Triisopropanolamine

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  • Identifiers

    CAS number
    122-20-3

    Molecular formula
    C9H21NO3

    SMILES
    CC(CN(CC(C)O)CC(C)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fishy 44.41%
    Odorless 43.66%
    Sweet 36.56%
    Alcoholic 23.82%
    Oily 19.96%
    Savory 19.91%
    Cheesy 15.5%
    Cooling 15.5%
    Ripe 14.99%
    Buttery 14.7%

    Scent© AI

  • Properties

    XLogP3-AA
    -0.5

    Molecular weight
    191.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 113 °F (NTP, 1992)
    • 45 °C

    Boiling point

    • 581 °F at 760 mmHg (NTP, 1992)
    • 306 °C
    • 305 °C

    Flash point est.
    156.63 ˚C

    Flash point expt.

    • 320 °F (NTP, 1992)
    • 320 °F (160 °C) (Open cup)
    • 160 °C o.c.

    Solubility expt.

    • Soluble (NTP, 1992)
    • Soluble in ethanol; slightly soluble in chloroform
    • Soluble in oxygenated and aromatic solvents
    • Solubility at 25 °C, g/100g: acetone, 450; methanol, >500; ethanol, 365; water, >500
    • In water, >1000 g/L at 25 °C
    • Solubility in water, g/100ml at 20 °C: 83 (good)

  • Synonyms

    • Triisopropanolamine
    • 122-20-3
    • 1,1',1''-Nitrilotripropan-2-ol
    • TIPA
    • TRIS(2-HYDROXYPROPYL)AMINE
    • Tri-2-propanolamine
    • Tri-iso-propanolamine
    • Tris(2-propanol)amine
    • 1-[bis(2-hydroxypropyl)amino]propan-2-ol
    • 2-Propanol, 1,1',1''-nitrilotris-
    • Tris(2-hydroxy-1-propyl)amine
    • Caswell No. 891
    • CCRIS 4884
    • 2-Propanol, 1,1',1''-nitrilotri-
    • 1,1',1''-Nitrilotris(propan-2-ol)
    • HSDB 5593
    • Triisopropanolamin
    • UNII-W9EN9DLM98
    • NSC 4010
    • 1,1',1''-Nitrilotri-2-propanol
    • EINECS 204-528-4
    • trisisopropanolamine
    • W9EN9DLM98
    • EPA Pesticide Chemical Code 004209
    • BRN 1071570
    • tris(isopropanol)amine
    • DTXSID5021415
    • UNICHEM TIPA
    • AI3-01450
    • NSC-4010
    • 1,1',1''-nitrilotris-2-propanol
    • 3,3',3''-Nitrilotri(2-propanol)
    • 1,1',1''-Nitrilotris(2-propanol)
    • tris-(2-hydroxypropyl)amine
    • DTXCID201415
    • EC 204-528-4
    • 4-04-00-01680 (Beilstein Handbook Reference)
    • Triisopropanolamine (mixture of isomers)
    • TRIS(2-HYDROXYPROPYL)AMINE [HSDB]
    • 1,1',1''-Nitrilotris[2-propanol]
    • 204-528-4
    • CAS-122-20-3
    • MFCD00004533
    • Tri2propanolamine
    • TiPlA
    • Tris(2propanol)amine
    • Tris(2hydroxypropyl)amine
    • Triisopropanolamine, 95%
    • Tris(2hydroxy1propyl)amine
    • tris(2-hydroxypropyl) amine
    • SCHEMBL28985
    • 1,1''-Nitrilotri-2-propanol
    • 1,1',1''Nitrilotri2propanol
    • CHEMBL1877948
    • 3,3''-Nitrilotri(2-propanol)
    • 3,3',3"Nitrilotri(2propanol)
    • tris-(2-hydroxy-1-propyl)amine
    • NSC4010
    • TRIISOPROPANOLAMINE [INCI]
    • 1,1''-Nitrilotris(2-propanol)
    • CHEBI:170017
    • 1,1',1"-Nitrilotripropan-2-ol
    • 2-Propanol,1',1''-nitrilotri-
    • 2Propanol, 1,1',1''nitrilotri
    • 1,1',1''Nitrilotris(2propanol)
    • 2-Propanol,1',1''-nitrilotris-
    • 2Propanol, 1,1',1''nitrilotris
    • AAA12220
    • Tox21_201952
    • Tox21_302748
    • 1,1', 1''-Nitrilotri-2-propanol
    • AKOS015965047
    • 1,1',1''-Nitrilotri(-2-propanol)
    • CS-W010723
    • NCGC00164112-01
    • NCGC00164112-02
    • NCGC00256448-01
    • NCGC00259501-01
    • LS-13727
    • WLN: QY1 & 1N1YQ1 & 1YQ1
    • 2-PROPANOL 1,1',1''-NITRILOTRI-
    • NS00010227
    • D70439
    • EN300-8108474
    • propane, 1-di(2-hydroxypropyl)amino-2-hydroxy-
    • Q1729503

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 214.3
    methanol 710.5
    isopropanol 62.66
    water 778.2
    ethyl acetate 15.87
    n-propanol 134.98
    acetone 17.45
    n-butanol 66.33
    acetonitrile 19.9
    DMF 139.67
    toluene 4.27
    isobutanol 53.33
    1,4-dioxane 66.48
    methyl acetate 18.58
    THF 99.83
    2-butanone 15.14
    n-pentanol 32.02
    sec-butanol 46.82
    n-hexane 3.05
    ethylene glycol 391.75
    NMP 353.15
    cyclohexane 6.67
    DMSO 177.97
    n-butyl acetate 17.21
    n-octanol 21.42
    chloroform 32.32
    n-propyl acetate 15.92
    acetic acid 568.11
    dichloromethane 37.49
    cyclohexanone 71.79
    propylene glycol 288.87
    isopropyl acetate 8.54
    DMAc 125.16
    2-ethoxyethanol 103.25
    isopentanol 24.45
    n-heptane 5.06
    ethyl formate 39.57
    1,2-dichloroethane 18.21
    n-hexanol 38.86
    2-methoxyethanol 238.21
    isobutyl acetate 11.42
    tetrachloromethane 7.8
    n-pentyl acetate 15.42
    transcutol 117.67
    n-heptanol 26.11
    ethylbenzene 3.91
    MIBK 5.78
    2-propoxyethanol 113.69
    tert-butanol 33.94
    MTBE 7.79
    2-butoxyethanol 65.58
    propionic acid 221.7
    o-xylene 6.49
    formic acid 871.67
    diethyl ether 10.59
    m-xylene 5.11
    p-xylene 6.31
    chlorobenzene 8.34
    dimethyl carbonate 13.62
    n-octane 1.93
    formamide 374.0
    cyclopentanone 87.04
    2-pentanone 10.38
    anisole 9.02
    cyclopentyl methyl ether 35.47
    gamma-butyrolactone 179.91
    1-methoxy-2-propanol 94.33
    pyridine 33.78
    3-pentanone 11.26
    furfural 145.85
    n-dodecane 1.18
    diethylene glycol 158.91
    diisopropyl ether 2.68
    tert-amyl alcohol 33.51
    acetylacetone 14.25
    n-hexadecane 1.25
    acetophenone 17.59
    methyl propionate 26.67
    isopentyl acetate 13.8
    trichloroethylene 31.15
    n-nonanol 18.98
    cyclohexanol 72.36
    benzyl alcohol 27.08
    2-ethylhexanol 18.27
    isooctanol 17.25
    dipropyl ether 15.8
    1,2-dichlorobenzene 11.5
    ethyl lactate 36.54
    propylene carbonate 79.36
    n-methylformamide 179.98
    2-pentanol 21.09
    n-pentane 3.46
    1-propoxy-2-propanol 62.86
    1-methoxy-2-propyl acetate 26.5
    2-(2-methoxypropoxy) propanol 43.79
    mesitylene 3.98
    ε-caprolactone 101.71
    p-cymene 6.9
    epichlorohydrin 69.69
    1,1,1-trichloroethane 8.28
    2-aminoethanol 408.5
    morpholine-4-carbaldehyde 220.39
    sulfolane 262.99
    2,2,4-trimethylpentane 1.85
    2-methyltetrahydrofuran 47.92
    n-hexyl acetate 21.51
    isooctane 0.9
    2-(2-butoxyethoxy)ethanol 62.22
    sec-butyl acetate 8.0
    tert-butyl acetate 8.44
    decalin 2.8
    glycerin 431.58
    diglyme 82.97
    acrylic acid 260.59
    isopropyl myristate 7.18
    n-butyric acid 114.77
    acetyl acetate 13.78
    di(2-ethylhexyl) phthalate 19.69
    ethyl propionate 15.81
    nitromethane 162.61
    1,2-diethoxyethane 16.97
    benzonitrile 18.88
    trioctyl phosphate 15.06
    1-bromopropane 8.63
    gamma-valerolactone 175.84
    n-decanol 13.03
    triethyl phosphate 16.97
    4-methyl-2-pentanol 8.57
    propionitrile 19.34
    vinylene carbonate 81.38
    1,1,2-trichlorotrifluoroethane 185.66
    DMS 23.76
    cumene 4.51
    2-octanol 13.08
    2-hexanone 9.84
    octyl acetate 12.52
    limonene 10.21
    1,2-dimethoxyethane 60.97
    ethyl orthosilicate 16.32
    tributyl phosphate 16.38
    diacetone alcohol 23.02
    N,N-dimethylaniline 12.66
    acrylonitrile 33.25
    aniline 19.53
    1,3-propanediol 222.63
    bromobenzene 5.3
    dibromomethane 21.16
    1,1,2,2-tetrachloroethane 31.25
    2-methyl-cyclohexyl acetate 23.42
    tetrabutyl urea 22.33
    diisobutyl methanol 9.0
    2-phenylethanol 25.94
    styrene 3.68
    dioctyl adipate 17.63
    dimethyl sulfate 38.8
    ethyl butyrate 16.96
    methyl lactate 56.26
    butyl lactate 37.57
    diethyl carbonate 13.51
    propanediol butyl ether 77.84
    triethyl orthoformate 19.67
    p-tert-butyltoluene 7.08
    methyl 4-tert-butylbenzoate 29.96
    morpholine 114.75
    tert-butylamine 17.19
    n-dodecanol 9.25
    dimethoxymethane 40.33
    ethylene carbonate 65.44
    cyrene 88.44
    2-ethoxyethyl acetate 22.33
    2-ethylhexyl acetate 12.85
    1,2,4-trichlorobenzene 16.76
    4-methylpyridine 21.77
    dibutyl ether 9.17
    2,6-dimethyl-4-heptanol 9.0
    DEF 37.49
    dimethyl isosorbide 77.38
    tetrachloroethylene 28.79
    eugenol 39.78
    triacetin 36.82
    span 80 63.62
    1,4-butanediol 103.17
    1,1-dichloroethane 8.09
    2-methyl-1-pentanol 17.72
    methyl formate 99.5
    2-methyl-1-butanol 35.61
    n-decane 2.11
    butyronitrile 16.35
    3,7-dimethyl-1-octanol 13.24
    1-chlorooctane 5.85
    1-chlorotetradecane 2.51
    n-nonane 2.18
    undecane 1.48
    tert-butylcyclohexane 2.42
    cyclooctane 2.86
    cyclopentanol 104.97
    tetrahydropyran 40.49
    tert-amyl methyl ether 10.37
    2,5,8-trioxanonane 68.59
    1-hexene 5.15
    2-isopropoxyethanol 44.4
    2,2,2-trifluoroethanol 219.04
    methyl butyrate 22.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction