Tricaprylin

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  • Identifiers

    CAS number
    538-23-8

    Molecular formula
    C27H50O6

    SMILES
    CCCCCCCC(=O)OCC(COC(=O)CCCCCCC)OC(=O)CCCCCCC

  • Odor profile

    Fragrance
    Fatty 60.96%
    Oily 58.02%
    Fruity 51.77%
    Winey 46.03%
    Waxy 40.13%
    Buttery 35.21%
    Peach 34.74%
    Lactonic 30.44%
    Creamy 30.36%
    Odorless 28.92%

     

    Flavor
    Waxy 59.13%
    Fruity 52.46%
    Oily 47.11%
    Fatty 41.64%
    Creamy 34.92%
    Mild 34.05%
    Soapy 33.66%
    Green 32.51%
    Sweet 32.17%
    Wine 31.15%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.9

    pKa est.
    6.84 (neutral)

    Molecular weight
    470.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 50 °F (NTP, 1992)
    • 10 °C
    • 9.00 to 11.00 °C. @ 760.00 mm Hg

    Boiling point

    • 451.6 °F at 760 mmHg (NTP, 1992)
    • 233 °C
    • 232.00 to 234.00 °C. @ 760.00 mm Hg

    Flash point

    • 210.04 ˚C est.
    • 351 °F (NTP, 1992)

    Solubility expt.

    • less than 1 mg/mL at 72 °F (NTP, 1992)
    • Miscible in ethanol; very soluble in ether, benzene, chloroform, ligroin
    • Very soluble in petroleum ether
    • In water, 8.5X10-7 mol/L (0.40 mg/L) at 37 °C
    • 0.4 mg/L @ 37 °C (exp)

  • Synonyms

    • Tricaprylin
    • Trioctanoin
    • 538-23-8
    • Tricaprilin
    • Glycerol tricaprylate
    • Glycerol trioctanoate
    • Caprylin
    • Trioctanoylglycerol
    • Rato
    • Maceight
    • Caprylic triglyceride
    • Glyceryl tricaprylate
    • Glyceryl trioctanoate
    • Tricaprylic glyceride
    • Caprylic acid triglyceride
    • Octanoin, tri-
    • Propane-1,2,3-triyl trioctanoate
    • Axona
    • 1,2,3-Tri-n-octanoylglycerol
    • Octanoic acid triglyceride
    • Tricaprylyl glycerin
    • Panacete 800
    • Octanoic acid, 1,2,3-propanetriyl ester
    • 2,3-di(octanoyloxy)propyl octanoate
    • Tricaprilin [JAN]
    • Miglyol 808
    • Sefsol 800
    • trioctanoylglyceride
    • Tricapryloylglycerol
    • Tricaprylyl glycerol
    • Glycerin tricaprylate
    • NSC 4059
    • Tricaprilina
    • Tricapriline
    • Glycerol Tri-n-octanoate
    • 1,2,3-Propanetriol trioctanoate
    • CER-0001
    • NSC-4059
    • EINECS 208-686-5
    • MFCD00036236
    • Glycerol trioctanoin
    • AC-1202
    • BRN 1717202
    • Caprylic acid, 1,2,3-propanetriyl ester
    • DTXSID6021375
    • Sefsol 810
    • CHEBI:76978
    • HSDB 7829
    • Captex 8000
    • Octanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester
    • TRICAPRYLIN [II]
    • TRICAPRILIN [INN]
    • Tricaprilin [USAN:JAN]
    • TRICAPRILIN [HSDB]
    • TRICAPRILIN [USAN]
    • TRICAPRYLIN [MART.]
    • TRICAPRILIN [WHO-DD]
    • DTXCID801375
    • Trioctanoin;Glyceryl trioctanoate
    • NSC4059
    • GLYCERYL TRICAPRYLATE [NF]
    • 4-02-00-00991 (Beilstein Handbook Reference)
    • CAPRYLIC TRIGLYCERIDE [VANDF]
    • 6P92858988
    • GLYCERYL TRICAPRYLATE [USP-RS]
    • AC-1204
    • NCGC00091285-01
    • TRICAPRYLIN (II)
    • TRICAPRYLIN (MART.)
    • TG(8:0/8:0/8:0)
    • caprylidene
    • Tri-n-octanoin
    • GLYCERYL TRICAPRYLATE (USP-RS)
    • CAS-538-23-8
    • glycerin trioctanoate
    • 352431-24-4
    • 1,2,3-Tricapryloylglycerol
    • tricaprilinum
    • tricaprylm
    • Tri-octanoin
    • Tri-n-caprylin
    • Octanoin, tri
    • Emalex KTG
    • UNII-6P92858988
    • Tricaprilin (Standard)
    • Octanoin, tri-(8CI)
    • AXONA [VANDF]
    • Glycerol trioctanoic acid
    • TRICAPRYL GLYCERIDE
    • Tricaprilin (JAN/USAN)
    • TRICAPRYLIN [INCI]
    • 1,2,3-Trioctanoylglycerol
    • PANACET 800
    • 1,2,3-trioctanoyl glycerol
    • SCHEMBL61958
    • MLS002454452
    • Glyceryl trioctanoate, >=99%
    • 1,2,3Propanetriol trioctanoate
    • Propane1,2,3triyl trioctanoate
    • CHEMBL1406148
    • HY-B1804R
    • Propane-1,2,3-triyltrioctanoate
    • Trioctanoin; Glyceryl trioctanoate
    • HMS3039H17
    • NI 01
    • HY-B1804
    • Tox21_111110
    • Tox21_201480
    • Tox21_302762
    • s6342
    • WHO 10584
    • Octanoic acid,2,3-propanetriyl ester
    • AKOS015899778
    • Tox21_111110_1
    • CCG-214786
    • DB12176
    • 2,3-Bis(octanoyloxy)propyl octanoate #
    • Caprylic acid, 1,2,3propanetriyl ester
    • Octanoic acid, 1,2,3propanetriyl ester
    • NCGC00091285-02
    • NCGC00091285-03
    • NCGC00256431-01
    • NCGC00259031-01
    • AS-75522
    • BP-29597
    • Caprylic acid, 1,2,3-propanetinyl ester
    • FT166788
    • Octanoic Acid, 1,2,3-propanetinyl ester

  • Applications

    Tricaprylin (glyceryl tri-octanoate; CAS 538-23-8) is a neutral, non-polar triglyceride widely employed as an emollient and solvent in cosmetics and personal care. It also serves as a vehicle for lipophilic actives in topical pharmaceutical formulations. In the food and nutraceutical sectors, it may be used as a component of medium-chain triglyceride (MCT) oils where permitted by regulations. In industrial contexts, it functions as a processing aid and carrier in coatings, inks, and plastics formulations, and can act as a lubricant or processing fluid in certain manufacturing applications. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 31.57
    methanol 42.36
    isopropanol 30.74
    water 1.12
    ethyl acetate 309.11
    n-propanol 43.88
    acetone 269.2
    n-butanol 39.57
    acetonitrile 130.52
    DMF 531.6
    toluene 129.37
    isobutanol 40.64
    1,4-dioxane 206.08
    methyl acetate 309.05
    THF 486.77
    2-butanone 293.73
    n-pentanol 41.99
    sec-butanol 52.66
    n-hexane 13.56
    ethylene glycol 8.81
    NMP 1497.42
    cyclohexane 36.03
    DMSO 649.56
    n-butyl acetate 182.35
    n-octanol 42.74
    chloroform 840.32
    n-propyl acetate 250.17
    acetic acid 289.36
    dichloromethane 1037.46
    cyclohexanone 647.3
    propylene glycol 17.73
    isopropyl acetate 230.56
    DMAc 1330.46
    2-ethoxyethanol 134.18
    isopentanol 44.45
    n-heptane 8.27
    ethyl formate 158.42
    1,2-dichloroethane 610.1
    n-hexanol 29.18
    2-methoxyethanol 137.4
    isobutyl acetate 130.63
    tetrachloromethane 182.5
    n-pentyl acetate 274.86
    transcutol 579.97
    n-heptanol 35.78
    ethylbenzene 75.35
    MIBK 154.63
    2-propoxyethanol 107.71
    tert-butanol 55.51
    MTBE 123.09
    2-butoxyethanol 135.48
    propionic acid 182.66
    o-xylene 127.81
    formic acid 87.55
    diethyl ether 93.62
    m-xylene 86.05
    p-xylene 114.94
    chlorobenzene 263.98
    dimethyl carbonate 196.99
    n-octane 5.73
    formamide 168.52
    cyclopentanone 740.37
    2-pentanone 236.45
    anisole 156.43
    cyclopentyl methyl ether 264.16
    gamma-butyrolactone 915.72
    1-methoxy-2-propanol 126.07
    pyridine 345.56
    3-pentanone 296.37
    furfural 699.96
    n-dodecane 3.91
    diethylene glycol 58.38
    diisopropyl ether 42.5
    tert-amyl alcohol 93.53
    acetylacetone 476.48
    n-hexadecane 4.7
    acetophenone 293.93
    methyl propionate 302.58
    isopentyl acetate 179.24
    trichloroethylene 1253.85
    n-nonanol 44.36
    cyclohexanol 104.44
    benzyl alcohol 104.23
    2-ethylhexanol 34.41
    isooctanol 37.83
    dipropyl ether 70.64
    1,2-dichlorobenzene 350.83
    ethyl lactate 120.67
    propylene carbonate 538.76
    n-methylformamide 213.61
    2-pentanol 38.06
    n-pentane 8.66
    1-propoxy-2-propanol 105.25
    1-methoxy-2-propyl acetate 239.46
    2-(2-methoxypropoxy) propanol 168.48
    mesitylene 56.24
    ε-caprolactone 669.89
    p-cymene 46.46
    epichlorohydrin 737.02
    1,1,1-trichloroethane 677.68
    2-aminoethanol 25.03
    morpholine-4-carbaldehyde 670.89
    sulfolane 1593.35
    2,2,4-trimethylpentane 13.41
    2-methyltetrahydrofuran 377.34
    n-hexyl acetate 262.27
    isooctane 4.7
    2-(2-butoxyethoxy)ethanol 183.0
    sec-butyl acetate 184.57
    tert-butyl acetate 276.05
    decalin 24.03
    glycerin 40.89
    diglyme 498.68
    acrylic acid 182.46
    isopropyl myristate 74.52
    n-butyric acid 247.85
    acetyl acetate 332.0
    di(2-ethylhexyl) phthalate 89.58
    ethyl propionate 259.93
    nitromethane 744.3
    1,2-diethoxyethane 207.01
    benzonitrile 156.92
    trioctyl phosphate 55.55
    1-bromopropane 209.42
    gamma-valerolactone 870.58
    n-decanol 27.59
    triethyl phosphate 150.86
    4-methyl-2-pentanol 27.82
    propionitrile 100.07
    vinylene carbonate 464.23
    1,1,2-trichlorotrifluoroethane 659.51
    DMS 289.87
    cumene 51.53
    2-octanol 34.84
    2-hexanone 196.27
    octyl acetate 107.74
    limonene 78.82
    1,2-dimethoxyethane 286.15
    ethyl orthosilicate 126.57
    tributyl phosphate 85.75
    diacetone alcohol 224.94
    N,N-dimethylaniline 133.15
    acrylonitrile 152.9
    aniline 123.9
    1,3-propanediol 38.72
    bromobenzene 318.95
    dibromomethane 536.12
    1,1,2,2-tetrachloroethane 1064.46
    2-methyl-cyclohexyl acetate 162.73
    tetrabutyl urea 133.16
    diisobutyl methanol 25.65
    2-phenylethanol 72.68
    styrene 98.15
    dioctyl adipate 160.41
    dimethyl sulfate 599.8
    ethyl butyrate 196.46
    methyl lactate 151.57
    butyl lactate 178.72
    diethyl carbonate 142.51
    propanediol butyl ether 107.25
    triethyl orthoformate 158.81
    p-tert-butyltoluene 42.8
    methyl 4-tert-butylbenzoate 283.75
    morpholine 279.46
    tert-butylamine 34.41
    n-dodecanol 18.93
    dimethoxymethane 237.04
    ethylene carbonate 374.23
    cyrene 225.42
    2-ethoxyethyl acetate 381.79
    2-ethylhexyl acetate 158.28
    1,2,4-trichlorobenzene 489.85
    4-methylpyridine 360.96
    dibutyl ether 90.3
    2,6-dimethyl-4-heptanol 25.65
    DEF 452.03
    dimethyl isosorbide 378.78
    tetrachloroethylene 690.58
    eugenol 187.04
    triacetin 434.37
    span 80 131.65
    1,4-butanediol 24.16
    1,1-dichloroethane 464.03
    2-methyl-1-pentanol 54.85
    methyl formate 177.81
    2-methyl-1-butanol 55.13
    n-decane 8.37
    butyronitrile 86.1
    3,7-dimethyl-1-octanol 46.39
    1-chlorooctane 53.68
    1-chlorotetradecane 16.98
    n-nonane 7.68
    undecane 5.34
    tert-butylcyclohexane 15.73
    cyclooctane 11.83
    cyclopentanol 123.15
    tetrahydropyran 228.79
    tert-amyl methyl ether 156.58
    2,5,8-trioxanonane 291.78
    1-hexene 39.86
    2-isopropoxyethanol 108.23
    2,2,2-trifluoroethanol 217.46
    methyl butyrate 336.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction