Trisodium Glycyrrhizate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    71277-78-6

    Molecular formula
    C42H59Na3O16

    SMILES
    C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)[O-])O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)[O-])O)O)O)C)(C)C(=O)[O-].[Na+].[Na+].[Na+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 52.76%
    Woody 40.87%
    Spicy 35.25%
    Dry 26.57%
    Cooling 25.95%
    Amber 25.76%
    Balsamic 23.76%
    Cedar 22.68%
    Warm 21.25%
    Sweet 20.7%

     

    Flavor
    Bitter 77.2%
    Odorless 28.43%
    Bland 26.52%
    Sweet-like 23.86%
    Cedarleaf 22.5%
    Ripe apricot 20.6%
    Red fruit 20.24%
    Parsley 20.07%
    Patchouli 19.68%
    Leaves 19.62%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    -0.91 (strong acid)

    Molecular weight
    888.9 g/mol

    Flash point

    • 248.29 ˚C est.

  • Synonyms

    • Trisodium glycyrrhizinate
    • Trisodium glycyrrhizin
    • Trisodium glycyrrhizate
    • CCRIS 9136
    • UNII-5VWB9ZP8JV
    • 5VWB9ZP8JV
    • ORISTAR TSG
    • GLYCYRRHIZINATE, TRISODIUM
    • TRISODIUM GLYCYRRHIZATE VINYALS
    • alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, trisodium salt
    • TRISODIUM GLYCYRRHIZINATE [WHO-DD]
    • .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, trisodium salt
    • .ALPHA.-D-GLUCOPYRANOSIDURONIC ACID, (3.BETA.,20.BETA.)-20-CARBOXY-11-OXO-30-NOROLEAN-12-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANURONOSYL-, SODIUM SALT (1:3)
    • RefChem:203385
    • TRISODIUM GLYCYRRHIZATE [INCI]
    • ALPHA-D-GLUCOPYRANOSIDURONIC ACID, (3BETA,20BETA)-20-CARBOXY-11-OXO-30-NOROLEAN-12-EN-3-YL 2-O-BETA-D-GLUCOPYRANURONOSYL-, SODIUM SALT (1:3)
    • ALPHA-D-GLUCOPYRANOSIDURONIC ACID, (3BETA,20BETA)-20-CARBOXY-11-OXO-30-NOROLEAN-12-EN-3-YL 2-O-BETA-D-GLUCOPYRANURONOSYL-, TRISODIUM SALT
    • 71277-78-6
    • Glycyrrhizic acid trisodium salt
    • Trisodium Glycyrrhizinate Hydrate
    • trisodium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate
    • Glycyrrhizin Trisodium Salt
    • SCHEMBL29393744
    • CCXAYLQLOLXXKE-DWJAGBRCSA-K
    • DTXSID301021951
    • FT41834
    • G0217
    • Q27262938
    • 71277-78-6

  • Applications

    Trisodium Glycyrrhizate (CAS 71277-78-6) is used in cosmetics and personal care as a skin-conditioning ingredient with soothing and anti-irritant properties, and, owing to its saponin-derived structure, as a mild surfactant/solubilizer in cleansers and emulsions. In pharmaceuticals, it may function as an inactive excipient and formulation stabilizer to support active ingredient compatibility. In cleaning and household products, it serves as a mild surfactant/solubilizer to aid cleaning performance and fragrance incorporation. In perfumery and fragrance applications, it can act as a solubilizer and carrier for fragrance compounds, improving formulation compatibility and aroma release.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.42
    methanol 23.05
    isopropanol 1.2
    water 0.07
    ethyl acetate 2.65
    n-propanol 1.83
    acetone 10.08
    n-butanol 0.65
    acetonitrile 2.6
    DMF 95.28
    toluene 0.95
    isobutanol 0.67
    1,4-dioxane 13.74
    methyl acetate 4.71
    THF 28.57
    2-butanone 3.99
    n-pentanol 0.63
    sec-butanol 0.56
    n-hexane 0.03
    ethylene glycol 7.38
    NMP 68.62
    cyclohexane 0.05
    DMSO 76.77
    n-butyl acetate 0.92
    n-octanol 0.51
    chloroform 5.37
    n-propyl acetate 1.37
    acetic acid 39.85
    dichloromethane 5.43
    cyclohexanone 4.22
    propylene glycol 6.31
    isopropyl acetate 1.52
    DMAc 57.96
    2-ethoxyethanol 10.23
    isopentanol 0.35
    n-heptane 0.04
    ethyl formate 2.87
    1,2-dichloroethane 2.7
    n-hexanol 0.45
    2-methoxyethanol 25.13
    isobutyl acetate 0.63
    tetrachloromethane 0.58
    n-pentyl acetate 1.35
    transcutol 15.25
    n-heptanol 0.57
    ethylbenzene 0.3
    MIBK 1.22
    2-propoxyethanol 10.34
    tert-butanol 0.81
    MTBE 0.68
    2-butoxyethanol 4.79
    propionic acid 4.4
    o-xylene 0.56
    formic acid 39.76
    diethyl ether 1.19
    m-xylene 0.58
    p-xylene 0.42
    chlorobenzene 0.96
    dimethyl carbonate 10.66
    n-octane 0.02
    formamide 34.33
    cyclopentanone 15.99
    2-pentanone 2.31
    anisole 1.73
    cyclopentyl methyl ether 3.26
    gamma-butyrolactone 26.37
    1-methoxy-2-propanol 13.77
    pyridine 8.29
    3-pentanone 2.13
    furfural 21.76
    n-dodecane 0.02
    diethylene glycol 16.65
    diisopropyl ether 0.21
    tert-amyl alcohol 0.51
    acetylacetone 10.38
    n-hexadecane 0.02
    acetophenone 2.69
    methyl propionate 5.32
    isopentyl acetate 0.63
    trichloroethylene 9.81
    n-nonanol 0.53
    cyclohexanol 0.51
    benzyl alcohol 2.12
    2-ethylhexanol 0.19
    isooctanol 0.36
    dipropyl ether 0.77
    1,2-dichlorobenzene 1.0
    ethyl lactate 2.39
    propylene carbonate 6.33
    n-methylformamide 32.26
    2-pentanol 0.31
    n-pentane 0.03
    1-propoxy-2-propanol 4.61
    1-methoxy-2-propyl acetate 4.41
    2-(2-methoxypropoxy) propanol 3.75
    mesitylene 0.29
    ε-caprolactone 4.65
    p-cymene 0.18
    epichlorohydrin 19.92
    1,1,1-trichloroethane 1.56
    2-aminoethanol 6.74
    morpholine-4-carbaldehyde 57.59
    sulfolane 51.25
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 3.67
    n-hexyl acetate 1.44
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 5.84
    sec-butyl acetate 0.62
    tert-butyl acetate 1.75
    decalin 0.03
    glycerin 18.1
    diglyme 13.16
    acrylic acid 11.26
    isopropyl myristate 0.34
    n-butyric acid 2.55
    acetyl acetate 4.16
    di(2-ethylhexyl) phthalate 0.78
    ethyl propionate 1.37
    nitromethane 65.25
    1,2-diethoxyethane 2.5
    benzonitrile 1.4
    trioctyl phosphate 0.46
    1-bromopropane 0.54
    gamma-valerolactone 37.58
    n-decanol 0.3
    triethyl phosphate 0.59
    4-methyl-2-pentanol 0.19
    propionitrile 1.33
    vinylene carbonate 7.75
    1,1,2-trichlorotrifluoroethane 32.32
    DMS 3.37
    cumene 0.18
    2-octanol 0.29
    2-hexanone 1.24
    octyl acetate 0.69
    limonene 0.21
    1,2-dimethoxyethane 12.19
    ethyl orthosilicate 0.52
    tributyl phosphate 0.41
    diacetone alcohol 4.35
    N,N-dimethylaniline 1.55
    acrylonitrile 4.09
    aniline 1.58
    1,3-propanediol 4.88
    bromobenzene 0.88
    dibromomethane 1.97
    1,1,2,2-tetrachloroethane 6.44
    2-methyl-cyclohexyl acetate 0.75
    tetrabutyl urea 0.95
    diisobutyl methanol 0.13
    2-phenylethanol 1.59
    styrene 0.4
    dioctyl adipate 0.92
    dimethyl sulfate 25.96
    ethyl butyrate 0.84
    methyl lactate 9.67
    butyl lactate 1.98
    diethyl carbonate 0.59
    propanediol butyl ether 6.1
    triethyl orthoformate 0.93
    p-tert-butyltoluene 0.21
    methyl 4-tert-butylbenzoate 3.3
    morpholine 13.87
    tert-butylamine 0.21
    n-dodecanol 0.18
    dimethoxymethane 37.43
    ethylene carbonate 4.18
    cyrene 11.52
    2-ethoxyethyl acetate 4.38
    2-ethylhexyl acetate 0.44
    1,2,4-trichlorobenzene 1.77
    4-methylpyridine 3.74
    dibutyl ether 0.35
    2,6-dimethyl-4-heptanol 0.13
    DEF 5.13
    dimethyl isosorbide 9.66
    tetrachloroethylene 4.62
    eugenol 3.45
    triacetin 4.35
    span 80 3.84
    1,4-butanediol 2.26
    1,1-dichloroethane 1.54
    2-methyl-1-pentanol 0.31
    methyl formate 31.06
    2-methyl-1-butanol 0.36
    n-decane 0.03
    butyronitrile 0.65
    3,7-dimethyl-1-octanol 0.27
    1-chlorooctane 0.17
    1-chlorotetradecane 0.05
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.03
    cyclopentanol 1.58
    tetrahydropyran 2.74
    tert-amyl methyl ether 0.58
    2,5,8-trioxanonane 7.83
    1-hexene 0.12
    2-isopropoxyethanol 4.05
    2,2,2-trifluoroethanol 12.72
    methyl butyrate 1.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction