Triethylene glycol monoethyl ether

Overview IFRA Request a quote

  • Identifiers

    CAS number
    112-50-5

    Molecular formula
    C8H18O4

    SMILES
    CCOCCOCCOCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Alcoholic 47.24%
    Odorless 43.76%
    Ethereal 43.15%
    Solvent 24.16%
    Oily 17.97%
    Fruity 17.21%
    Sweet 17.12%
    Fishy 16.69%
    Fermented 15.77%
    Fresh 15.52%

     

    Flavor
    Sweet 46.42%
    Alcoholic 38.85%
    Musty 34.89%
    Bitter 33.54%
    Vegetable 32.68%
    Odorless 30.05%
    Fruit 27.39%
    Earthy 25.74%
    Fatty 24.88%
    Oily 24.49%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    5.06 (weak acid)

    Molecular weight
    178.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • -1.7 °F (USCG, 1999)
    • -18.7 °C
    • -19 °C

    Boiling point

    • 493 °F at 760 mmHg (USCG, 1999)
    • 256 °C
    • 255 °C

    Flash point

    • 125.45 ˚C est.
    • 275 °F (USCG, 1999)
    • 275 °F (Open cup) /From table/
    • 275 °F (135 °C) (OPEN CUP)
    • 135 °C o.c.

    Solubility expt.

    • Miscible with most organic solvents.
    • In water, miscible
    • Solubility in water: very good

  • Synonyms

    • TRIETHYLENE GLYCOL MONOETHYL ETHER
    • 112-50-5
    • Ethyltriglycol
    • Ethoxytriglycol
    • 2-(2-(2-Ethoxyethoxy)ethoxy)ethanol
    • 2-[2-(2-ethoxyethoxy)ethoxy]ethanol
    • Dowanol TE
    • Ethoxytriethylene glycol
    • Tri(ethylene glycol) monoethyl ether
    • Triglycol monoethyl ether
    • Ethoxy triglycol
    • Ethanol, 2-[2-(2-ethoxyethoxy)ethoxy]-
    • 3,6,9-Trioxaundecan-1-ol
    • Triethylene glycol ethyl ether
    • HSDB 899
    • Ethanol, 2-(2-(2-ethoxyethoxy)ethoxy)-
    • EINECS 203-978-9
    • BRN 1700466
    • DTXSID3024368
    • UNII-4G0E2G9582
    • Ethyltriethylene glycol
    • AI3-14498
    • 3,6,9-Trioxaundecanol
    • 4G0E2G9582
    • DTXCID004368
    • 110925-64-9
    • Triethylene glycol monoethyl ether, tech grade
    • EC 203-978-9
    • 1-Phenyl-1-chloro-2-methylaminopropane hydrochloride, Chloroephedrine HCL
    • TRIETHYLENE GLYCOL MONOETHYL ETHER [HSDB]
    • CAS-112-50-5
    • 2-[2-(2-ethoxyethoxy)ethoxy]ethan-1-ol
    • Triethylene glycol, monoethyl ether
    • PolySolv TE
    • FWN
    • MFCD00020605
    • TEGEE
    • TRIOXIOL
    • 3,6,9Trioxaundecan1ol
    • PEG-4EO
    • SCHEMBL15659
    • CHEMBL1900144
    • Polyethylene glycol-4-ethoxylate
    • 2(2(2Ethoxyethoxy)ethoxy)ethanol
    • Tox21_201320
    • Tox21_300369
    • Ethanol, 2(2(2ethoxyethoxy)ethoxy)
    • AKOS015918286
    • 2-(2-(2-ethoxyethoxy)-ethoxy)-ethanol
    • NCGC00164207-01
    • NCGC00164207-02
    • NCGC00164207-03
    • NCGC00254490-01
    • NCGC00258872-01
    • BS-49431
    • NS00011450
    • D90448
    • EN300-7412246
    • Q2379098
    • Tri(ethylene glycol) monoethyl ether, technical grade
    • TGME /SRP: Also used for triethylene glycol monomethyl ether/

  • Applications

    Triethylene glycol monoethyl ether (CAS 112-50-5) is widely used as a high-boiling solvent and co-solvent in industrial formulations; in coatings, inks and adhesives it helps dissolve resins, pigments and additives. It also serves as a processing aid and plasticizer in polymer formulations, improving viscosity control and film formation. In cleaning and degreasing applications, it provides effective solvency for oils, waxes and residues. It is often used as an intermediate in the synthesis of other glycol ethers and related solvents. In electronics-related formulations and specialty cleaners, it can function as a solvent or co-solvent for cleaning, etching and surface treatment processes. In cosmetics and personal care, it may be used as a solvent for fragrance oils and other ingredients, depending on formulation requirements and regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 226.56
    methanol 505.89
    isopropanol 114.7
    water 17.83
    ethyl acetate 83.65
    n-propanol 150.58
    acetone 121.83
    n-butanol 101.71
    acetonitrile 144.13
    DMF 353.17
    toluene 28.17
    isobutanol 81.85
    1,4-dioxane 266.26
    methyl acetate 102.06
    THF 258.32
    2-butanone 74.73
    n-pentanol 62.59
    sec-butanol 91.09
    n-hexane 11.59
    ethylene glycol 171.39
    NMP 317.59
    cyclohexane 53.26
    DMSO 851.66
    n-butyl acetate 54.04
    n-octanol 28.38
    chloroform 356.61
    n-propyl acetate 55.37
    acetic acid 538.92
    dichloromethane 398.18
    cyclohexanone 164.4
    propylene glycol 119.79
    isopropyl acetate 36.7
    DMAc 275.53
    2-ethoxyethanol 196.43
    isopentanol 55.68
    n-heptane 16.27
    ethyl formate 94.35
    1,2-dichloroethane 226.38
    n-hexanol 49.72
    2-methoxyethanol 341.33
    isobutyl acetate 28.75
    tetrachloromethane 69.53
    n-pentyl acetate 32.17
    transcutol 337.43
    n-heptanol 24.64
    ethylbenzene 16.19
    MIBK 23.05
    2-propoxyethanol 126.08
    tert-butanol 111.42
    MTBE 50.13
    2-butoxyethanol 64.89
    propionic acid 216.83
    o-xylene 29.18
    formic acid 415.47
    diethyl ether 76.55
    m-xylene 19.22
    p-xylene 25.25
    chlorobenzene 59.36
    dimethyl carbonate 33.28
    n-octane 5.48
    formamide 413.67
    cyclopentanone 174.25
    2-pentanone 44.76
    anisole 46.34
    cyclopentyl methyl ether 93.35
    gamma-butyrolactone 252.87
    1-methoxy-2-propanol 153.67
    pyridine 197.98
    3-pentanone 49.64
    furfural 297.08
    n-dodecane 4.2
    diethylene glycol 173.78
    diisopropyl ether 14.3
    tert-amyl alcohol 83.22
    acetylacetone 67.17
    n-hexadecane 4.68
    acetophenone 58.79
    methyl propionate 73.38
    isopentyl acetate 40.37
    trichloroethylene 337.8
    n-nonanol 27.08
    cyclohexanol 127.57
    benzyl alcohol 64.22
    2-ethylhexanol 32.99
    isooctanol 19.59
    dipropyl ether 52.35
    1,2-dichlorobenzene 68.75
    ethyl lactate 54.63
    propylene carbonate 112.54
    n-methylformamide 229.57
    2-pentanol 43.98
    n-pentane 14.44
    1-propoxy-2-propanol 80.87
    1-methoxy-2-propyl acetate 53.85
    2-(2-methoxypropoxy) propanol 82.37
    mesitylene 14.99
    ε-caprolactone 144.57
    p-cymene 19.15
    epichlorohydrin 223.84
    1,1,1-trichloroethane 123.26
    2-aminoethanol 212.8
    morpholine-4-carbaldehyde 302.79
    sulfolane 371.9
    2,2,4-trimethylpentane 7.19
    2-methyltetrahydrofuran 145.15
    n-hexyl acetate 44.65
    isooctane 3.17
    2-(2-butoxyethoxy)ethanol 99.2
    sec-butyl acetate 29.96
    tert-butyl acetate 36.84
    decalin 12.17
    glycerin 217.4
    diglyme 219.29
    acrylic acid 232.93
    isopropyl myristate 20.88
    n-butyric acid 174.25
    acetyl acetate 76.45
    di(2-ethylhexyl) phthalate 29.75
    ethyl propionate 50.25
    nitromethane 455.94
    1,2-diethoxyethane 79.22
    benzonitrile 71.6
    trioctyl phosphate 19.53
    1-bromopropane 94.87
    gamma-valerolactone 252.68
    n-decanol 19.46
    triethyl phosphate 50.64
    4-methyl-2-pentanol 19.29
    propionitrile 100.77
    vinylene carbonate 126.39
    1,1,2-trichlorotrifluoroethane 356.16
    DMS 53.98
    cumene 14.77
    2-octanol 15.39
    2-hexanone 41.7
    octyl acetate 27.55
    limonene 31.16
    1,2-dimethoxyethane 242.99
    ethyl orthosilicate 45.84
    tributyl phosphate 28.94
    diacetone alcohol 55.43
    N,N-dimethylaniline 43.08
    acrylonitrile 144.8
    aniline 80.22
    1,3-propanediol 193.51
    bromobenzene 53.8
    dibromomethane 239.04
    1,1,2,2-tetrachloroethane 310.54
    2-methyl-cyclohexyl acetate 49.45
    tetrabutyl urea 42.06
    diisobutyl methanol 20.13
    2-phenylethanol 45.86
    styrene 24.49
    dioctyl adipate 48.85
    dimethyl sulfate 85.52
    ethyl butyrate 56.94
    methyl lactate 72.24
    butyl lactate 43.5
    diethyl carbonate 50.03
    propanediol butyl ether 67.82
    triethyl orthoformate 57.83
    p-tert-butyltoluene 18.56
    methyl 4-tert-butylbenzoate 54.07
    morpholine 322.46
    tert-butylamine 67.62
    n-dodecanol 15.62
    dimethoxymethane 118.81
    ethylene carbonate 106.29
    cyrene 95.77
    2-ethoxyethyl acetate 50.69
    2-ethylhexyl acetate 34.04
    1,2,4-trichlorobenzene 85.6
    4-methylpyridine 103.4
    dibutyl ether 41.18
    2,6-dimethyl-4-heptanol 20.13
    DEF 115.67
    dimethyl isosorbide 130.73
    tetrachloroethylene 256.93
    eugenol 63.48
    triacetin 80.82
    span 80 77.48
    1,4-butanediol 84.28
    1,1-dichloroethane 131.33
    2-methyl-1-pentanol 41.1
    methyl formate 141.02
    2-methyl-1-butanol 62.91
    n-decane 7.44
    butyronitrile 79.95
    3,7-dimethyl-1-octanol 26.96
    1-chlorooctane 21.42
    1-chlorotetradecane 9.51
    n-nonane 7.45
    undecane 5.26
    tert-butylcyclohexane 8.12
    cyclooctane 13.09
    cyclopentanol 148.83
    tetrahydropyran 190.67
    tert-amyl methyl ether 43.45
    2,5,8-trioxanonane 168.38
    1-hexene 25.55
    2-isopropoxyethanol 90.2
    2,2,2-trifluoroethanol 215.88
    methyl butyrate 71.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction