Tryptamine hydrochloride

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  • Identifiers

    CAS number
    343-94-2

    Molecular formula
    C10H13ClN2

    SMILES
    C1=CC=C2C(=C1)C(=CN2)CCN.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 51.61%
    Cheesy 48.49%
    Meaty 42.19%
    Animal 41.14%
    Ripe 36.91%
    Odorless 34.12%
    Burnt 30.81%
    Cooked 28.98%
    Savory 28.26%
    Roasted 26.64%

     

    Flavor
    Bitter 31.15%
    Mild 30.37%
    Meaty 28.84%
    Roasted 25.03%
    Very strong 22.49%
    Indole 22.14%
    Fishy 21.72%
    Nitrile 21.6%
    Animal 21.29%
    Moth ball 21.14%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    5.9 (weak acid)

    Molecular weight
    196.67 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    352°C

    Flash point

    • 179.36 ˚C est.

  • Synonyms

    • Tryptamine hydrochloride
    • 343-94-2
    • 3-(2-Aminoethyl)indole hydrochloride
    • 2-(1H-indol-3-yl)ethanamine hydrochloride
    • 1H-Indole-3-ethanamine, monohydrochloride
    • Tryptamine monohydrochloride
    • CCRIS 4419
    • Indole-3-ethylamine hydrochloride
    • Tryptamine HCl
    • beta-Indole-ethylamine hydrochloride
    • EINECS 206-446-4
    • 3-(2-Aminoethyl)-1H-indole monohydrochloride
    • beta-3-Indolylethylamine hydrochloride
    • 1H-Indole-3-ethanamine, hydrochloride (1:1)
    • NSC 522258
    • beta-Indolaethylamin-chlorhydrat
    • beta-Indolaethylamin-chlorhydrat [German]
    • UNII-2942LD1Q06
    • AI3-24258
    • MFCD00012682
    • Tryptamine (hydrochloride)
    • 2-(3-Indolyl)ethylamine hydrochloride
    • NSC-522258
    • DTXSID9059836
    • Indole, 3-(2-aminoethyl)-, monohydrochloride
    • 2942LD1Q06
    • 2-(1H-indol-3-yl)ethanamine;hydrochloride
    • 2-(1H-indol-3-yl)ethan-1-amine hydrochloride
    • 1H-Indole-3-ethanamine HCl
    • TRYPTAMINEHYDROCHLORIDE
    • 362049-49-8
    • 2-(Indol-3-yl)ethylamine hydrochloride
    • tryptamine-hcl
    • 2-(1H-indol-3-yl)ethanamine,hydrochloride
    • SR-01000075589
    • Tryptamine hydrochloride salt
    • SCHEMBL274183
    • Tryptamine hydrochloride, 99%
    • CHEMBL1255796
    • DTXCID1038820
    • Tryptamine-?,?-d2 hydrochloride
    • .beta.-Indolaethylamin-chlorhydrat
    • MPA04949
    • Tox21_500061
    • WLN: T56 BMJ D2Z & GH
    • NSC522258
    • AKOS004910399
    • CCG-221365
    • CS-W015687
    • FT37087
    • HY-W014971
    • LP00061
    • .beta.-Indole-ethylamine, hydrochloride
    • 3-(beta-aminoethyl)-indole hydrochloride
    • NCGC00093575-01
    • NCGC00260746-01
    • .beta.-3-Indolylethylamine, hydrochloride
    • AC-25536
    • AS-11527
    • DB-048617
    • A0300
    • EU-0100061
    • NS00079741
    • D88241
    • T-8150
    • 2-(1H-indol-3-yl)-ethylamine hydrochloride salt
    • SR-01000075589-1
    • Q27254385
    • 206-446-4

  • Applications

    Tryptamine hydrochloride is commonly used as an intermediate or reagent in organic synthesis, particularly for indole-based compounds in pharmaceutical research and development, serving as a building block for tryptamine-derived molecules and related pharmacophore structures. It also finds use in R&D laboratories across research and industrial settings to perform chemical transformations and optimize synthesis workflows. In industrial chemical manufacturing, it can act as a precursor for downstream synthetic sequences to produce other indole-containing compounds. It may also be employed as an analytical reference standard in quality control and analysis of related chemicals. Use should comply with local regulations and application-specific limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 104.6
    methanol 229.03
    isopropanol 44.81
    water 3.49
    ethyl acetate 60.41
    n-propanol 81.44
    acetone 130.9
    n-butanol 69.07
    acetonitrile 57.0
    DMF 365.59
    toluene 5.01
    isobutanol 57.22
    1,4-dioxane 92.26
    methyl acetate 64.13
    THF 318.52
    2-butanone 69.86
    n-pentanol 58.8
    sec-butanol 37.6
    n-hexane 0.85
    ethylene glycol 89.56
    NMP 186.68
    cyclohexane 0.77
    DMSO 360.2
    n-butyl acetate 45.74
    n-octanol 13.01
    chloroform 49.05
    n-propyl acetate 41.62
    acetic acid 189.05
    dichloromethane 57.92
    cyclohexanone 91.74
    propylene glycol 61.03
    isopropyl acetate 27.22
    DMAc 204.48
    2-ethoxyethanol 167.68
    isopentanol 54.64
    n-heptane 1.43
    ethyl formate 81.91
    1,2-dichloroethane 39.14
    n-hexanol 59.1
    2-methoxyethanol 337.01
    isobutyl acetate 36.0
    tetrachloromethane 11.37
    n-pentyl acetate 26.25
    transcutol 147.74
    n-heptanol 26.8
    ethylbenzene 3.67
    MIBK 31.11
    2-propoxyethanol 157.57
    tert-butanol 49.31
    MTBE 21.78
    2-butoxyethanol 68.67
    propionic acid 93.67
    o-xylene 4.23
    formic acid 202.47
    diethyl ether 18.78
    m-xylene 5.04
    p-xylene 6.52
    chlorobenzene 18.43
    dimethyl carbonate 53.63
    n-octane 0.78
    formamide 265.83
    cyclopentanone 243.06
    2-pentanone 58.05
    anisole 23.53
    cyclopentyl methyl ether 54.35
    gamma-butyrolactone 297.78
    1-methoxy-2-propanol 160.16
    pyridine 76.89
    3-pentanone 31.75
    furfural 209.44
    n-dodecane 0.67
    diethylene glycol 183.46
    diisopropyl ether 4.8
    tert-amyl alcohol 39.89
    acetylacetone 85.71
    n-hexadecane 0.73
    acetophenone 33.51
    methyl propionate 68.54
    isopentyl acetate 41.69
    trichloroethylene 81.97
    n-nonanol 12.99
    cyclohexanol 27.17
    benzyl alcohol 41.23
    2-ethylhexanol 26.17
    isooctanol 21.46
    dipropyl ether 18.92
    1,2-dichlorobenzene 19.15
    ethyl lactate 35.97
    propylene carbonate 120.99
    n-methylformamide 273.46
    2-pentanol 24.98
    n-pentane 0.71
    1-propoxy-2-propanol 73.61
    1-methoxy-2-propyl acetate 57.15
    2-(2-methoxypropoxy) propanol 43.15
    mesitylene 3.38
    ε-caprolactone 81.78
    p-cymene 5.72
    epichlorohydrin 237.21
    1,1,1-trichloroethane 24.11
    2-aminoethanol 130.41
    morpholine-4-carbaldehyde 175.46
    sulfolane 244.17
    2,2,4-trimethylpentane 0.98
    2-methyltetrahydrofuran 109.33
    n-hexyl acetate 25.05
    isooctane 0.7
    2-(2-butoxyethoxy)ethanol 63.12
    sec-butyl acetate 21.52
    tert-butyl acetate 26.67
    decalin 0.97
    glycerin 141.83
    diglyme 122.4
    acrylic acid 101.84
    isopropyl myristate 9.25
    n-butyric acid 140.55
    acetyl acetate 34.5
    di(2-ethylhexyl) phthalate 18.84
    ethyl propionate 30.43
    nitromethane 339.37
    1,2-diethoxyethane 41.31
    benzonitrile 35.47
    trioctyl phosphate 14.09
    1-bromopropane 11.81
    gamma-valerolactone 237.94
    n-decanol 10.24
    triethyl phosphate 18.63
    4-methyl-2-pentanol 17.41
    propionitrile 43.2
    vinylene carbonate 93.71
    1,1,2-trichlorotrifluoroethane 150.79
    DMS 29.93
    cumene 4.37
    2-octanol 12.69
    2-hexanone 41.38
    octyl acetate 14.85
    limonene 8.2
    1,2-dimethoxyethane 166.08
    ethyl orthosilicate 17.9
    tributyl phosphate 16.21
    diacetone alcohol 56.34
    N,N-dimethylaniline 15.55
    acrylonitrile 76.8
    aniline 28.44
    1,3-propanediol 155.67
    bromobenzene 12.65
    dibromomethane 24.83
    1,1,2,2-tetrachloroethane 57.67
    2-methyl-cyclohexyl acetate 26.81
    tetrabutyl urea 21.13
    diisobutyl methanol 10.84
    2-phenylethanol 43.04
    styrene 4.81
    dioctyl adipate 16.46
    dimethyl sulfate 82.37
    ethyl butyrate 30.25
    methyl lactate 64.78
    butyl lactate 33.76
    diethyl carbonate 22.11
    propanediol butyl ether 45.54
    triethyl orthoformate 23.05
    p-tert-butyltoluene 5.35
    methyl 4-tert-butylbenzoate 30.35
    morpholine 122.1
    tert-butylamine 18.22
    n-dodecanol 8.12
    dimethoxymethane 154.14
    ethylene carbonate 78.0
    cyrene 58.87
    2-ethoxyethyl acetate 43.52
    2-ethylhexyl acetate 28.45
    1,2,4-trichlorobenzene 24.48
    4-methylpyridine 47.83
    dibutyl ether 10.34
    2,6-dimethyl-4-heptanol 10.84
    DEF 68.87
    dimethyl isosorbide 73.21
    tetrachloroethylene 53.49
    eugenol 40.38
    triacetin 31.5
    span 80 37.64
    1,4-butanediol 76.25
    1,1-dichloroethane 22.75
    2-methyl-1-pentanol 45.44
    methyl formate 193.71
    2-methyl-1-butanol 53.08
    n-decane 0.92
    butyronitrile 46.56
    3,7-dimethyl-1-octanol 14.01
    1-chlorooctane 4.58
    1-chlorotetradecane 2.22
    n-nonane 0.77
    undecane 0.76
    tert-butylcyclohexane 1.1
    cyclooctane 0.42
    cyclopentanol 65.36
    tetrahydropyran 51.32
    tert-amyl methyl ether 16.89
    2,5,8-trioxanonane 79.3
    1-hexene 4.52
    2-isopropoxyethanol 86.08
    2,2,2-trifluoroethanol 88.25
    methyl butyrate 53.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction