Trolamine Salicylate

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  • Identifiers

    CAS number
    2174-16-5

    Molecular formula
    C13H21NO6

    SMILES
    C1=CC=C(C(=C1)C(=O)O)O.C(CO)N(CCO)CCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 73.11%
    Odorless 44.99%
    Nutty 44.38%
    Medicinal 41.62%
    Balsamic 38.6%
    Bitter 34.97%
    Burnt 34.81%
    Aromatic 33.52%
    Sweet 31.1%
    Almond 31.05%

     

    Flavor
    Phenolic 72.6%
    Nutty 56.97%
    Mild 44.81%
    Odorless 41.76%
    Faint 37.92%
    Sour 33.21%
    Balsam 31.72%
    Balsamic 29.54%
    Urine 26.21%
    Musty 26.12%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    8.08 (weak base)

    Molecular weight
    287.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 50 undefined

    Boiling point

    • Decomposes

    Flash point

    • 144.7 ˚C est.

    Solubility expt.

    • Soluble

  • Synonyms

    • Triethanolamine salicylate
    • TROLAMINE SALICYLATE
    • 2174-16-5
    • TEA-Salicylate
    • TEA salicylate
    • Neo heliopan ts
    • Neotan w
    • Arthricream
    • Myoflex
    • Salicylic acid trolamine
    • Sunarome W
    • H8O4040BHD
    • DTXSID4047969
    • Trolamine salicylate (USP)
    • UNII-H8O4040BHD
    • Salicylic acid triethanolamine
    • DTXCID4027945
    • TRIETHANOLAMINE, SALICYLATE
    • salicylic acid triethanolamine salt
    • EINECS 218-531-3
    • Trolamine salicylate [USP]
    • TROLAMINE SALICYLATE (MART.)
    • TROLAMINE SALICYLATE [MART.]
    • TROLAMINE SALICYLATE (USP IMPURITY)
    • TROLAMINE SALICYLATE [USP IMPURITY]
    • TROLAMINE SALICYLATE (USP MONOGRAPH)
    • TROLAMINE SALICYLATE [USP MONOGRAPH]
    • Sportscreme
    • Arthritis
    • ArthritisLeader
    • Cannaflex
    • Hempvana
    • Arthritis Cream
    • Arthritis Creme
    • Asper-FlexCream
    • Arthricream (TN)
    • HempvanaPain Relief
    • Arthricreamwith Aloe
    • basic care arthritis
    • DCH Arthritis Relief
    • Copperlife Pain Relief
    • sunmark arthricream rub
    • ULTRACIN T
    • 2-[bis(2-hydroxyethyl)amino]ethanol;2-hydroxybenzoic acid
    • Arthritis with AloeCVS
    • CBD Pain Relief Cream
    • Warrior Arthritis Relief
    • Aspercreme Pain Relieving
    • KRT Athletic Muscle Gel
    • Trolamin Salicylate 10%
    • Trolamine salicylate salve
    • Trolamine Salicylate 10%
    • Meijer Analgesic with Aloe
    • Meijer Pain Relieving Balm
    • XCEPTOL PAINUNSCENTED
    • SCHEMBL15847
    • Uncle Buds Hemp Pain Relief
    • Blue-Emu Maximum Pain Relief
    • teds topical pain gel roll on
    • CannEssentia Pain Relief Cream
    • XCEPTOR CBD PAINLAVENDER
    • Alcis Daily Relief Pain Relief
    • Blue-Emu Ultra with Hemp Seed
    • Arthritis ReliefMaximum Strength
    • XCEPTOR CBD PAINUNSCENTED
    • CHEMBL2107288
    • Pain Relieving Topical Analgesic
    • Blue-Emu Pain Relief Micro-Foam
    • UEVAMYPIMMOEFW-UHFFFAOYSA-N
    • Equate Odor-Free Therapy Arthritis
    • Meijer Pain Relieving BalmAnalgesic
    • Tox21_201084
    • Hempvana Maximum Strength Pain Relief
    • TROLAMINE SALICYLATE [WHO-DD]
    • Good Neighbor Pharmacy Arthritis Cream
    • Leader Maximum Strength Pain Relieving
    • Maximum Strength Blue Emu Pain Relief
    • Walgreens Pain Relieving Plus Turmeric
    • DB11079
    • TRIETHANOLAMINE SALICYLATE [MI]
    • Dr Joe lab ARTHRITIS EXTRA STRENGTH
    • NCGC00248985-01
    • NCGC00258636-01
    • Tommie Copper Pain ReliefMaximum Strength
    • TRIETHANOLAMINE SALICYLATE [VANDF]
    • CAS-2174-16-5
    • DB-257169
    • Equate Odor-Free Therapy ArthritisAnalgesic
    • Meijer Analgesic with AloeTopical Analgesic
    • NS00083243
    • Maximum Strength Blue Emu Pain ReliefBlu Emu
    • Real Time Pain Relief Therapeutic Hand Cream
    • D08501
    • Hempvana Maximum Strength Pain Relief-Platinum
    • Leader Maximum Strength Pain RelievingAnalgesic
    • Walgreens Pain Relieving Plus TurmericAnalgesic
    • Kroger Odor Free Arthricream Rub Pain Relieving
    • Q7845153
    • Salicylic acid, compound with 2,2',2''-nitrilotriethanol (1:1)
    • 218-531-3

  • Applications

    Trolamine Salicylate (CAS 2174-16-5) is used as an active ingredient in topical pharmaceutical formulations for pain-relief and anti-inflammatory applications; in cosmetics and personal care, it functions as an emollient, solvent, and pH-adjusting agent in creams, lotions, and balms; as a salicylate salt, it can improve solubility and act as a carrier for other actives in formulation systems; in chemical manufacturing, it is used as an intermediate to synthesize salicylate esters and related triethanolamine salts; and it may serve as a salt form that enhances solubility and stability of salicylates in certain formulation chemistries.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 379.31
    methanol 459.33
    isopropanol 266.01
    water 2.43
    ethyl acetate 220.92
    n-propanol 263.5
    acetone 378.21
    n-butanol 229.73
    acetonitrile 98.5
    DMF 1155.91
    toluene 10.99
    isobutanol 163.48
    1,4-dioxane 510.45
    methyl acetate 222.61
    THF 2479.16
    2-butanone 268.37
    n-pentanol 214.95
    sec-butanol 188.28
    n-hexane 7.28
    ethylene glycol 209.34
    NMP 626.39
    cyclohexane 1.18
    DMSO 2096.18
    n-butyl acetate 100.85
    n-octanol 102.48
    chloroform 25.13
    n-propyl acetate 160.94
    acetic acid 140.28
    dichloromethane 25.36
    cyclohexanone 209.61
    propylene glycol 192.09
    isopropyl acetate 158.71
    DMAc 439.9
    2-ethoxyethanol 426.36
    isopentanol 173.14
    n-heptane 6.89
    ethyl formate 145.37
    1,2-dichloroethane 56.29
    n-hexanol 224.27
    2-methoxyethanol 647.94
    isobutyl acetate 73.22
    tetrachloromethane 9.85
    n-pentyl acetate 75.83
    transcutol 345.92
    n-heptanol 130.41
    ethylbenzene 14.18
    MIBK 208.2
    2-propoxyethanol 448.98
    tert-butanol 333.4
    MTBE 154.91
    2-butoxyethanol 215.66
    propionic acid 177.91
    o-xylene 13.58
    formic acid 152.52
    diethyl ether 162.01
    m-xylene 23.4
    p-xylene 16.08
    chlorobenzene 17.07
    dimethyl carbonate 157.17
    n-octane 4.03
    formamide 279.48
    cyclopentanone 628.07
    2-pentanone 305.92
    anisole 89.97
    cyclopentyl methyl ether 340.64
    gamma-butyrolactone 739.23
    1-methoxy-2-propanol 566.41
    pyridine 75.22
    3-pentanone 137.12
    furfural 291.63
    n-dodecane 5.27
    diethylene glycol 414.71
    diisopropyl ether 58.3
    tert-amyl alcohol 197.94
    acetylacetone 321.79
    n-hexadecane 5.72
    acetophenone 78.15
    methyl propionate 224.97
    isopentyl acetate 78.3
    trichloroethylene 66.57
    n-nonanol 90.22
    cyclohexanol 100.25
    benzyl alcohol 81.67
    2-ethylhexanol 84.93
    isooctanol 93.22
    dipropyl ether 95.03
    1,2-dichlorobenzene 18.96
    ethyl lactate 122.81
    propylene carbonate 225.55
    n-methylformamide 486.61
    2-pentanol 182.43
    n-pentane 4.91
    1-propoxy-2-propanol 253.24
    1-methoxy-2-propyl acetate 162.87
    2-(2-methoxypropoxy) propanol 147.87
    mesitylene 20.6
    ε-caprolactone 189.97
    p-cymene 17.15
    epichlorohydrin 666.75
    1,1,1-trichloroethane 37.25
    2-aminoethanol 295.56
    morpholine-4-carbaldehyde 441.01
    sulfolane 1051.68
    2,2,4-trimethylpentane 5.45
    2-methyltetrahydrofuran 586.46
    n-hexyl acetate 107.85
    isooctane 8.81
    2-(2-butoxyethoxy)ethanol 224.68
    sec-butyl acetate 92.96
    tert-butyl acetate 185.8
    decalin 4.23
    glycerin 296.47
    diglyme 315.07
    acrylic acid 142.02
    isopropyl myristate 57.01
    n-butyric acid 188.7
    acetyl acetate 89.93
    di(2-ethylhexyl) phthalate 41.65
    ethyl propionate 154.89
    nitromethane 391.0
    1,2-diethoxyethane 103.22
    benzonitrile 51.9
    trioctyl phosphate 51.04
    1-bromopropane 33.61
    gamma-valerolactone 504.57
    n-decanol 72.99
    triethyl phosphate 42.37
    4-methyl-2-pentanol 120.4
    propionitrile 117.11
    vinylene carbonate 128.81
    1,1,2-trichlorotrifluoroethane 235.85
    DMS 76.8
    cumene 15.6
    2-octanol 80.43
    2-hexanone 202.97
    octyl acetate 74.97
    limonene 25.28
    1,2-dimethoxyethane 494.61
    ethyl orthosilicate 38.7
    tributyl phosphate 46.0
    diacetone alcohol 329.15
    N,N-dimethylaniline 61.42
    acrylonitrile 147.52
    aniline 43.5
    1,3-propanediol 329.94
    bromobenzene 11.0
    dibromomethane 16.69
    1,1,2,2-tetrachloroethane 70.42
    2-methyl-cyclohexyl acetate 57.15
    tetrabutyl urea 66.94
    diisobutyl methanol 60.06
    2-phenylethanol 99.78
    styrene 13.04
    dioctyl adipate 66.08
    dimethyl sulfate 294.99
    ethyl butyrate 84.86
    methyl lactate 211.47
    butyl lactate 80.09
    diethyl carbonate 48.32
    propanediol butyl ether 166.38
    triethyl orthoformate 51.94
    p-tert-butyltoluene 20.53
    methyl 4-tert-butylbenzoate 104.86
    morpholine 559.72
    tert-butylamine 144.01
    n-dodecanol 55.34
    dimethoxymethane 688.76
    ethylene carbonate 115.93
    cyrene 165.22
    2-ethoxyethyl acetate 94.5
    2-ethylhexyl acetate 49.79
    1,2,4-trichlorobenzene 26.32
    4-methylpyridine 81.12
    dibutyl ether 59.8
    2,6-dimethyl-4-heptanol 60.06
    DEF 238.78
    dimethyl isosorbide 233.07
    tetrachloroethylene 39.9
    eugenol 124.2
    triacetin 81.16
    span 80 121.61
    1,4-butanediol 183.54
    1,1-dichloroethane 47.46
    2-methyl-1-pentanol 133.72
    methyl formate 389.49
    2-methyl-1-butanol 135.45
    n-decane 7.53
    butyronitrile 141.24
    3,7-dimethyl-1-octanol 74.1
    1-chlorooctane 36.27
    1-chlorotetradecane 16.55
    n-nonane 6.52
    undecane 6.29
    tert-butylcyclohexane 6.85
    cyclooctane 1.47
    cyclopentanol 262.92
    tetrahydropyran 264.08
    tert-amyl methyl ether 115.02
    2,5,8-trioxanonane 242.69
    1-hexene 34.49
    2-isopropoxyethanol 274.32
    2,2,2-trifluoroethanol 88.14
    methyl butyrate 181.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction