Triclosan

Overview IFRA Request a quote

  • Identifiers

    CAS number
    3380-34-5

    Molecular formula
    C12H7Cl3O2

    SMILES
    C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 56.83%
    Burnt 36.51%
    Spicy 35.16%
    Smoky 34.47%
    Odorless 32.31%
    Medicinal 25.18%
    Vanilla 24.34%
    Woody 23.88%
    Animal 22.95%
    Fruity 22.42%

     

    Flavor
    Bitter 74.41%
    Mild 27.84%
    Odorless 27.38%
    Sweet-like 20.91%
    Very strong 20.8%
    Phenolic 20.49%
    Indole 20.13%
    Flat 19.95%
    Nitrile 19.91%
    Orange flower 19.72%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    9.58 (weak base)

    Molecular weight
    289.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 55-57 °C
    • 54-57.3 °C

    Boiling point

    • 120 °C
    • 280 to 290 °C (decomposes)

    Flash point

    • 155.47 ˚C est.

    Solubility expt.

    • In water, 10 mg/L at 20 °C
    • Slightly soluble in water
    • Readily soluble in alkaline solutions and many organic solvents; soluble in methanol, alcohol, acetone
    • Readily soluble in organic solvents

  • Synonyms

    • triclosan
    • 3380-34-5
    • 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL
    • Cloxifenolum
    • Irgasan
    • 2,4,4'-Trichloro-2'-hydroxydiphenyl ether
    • Triclosanum
    • Irgasan DP300
    • Stri-Dex Cleansing Bar
    • CH 3565
    • Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
    • Lexol 300
    • 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol
    • Caswell No. 186A
    • DP-300
    • Triclosanum [INN-Latin]
    • Trichlorosan
    • 2,4,4'-Trichloro-2'-hydroxy diphenyl ether
    • HSDB 7194
    • CHEBI:164200
    • EINECS 222-182-2
    • Ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl
    • Phenyl ether, 2'-hydroxy-2,4,4'-trichloro-
    • EPA Pesticide Chemical Code 054901
    • NSC-759151
    • UNII-4NM5039Y5X
    • CH-3565
    • BRN 2057142
    • CCRIS 9253
    • DTXSID5032498
    • 4NM5039Y5X
    • DNDI1246774
    • MFCD00800992
    • CHEMBL849
    • Neostrata Antibacterial Facial Cleanser
    • DTXCID3012498
    • Triclosan [USAN:USP:INN:BAN]
    • NSC 759151
    • Triclosan 10 microg/mL in Cyclohexane
    • TCL
    • TCS
    • COLGATE TOTAL COMPONENT TRICLOSAN
    • NCGC00159417-02
    • NCGC00159417-05
    • NCGC00159417-06
    • Stri-Dex Face Wash
    • Aquasept
    • Sapoderm
    • Triclosanum (INN-Latin)
    • C12H7Cl3O2
    • TRICLOSAN (MART.)
    • TRICLOSAN [MART.]
    • TRICLOSAN (USP-RS)
    • TRICLOSAN [USP-RS]
    • TRICLOSAN (USP MONOGRAPH)
    • TRICLOSAN [USP MONOGRAPH]
    • Cloxifenol
    • Triclosan (USAN:USP:INN:BAN)
    • 2-Hydroxy-2',4,4'-trichlorodiphenyl Ether
    • SMR000471847
    • CAS-3380-34-5
    • Triclosan (USP/INN)
    • SR-01000762974
    • 88032-08-0
    • triclosano
    • Germasidol
    • Therazcream
    • Dermacare
    • EcolabDigiclean
    • EqualineLiquid
    • Freshands
    • Pacific
    • Prevens
    • Quiksan
    • Tricolsan
    • Wegmans
    • Orchid
    • Stri-Dex cleansing bar (TN)
    • Jabonito Fresh
    • Sbs Ultragreen
    • Cv Medicated
    • Forest Fresh
    • Fresh Citrus
    • Hand Cleanse
    • Sbs Ultrapink
    • Stoko Refresh
    • Tc Spraysoap
    • Tork Premium
    • Vanilla Cream
    • Rite AidLiquid
    • Foamy Mango
    • Health Stat
    • Holiday Elegance
    • Lynx medi foam
    • Purgo Ultra
    • Satin Pink
    • Antibacterial Bar
    • Deb Gold
    • Servo-stat Te
    • Thera Rx
    • Health-stat Foam
    • Servo-stat T
    • 1nhg
    • Purgo Satin Foam
    • Purgo Ultra Foam
    • Hand CleanseRefill
    • Antibac Foam Wash
    • Deluxe All-purpose
    • Scott Antibacterial
    • Triclosan; Irgasan
    • Servo-stat T Foam
    • Harris TeeterFoaming
    • Liquid Hand Cleanse
    • Market Basket Ultra
    • Antibacterial Foaming
    • Astound Antibacterial
    • Foaming Antibacterial
    • Foaming Antimicrobial
    • Irgaguard B1000
    • Triclosanum (Latin)
    • Anchor Foaming Mango
    • Ecocare 250
    • Fu ER Jie
    • GermicidaAntimicrobial
    • Irgasan DP 30
    • Rite AidAntibacterial
    • Wegmans Orange Scent
    • Rite AidFoaming Hand

  • Applications

    Triclosan, CAS 3380-34-5, is primarily used as an antimicrobial agent and preservative across several sectors: cosmetics/personal care (soap, cleansers, and historically in some toothpaste products) and household cleaning products; as an antimicrobial additive for plastics and polymer systems, as well as in coatings and inks to suppress microbial growth on surfaces; antimicrobial finishes for textiles and fabrics; and in dental products such as toothpaste and mouth rinses where allowed by regulation. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1180.66
    methanol 390.6
    isopropanol 259.13
    water 0.09
    ethyl acetate 756.04
    n-propanol 500.63
    acetone 499.66
    n-butanol 340.85
    acetonitrile 311.21
    DMF 152.73
    toluene 132.79
    isobutanol 161.93
    1,4-dioxane 756.77
    methyl acetate 525.83
    THF 1892.07
    2-butanone 610.08
    n-pentanol 300.47
    sec-butanol 341.11
    n-hexane 10.58
    ethylene glycol 34.23
    NMP 91.0
    cyclohexane 18.11
    DMSO 168.33
    n-butyl acetate 427.66
    n-octanol 101.17
    chloroform 958.6
    n-propyl acetate 428.8
    acetic acid 200.19
    dichloromethane 835.82
    cyclohexanone 334.31
    propylene glycol 55.19
    isopropyl acetate 319.85
    DMAc 308.51
    2-ethoxyethanol 656.1
    isopentanol 183.15
    n-heptane 44.48
    ethyl formate 303.67
    1,2-dichloroethane 275.72
    n-hexanol 191.53
    2-methoxyethanol 770.88
    isobutyl acetate 182.9
    tetrachloromethane 27.16
    n-pentyl acetate 232.51
    transcutol 1203.85
    n-heptanol 94.29
    ethylbenzene 117.56
    MIBK 206.48
    2-propoxyethanol 440.69
    tert-butanol 165.03
    MTBE 335.63
    2-butoxyethanol 225.0
    propionic acid 126.88
    o-xylene 72.22
    formic acid 70.94
    diethyl ether 581.36
    m-xylene 69.55
    p-xylene 111.17
    chlorobenzene 98.55
    dimethyl carbonate 126.51
    n-octane 19.21
    formamide 275.06
    cyclopentanone 373.94
    2-pentanone 530.15
    anisole 364.9
    cyclopentyl methyl ether 384.76
    gamma-butyrolactone 358.66
    1-methoxy-2-propanol 384.2
    pyridine 543.15
    3-pentanone 292.34
    furfural 335.95
    n-dodecane 16.35
    diethylene glycol 231.18
    diisopropyl ether 96.91
    tert-amyl alcohol 250.2
    acetylacetone 438.98
    n-hexadecane 18.66
    acetophenone 250.74
    methyl propionate 385.89
    isopentyl acetate 305.8
    trichloroethylene 747.13
    n-nonanol 97.66
    cyclohexanol 194.38
    benzyl alcohol 215.84
    2-ethylhexanol 148.6
    isooctanol 77.58
    dipropyl ether 328.86
    1,2-dichlorobenzene 83.74
    ethyl lactate 122.9
    propylene carbonate 187.34
    n-methylformamide 184.89
    2-pentanol 222.73
    n-pentane 12.31
    1-propoxy-2-propanol 301.88
    1-methoxy-2-propyl acetate 372.32
    2-(2-methoxypropoxy) propanol 243.84
    mesitylene 39.72
    ε-caprolactone 386.06
    p-cymene 91.58
    epichlorohydrin 750.41
    1,1,1-trichloroethane 227.7
    2-aminoethanol 119.6
    morpholine-4-carbaldehyde 309.62
    sulfolane 141.2
    2,2,4-trimethylpentane 11.8
    2-methyltetrahydrofuran 800.19
    n-hexyl acetate 237.95
    isooctane 8.15
    2-(2-butoxyethoxy)ethanol 358.11
    sec-butyl acetate 279.44
    tert-butyl acetate 282.41
    decalin 16.23
    glycerin 60.89
    diglyme 703.73
    acrylic acid 88.63
    isopropyl myristate 121.54
    n-butyric acid 238.18
    acetyl acetate 275.77
    di(2-ethylhexyl) phthalate 76.28
    ethyl propionate 334.8
    nitromethane 394.73
    1,2-diethoxyethane 736.6
    benzonitrile 177.67
    trioctyl phosphate 58.98
    1-bromopropane 258.92
    gamma-valerolactone 526.9
    n-decanol 77.05
    triethyl phosphate 118.94
    4-methyl-2-pentanol 89.79
    propionitrile 235.08
    vinylene carbonate 201.25
    1,1,2-trichlorotrifluoroethane 274.28
    DMS 199.45
    cumene 68.0
    2-octanol 85.71
    2-hexanone 372.2
    octyl acetate 138.03
    limonene 117.55
    1,2-dimethoxyethane 958.55
    ethyl orthosilicate 122.4
    tributyl phosphate 83.55
    diacetone alcohol 238.11
    N,N-dimethylaniline 157.58
    acrylonitrile 257.64
    aniline 135.69
    1,3-propanediol 268.89
    bromobenzene 108.93
    dibromomethane 451.41
    1,1,2,2-tetrachloroethane 384.26
    2-methyl-cyclohexyl acetate 203.35
    tetrabutyl urea 116.15
    diisobutyl methanol 89.62
    2-phenylethanol 210.52
    styrene 138.89
    dioctyl adipate 165.29
    dimethyl sulfate 82.7
    ethyl butyrate 379.43
    methyl lactate 90.68
    butyl lactate 141.97
    diethyl carbonate 224.58
    propanediol butyl ether 167.7
    triethyl orthoformate 237.91
    p-tert-butyltoluene 83.21
    methyl 4-tert-butylbenzoate 154.26
    morpholine 955.46
    tert-butylamine 83.69
    n-dodecanol 64.38
    dimethoxymethane 490.1
    ethylene carbonate 160.01
    cyrene 181.8
    2-ethoxyethyl acetate 380.89
    2-ethylhexyl acetate 246.75
    1,2,4-trichlorobenzene 110.76
    4-methylpyridine 331.47
    dibutyl ether 278.64
    2,6-dimethyl-4-heptanol 89.62
    DEF 351.4
    dimethyl isosorbide 410.34
    tetrachloroethylene 231.83
    eugenol 173.48
    triacetin 236.79
    span 80 162.68
    1,4-butanediol 102.31
    1,1-dichloroethane 303.09
    2-methyl-1-pentanol 221.08
    methyl formate 155.54
    2-methyl-1-butanol 207.9
    n-decane 27.12
    butyronitrile 285.4
    3,7-dimethyl-1-octanol 109.44
    1-chlorooctane 80.24
    1-chlorotetradecane 37.6
    n-nonane 25.39
    undecane 20.16
    tert-butylcyclohexane 16.12
    cyclooctane 9.32
    cyclopentanol 179.61
    tetrahydropyran 846.13
    tert-amyl methyl ether 324.2
    2,5,8-trioxanonane 466.49
    1-hexene 94.46
    2-isopropoxyethanol 343.16
    2,2,2-trifluoroethanol 55.54
    methyl butyrate 385.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction