Triprolidine hydrochloride monohydrate

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  • Identifiers

    CAS number
    6138-79-0

    Molecular formula
    C19H25ClN2O

    SMILES
    CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3.O.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Animal 35.31%
    Roasted 31.36%
    Nutty 26.83%
    Floral 26.82%
    Fishy 26.63%
    Meaty 23.77%
    Earthy 23.12%
    Fresh 23.05%
    Cooked 22.73%
    Burnt 22.72%

     

    Flavor
    Bitter 64.93%
    Nitrile 21.43%
    Animal 21.41%
    Very strong 20.8%
    Indole 20.18%
    Cedarleaf 20.0%
    Cereal 19.81%
    Moth ball 19.69%
    Oriental 19.6%
    Alkaline 19.39%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.35 (neutral)

    Molecular weight
    332.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    434°C

    Melting point expt.

    • 239 to 248 °F (NTP, 1992)

    Flash point

    • 194.57 ˚C est.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)

  • Synonyms

    • 6138-79-0
    • TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE
    • Actidilon
    • Pro-Actidil
    • Pro-Entra
    • Venen
    • DTXSID0021410
    • DTXCID201410
    • CHEBI:32265
    • Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, monohydrate, stereoisomer
    • RefChem:1100506
    • Triprolidine hydrochloride hydrate
    • Triprolidine.HCl monohydrate
    • trans-TriprolidineHydrochloride
    • (E)-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine monohydrochloride monohydrate
    • (E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine hydrochloride hydrate
    • Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride, monohydrate, (E)-
    • Triprolidine hydrochloride hydrate (JAN)
    • Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)-
    • CCRIS 7215
    • TRIPROLIDINE HYDROCHLORIDE HYDRATE [JAN]
    • Triprolidine (hydrochloride monohydrate)
    • UNII-YAN7R5L890
    • Pyridine, 2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate; Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)-; Pyridine, 2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]-, monohydrochloride, monohydrate, stereoisomer; Triprolidine hydrochloride monohydrate
    • Triprolidine hydrochloride [USP:JAN]
    • Venen (TN)
    • 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine;chloride;hydrate
    • Triprolidinehydrochloridehydrate
    • orb1310005
    • SCHEMBL1140974
    • CHEMBL3188034
    • SCHEMBL29730199
    • HY-B1301R
    • Triprolidine hydrochloride (USP)
    • Triprolidinhydrochlorid Monohydrat
    • CUZMOIXUFHOLLN-UMVVUDSKSA-N
    • HMS5084B04
    • HY-B1301
    • Tox21_200848
    • EBC-15051
    • s5447
    • Triprolidine Hydrochloride?Monohydrate
    • AKOS024370814
    • CCG-267838
    • FT61470
    • NSC 757361
    • W38T790
    • 2-[(1E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-en-1-yl]pyridine hydrochloride hydrate
    • NCGC00258402-01
    • BS-17733
    • TRIPROLIDINE HYDROCHLORIDE [MART.]
    • TRIPROLIDINE HYDROCHLORIDE [VANDF]
    • CAS-6138-79-0
    • TRIPROLIDINE HYDROCHLORIDE [USP-RS]
    • CS-0013069
    • NS00076143
    • ST51006684
    • D01782
    • D70442
    • TRIPROLIDINE HYDROCHLORIDE [ORANGE BOOK]
    • EN300-1692895
    • MYFED COMPONENT TRIPROLIDINE HYDROCHLORIDE
    • ACTIFED COMPONENT TRIPROLIDINE HYDROCHLORIDE
    • CORPHED COMPONENT TRIPROLIDINE HYDROCHLORIDE
    • TRIPHED COMPONENT TRIPROLIDINE HYDROCHLORIDE
    • TRIPROLIDINE HYDROCHLORIDE [USP MONOGRAPH]
    • TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE [MI]
    • ACTAHIST COMPONENT TRIPROLIDINE HYDROCHLORIDE
    • ALLERFED COMPONENT TRIPROLIDINE HYDROCHLORIDE
    • HISTAFED COMPONENT TRIPROLIDINE HYDROCHLORIDE
    • TRILITRON COMPONENT TRIPROLIDINE HYDROCHLORIDE
    • Triprolidine (hydrochloride monohydrate) (Standard)
    • Q27114841
    • TRIACIN-C COMPONENT TRIPROLIDINE HYDROCHLORIDE
    • TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE [MART.]
    • TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE [WHO-DD]
    • TRIPROLIDINE HYDROCHLORIDE MONOHYDROCHLORIDE MONOHYDRATE
    • 2-[(1E)-1-(4-methylphenyl)-3-pyrrolidinylprop-1-enyl]pyridine, chloride, hydra te
    • 2-[(E)-1-(p-tolyl)-3-pyrrolidin-1-ium-1-yl-prop-1-enyl]pyridine;chloride;hydrate
    • 1-[(2E)-3-(4-methylphenyl)-3-(pyridin-2-yl)prop-2-en-1-yl]pyrrolidinium chloride--water (1/1)
    • 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine hydrate hydrochloride
    • 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine hydrochloride--water (1/1)
    • 2-[(1E)-1-(4-Methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine--hydrogen chloride--water (1/1/1)
    • 6138-79-0

  • Applications

    Triprolidine hydrochloride monohydrate is used as an active pharmaceutical ingredient in antihistamine medications for allergic symptoms such as allergic rhinitis and itching; it is commonly formulated in oral dosage forms including tablets, capsules, and syrups, and is frequently found in over-the-counter cold and allergy combination products with decongestants; the compound is also used in pharmaceutical research and development and may serve as an intermediate in the synthesis of related antihistamines.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 197.43
    methanol 192.79
    isopropanol 85.18
    water 0.22
    ethyl acetate 495.28
    n-propanol 189.63
    acetone 345.33
    n-butanol 194.82
    acetonitrile 144.93
    DMF 292.4
    toluene 538.75
    isobutanol 138.01
    1,4-dioxane 657.09
    methyl acetate 337.92
    THF 586.66
    2-butanone 407.07
    n-pentanol 141.64
    sec-butanol 119.61
    n-hexane 18.17
    ethylene glycol 71.08
    NMP 228.67
    cyclohexane 58.21
    DMSO 344.09
    n-butyl acetate 240.67
    n-octanol 36.3
    chloroform 1905.7
    n-propyl acetate 199.38
    acetic acid 246.91
    dichloromethane 1998.47
    cyclohexanone 418.59
    propylene glycol 107.08
    isopropyl acetate 233.08
    DMAc 562.13
    2-ethoxyethanol 312.18
    isopentanol 167.09
    n-heptane 14.4
    ethyl formate 223.25
    1,2-dichloroethane 1241.88
    n-hexanol 134.74
    2-methoxyethanol 433.58
    isobutyl acetate 159.41
    tetrachloromethane 152.65
    n-pentyl acetate 100.06
    transcutol 1278.49
    n-heptanol 50.73
    ethylbenzene 125.62
    MIBK 176.42
    2-propoxyethanol 329.98
    tert-butanol 78.51
    MTBE 186.94
    2-butoxyethanol 150.77
    propionic acid 172.94
    o-xylene 184.54
    formic acid 89.55
    diethyl ether 435.73
    m-xylene 207.44
    p-xylene 147.79
    chlorobenzene 491.3
    dimethyl carbonate 203.82
    n-octane 5.16
    formamide 130.07
    cyclopentanone 388.04
    2-pentanone 304.77
    anisole 264.07
    cyclopentyl methyl ether 316.3
    gamma-butyrolactone 430.9
    1-methoxy-2-propanol 262.81
    pyridine 795.25
    3-pentanone 370.82
    furfural 516.21
    n-dodecane 4.61
    diethylene glycol 241.86
    diisopropyl ether 85.93
    tert-amyl alcohol 101.2
    acetylacetone 386.98
    n-hexadecane 5.52
    acetophenone 222.02
    methyl propionate 396.49
    isopentyl acetate 224.43
    trichloroethylene 2055.94
    n-nonanol 41.13
    cyclohexanol 180.07
    benzyl alcohol 225.7
    2-ethylhexanol 96.99
    isooctanol 48.53
    dipropyl ether 151.69
    1,2-dichlorobenzene 379.45
    ethyl lactate 110.98
    propylene carbonate 281.29
    n-methylformamide 160.27
    2-pentanol 111.34
    n-pentane 23.82
    1-propoxy-2-propanol 194.97
    1-methoxy-2-propyl acetate 313.53
    2-(2-methoxypropoxy) propanol 187.61
    mesitylene 94.07
    ε-caprolactone 357.9
    p-cymene 69.48
    epichlorohydrin 955.15
    1,1,1-trichloroethane 599.97
    2-aminoethanol 139.59
    morpholine-4-carbaldehyde 423.35
    sulfolane 373.55
    2,2,4-trimethylpentane 17.67
    2-methyltetrahydrofuran 376.81
    n-hexyl acetate 119.65
    isooctane 10.16
    2-(2-butoxyethoxy)ethanol 273.31
    sec-butyl acetate 157.49
    tert-butyl acetate 180.3
    decalin 25.54
    glycerin 150.41
    diglyme 555.58
    acrylic acid 184.47
    isopropyl myristate 60.24
    n-butyric acid 280.55
    acetyl acetate 296.11
    di(2-ethylhexyl) phthalate 78.18
    ethyl propionate 193.74
    nitromethane 375.44
    1,2-diethoxyethane 397.31
    benzonitrile 223.79
    trioctyl phosphate 42.79
    1-bromopropane 543.5
    gamma-valerolactone 564.56
    n-decanol 33.0
    triethyl phosphate 99.85
    4-methyl-2-pentanol 73.06
    propionitrile 177.69
    vinylene carbonate 301.7
    1,1,2-trichlorotrifluoroethane 595.5
    DMS 199.64
    cumene 75.8
    2-octanol 27.04
    2-hexanone 173.6
    octyl acetate 73.53
    limonene 96.93
    1,2-dimethoxyethane 421.69
    ethyl orthosilicate 99.95
    tributyl phosphate 63.35
    diacetone alcohol 155.91
    N,N-dimethylaniline 144.45
    acrylonitrile 223.41
    aniline 428.58
    1,3-propanediol 171.67
    bromobenzene 607.7
    dibromomethane 1144.55
    1,1,2,2-tetrachloroethane 1427.23
    2-methyl-cyclohexyl acetate 148.47
    tetrabutyl urea 74.34
    diisobutyl methanol 52.49
    2-phenylethanol 194.47
    styrene 193.36
    dioctyl adipate 106.45
    dimethyl sulfate 226.62
    ethyl butyrate 188.9
    methyl lactate 157.3
    butyl lactate 95.89
    diethyl carbonate 148.77
    propanediol butyl ether 113.0
    triethyl orthoformate 151.65
    p-tert-butyltoluene 62.31
    methyl 4-tert-butylbenzoate 135.7
    morpholine 698.17
    tert-butylamine 56.48
    n-dodecanol 27.72
    dimethoxymethane 443.89
    ethylene carbonate 263.78
    cyrene 158.15
    2-ethoxyethyl acetate 235.94
    2-ethylhexyl acetate 185.14
    1,2,4-trichlorobenzene 447.27
    4-methylpyridine 568.7
    dibutyl ether 92.58
    2,6-dimethyl-4-heptanol 52.49
    DEF 372.68
    dimethyl isosorbide 282.85
    tetrachloroethylene 868.26
    eugenol 143.11
    triacetin 172.89
    span 80 121.8
    1,4-butanediol 84.3
    1,1-dichloroethane 782.04
    2-methyl-1-pentanol 154.82
    methyl formate 156.42
    2-methyl-1-butanol 179.44
    n-decane 7.36
    butyronitrile 182.78
    3,7-dimethyl-1-octanol 60.5
    1-chlorooctane 43.96
    1-chlorotetradecane 20.83
    n-nonane 6.22
    undecane 5.57
    tert-butylcyclohexane 19.66
    cyclooctane 19.66
    cyclopentanol 121.91
    tetrahydropyran 570.57
    tert-amyl methyl ether 155.78
    2,5,8-trioxanonane 372.23
    1-hexene 90.89
    2-isopropoxyethanol 198.56
    2,2,2-trifluoroethanol 100.85
    methyl butyrate 225.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction