Trisodium Nitrilotriacetate

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  • Identifiers

    CAS number
    5064-31-3

    Molecular formula
    C6H6NNa3O6

    SMILES
    C(C(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 64.32%
    Sweet 43.49%
    Savory 20.8%
    Clean 15.84%
    Buttery 15.74%
    Alcoholic 15.22%
    Fatty 15.06%
    Fishy 14.51%
    Winey 14.39%
    Caramellic 14.2%

     

    Flavor
    Odorless 58.8%
    Mild 28.69%
    Bland 26.73%
    Very mild 26.5%
    Bitter 25.35%
    Nutty 21.68%
    Yeast 21.26%
    Sweet-like 20.53%
    Bread crust 19.49%
    Taco 19.02%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    -0.7 (strong acid)

    Molecular weight
    257.08 g/mol

    Flash point

    • 222.09 ˚C est.

    Solubility expt.

    • Solubility in water, g/100ml at 20 °C: 93

  • Synonyms

    • TRISODIUM NITRILOTRIACETATE
    • 5064-31-3
    • Nitrilotriacetic acid trisodium salt
    • Trisodium NTA
    • Hampshire NTA
    • Ntana3
    • Sodium nitrilotriacetate
    • NTA Trisodium salt
    • Syntron A
    • Trisodium aminotriacetate
    • Masquol np 140
    • Versene NTA 150
    • Versene NTA 335
    • Hampshire NTA 150
    • Chemcolox 365 powder
    • Nitrilotriacetic acid, trisodium salt
    • Trisodium 2,2',2''-nitrilotriacetate
    • Trisodium nitrilotriacetic acid
    • Nitrilotriacetate trisodium salt
    • Trisodium N,N-bis(carboxymethyl)glycinate
    • E3C8R2M0XD
    • Acetic acid, nitrilotri-, trisodium salt
    • N,N-Bis(carboxymethyl)glycine, trisodium salt
    • Glycine, N,N-bis(carboxymethyl)-, trisodium salt
    • DTXSID8027587
    • CHEBI:132766
    • RefChem:192175
    • Nitrilotriacetate, Trisodium
    • DTXCID907587
    • 225-768-6
    • trisodium;2-[bis(carboxylatomethyl)amino]acetate
    • NITRILOTRIACETICACIDTRISODIUMSALT
    • MFCD00064231
    • Cheelox nta-14, -Na3
    • CCRIS 1404
    • HSDB 1013
    • EINECS 225-768-6
    • UNII-E3C8R2M0XD
    • Nitrilotriacetic acid trisodium
    • nitrilotriacetic acid trisodium*sigma grade
    • trisodiumnitrilotriacetate
    • NTA 3NA
    • C6H6NNa3O6
    • EC 225-768-6
    • SCHEMBL93358
    • Trisodium nitrilotriacetate(NTA)
    • Triglycollamic Acid Trisodium Salt
    • AKOS015914086
    • AKOS025295393
    • HY-W127847
    • TRISODIUM NITRILOTRIACETATE [HSDB]
    • DB-051811
    • CS-0186015
    • N0101
    • NS00077214
    • NITRILOTRIACETIC ACID TRISODIUM SALT [MI]
    • F626291
    • Q27225645
    • Glycine, N,N-bis(carboxymethyl)-, sodium salt (1:3)
    • trisodium,2-[bis(carboxylatomethyl)amino]acetate,hydrate
    • Nitrilotriacetic acid trisodium salt, Sigma Grade, >=98%
    • 5064-31-3

  • Applications

    Trisodium Nitrilotriacetate (CAS 5064-31-3) is a chelating agent widely used to sequester metal ions in formulations, providing stability and reducing scale and precipitation. In practice, it is commonly employed in detergents and household and industrial cleaners as a water-softening builder; in textile processing to improve dye uptake by removing trace metals; in the pulp and paper industry to mitigate metal-catalyzed degradation and scale formation; in electroplating and metal finishing baths to keep metal ions in solution; and in coatings and inks or electronics-cleaning formulations where metal ion control supports pigment dispersion and process stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 42.28
    methanol 135.1
    isopropanol 16.84
    water 119.5
    ethyl acetate 41.8
    n-propanol 24.7
    acetone 111.97
    n-butanol 13.11
    acetonitrile 59.54
    DMF 1104.49
    toluene 14.28
    isobutanol 12.79
    1,4-dioxane 28.99
    methyl acetate 71.23
    THF 87.06
    2-butanone 56.84
    n-pentanol 8.09
    sec-butanol 12.83
    n-hexane 0.84
    ethylene glycol 75.36
    NMP 1083.46
    cyclohexane 0.7
    DMSO 667.13
    n-butyl acetate 19.88
    n-octanol 6.46
    chloroform 15.38
    n-propyl acetate 24.57
    acetic acid 143.36
    dichloromethane 39.32
    cyclohexanone 65.5
    propylene glycol 57.4
    isopropyl acetate 17.69
    DMAc 799.33
    2-ethoxyethanol 60.93
    isopentanol 7.65
    n-heptane 1.27
    ethyl formate 63.18
    1,2-dichloroethane 36.04
    n-hexanol 7.46
    2-methoxyethanol 160.48
    isobutyl acetate 9.13
    tetrachloromethane 1.92
    n-pentyl acetate 11.67
    transcutol 101.67
    n-heptanol 4.92
    ethylbenzene 5.2
    MIBK 14.78
    2-propoxyethanol 59.74
    tert-butanol 16.61
    MTBE 9.58
    2-butoxyethanol 22.15
    propionic acid 95.61
    o-xylene 14.38
    formic acid 317.36
    diethyl ether 13.73
    m-xylene 11.78
    p-xylene 6.81
    chlorobenzene 13.21
    dimethyl carbonate 115.71
    n-octane 0.54
    formamide 388.1
    cyclopentanone 134.48
    2-pentanone 37.53
    anisole 20.48
    cyclopentyl methyl ether 33.29
    gamma-butyrolactone 315.54
    1-methoxy-2-propanol 101.89
    pyridine 68.27
    3-pentanone 41.78
    furfural 275.35
    n-dodecane 0.46
    diethylene glycol 85.95
    diisopropyl ether 3.07
    tert-amyl alcohol 13.37
    acetylacetone 68.9
    n-hexadecane 0.5
    acetophenone 43.84
    methyl propionate 109.51
    isopentyl acetate 11.15
    trichloroethylene 54.83
    n-nonanol 6.19
    cyclohexanol 12.23
    benzyl alcohol 28.33
    2-ethylhexanol 5.1
    isooctanol 3.43
    dipropyl ether 12.56
    1,2-dichlorobenzene 14.54
    ethyl lactate 48.13
    propylene carbonate 120.92
    n-methylformamide 416.25
    2-pentanol 6.88
    n-pentane 0.94
    1-propoxy-2-propanol 39.99
    1-methoxy-2-propyl acetate 45.51
    2-(2-methoxypropoxy) propanol 44.62
    mesitylene 6.41
    ε-caprolactone 86.15
    p-cymene 5.32
    epichlorohydrin 118.19
    1,1,1-trichloroethane 9.71
    2-aminoethanol 77.77
    morpholine-4-carbaldehyde 450.39
    sulfolane 489.09
    2,2,4-trimethylpentane 0.54
    2-methyltetrahydrofuran 34.16
    n-hexyl acetate 15.52
    isooctane 0.3
    2-(2-butoxyethoxy)ethanol 40.83
    sec-butyl acetate 9.84
    tert-butyl acetate 15.78
    decalin 0.66
    glycerin 133.19
    diglyme 72.54
    acrylic acid 161.64
    isopropyl myristate 6.6
    n-butyric acid 49.52
    acetyl acetate 24.69
    di(2-ethylhexyl) phthalate 12.59
    ethyl propionate 34.49
    nitromethane 394.25
    1,2-diethoxyethane 19.34
    benzonitrile 28.31
    trioctyl phosphate 7.78
    1-bromopropane 10.72
    gamma-valerolactone 245.31
    n-decanol 4.83
    triethyl phosphate 15.68
    4-methyl-2-pentanol 3.57
    propionitrile 34.08
    vinylene carbonate 137.52
    1,1,2-trichlorotrifluoroethane 148.52
    DMS 49.46
    cumene 3.77
    2-octanol 3.29
    2-hexanone 17.51
    octyl acetate 10.26
    limonene 7.14
    1,2-dimethoxyethane 80.38
    ethyl orthosilicate 11.68
    tributyl phosphate 11.73
    diacetone alcohol 36.07
    N,N-dimethylaniline 27.28
    acrylonitrile 95.0
    aniline 31.93
    1,3-propanediol 46.92
    bromobenzene 9.44
    dibromomethane 18.34
    1,1,2,2-tetrachloroethane 36.78
    2-methyl-cyclohexyl acetate 14.12
    tetrabutyl urea 24.2
    diisobutyl methanol 3.55
    2-phenylethanol 18.28
    styrene 6.74
    dioctyl adipate 16.41
    dimethyl sulfate 337.15
    ethyl butyrate 21.57
    methyl lactate 140.61
    butyl lactate 23.33
    diethyl carbonate 16.82
    propanediol butyl ether 31.49
    triethyl orthoformate 15.83
    p-tert-butyltoluene 5.13
    methyl 4-tert-butylbenzoate 34.97
    morpholine 61.55
    tert-butylamine 7.53
    n-dodecanol 3.77
    dimethoxymethane 209.04
    ethylene carbonate 77.17
    cyrene 94.92
    2-ethoxyethyl acetate 26.16
    2-ethylhexyl acetate 9.43
    1,2,4-trichlorobenzene 20.54
    4-methylpyridine 69.64
    dibutyl ether 6.38
    2,6-dimethyl-4-heptanol 3.55
    DEF 137.71
    dimethyl isosorbide 83.76
    tetrachloroethylene 22.85
    eugenol 37.15
    triacetin 47.29
    span 80 32.54
    1,4-butanediol 21.96
    1,1-dichloroethane 15.35
    2-methyl-1-pentanol 5.19
    methyl formate 325.9
    2-methyl-1-butanol 9.5
    n-decane 0.75
    butyronitrile 19.06
    3,7-dimethyl-1-octanol 5.18
    1-chlorooctane 3.01
    1-chlorotetradecane 1.46
    n-nonane 0.7
    undecane 0.57
    tert-butylcyclohexane 0.57
    cyclooctane 0.44
    cyclopentanol 22.08
    tetrahydropyran 15.14
    tert-amyl methyl ether 12.32
    2,5,8-trioxanonane 64.1
    1-hexene 2.98
    2-isopropoxyethanol 28.45
    2,2,2-trifluoroethanol 111.19
    methyl butyrate 44.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction