    ethylene glycol 75.84
    NMP 111.74
    cyclohexane 0.31
    DMSO 126.08
    n-butyl acetate 29.21
    n-octanol 12.85
    chloroform 9.11
    n-propyl acetate 30.18
    acetic acid 89.48
    dichloromethane 13.49
    cyclohexanone 50.78
    propylene glycol 54.93
    isopropyl acetate 16.89
    DMAc 135.97
    2-ethoxyethanol 147.62
    isopentanol 44.81
    n-heptane 1.06
    ethyl formate 30.62
    1,2-dichloroethane 12.1
    n-hexanol 46.13
    2-methoxyethanol 207.17
    isobutyl acetate 25.13
    tetrachloromethane 4.09
    n-pentyl acetate 20.83
    transcutol 192.86
    n-heptanol 23.25
    ethylbenzene 2.69
    MIBK 26.13
    2-propoxyethanol 122.14
    tert-butanol 46.66
    MTBE 17.14
    2-butoxyethanol 61.16
    propionic acid 57.03
    o-xylene 2.66
    formic acid 119.66
    diethyl ether 9.5
    m-xylene 2.97
    p-xylene 4.36
    chlorobenzene 5.36
    dimethyl carbonate 24.63
    n-octane 0.58
    formamide 176.95
    cyclopentanone 110.57
    2-pentanone 31.52
    anisole 17.65
    cyclopentyl methyl ether 30.73
    gamma-butyrolactone 142.08
    1-methoxy-2-propanol 112.1
    pyridine 23.1
    3-pentanone 19.95
    furfural 92.37
    n-dodecane 0.54
    diethylene glycol 141.11
    diisopropyl ether 4.71
    tert-amyl alcohol 45.23
    acetylacetone 45.43
    n-hexadecane 0.58
    acetophenone 25.95
    methyl propionate 35.86
    isopentyl acetate 30.61
    trichloroethylene 24.86
    n-nonanol 13.13
    cyclohexanol 20.8
    benzyl alcohol 29.21
    2-ethylhexanol 23.0
    isooctanol 21.11
    dipropyl ether 13.91
    1,2-dichlorobenzene 8.3
    ethyl lactate 30.51
    propylene carbonate 58.54
    n-methylformamide 105.04
    2-pentanol 21.71
    n-pentane 0.35
    1-propoxy-2-propanol 60.17
    1-methoxy-2-propyl acetate 40.72
    2-(2-methoxypropoxy) propanol 55.22
    mesitylene 2.48
    ε-caprolactone 54.15
    p-cymene 5.03
    epichlorohydrin 113.45
    1,1,1-trichloroethane 8.18
    2-aminoethanol 109.17
    morpholine-4-carbaldehyde 106.81
    sulfolane 150.29
    2,2,4-trimethylpentane 0.77
    2-methyltetrahydrofuran 67.0
    n-hexyl acetate 24.02
    isooctane 0.64
    2-(2-butoxyethoxy)ethanol 75.57
    sec-butyl acetate 18.49
    tert-butyl acetate 23.16
    decalin 0.78
    glycerin 117.87
    diglyme 118.46
    acrylic acid 54.73
    isopropyl myristate 9.94
    n-butyric acid 67.19
    acetyl acetate 15.71
    di(2-ethylhexyl) phthalate 17.57
    ethyl propionate 24.04
    nitromethane 125.69
    1,2-diethoxyethane 32.42
    benzonitrile 17.46
    trioctyl phosphate 13.27
    1-bromopropane 4.27
    gamma-valerolactone 124.03
    n-decanol 10.54
    triethyl phosphate 16.74
    4-methyl-2-pentanol 18.72
    propionitrile 17.48
    vinylene carbonate 39.42
    1,1,2-trichlorotrifluoroethane 82.06
    DMS 25.43
    cumene 3.97
    2-octanol 12.59
    2-hexanone 32.3
    octyl acetate 14.52
    limonene 6.77
    1,2-dimethoxyethane 114.4
    ethyl orthosilicate 15.59
    tributyl phosphate 14.64
    diacetone alcohol 55.91
    N,N-dimethylaniline 14.22
    acrylonitrile 27.87
    aniline 10.68
    1,3-propanediol 110.57
    bromobenzene 3.66
    dibromomethane 5.52
    1,1,2,2-tetrachloroethane 19.27
    2-methyl-cyclohexyl acetate 23.9
    tetrabutyl urea 21.79
    diisobutyl methanol 11.24
    2-phenylethanol 30.59
    styrene 2.57
    dioctyl adipate 17.51
    dimethyl sulfate 44.5
    ethyl butyrate 22.87
    methyl lactate 40.94
    butyl lactate 30.41
    diethyl carbonate 17.43
    propanediol butyl ether 51.74
    triethyl orthoformate 18.32
    p-tert-butyltoluene 4.45
    methyl 4-tert-butylbenzoate 30.29
    morpholine 56.42
    tert-butylamine 16.41
    n-dodecanol 8.12
    dimethoxymethane 63.97
    ethylene carbonate 33.18
    cyrene 58.2
    2-ethoxyethyl acetate 37.39
    2-ethylhexyl acetate 21.06
    1,2,4-trichlorobenzene 11.98
    4-methylpyridine 16.74
    dibutyl ether 9.32
    2,6-dimethyl-4-heptanol 11.24
    DEF 41.01
    dimethyl isosorbide 72.92
    tetrachloroethylene 18.65
    eugenol 41.51
    triacetin 31.16
    span 80 38.36
    1,4-butanediol 70.38
    1,1-dichloroethane 6.22
    2-methyl-1-pentanol 44.62
    methyl formate 67.03
    2-methyl-1-butanol 45.38
    n-decane 0.73
    butyronitrile 18.7
    3,7-dimethyl-1-octanol 15.51
    1-chlorooctane 3.88
    1-chlorotetradecane 1.93
    n-nonane 0.62
    undecane 0.61
    tert-butylcyclohexane 1.01
    cyclooctane 0.22
    cyclopentanol 45.79
    tetrahydropyran 19.92
    tert-amyl methyl ether 16.3
    2,5,8-trioxanonane 85.55
    1-hexene 3.13
    2-isopropoxyethanol 89.14
    2,2,2-trifluoroethanol 49.87
    methyl butyrate 37.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction