Trehalulose

Overview IFRA Request a quote

  • Identifiers

    CAS number
    51411-23-5

    Molecular formula
    C12H22O11

    SMILES
    C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)OCC(=O)[C@H]([C@@H]([C@@H](CO)O)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 65.37%
    Sweet 58.76%
    Caramellic 26.24%
    Buttery 20.77%
    Alcoholic 20.73%
    Milky 18.8%
    Bitter 17.96%
    Savory 17.92%
    Cooling 17.47%
    Clean 15.72%

     

    Flavor
    Odorless 63.49%
    Sweet 55.65%
    Bitter 36.9%
    Sweet-like 34.46%
    Very mild 28.21%
    Bland 25.21%
    Very slight 21.75%
    Cauliflower 20.28%
    Soup 19.34%
    Fenugreek 19.2%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.8

    pKa est.
    3.9 (weak acid)

    Molecular weight
    342.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2898°C

    Flash point

    • 291.3 ˚C est.

  • Synonyms

    • Trehalulose
    • 51411-23-5
    • 1-O-alpha-D-Glucopyranosyl-D-fructose
    • H39U51DD7Q
    • DTXSID60965727
    • RefChem:190722
    • GlyTouCan:G87479YI
    • DTXCID201393389
    • G87479YI
    • 257-183-7
    • CHEBI:79284
    • (3S,4R,5R)-3,4,5,6-tetrahydroxy-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexan-2-one
    • UNII-H39U51DD7Q
    • 1-O-alpha-D-Glucopyranosyl-D-fructose; 1-O-alpha-D-Glucosylfructose; Mildear;Mildear 75; Trehalulose; Vitalose
    • TEU
    • EINECS 257-183-7
    • MILDEAR
    • ISOMALT IMPURITY D
    • MILDEAR 75
    • SCHEMBL165502
    • 1-O-?-D-Glucopyranosyl-D-fructose
    • MSK160845
    • OT09774
    • 1-O-.ALPHA.-D-GLUCOSYLFRUCTOSE
    • ISOMALT IMPURITY D [EP IMPURITY]
    • DB-250461
    • NS00056094
    • 1-O-.ALPHA.-D-GLUCOPYRANOSYL-D-FRUCTOSE
    • D-FRUCTOSE, 1-O-.ALPHA.-D-GLUCOPYRANOSYL-
    • Q3541289
    • 1-O-alpha-D-glucosyl-D-fructose; 1-O-D-glucosyl-D-fructose; 1-O-glucosyl-D-fructose
    • (3S,4R,5R)-3,4,5,6-Tetrahydroxy-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexan-2-one
    • (3S,4R,5R)-3,4,5,6-tetrahydroxy-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-hexan-2-one
    • 51411-23-5

  • Applications

    Trehalulose (CAS 51411-23-5) is a rare disaccharide that is an isomer of sucrose and is studied primarily as a low-glycemic sweetener. In food processing, it may be used as a sugar substitute in formulations to reduce GI, particularly in beverages, confectionery, and bakery products. Trehalulose is also evaluated for nutraceutical and functional-food applications where its sweet profile can support products aimed at glycemic management. Additionally, it can serve as a substrate or intermediate for enzymatic synthesis of rare sugars in industrial biocatalysis and research. In cosmetics and personal care, trehalulose may be explored as a humectant or stabilizing component, depending on formulation and mixing limits, with use subject to local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.17
    methanol 6.13
    isopropanol 0.51
    water 567.02
    ethyl acetate 0.27
    n-propanol 0.71
    acetone 0.59
    n-butanol 0.71
    acetonitrile 0.35
    DMF 59.96
    toluene 0.16
    isobutanol 0.31
    1,4-dioxane 1.67
    methyl acetate 0.24
    THF 1.11
    2-butanone 0.37
    n-pentanol 0.25
    sec-butanol 0.5
    n-hexane 0.04
    ethylene glycol 51.6
    NMP 46.27
    cyclohexane 0.3
    DMSO 306.28
    n-butyl acetate 0.12
    n-octanol 0.35
    chloroform 0.05
    n-propyl acetate 0.09
    acetic acid 7.88
    dichloromethane 0.07
    cyclohexanone 1.11
    propylene glycol 16.73
    isopropyl acetate 0.19
    DMAc 33.28
    2-ethoxyethanol 5.79
    isopentanol 0.4
    n-heptane 0.19
    ethyl formate 0.29
    1,2-dichloroethane 0.15
    n-hexanol 0.38
    2-methoxyethanol 24.29
    isobutyl acetate 0.04
    tetrachloromethane 0.05
    n-pentyl acetate 0.16
    transcutol 8.07
    n-heptanol 0.5
    ethylbenzene 0.07
    MIBK 0.27
    2-propoxyethanol 3.43
    tert-butanol 0.61
    MTBE 0.15
    2-butoxyethanol 2.13
    propionic acid 1.46
    o-xylene 0.28
    formic acid 157.65
    diethyl ether 0.28
    m-xylene 0.19
    p-xylene 0.06
    chlorobenzene 0.03
    dimethyl carbonate 1.57
    n-octane 0.1
    formamide 100.83
    cyclopentanone 1.45
    2-pentanone 0.48
    anisole 0.15
    cyclopentyl methyl ether 1.02
    gamma-butyrolactone 1.91
    1-methoxy-2-propanol 12.14
    pyridine 0.69
    3-pentanone 0.53
    furfural 2.88
    n-dodecane 0.04
    diethylene glycol 16.57
    diisopropyl ether 0.12
    tert-amyl alcohol 0.58
    acetylacetone 1.17
    n-hexadecane 0.05
    acetophenone 0.33
    methyl propionate 0.86
    isopentyl acetate 0.09
    trichloroethylene 0.16
    n-nonanol 0.36
    cyclohexanol 1.49
    benzyl alcohol 0.45
    2-ethylhexanol 0.2
    isooctanol 0.28
    dipropyl ether 0.44
    1,2-dichlorobenzene 0.04
    ethyl lactate 0.95
    propylene carbonate 0.56
    n-methylformamide 13.13
    2-pentanol 0.49
    n-pentane 0.09
    1-propoxy-2-propanol 1.96
    1-methoxy-2-propyl acetate 0.77
    2-(2-methoxypropoxy) propanol 2.4
    mesitylene 0.16
    ε-caprolactone 1.13
    p-cymene 0.12
    epichlorohydrin 0.73
    1,1,1-trichloroethane 0.03
    2-aminoethanol 19.92
    morpholine-4-carbaldehyde 26.77
    sulfolane 19.89
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 0.53
    n-hexyl acetate 0.2
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 3.55
    sec-butyl acetate 0.06
    tert-butyl acetate 0.25
    decalin 0.05
    glycerin 112.33
    diglyme 5.75
    acrylic acid 3.82
    isopropyl myristate 0.1
    n-butyric acid 1.12
    acetyl acetate 0.29
    di(2-ethylhexyl) phthalate 0.17
    ethyl propionate 0.18
    nitromethane 7.39
    1,2-diethoxyethane 0.51
    benzonitrile 0.12
    trioctyl phosphate 0.19
    1-bromopropane 0.06
    gamma-valerolactone 5.72
    n-decanol 0.28
    triethyl phosphate 0.26
    4-methyl-2-pentanol 0.21
    propionitrile 0.17
    vinylene carbonate 0.63
    1,1,2-trichlorotrifluoroethane 7.89
    DMS 0.42
    cumene 0.06
    2-octanol 0.26
    2-hexanone 0.12
    octyl acetate 0.16
    limonene 0.23
    1,2-dimethoxyethane 2.38
    ethyl orthosilicate 0.25
    tributyl phosphate 0.14
    diacetone alcohol 2.13
    N,N-dimethylaniline 0.33
    acrylonitrile 0.43
    aniline 0.52
    1,3-propanediol 13.25
    bromobenzene 0.02
    dibromomethane 0.05
    1,1,2,2-tetrachloroethane 0.24
    2-methyl-cyclohexyl acetate 0.15
    tetrabutyl urea 0.44
    diisobutyl methanol 0.18
    2-phenylethanol 0.38
    styrene 0.05
    dioctyl adipate 0.19
    dimethyl sulfate 7.84
    ethyl butyrate 0.19
    methyl lactate 7.12
    butyl lactate 0.59
    diethyl carbonate 0.12
    propanediol butyl ether 3.52
    triethyl orthoformate 0.31
    p-tert-butyltoluene 0.14
    methyl 4-tert-butylbenzoate 0.91
    morpholine 3.32
    tert-butylamine 0.22
    n-dodecanol 0.22
    dimethoxymethane 7.0
    ethylene carbonate 0.45
    cyrene 5.61
    2-ethoxyethyl acetate 0.38
    2-ethylhexyl acetate 0.08
    1,2,4-trichlorobenzene 0.07
    4-methylpyridine 0.36
    dibutyl ether 0.17
    2,6-dimethyl-4-heptanol 0.18
    DEF 3.71
    dimethyl isosorbide 2.82
    tetrachloroethylene 0.27
    eugenol 1.04
    triacetin 0.63
    span 80 2.22
    1,4-butanediol 3.58
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 0.15
    methyl formate 4.73
    2-methyl-1-butanol 0.43
    n-decane 0.08
    butyronitrile 0.15
    3,7-dimethyl-1-octanol 0.17
    1-chlorooctane 0.1
    1-chlorotetradecane 0.05
    n-nonane 0.09
    undecane 0.06
    tert-butylcyclohexane 0.02
    cyclooctane 0.21
    cyclopentanol 1.31
    tetrahydropyran 0.62
    tert-amyl methyl ether 0.32
    2,5,8-trioxanonane 5.64
    1-hexene 0.05
    2-isopropoxyethanol 1.7
    2,2,2-trifluoroethanol 9.9
    methyl butyrate 0.22

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction