Triglyme

Overview IFRA Request a quote

  • Identifiers

    CAS number
    112-49-2

    Molecular formula
    C8H18O4

    SMILES
    COCCOCCOCCOC

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Ethereal 57.07%
    Alcoholic 44.85%
    Sweet 30.59%
    Solvent 28.53%
    Odorless 27.09%
    Fruity 22.44%
    Fermented 20.78%
    Fresh 20.71%
    Musty 19.89%
    Oily 16.09%

    Scent© AI

  • Properties

    XLogP3-AA
    -0.5

    Molecular weight
    178.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Melting point expt.

    • -49 °F (NTP, 1992)
    • -45 °C

    Boiling point

    • 421 °F at 760 mmHg (NTP, 1992)
    • 216 °C

    Flash point est.
    96.1 ˚C

    Flash point expt.

    • 232 °F (NTP, 1992)
    • 111 °C o.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
    • Solubility in water: miscible

  • Synonyms

    • Triglyme
    • 112-49-2
    • 2,5,8,11-TETRAOXADODECANE
    • Triethylene glycol dimethyl ether
    • 1,2-Bis(2-methoxyethoxy)ethane
    • Glyme 4
    • Ansul ether 161
    • Glyme-3
    • 1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane
    • TEGDIME
    • TEGDME
    • Dimethyl ether of triethylene glycol
    • NSC 66400
    • Ethane, 1,2-bis(2-methoxyethoxy)-
    • DTXSID8026224
    • EINECS 203-977-3
    • Glycol, triethylene-, dimethyl ether
    • BRN 1700630
    • 32YXG88KK0
    • 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE
    • CHEBI:44842
    • AI3-28582
    • TRIGLYME [MI]
    • NSC-66400
    • 1,2-Bis(methoxyethoxy)ethane
    • Triethylene glycol dimethyl ether (stabilized with BHT)
    • DTXCID206224
    • triethyleneglycol dimethyl ether
    • EC 203-977-3
    • PG5
    • 1-methoxy-2-(2-(2-methoxyethoxy)ethoxy)ethane
    • UNII-32YXG88KK0
    • Dimethyltriglycol
    • Glyme-4
    • MFCD00008504
    • METHYLTRIGLYME
    • HISOLVE MTM
    • 1,2-Bis(2-methoxyethoxy) Ethane, Reagent
    • 2,8,11-Tetraoxadodecane
    • 1,2Bis(methoxyethoxy)ethane
    • 2,5,8,11Tetraoxadodecane
    • SCHEMBL16126
    • 1,2Bis(2methoxyethoxy)ethane
    • triethylene glycol dimethylether
    • CHEMBL1235255
    • Ethane, 1,2bis(2methoxyethoxy)
    • Ethane,2-bis(2-methoxyethoxy)-
    • (CH3O(CH2)2OCH2)2
    • Glycol, triethylene, dimethyl ether
    • NSC66400
    • UYB19216
    • Tox21_300509
    • AKOS009158244
    • CS-W017328
    • DB02078
    • NCGC00164017-01
    • NCGC00164017-02
    • NCGC00254323-01
    • CAS-112-49-2
    • DB-060211
    • B0496
    • NS00010633
    • EN300-40253
    • E75964
    • Q2453066
    • Triethylene glycol dimethyl ether, ReagentPlus(R), 99%
    • Z409380232
    • Triethylene glycol dimethyl ether 100 microg/mL in Acetonitrile
    • Triethylene glycol dimethyl ether, analytical reference material
    • 2,5,8,11-tetraoxadodecane;1,2-bis(2-methoxyethoxy)ethane;triethylene glycol dimethyl ether;1,2bis(2methoxyethoxy)ethane;triethylene glycoldimethylether (tegdme);2,5,8,11-tetraoxadodecane 1,2-bis(2-methoxyethoxy)ethane triethylene glycol dimethyl ether 1,2bis(2methoxyethoxy)ethane triethylene glycoldimethylether (tegdme)
    • 203-977-3

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 101.27
    methanol 192.29
    isopropanol 53.49
    water 11.04
    ethyl acetate 78.13
    n-propanol 74.31
    acetone 91.14
    n-butanol 46.54
    acetonitrile 108.01
    DMF 244.68
    toluene 25.57
    isobutanol 43.08
    1,4-dioxane 183.42
    methyl acetate 97.37
    THF 206.27
    2-butanone 65.87
    n-pentanol 27.95
    sec-butanol 50.13
    n-hexane 7.63
    ethylene glycol 85.65
    NMP 299.88
    cyclohexane 45.91
    DMSO 493.47
    n-butyl acetate 45.0
    n-octanol 17.98
    chloroform 564.22
    n-propyl acetate 46.01
    acetic acid 478.12
    dichloromethane 556.87
    cyclohexanone 142.2
    propylene glycol 64.79
    isopropyl acetate 31.36
    DMAc 208.61
    2-ethoxyethanol 105.22
    isopentanol 27.42
    n-heptane 13.38
    ethyl formate 86.29
    1,2-dichloroethane 250.07
    n-hexanol 29.39
    2-methoxyethanol 194.5
    isobutyl acetate 22.83
    tetrachloromethane 111.01
    n-pentyl acetate 27.52
    transcutol 195.79
    n-heptanol 16.45
    ethylbenzene 14.85
    MIBK 16.17
    2-propoxyethanol 78.21
    tert-butanol 60.43
    MTBE 30.44
    2-butoxyethanol 43.99
    propionic acid 181.8
    o-xylene 27.79
    formic acid 297.91
    diethyl ether 44.42
    m-xylene 15.82
    p-xylene 23.14
    chlorobenzene 70.81
    dimethyl carbonate 34.69
    n-octane 4.62
    formamide 328.93
    cyclopentanone 173.53
    2-pentanone 33.7
    anisole 41.04
    cyclopentyl methyl ether 73.63
    gamma-butyrolactone 264.55
    1-methoxy-2-propanol 96.13
    pyridine 189.26
    3-pentanone 45.73
    furfural 328.12
    n-dodecane 3.26
    diethylene glycol 96.54
    diisopropyl ether 9.7
    tert-amyl alcohol 52.91
    acetylacetone 59.21
    n-hexadecane 3.75
    acetophenone 56.08
    methyl propionate 68.48
    isopentyl acetate 32.0
    trichloroethylene 503.81
    n-nonanol 17.68
    cyclohexanol 87.47
    benzyl alcohol 52.44
    2-ethylhexanol 23.24
    isooctanol 13.52
    dipropyl ether 38.48
    1,2-dichlorobenzene 87.96
    ethyl lactate 46.07
    propylene carbonate 124.98
    n-methylformamide 177.71
    2-pentanol 25.14
    n-pentane 9.27
    1-propoxy-2-propanol 57.56
    1-methoxy-2-propyl acetate 46.6
    2-(2-methoxypropoxy) propanol 58.92
    mesitylene 12.09
    ε-caprolactone 136.75
    p-cymene 18.19
    epichlorohydrin 215.4
    1,1,1-trichloroethane 175.06
    2-aminoethanol 107.59
    morpholine-4-carbaldehyde 231.2
    sulfolane 413.56
    2,2,4-trimethylpentane 5.35
    2-methyltetrahydrofuran 116.39
    n-hexyl acetate 36.11
    isooctane 2.04
    2-(2-butoxyethoxy)ethanol 63.36
    sec-butyl acetate 24.6
    tert-butyl acetate 29.83
    decalin 11.05
    glycerin 135.28
    diglyme 148.53
    acrylic acid 227.41
    isopropyl myristate 16.58
    n-butyric acid 137.53
    acetyl acetate 78.98
    di(2-ethylhexyl) phthalate 24.18
    ethyl propionate 45.3
    nitromethane 455.29
    1,2-diethoxyethane 48.51
    benzonitrile 67.08
    trioctyl phosphate 15.75
    1-bromopropane 83.55
    gamma-valerolactone 220.89
    n-decanol 12.83
    triethyl phosphate 50.18
    4-methyl-2-pentanol 10.36
    propionitrile 73.0
    vinylene carbonate 146.03
    1,1,2-trichlorotrifluoroethane 396.03
    DMS 51.83
    cumene 12.93
    2-octanol 10.59
    2-hexanone 29.55
    octyl acetate 22.37
    limonene 28.69
    1,2-dimethoxyethane 142.43
    ethyl orthosilicate 42.23
    tributyl phosphate 23.43
    diacetone alcohol 41.21
    N,N-dimethylaniline 35.54
    acrylonitrile 123.54
    aniline 74.19
    1,3-propanediol 99.54
    bromobenzene 67.93
    dibromomethane 316.86
    1,1,2,2-tetrachloroethane 432.69
    2-methyl-cyclohexyl acetate 47.19
    tetrabutyl urea 32.5
    diisobutyl methanol 14.72
    2-phenylethanol 37.24
    styrene 22.98
    dioctyl adipate 39.69
    dimethyl sulfate 92.18
    ethyl butyrate 53.93
    methyl lactate 63.23
    butyl lactate 34.38
    diethyl carbonate 52.81
    propanediol butyl ether 43.87
    triethyl orthoformate 52.38
    p-tert-butyltoluene 17.07
    methyl 4-tert-butylbenzoate 53.99
    morpholine 214.23
    tert-butylamine 39.59
    n-dodecanol 10.3
    dimethoxymethane 80.61
    ethylene carbonate 107.98
    cyrene 81.74
    2-ethoxyethyl acetate 42.9
    2-ethylhexyl acetate 30.05
    1,2,4-trichlorobenzene 118.08
    4-methylpyridine 96.24
    dibutyl ether 27.13
    2,6-dimethyl-4-heptanol 14.72
    DEF 83.91
    dimethyl isosorbide 112.54
    tetrachloroethylene 364.21
    eugenol 51.97
    triacetin 74.03
    span 80 55.61
    1,4-butanediol 39.57
    1,1-dichloroethane 153.56
    2-methyl-1-pentanol 20.54
    methyl formate 133.97
    2-methyl-1-butanol 33.86
    n-decane 5.87
    butyronitrile 51.57
    3,7-dimethyl-1-octanol 17.78
    1-chlorooctane 18.23
    1-chlorotetradecane 8.2
    n-nonane 5.92
    undecane 4.11
    tert-butylcyclohexane 6.92
    cyclooctane 11.42
    cyclopentanol 108.15
    tetrahydropyran 132.3
    tert-amyl methyl ether 29.7
    2,5,8-trioxanonane 111.54
    1-hexene 16.3
    2-isopropoxyethanol 51.64
    2,2,2-trifluoroethanol 235.39
    methyl butyrate 61.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction