Trimellitic anhydride

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  • Identifiers

    CAS number
    552-30-7

    Molecular formula
    C9H4O5

    SMILES
    C1=CC2=C(C=C1C(=O)O)C(=O)OC2=O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 60.68%
    Burnt 35.84%
    Phenolic 34.95%
    Nutty 34.28%
    Sour 29.92%
    Balsamic 26.71%
    Sweet 26.0%
    Aromatic 24.13%
    Sharp 23.38%
    Bitter 23.2%

     

    Flavor
    Odorless 42.0%
    Bitter 40.62%
    Faint 28.36%
    Very mild 27.47%
    Nutty 24.12%
    Balsam 22.64%
    Urine 22.31%
    Fenugreek 21.08%
    Extremely sweet 20.51%
    Cadaverous 20.51%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    5.2 (weak acid)

    Molecular weight
    192.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 329 to 336 °F (NTP, 1992)
    • 161-163.5 °C
    • 329-336 °F
    • 322 °F

    Boiling point

    • 464 to 473 °F at 14 mmHg (NTP, 1992)
    • 390 °C
    • Boiling point: 240-245 °C at 14 mm Hg
    • Boiling point 240-245 °C at 14 mm Hg
    • at 1.87kPa: 240-245 °C
    • 464-473 °F at 14 mmHg

    Flash point

    • 218.92 ˚C est.
    • 440.6 °F (NTP, 1992)
    • 227 °C o.c.
    • 440.6 °F

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • Sol at 25 °C: 0.002 g/100 g carbon tetrachloride; 0.06 g/100 g ligroin; 0.4 g/100 g mixed xylenes; 15.5 g/100 g dimethyl formamide; 49.6 g/100 g acetone; 21.6 g/100 g ethyl acetate
    • 36.5 g/100 g 2-butanone at 25 °C; 38.4 g/100 g cyclohexanone at 25 °C; 0.06 g/100 g mineral spirits at 25 °C
    • Solubility in water: reaction

  • Synonyms

    • TRIMELLITIC ANHYDRIDE
    • 552-30-7
    • 1,2,4-Benzenetricarboxylic anhydride
    • Anhydrotrimellitic acid
    • Trimellitic acid anhydride
    • TMAN
    • 4-Carboxyphthalic anhydride
    • Trimellitic acid 1,2-anhydride
    • Trimellic acid anhydride
    • 1,3-Dioxo-5-phthalancarboxylic acid
    • Trimellic acid 1,2-anhydride
    • 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid
    • Trimellitic acid cyclic 1,2-anhydride
    • 1,2,4-Benzenetricarboxylic acid anhydride
    • 1,3-Dioxo-1,3-dihydro-2-benzofuran-5-carboxylic acid
    • Epon 9150
    • 5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-
    • NCI-C56633
    • 1,2,4-Benzenetricarboxylic acid 1,2-anhydride
    • 1,2,4-Benzenetricarboxylic acid, cyclic 1,2-anhydride
    • 5-Phthalanacarboxylic acid, 1,3-dioxo-
    • 80T61EUU7H
    • DTXSID7026235
    • CHEBI:53050
    • NSC-60252
    • DTXCID906235
    • tri-mellitic anhydride
    • RefChem:899716
    • 209-008-0
    • 1,3-Dioxo-1,3-dihydroisobenzofuran-5-carboxylic acid
    • Anhydrotrimellic acid
    • MFCD00005925
    • C9H4O5
    • 1,3-dioxoisobenzofuran-5-carboxylic acid
    • 1,3-dioxo-2-benzofuran-5-carboxylic acid
    • NSC 60252
    • Benzene-1,2,4-tricarboxylic-1,2-anhydride
    • 1,2,4-Benzenetricarboxylic 1,2-Anhydride
    • NSC60252
    • 1,2,4-benzene tricarboxylic anhydride
    • Benzene-1,2,4-tricarboxylic anhydride
    • Benzene-1,2,4-tricarboxylic acidanhydride
    • 1,2,4-Benzenetricarboxylic anhydride (TMA)
    • 1,3-Dioxo-1,3-dihydro-isobenzofuran-5-carboxylic acid
    • CAS-552-30-7
    • CCRIS 6282
    • HSDB 4299
    • EINECS 209-008-0
    • BRN 0009394
    • UNII-80T61EUU7H
    • Benzene-1,2,4-tricarboxylic acid 1,2-anhydride
    • cyclic 1,2-anhydride
    • Epitope ID:113235
    • EC 209-008-0
    • SCHEMBL22458
    • Trimellitic acid,2-anhydride
    • 5-18-08-00562 (Beilstein Handbook Reference)
    • Trimellic acid-1,2-anhydride
    • WLN: T56 BVOVJ GVQ
    • Trimellitic anhydride-dendrimers
    • CHEMBL2137687
    • SCHEMBL29288713
    • SCHEMBL29355829
    • Trimellitic anhydride treated BSA
    • Trimellitic anhydride treated HSA
    • Trimellitic anhydride treated IgG
    • 1,4-Benzenetricarboxylic anhydride
    • TRIMELLITIC ANHYDRIDE [MI]
    • TRIMELLITIC ANHYDRIDE (TMA)
    • BB_SC-07233
    • Trimellitic anhydride treated casein
    • Tox21_202066
    • Tox21_303117
    • TRIMELLITIC ANHYDRIDE [HSDB]
    • 5-Phthalanacarboxylic acid,3-dioxo-
    • AC-811
    • AC8872
    • BBL010496
    • SBB040551
    • STL146149
    • 1,2,4 benzenetricarboxylic anhydride
    • AKOS000120069
    • CS-W015822
    • FT36717
    • Trimellitic anhydride treated hemoglobin
    • 1,4-Benzenetricarboxylic acid anhydride
    • NCGC00164022-01
    • NCGC00164022-02
    • NCGC00256953-01
    • NCGC00259615-01
    • 1,3-dioxo-5-isobenzofurancarboxylic acid
    • BP-13468
    • SY001151
    • Trimellitic anhydride-trypsin treated BSA
    • VS-02531
    • 1,2,4 benzenetricarboxylic acid anhydride
    • 1,2,4-Benzenetricarboxylic anhydride, 97%
    • 1,4-Benzenetricarboxylic acid 1,2-anhydride
    • C0959
    • NS00006728
    • ST50213924
    • EN300-18016
    • Trimellitic anhydride treated human transferrin
    • Trimellitic anhydride, purum, >=97.0% (T)
    • 1,2,4-Benzenetricarboxylic acid anhydride-1,2
    • F235689
    • Q1675143
    • 1,4-Benzenetricarboxylic acid, cyclic 1,2-anhydride
    • 5-Isobenzofurancarboxylic acid,3-dihydro-1,3-dioxo-
    • Z57127496
    • 1,2,4-Benzenetricarboxylic anhydride treated hemoglobin
    • 5-Isobenzofurancarboxylicacid, 1,3-dihydro-1,3-dioxo-
    • F0001-1448
    • 1,3-Dioxo-1,3-dihydro-isobenzofuran-5-carboxylic acid #
    • 1,2,4-Benzenetricarboxylic anhydride Trimellitic anhydride TMA
    • Trimellitic anhydride treated .beta.-lactoglobulin from bovine whey
    • 1,2,4-Benzenetricarboxylic anhydride treated .beta.-lactoglobulin from bovine whey
    • InChI=1/C9H4O5/c10-7(11)4-1-2-5-6(3-4)9(13)14-8(5)12/h1-3H,(H,10,11
    • 552-30-7

  • Applications

    Trimellitic anhydride (CAS 552-30-7) is primarily used as a precursor for trimellitate plasticizers, exemplified by tri(2-ethylhexyl) trimellitate (TOTM), to improve flexibility and thermal stability in PVC and other polymers. It also serves as a building block for alkyd and specialty polyester resins used in coatings and industrial paints, enhancing film durability and heat resistance. It is a functional building block in the synthesis of high-temperature polymers such as polyimides and related polyesters for electronics and industrial applications. In epoxy and adhesive systems, it provides carboxyl functionalities to facilitate crosslinking and improve resin rigidity and thermal stability. These roles position trimellitic anhydride as an important intermediate in coatings, adhesives, and electronic materials.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 108.04
    methanol 199.59
    isopropanol 59.85
    water 10.08
    ethyl acetate 45.18
    n-propanol 52.96
    acetone 76.78
    n-butanol 36.22
    acetonitrile 20.03
    DMF 348.5
    toluene 8.6
    isobutanol 26.15
    1,4-dioxane 66.02
    methyl acetate 51.75
    THF 83.02
    2-butanone 67.97
    n-pentanol 24.36
    sec-butanol 55.59
    n-hexane 0.68
    ethylene glycol 92.59
    NMP 246.09
    cyclohexane 0.55
    DMSO 456.54
    n-butyl acetate 23.06
    n-octanol 24.05
    chloroform 3.24
    n-propyl acetate 15.44
    acetic acid 27.07
    dichloromethane 8.74
    cyclohexanone 25.73
    propylene glycol 62.1
    isopropyl acetate 25.63
    DMAc 222.79
    2-ethoxyethanol 142.25
    isopentanol 29.96
    n-heptane 1.24
    ethyl formate 23.57
    1,2-dichloroethane 13.33
    n-hexanol 24.88
    2-methoxyethanol 294.21
    isobutyl acetate 2.47
    tetrachloromethane 1.47
    n-pentyl acetate 23.93
    transcutol 343.67
    n-heptanol 22.68
    ethylbenzene 5.23
    MIBK 25.09
    2-propoxyethanol 108.41
    tert-butanol 56.88
    MTBE 32.71
    2-butoxyethanol 70.88
    propionic acid 34.16
    o-xylene 9.9
    formic acid 78.34
    diethyl ether 54.28
    m-xylene 7.03
    p-xylene 3.28
    chlorobenzene 3.84
    dimethyl carbonate 46.62
    n-octane 0.63
    formamide 230.76
    cyclopentanone 52.26
    2-pentanone 53.91
    anisole 25.95
    cyclopentyl methyl ether 33.94
    gamma-butyrolactone 68.53
    1-methoxy-2-propanol 214.83
    pyridine 41.73
    3-pentanone 44.42
    furfural 75.44
    n-dodecane 0.59
    diethylene glycol 139.78
    diisopropyl ether 11.44
    tert-amyl alcohol 60.53
    acetylacetone 55.5
    n-hexadecane 0.67
    acetophenone 30.18
    methyl propionate 66.58
    isopentyl acetate 14.28
    trichloroethylene 13.67
    n-nonanol 21.3
    cyclohexanol 17.2
    benzyl alcohol 25.9
    2-ethylhexanol 12.23
    isooctanol 13.94
    dipropyl ether 17.24
    1,2-dichlorobenzene 5.08
    ethyl lactate 29.07
    propylene carbonate 24.05
    n-methylformamide 168.61
    2-pentanol 37.51
    n-pentane 1.29
    1-propoxy-2-propanol 70.69
    1-methoxy-2-propyl acetate 50.29
    2-(2-methoxypropoxy) propanol 75.09
    mesitylene 4.23
    ε-caprolactone 36.18
    p-cymene 5.63
    epichlorohydrin 69.93
    1,1,1-trichloroethane 3.52
    2-aminoethanol 94.89
    morpholine-4-carbaldehyde 176.45
    sulfolane 132.53
    2,2,4-trimethylpentane 0.81
    2-methyltetrahydrofuran 52.35
    n-hexyl acetate 34.74
    isooctane 0.47
    2-(2-butoxyethoxy)ethanol 110.66
    sec-butyl acetate 10.35
    tert-butyl acetate 29.73
    decalin 0.53
    glycerin 116.9
    diglyme 164.21
    acrylic acid 38.44
    isopropyl myristate 11.78
    n-butyric acid 24.18
    acetyl acetate 15.57
    di(2-ethylhexyl) phthalate 13.43
    ethyl propionate 24.56
    nitromethane 92.21
    1,2-diethoxyethane 54.04
    benzonitrile 11.45
    trioctyl phosphate 10.26
    1-bromopropane 6.87
    gamma-valerolactone 84.99
    n-decanol 14.91
    triethyl phosphate 12.78
    4-methyl-2-pentanol 16.76
    propionitrile 16.59
    vinylene carbonate 19.79
    1,1,2-trichlorotrifluoroethane 65.44
    DMS 33.71
    cumene 3.44
    2-octanol 17.04
    2-hexanone 18.07
    octyl acetate 18.39
    limonene 7.21
    1,2-dimethoxyethane 109.7
    ethyl orthosilicate 10.65
    tributyl phosphate 11.03
    diacetone alcohol 75.58
    N,N-dimethylaniline 19.38
    acrylonitrile 26.4
    aniline 22.87
    1,3-propanediol 97.87
    bromobenzene 2.63
    dibromomethane 4.43
    1,1,2,2-tetrachloroethane 12.78
    2-methyl-cyclohexyl acetate 10.69
    tetrabutyl urea 20.74
    diisobutyl methanol 7.9
    2-phenylethanol 28.02
    styrene 5.38
    dioctyl adipate 17.06
    dimethyl sulfate 88.26
    ethyl butyrate 17.39
    methyl lactate 80.7
    butyl lactate 30.34
    diethyl carbonate 12.49
    propanediol butyl ether 77.45
    triethyl orthoformate 13.75
    p-tert-butyltoluene 5.32
    methyl 4-tert-butylbenzoate 38.85
    morpholine 95.49
    tert-butylamine 20.73
    n-dodecanol 9.74
    dimethoxymethane 206.81
    ethylene carbonate 13.7
    cyrene 54.91
    2-ethoxyethyl acetate 49.08
    2-ethylhexyl acetate 11.04
    1,2,4-trichlorobenzene 7.38
    4-methylpyridine 33.35
    dibutyl ether 14.92
    2,6-dimethyl-4-heptanol 7.9
    DEF 107.63
    dimethyl isosorbide 77.6
    tetrachloroethylene 10.75
    eugenol 44.37
    triacetin 37.23
    span 80 41.78
    1,4-butanediol 40.73
    1,1-dichloroethane 5.5
    2-methyl-1-pentanol 20.23
    methyl formate 90.03
    2-methyl-1-butanol 32.62
    n-decane 1.06
    butyronitrile 12.72
    3,7-dimethyl-1-octanol 16.14
    1-chlorooctane 5.59
    1-chlorotetradecane 1.96
    n-nonane 0.95
    undecane 0.81
    tert-butylcyclohexane 0.4
    cyclooctane 0.45
    cyclopentanol 24.47
    tetrahydropyran 24.57
    tert-amyl methyl ether 40.53
    2,5,8-trioxanonane 119.79
    1-hexene 3.0
    2-isopropoxyethanol 69.22
    2,2,2-trifluoroethanol 25.44
    methyl butyrate 22.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction