Trimethylamine

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  • Identifiers

    CAS number
    75-50-3

    Molecular formula
    C3H9N

    SMILES
    CN(C)C

    Safety labels

    Flammable
    Flammable

    Compressed Gas
    Compressed Gas

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fruity 70.95%
    Cheesy 64.62%
    Fishy 50.85%
    Oily 48.79%
    Ripe 47.38%
    Pungent 42.47%
    Fermented 42.38%
    Sweaty 32.32%
    Ethereal 31.2%
    Solvent 28.54%

    Scent© AI

    Odor threshold>

    • Odor Threshold Low: 0.0002 [ppm]. Odor Threshold High: 0.00087 [ppm]. Odor threshold from AIHA
    • 1.70 ppm (detection in water, chemically pure)
    • 2.10X10-4 ppm (recognition in air, chemically pure)
    • 2.20X10+11 molecules/cu cm (in air, purity, not specified)
    • 5.00X10-4 mg/kg ppm (detection in water, other)
    • For more Odor Threshold (Complete) data for Trimethylamine (7 total), please visit the HSDB record page.

  • Properties

    XLogP3-AA
    0.3

    Molecular weight
    59.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -178.8 °F (USCG, 1999)
    • -179 °F (NTP, 1992)
    • -117.08 °C
    • -117.1 °C
    • -117 °C
    • -3 °C
    • -179 °F

    Boiling point

    • 37.2 °F at 760 mmHg (USCG, 1999)
    • 37.17 °F at 760 mmHg (NTP, 1992)
    • 2.87 °C at 760 mm Hg
    • 3 °C
    • 30 °C
    • 37.2 °F
    • 37 °F

    Flash point est.
    -34.21 ˚C

    Flash point expt.

    • Not Applicable. Gas. (USCG, 1999)
    • 10 °F (NTP, 1992)
    • -7 °C (19 °F) - closed cup
    • 20 °F (Closed cup)
    • 10 °F (-12.2 °C) (closed cup)
    • 25% solution: 38 °F (3.3 °C) (open cup)
    • Flammable gas
    • -7 °C
    • NA (Gas) 20 °F (Liquid)

    Solubility expt.

    • 48 % at 86 °F (NIOSH, 2024)
    • Very soluble (NTP, 1992)
    • In water, 8.9X10+5 mg/L at 30 °C
    • Soluble in water
    • Soluble in alcohol, ether
    • Readily absorbed by alcohol with which it is miscible; also soluble in ether, benzene, toluene, xylene, ethylbenzene, chloroform.
    • For more Solubility (Complete) data for Trimethylamine (7 total), please visit the HSDB record page.
    • 890.0 mg/mL
    • Solubility in water: very good
    • Soluble in water, ether
    • Soluble (in ethanol)
    • (86 °F): 48%

  • Synonyms

    • trimethylamine
    • N,N-dimethylmethanamine
    • 75-50-3
    • Methanamine, N,N-dimethyl-
    • N-Trimethylamine
    • Dimethylmethaneamine
    • Trimethylamin
    • (CH3)3N
    • FEMA No. 3241
    • FEMA Number 3241
    • N,N,N-trimethylamine
    • NMe3
    • Trimethylamine anhydrous
    • CCRIS 6283
    • HSDB 808
    • trimethyl-amine
    • AI3-15639
    • EINECS 200-875-0
    • UNII-LHH7G8O305
    • UN1083
    • UN1297
    • TRIMETHYLAMINUM
    • LHH7G8O305
    • tridimethylaminomethane
    • DTXSID2026238
    • CHEBI:18139
    • Trimethylamine, anhydrous
    • Methylamine, N,N-dimethyl-
    • DTXCID106238
    • N(CH3)3
    • EC 200-875-0
    • MFCD00008327
    • methane, dimethylamino-
    • Trimethylamine (~25 wt. % solution in methanol)
    • Trimethylamine, anhydrous [UN1083] [Flammable gas]
    • TRIMETHYL AMINE
    • (CH3)3NH
    • (CH3)3NH+
    • Trimethylamine (~30 wt. % Solution in Ethanol)
    • MELDONIUM DIHYDRATE IMPURITY A (EP IMPURITY)
    • MELDONIUM DIHYDRATE IMPURITY A [EP IMPURITY]
    • ACETYLCHOLINE CHLORIDE IMPURITY C (EP IMPURITY)
    • ACETYLCHOLINE CHLORIDE IMPURITY C [EP IMPURITY]
    • tri-methylamine
    • KEN
    • Trimethylamine (8CI); N,N-Dimethylmethanamine; N,N,N-Trimethylamine; N-Trimethylamine; Methanamine, N,N-dimethyl-
    • dimethylamino methane
    • trimethylamine (tma)
    • N,N-dimethyl-Methanamine
    • N,N-Dimethylmethanamine #
    • bmse000224
    • TRIMETHYLAMINE [MI]
    • NCIOpen2_007868
    • TRIMETHYLAMINE [FCC]
    • TRIMETHYLAMINE [FHFI]
    • TRIMETHYLAMINE [HSDB]
    • Trimethylamine, >=99.0%
    • Trimethylamine, >=99.5%
    • Trimethylamine 2.0M in THF
    • TRIMETHYLAMINUM [HPUS]
    • CHEMBL439723
    • GTPL5521
    • Trimethylamine 2M in Isopropanol
    • MSK3058
    • TRIMETHYLAMINE, (ANHYDROUS)
    • Trimethylamine, 43-49% in water
    • Trimethylamine, anhydrous, >=99%
    • Tox21_302355
    • BDBM50416499
    • NSC101179
    • STL264242
    • AKOS000119986
    • NSC-101179
    • UN 1083
    • UN 1297
    • CAS-75-50-3
    • NCGC00255170-01
    • InChI=1/C3H9N/c1-4(2)3/h1-3H
    • NS00006832
    • T0464
    • T2268
    • T2704
    • T2892
    • T2893
    • T3567
    • T3614
    • T3847
    • C00565
    • Trimethylamine (ca.8% in N,N-Dimethylformamide)
    • Q423953
    • Trimethylamine (ca. 8% in Toluene, ca. 1mol/L)
    • F1908-0091
    • Trimethylamine (ca. 13% in Acetonitrile, ca. 2mol/L)
    • Trimethylamine (ca. 25% in Isopropyl Alcohol, ca. 3mol/L)
    • Trimethylamine solution (ca. 28% in Water, ca. 4.3mol/L)
    • Trimethylamine solution (ca. 25% in Isopropyl Alcohol, ca. 3mol/L)
    • Trimethylamine, anhydrous, cylinder, with 316SS needle valve, 99%
    • 200-875-0

  • Applications

    Trimethylamine solution, CAS 75-50-3, is a volatile, fishy-smelling tertiary amine widely used as an alkaline agent and versatile building block for quaternary ammonium salts in surfactants, disinfectants, antistatic additives and ion-exchange resins; for manufacturing choline chloride in animal feed, pharmaceuticals, herbicides, gasoline additives and polymerization catalysts; and for applications in gas-sensor technology, molecular biology research, water-treatment pH control, odor-marker deployment, seafood-flavor intermediates and odor-neutralizing agents in specialized chemical processes.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 199.19
    methanol 283.43
    isopropanol 104.74
    water 87.55
    ethyl acetate 52.21
    n-propanol 153.01
    acetone 41.34
    n-butanol 106.26
    acetonitrile 62.19
    DMF 83.41
    toluene 12.67
    isobutanol 81.43
    1,4-dioxane 79.23
    methyl acetate 70.01
    THF 82.92
    2-butanone 48.05
    n-pentanol 36.05
    sec-butanol 97.73
    n-hexane 11.2
    ethylene glycol 227.18
    NMP 127.08
    cyclohexane 19.26
    DMSO 46.41
    n-butyl acetate 57.93
    n-octanol 38.23
    chloroform 167.4
    n-propyl acetate 25.09
    acetic acid 493.75
    dichloromethane 93.63
    cyclohexanone 58.09
    propylene glycol 224.71
    isopropyl acetate 21.77
    DMAc 91.77
    2-ethoxyethanol 72.54
    isopentanol 43.8
    n-heptane 28.21
    ethyl formate 56.03
    1,2-dichloroethane 39.16
    n-hexanol 98.29
    2-methoxyethanol 197.15
    isobutyl acetate 15.87
    tetrachloromethane 74.32
    n-pentyl acetate 26.7
    transcutol 121.73
    n-heptanol 57.08
    ethylbenzene 6.75
    MIBK 10.55
    2-propoxyethanol 141.77
    tert-butanol 79.46
    MTBE 31.55
    2-butoxyethanol 92.48
    propionic acid 262.87
    o-xylene 13.29
    formic acid 346.04
    diethyl ether 36.02
    m-xylene 9.0
    p-xylene 9.45
    chlorobenzene 24.7
    dimethyl carbonate 26.13
    n-octane 7.2
    formamide 175.58
    cyclopentanone 68.89
    2-pentanone 25.96
    anisole 19.58
    cyclopentyl methyl ether 43.02
    gamma-butyrolactone 107.27
    1-methoxy-2-propanol 105.94
    pyridine 68.12
    3-pentanone 31.84
    furfural 111.75
    n-dodecane 5.0
    diethylene glycol 150.84
    diisopropyl ether 8.37
    tert-amyl alcohol 83.38
    acetylacetone 22.25
    n-hexadecane 4.97
    acetophenone 19.97
    methyl propionate 57.41
    isopentyl acetate 38.93
    trichloroethylene 92.99
    n-nonanol 34.43
    cyclohexanol 81.88
    benzyl alcohol 29.46
    2-ethylhexanol 58.18
    isooctanol 33.04
    dipropyl ether 48.92
    1,2-dichlorobenzene 28.04
    ethyl lactate 38.51
    propylene carbonate 69.46
    n-methylformamide 109.61
    2-pentanol 51.53
    n-pentane 16.9
    1-propoxy-2-propanol 117.43
    1-methoxy-2-propyl acetate 49.9
    2-(2-methoxypropoxy) propanol 57.88
    mesitylene 5.43
    ε-caprolactone 73.64
    p-cymene 18.29
    epichlorohydrin 62.21
    1,1,1-trichloroethane 56.74
    2-aminoethanol 267.08
    morpholine-4-carbaldehyde 112.43
    sulfolane 95.8
    2,2,4-trimethylpentane 8.82
    2-methyltetrahydrofuran 67.25
    n-hexyl acetate 36.15
    isooctane 3.22
    2-(2-butoxyethoxy)ethanol 74.13
    sec-butyl acetate 16.2
    tert-butyl acetate 20.26
    decalin 5.66
    glycerin 282.68
    diglyme 95.54
    acrylic acid 284.66
    isopropyl myristate 15.5
    n-butyric acid 163.3
    acetyl acetate 40.25
    di(2-ethylhexyl) phthalate 24.79
    ethyl propionate 28.4
    nitromethane 164.49
    1,2-diethoxyethane 29.28
    benzonitrile 26.57
    trioctyl phosphate 19.72
    1-bromopropane 31.31
    gamma-valerolactone 94.23
    n-decanol 26.07
    triethyl phosphate 30.36
    4-methyl-2-pentanol 17.87
    propionitrile 60.65
    vinylene carbonate 74.68
    1,1,2-trichlorotrifluoroethane 185.26
    DMS 34.15
    cumene 6.54
    2-octanol 25.75
    2-hexanone 15.68
    octyl acetate 26.41
    limonene 30.61
    1,2-dimethoxyethane 48.2
    ethyl orthosilicate 30.97
    tributyl phosphate 23.96
    diacetone alcohol 38.38
    N,N-dimethylaniline 15.56
    acrylonitrile 75.19
    aniline 50.1
    1,3-propanediol 192.92
    bromobenzene 17.88
    dibromomethane 68.62
    1,1,2,2-tetrachloroethane 85.42
    2-methyl-cyclohexyl acetate 37.98
    tetrabutyl urea 24.72
    diisobutyl methanol 24.29
    2-phenylethanol 47.5
    styrene 8.88
    dioctyl adipate 26.79
    dimethyl sulfate 36.04
    ethyl butyrate 44.28
    methyl lactate 69.66
    butyl lactate 44.35
    diethyl carbonate 34.92
    propanediol butyl ether 75.72
    triethyl orthoformate 40.98
    p-tert-butyltoluene 19.56
    methyl 4-tert-butylbenzoate 38.59
    morpholine 113.77
    tert-butylamine 58.6
    n-dodecanol 20.94
    dimethoxymethane 41.4
    ethylene carbonate 57.73
    cyrene 44.69
    2-ethoxyethyl acetate 34.32
    2-ethylhexyl acetate 36.96
    1,2,4-trichlorobenzene 43.64
    4-methylpyridine 40.1
    dibutyl ether 21.88
    2,6-dimethyl-4-heptanol 24.29
    DEF 48.98
    dimethyl isosorbide 68.82
    tetrachloroethylene 94.44
    eugenol 46.04
    triacetin 46.66
    span 80 80.62
    1,4-butanediol 66.04
    1,1-dichloroethane 49.27
    2-methyl-1-pentanol 22.02
    methyl formate 71.41
    2-methyl-1-butanol 64.07
    n-decane 7.76
    butyronitrile 42.34
    3,7-dimethyl-1-octanol 28.4
    1-chlorooctane 18.05
    1-chlorotetradecane 8.59
    n-nonane 7.72
    undecane 5.97
    tert-butylcyclohexane 6.58
    cyclooctane 6.33
    cyclopentanol 105.46
    tetrahydropyran 64.38
    tert-amyl methyl ether 33.23
    2,5,8-trioxanonane 73.41
    1-hexene 17.96
    2-isopropoxyethanol 41.22
    2,2,2-trifluoroethanol 239.61
    methyl butyrate 32.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction