Triethylene glycol monomethyl ether

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  • Identifiers

    CAS number
    112-35-6

    Molecular formula
    C7H16O4

    SMILES
    COCCOCCOCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 45.38%
    Alcoholic 44.39%
    Ethereal 41.02%
    Solvent 23.72%
    Sweet 18.97%
    Fishy 18.43%
    Fresh 16.49%
    Oily 16.39%
    Musty 15.83%
    Fermented 14.64%

     

    Flavor
    Sweet 43.84%
    Alcoholic 40.23%
    Bitter 37.89%
    Musty 36.07%
    Odorless 31.19%
    Vegetable 30.53%
    Fruit 24.83%
    Earthy 24.13%
    Very slight 23.81%
    Fatty 23.77%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.0

    pKa est.
    5.0 (weak acid)

    Molecular weight
    164.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • Freezing point: -44 °C
    • -44 °C

    Boiling point

    • 246 °C
    • 249 °C

    Flash point

    • 120.75 ˚C est.
    • greater than 230 °F (USCG, 1999)
    • 245 °F (118 °C) (OPEN CUP)
    • 114.4 °C c.c.

    Solubility expt.

    • In water, miscible
    • Soluble in water
    • Solubility in heptane = 1.5 wt%, completely soluble in acetone, benzene, ethyl ether, methanol, and carbon tetrachloride at 25 °C.
    • Solubility in water: miscible

  • Synonyms

    • TRIETHYLENE GLYCOL MONOMETHYL ETHER
    • 112-35-6
    • m-PEG3-alcohol
    • Methyltrioxitol
    • 2-(2-(2-Methoxyethoxy)ethoxy)ethanol
    • Methoxytriglycol
    • 2-[2-(2-Methoxyethoxy)ethoxy]ethanol
    • Dowanol TMAT
    • Methyltriglycol
    • Methoxytriethylene glycol
    • 3,6,9-Trioxa-1-decanol
    • Methyl triethylene glycol
    • Triglycol monomethyl ether
    • Triethylene glycol methyl ether
    • Ethanol, 2-[2-(2-methoxyethoxy)ethoxy]-
    • Triethylene glycolmonomethyl ether
    • NSC 97395
    • 3,6,9-trioxadecanol
    • mPEG3-OH
    • HSDB 1001
    • m-PEG3-OH
    • EINECS 203-962-1
    • UNII-DN0P4Q4I16
    • BRN 1700198
    • DN0P4Q4I16
    • DTXSID5026912
    • CHEBI:84233
    • Ethanol, 2-(2-(2-methoxyethoxy)ethoxy)-
    • METHOXY PEG-3
    • MFCD00002875
    • NSC-97395
    • MPEG-3
    • PEG-3 METHYL ETHER
    • 3,6,9-trioxadecane-1-ol
    • 2-[2-(2-methoxyethoxy)ethoxy]ethan-1-ol
    • PEG-3 MONOMETHYL ETHER
    • DTXCID506912
    • EC 203-962-1
    • MACROGOL 150 METHYL ETHER
    • 2-(2-(2-methoxyethoxy)ethoxy)ethan-1-ol
    • 2-[2-(2-Methoxy-Ethoxy)-Ethoxy]-Ethoxyl
    • TRIETHYLENE GLYCOL MONOMETHYL ETHER [HSDB]
    • Methyl Triglycol
    • Methoxy triglycol
    • CAS-112-35-6
    • PolySolv TM
    • triethylene glycol monomethylether
    • Triethyleneglycol monomethyl ether
    • Methyl-PEG3-alcohol
    • triglycol methyl ether
    • 3,6,9Trioxa1decanol
    • 3,6,9-Trioxadecan-1-ol
    • SCHEMBL15587
    • WLN: Q2O2O2O1
    • triethyleneglycol monomethylether
    • CHEMBL1794613
    • 2(2(2Methoxyethoxy)ethoxy)ethanol
    • NSC97395
    • PEG-3 METHYL ETHER [INCI]
    • Tox21_201820
    • Tox21_303115
    • Triethyl ene glycol monomethyl ether
    • Ethanol, 2(2(2methoxyethoxy)ethoxy)
    • AKOS015915321
    • FT42970
    • 2-(2-(2-methoxyethoxyl)ethoxy)ethanol
    • NCGC00164137-01
    • NCGC00164137-02
    • NCGC00257220-01
    • NCGC00259369-01
    • 2-[2-(2-methoxyethoxy)-ethoxy]-ethanol
    • BP-21397
    • LS-13383
    • Triethylene glycol monomethyl ether, 95%
    • 2-(2'-(2"-methoxy ethoxy)ethoxy)ethanol
    • DB-299325
    • HY-135796
    • CS-0114074
    • NS00009206
    • T0709
    • C70224
    • EN300-108122
    • Q27157604
    • Triethylene glycol monomethyl ether, purum, >=97.0% (GC)

  • Applications

    Triethylene glycol monomethyl ether, CAS 112-35-6, is a high-boiling solvent and formulation aid used widely in coatings, varnishes, and inks; it also serves as a co-solvent and processing solvent in polymer and adhesive formulations; it is employed in cleaning formulations for industrial equipment and electronics; it functions as an intermediate/precursor for the synthesis of other glycol ethers and specialty solvents; and it is used as a solvent for fragrance ingredients in perfumery/fragrance and may be used in agrochemical formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 329.5
    methanol 829.66
    isopropanol 140.91
    water 68.18
    ethyl acetate 68.62
    n-propanol 201.07
    acetone 120.9
    n-butanol 114.85
    acetonitrile 135.23
    DMF 566.29
    toluene 13.36
    isobutanol 94.79
    1,4-dioxane 232.41
    methyl acetate 97.12
    THF 216.6
    2-butanone 65.53
    n-pentanol 53.11
    sec-butanol 98.77
    n-hexane 4.29
    ethylene glycol 386.92
    NMP 421.74
    cyclohexane 24.87
    DMSO 1163.68
    n-butyl acetate 37.18
    n-octanol 23.29
    chloroform 256.98
    n-propyl acetate 38.25
    acetic acid 917.9
    dichloromethane 299.26
    cyclohexanone 141.58
    propylene glycol 246.18
    isopropyl acetate 25.97
    DMAc 328.18
    2-ethoxyethanol 226.51
    isopentanol 50.7
    n-heptane 8.62
    ethyl formate 100.77
    1,2-dichloroethane 165.07
    n-hexanol 42.3
    2-methoxyethanol 508.16
    isobutyl acetate 18.73
    tetrachloromethane 48.41
    n-pentyl acetate 22.15
    transcutol 324.87
    n-heptanol 21.96
    ethylbenzene 7.58
    MIBK 14.82
    2-propoxyethanol 125.49
    tert-butanol 119.63
    MTBE 34.06
    2-butoxyethanol 66.04
    propionic acid 315.38
    o-xylene 16.42
    formic acid 957.75
    diethyl ether 45.11
    m-xylene 10.1
    p-xylene 11.97
    chlorobenzene 36.93
    dimethyl carbonate 36.55
    n-octane 2.89
    formamide 887.73
    cyclopentanone 167.74
    2-pentanone 33.94
    anisole 30.61
    cyclopentyl methyl ether 64.84
    gamma-butyrolactone 268.62
    1-methoxy-2-propanol 198.48
    pyridine 160.02
    3-pentanone 38.4
    furfural 326.58
    n-dodecane 2.53
    diethylene glycol 215.19
    diisopropyl ether 7.71
    tert-amyl alcohol 84.28
    acetylacetone 55.95
    n-hexadecane 2.76
    acetophenone 43.61
    methyl propionate 73.76
    isopentyl acetate 26.47
    trichloroethylene 273.64
    n-nonanol 21.29
    cyclohexanol 128.44
    benzyl alcohol 55.43
    2-ethylhexanol 24.33
    isooctanol 16.88
    dipropyl ether 32.81
    1,2-dichlorobenzene 47.55
    ethyl lactate 55.98
    propylene carbonate 114.13
    n-methylformamide 417.66
    2-pentanol 40.72
    n-pentane 6.73
    1-propoxy-2-propanol 78.54
    1-methoxy-2-propyl acetate 43.81
    2-(2-methoxypropoxy) propanol 76.24
    mesitylene 8.3
    ε-caprolactone 130.7
    p-cymene 11.94
    epichlorohydrin 201.99
    1,1,1-trichloroethane 76.63
    2-aminoethanol 417.55
    morpholine-4-carbaldehyde 363.67
    sulfolane 441.3
    2,2,4-trimethylpentane 3.95
    2-methyltetrahydrofuran 109.86
    n-hexyl acetate 32.22
    isooctane 1.67
    2-(2-butoxyethoxy)ethanol 94.15
    sec-butyl acetate 18.43
    tert-butyl acetate 24.31
    decalin 5.94
    glycerin 444.11
    diglyme 208.21
    acrylic acid 381.87
    isopropyl myristate 13.72
    n-butyric acid 215.51
    acetyl acetate 60.76
    di(2-ethylhexyl) phthalate 24.79
    ethyl propionate 36.27
    nitromethane 692.55
    1,2-diethoxyethane 48.42
    benzonitrile 54.52
    trioctyl phosphate 16.17
    1-bromopropane 51.09
    gamma-valerolactone 264.12
    n-decanol 15.15
    triethyl phosphate 37.59
    4-methyl-2-pentanol 14.64
    propionitrile 86.95
    vinylene carbonate 133.15
    1,1,2-trichlorotrifluoroethane 440.93
    DMS 43.75
    cumene 7.83
    2-octanol 12.22
    2-hexanone 25.27
    octyl acetate 20.18
    limonene 20.32
    1,2-dimethoxyethane 215.23
    ethyl orthosilicate 32.05
    tributyl phosphate 22.49
    diacetone alcohol 52.55
    N,N-dimethylaniline 30.55
    acrylonitrile 153.79
    aniline 70.33
    1,3-propanediol 327.75
    bromobenzene 27.98
    dibromomethane 159.6
    1,1,2,2-tetrachloroethane 245.24
    2-methyl-cyclohexyl acetate 35.32
    tetrabutyl urea 34.48
    diisobutyl methanol 14.51
    2-phenylethanol 37.64
    styrene 11.77
    dioctyl adipate 36.18
    dimethyl sulfate 98.67
    ethyl butyrate 40.31
    methyl lactate 95.42
    butyl lactate 40.04
    diethyl carbonate 36.76
    propanediol butyl ether 77.79
    triethyl orthoformate 41.33
    p-tert-butyltoluene 11.84
    methyl 4-tert-butylbenzoate 49.18
    morpholine 331.43
    tert-butylamine 61.56
    n-dodecanol 12.12
    dimethoxymethane 127.77
    ethylene carbonate 101.13
    cyrene 97.7
    2-ethoxyethyl acetate 38.14
    2-ethylhexyl acetate 21.79
    1,2,4-trichlorobenzene 62.04
    4-methylpyridine 76.19
    dibutyl ether 23.26
    2,6-dimethyl-4-heptanol 14.51
    DEF 111.29
    dimethyl isosorbide 115.09
    tetrachloroethylene 218.41
    eugenol 59.81
    triacetin 66.79
    span 80 74.46
    1,4-butanediol 120.72
    1,1-dichloroethane 82.96
    2-methyl-1-pentanol 30.76
    methyl formate 233.24
    2-methyl-1-butanol 63.86
    n-decane 4.16
    butyronitrile 61.66
    3,7-dimethyl-1-octanol 20.59
    1-chlorooctane 13.24
    1-chlorotetradecane 5.95
    n-nonane 4.0
    undecane 3.1
    tert-butylcyclohexane 3.87
    cyclooctane 6.14
    cyclopentanol 158.23
    tetrahydropyran 136.34
    tert-amyl methyl ether 28.67
    2,5,8-trioxanonane 156.98
    1-hexene 10.9
    2-isopropoxyethanol 87.03
    2,2,2-trifluoroethanol 366.63
    methyl butyrate 56.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction