Trehalose

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  • Identifiers

    CAS number
    99-20-7

    Molecular formula
    C12H22O11

    SMILES
    C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 73.85%
    Sweet 44.33%
    Alcoholic 22.39%
    Caramellic 21.69%
    Woody 20.04%
    Clean 16.12%
    Cooling 15.8%
    Milky 15.73%
    Vanilla 15.64%
    Bitter 15.41%

     

    Flavor
    Sweet 82.4%
    Odorless 56.34%
    Bitter 46.17%
    Sweet-like 32.25%
    Cauliflower 22.2%
    Very slight 22.08%
    Soup 20.57%
    Fatty 20.46%
    Alkaline 20.39%
    Mentholic 20.01%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.2

    pKa est.
    3.89 (weak acid)

    Molecular weight
    342.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    3039°C

    Melting point expt.

    • 203 °C

    Flash point

    • 276.86 ˚C est.

  • Synonyms

    • trehalose
    • 99-20-7
    • D-(+)-Trehalose
    • Mycose
    • alpha,alpha-trehalose
    • Ergot sugar
    • alpha-D-Trehalose
    • Cabaletta
    • Mushroom sugar
    • Natural trehalose
    • alpha-D-glucopyranosyl-alpha-D-glucopyranoside
    • alpha,alpha'-Trehalose
    • alpha-D-glucopyranosyl alpha-D-glucopyranoside
    • B8WCK70T7I
    • CHEBI:16551
    • NSC-2093
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxane-3,4,5-triol
    • CHEBI:27082
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy)oxane-3,4,5-triol
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyoxane-3,4,5-triol
    • RefChem:6317
    • GlyTouCan:G92130SN
    • zozu abundant charming hips cream
    • zozu plump beautiful breast cream
    • G92130SN
    • 202-739-6
    • D-Trehalose
    • D-(+)-Trehalose Anhydrous
    • D-(+)-Trehalose, anhydrous
    • MFCD00006628
    • Trehaose
    • Treha
    • alpha-Trehalose
    • alpha,alpha'-D-Trehalose
    • alpha-D-Glucopyranoside, alpha-D-glucopyranosyl
    • (2R,2'R,3S,3'S,4S,4'S,5R,5'R,6R,6'R)-6,6'-oxybis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol)
    • .alpha.,.alpha.-Trehalose
    • Thealoz
    • NSC 2093
    • TRE
    • Trehalose, alpha,alpha'-
    • UNII-B8WCK70T7I
    • Trehalose [INN:BAN:NF]
    • D-Trehalose, Carrier Protein
    • Trehalose P
    • DTXSID3048102
    • D(+)Trehalose
    • Trehalose (8CI)
    • EINECS 202-739-6
    • alpha-alpha-Trehalose
    • D-trehalose-anhydrous
    • ​Trehalose
    • 2b1q
    • TREHALOSE [FCC]
    • .alpha.-d-Glucopyranosyl-.alpha.-d-glucopyranoside
    • delta-trehalose-anhydrous
    • TREHALOSE [MI]
    • bmse000125
    • bmse000815
    • bmse000876
    • SCHEMBL8739
    • TREHALOSE [USP-RS]
    • TREHALOSE [WHO-DD]
    • D-(+)-Trehalose Anhydrous
    • HY-CP001
    • orb1304727
    • CHEMBL1236395
    • MSK3223
    • CHEBI:140775
    • GLXC-21554
    • HMS3886N22
    • HY-N1132
    • BDBM50235450
    • EBC-44240
    • s9348
    • a-D-Glucopyranosyl a-D-glucopyranoside
    • AKOS016010347
    • Trehalose (for injection, Sterilized)
    • CCG-208048
    • DB12310
    • OT03932
    • alpha-D-Glcp-(1<->1)-alpha-D-Glcp
    • SMP1_000299
    • alpha-D-Glcp-(1↔1)-alpha-D-Glcp
    • NCGC00248923-01
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-3,4,5-triol
    • AS-10470
    • DA-52734
    • SY009512
    • |_-D-Glucopyranoside, |_-D-glucopyranosyl
    • CS-0016421
    • NS00015235
    • T0331
    • T0832
    • Alpha-D-Glucopyranosyl-Alpha-D-Glucopyranoside.
    • C01083
    • F14769
    • a-D-Glucopyranosyl-a-D-glucopyranoside anhydrous
    • EN300-7445442
    • Q421773
    • alpha-D-Glucopyranoside, a-D-glucopyranosyl (9CI)
    • BRD-K54028654-001-01-8
    • BRD-K54028654-001-02-6
    • 1-[(1->4)-alpha-D-glucosyl]n-alpha-D-glucopyranoside
    • Z2417819595
    • 695EE371-8DF9-4915-942E-8B5EA4C7CF09
    • 99-20-7

  • Applications

    Trehalose (CAS 99-20-7) is used as a humectant and stabilizer in food processing and cosmetics, helping retain moisture and stabilize texture in formulations. In pharmaceutical and biotechnology contexts, it serves as a stabilizer and cryoprotectant for proteins, enzymes, and other biomolecules, particularly during drying and storage of lyophilized products. It is also employed as a protective additive in industrial formulations and enzyme preparations. In agricultural research, trehalose has been evaluated as an osmoprotectant to support plant stress tolerance under drought or salinity. Applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.06
    methanol 6.4
    isopropanol 0.46
    water 320.69
    ethyl acetate 0.14
    n-propanol 0.74
    acetone 0.24
    n-butanol 0.45
    acetonitrile 0.17
    DMF 27.29
    toluene 0.08
    isobutanol 0.26
    1,4-dioxane 1.15
    methyl acetate 0.15
    THF 0.92
    2-butanone 0.18
    n-pentanol 0.2
    sec-butanol 0.35
    n-hexane 0.03
    ethylene glycol 31.11
    NMP 29.79
    cyclohexane 0.22
    DMSO 134.41
    n-butyl acetate 0.16
    n-octanol 0.38
    chloroform 0.06
    n-propyl acetate 0.08
    acetic acid 7.83
    dichloromethane 0.07
    cyclohexanone 0.7
    propylene glycol 10.9
    isopropyl acetate 0.1
    DMAc 16.41
    2-ethoxyethanol 3.76
    isopentanol 0.21
    n-heptane 0.18
    ethyl formate 0.26
    1,2-dichloroethane 0.11
    n-hexanol 0.38
    2-methoxyethanol 13.84
    isobutyl acetate 0.03
    tetrachloromethane 0.05
    n-pentyl acetate 0.2
    transcutol 7.16
    n-heptanol 0.54
    ethylbenzene 0.05
    MIBK 0.12
    2-propoxyethanol 3.24
    tert-butanol 0.38
    MTBE 0.09
    2-butoxyethanol 2.46
    propionic acid 1.38
    o-xylene 0.15
    formic acid 126.67
    diethyl ether 0.16
    m-xylene 0.09
    p-xylene 0.05
    chlorobenzene 0.03
    dimethyl carbonate 0.99
    n-octane 0.09
    formamide 78.11
    cyclopentanone 0.95
    2-pentanone 0.17
    anisole 0.1
    cyclopentyl methyl ether 0.61
    gamma-butyrolactone 1.83
    1-methoxy-2-propanol 6.08
    pyridine 0.55
    3-pentanone 0.23
    furfural 2.66
    n-dodecane 0.04
    diethylene glycol 13.37
    diisopropyl ether 0.07
    tert-amyl alcohol 0.37
    acetylacetone 0.47
    n-hexadecane 0.04
    acetophenone 0.23
    methyl propionate 0.44
    isopentyl acetate 0.11
    trichloroethylene 0.12
    n-nonanol 0.38
    cyclohexanol 0.89
    benzyl alcohol 0.33
    2-ethylhexanol 0.2
    isooctanol 0.3
    dipropyl ether 0.37
    1,2-dichlorobenzene 0.04
    ethyl lactate 0.8
    propylene carbonate 0.64
    n-methylformamide 8.74
    2-pentanol 0.25
    n-pentane 0.07
    1-propoxy-2-propanol 1.95
    1-methoxy-2-propyl acetate 0.8
    2-(2-methoxypropoxy) propanol 2.24
    mesitylene 0.09
    ε-caprolactone 0.94
    p-cymene 0.12
    epichlorohydrin 0.62
    1,1,1-trichloroethane 0.03
    2-aminoethanol 15.51
    morpholine-4-carbaldehyde 17.83
    sulfolane 15.05
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 0.41
    n-hexyl acetate 0.23
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.47
    sec-butyl acetate 0.05
    tert-butyl acetate 0.14
    decalin 0.04
    glycerin 56.28
    diglyme 5.24
    acrylic acid 3.5
    isopropyl myristate 0.1
    n-butyric acid 0.76
    acetyl acetate 0.17
    di(2-ethylhexyl) phthalate 0.23
    ethyl propionate 0.12
    nitromethane 4.31
    1,2-diethoxyethane 0.5
    benzonitrile 0.11
    trioctyl phosphate 0.25
    1-bromopropane 0.05
    gamma-valerolactone 4.09
    n-decanol 0.29
    triethyl phosphate 0.33
    4-methyl-2-pentanol 0.13
    propionitrile 0.12
    vinylene carbonate 0.69
    1,1,2-trichlorotrifluoroethane 6.61
    DMS 0.41
    cumene 0.04
    2-octanol 0.27
    2-hexanone 0.08
    octyl acetate 0.18
    limonene 0.21
    1,2-dimethoxyethane 1.62
    ethyl orthosilicate 0.28
    tributyl phosphate 0.19
    diacetone alcohol 1.1
    N,N-dimethylaniline 0.22
    acrylonitrile 0.29
    aniline 0.34
    1,3-propanediol 8.51
    bromobenzene 0.02
    dibromomethane 0.05
    1,1,2,2-tetrachloroethane 0.2
    2-methyl-cyclohexyl acetate 0.19
    tetrabutyl urea 0.51
    diisobutyl methanol 0.18
    2-phenylethanol 0.38
    styrene 0.04
    dioctyl adipate 0.22
    dimethyl sulfate 4.73
    ethyl butyrate 0.19
    methyl lactate 4.31
    butyl lactate 0.76
    diethyl carbonate 0.15
    propanediol butyl ether 3.57
    triethyl orthoformate 0.34
    p-tert-butyltoluene 0.13
    methyl 4-tert-butylbenzoate 0.88
    morpholine 2.42
    tert-butylamine 0.18
    n-dodecanol 0.21
    dimethoxymethane 3.48
    ethylene carbonate 0.5
    cyrene 4.29
    2-ethoxyethyl acetate 0.42
    2-ethylhexyl acetate 0.1
    1,2,4-trichlorobenzene 0.07
    4-methylpyridine 0.23
    dibutyl ether 0.17
    2,6-dimethyl-4-heptanol 0.18
    DEF 1.67
    dimethyl isosorbide 2.73
    tetrachloroethylene 0.25
    eugenol 1.03
    triacetin 0.68
    span 80 2.32
    1,4-butanediol 2.67
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 0.11
    methyl formate 3.31
    2-methyl-1-butanol 0.26
    n-decane 0.08
    butyronitrile 0.09
    3,7-dimethyl-1-octanol 0.19
    1-chlorooctane 0.1
    1-chlorotetradecane 0.05
    n-nonane 0.08
    undecane 0.05
    tert-butylcyclohexane 0.02
    cyclooctane 0.14
    cyclopentanol 0.95
    tetrahydropyran 0.43
    tert-amyl methyl ether 0.18
    2,5,8-trioxanonane 4.77
    1-hexene 0.04
    2-isopropoxyethanol 1.12
    2,2,2-trifluoroethanol 8.87
    methyl butyrate 0.16

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction