Thymidine

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  • Identifiers

    CAS number
    50-89-5

    Molecular formula
    C10H14N2O5

    SMILES
    CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 77.94%
    Bitter 22.14%
    Burnt 19.86%
    Roasted 18.99%
    Savory 18.75%
    Caramellic 18.48%
    Nutty 17.04%
    Popcorn 16.81%
    Milky 16.73%
    Sweet 15.17%

     

    Flavor
    Bitter 83.12%
    Odorless 34.82%
    Bland 22.85%
    Sweet-like 22.01%
    Cedarleaf 19.81%
    Bread crust 19.27%
    Nitrile 19.12%
    Lovage 19.12%
    Taco 18.83%
    Roasted peanuts 18.73%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    6.82 (neutral)

    Molecular weight
    242.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    965°C

    Melting point expt.

    • 187-189

    Flash point

    • 251.56 ˚C est.

    Solubility expt.

    • 73.5 mg/mL
    • Water 50 (mg/mL)

  • Synonyms

    • thymidine
    • 50-89-5
    • 2'-Deoxythymidine
    • DThyd
    • Thymidin
    • 5-Methyl-2'-deoxyuridine
    • Thymine-2-desoxyriboside
    • Thyminedeoxyriboside
    • dThd
    • Deoxyribothymidine
    • Doxribtimine
    • 2'-thymidine
    • thymine 2'-deoxyriboside
    • 2'-deoxy-5-methyluridine
    • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
    • DTXSID5023661
    • VC2W18DGKR
    • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
    • CHEBI:17748
    • NSC-21548
    • DTXCID703661
    • MT-1621 COMPONENT 2'-DEOXYTHYMIDINE
    • 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
    • 2' Deoxythymidine
    • 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methylpyrimidine-2,4-dione
    • 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
    • RefChem:189836
    • 200-070-4
    • deoxythymidine
    • 5-Methyldeoxyuridine
    • Beta-Thymidine
    • 5-Methyldeoxyurindine
    • Thymine-2-deoxyriboside
    • Uridine, 2'-deoxy-5-methyl-
    • Thymine deoxyriboside
    • MFCD00006537
    • 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
    • dT
    • 157049-39-3
    • AI3-52267
    • beta-D-Ribofuranoside, thymine-1 2-deoxy-
    • 1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
    • 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methyl-
    • Thymine 2-desoxyriboside
    • 146183-25-7
    • NCGC00142484-03
    • alpha-tritiated thymidine
    • THM
    • 1-(2-Deoxy-beta-D-ribofuranosyl)-5-methyluracil
    • 1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione (Thymidine)
    • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
    • 1-[(4S,2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-dihydropyri midine-2,4-dione
    • 157049-40-6
    • CCRIS 1283
    • EINECS 200-070-4
    • UNII-VC2W18DGKR
    • NSC 21548
    • 2'deoxythymidine
    • deoxyribosylthymine
    • 4qsv
    • 1-(2-Deoxy-beta-D-ribofuranosyl)thymine
    • [3H]-Thymidine
    • Thymidinedeoxyriboside
    • Thymidine(2'-dT)
    • Thymidine (Standard)
    • 30819-56-8
    • beta-Methyldeoxyuridine
    • 1w2g
    • Thymidine, >=99%
    • BDBM1
    • THYMIDINE [MI]
    • Thymidine (8CI,9CI)
    • Doxribtimine (USAN/INN)
    • DOXRIBTIMINE [INN]
    • 2-dT
    • bmse000244
    • Epitope ID:138113
    • THYMIDINE [MART.]
    • DOXRIBTIMINE [USAN]
    • EC 200-070-4
    • THYMIDINE [WHO-DD]
    • THYMIDINE [WHO-IP]
    • 2'-deoxy-5-methyl-Uridine
    • SCHEMBL19894
    • 50-88-4
    • 2'-dT
    • CHEMBL52609
    • SCHEMBL655193
    • SCHEMBL932666
    • Thymidine,labeledwithcarbon-14
    • GTPL4718
    • orb1296048
    • SCHEMBL2722555
    • HY-N1150R
    • IMPURITY C [EP IMPURITY]
    • MSK6808
    • MT1621 (dT)
    • BB_NC-03215
    • HY-N1150
    • STR05630
    • Thymidine, >=99.0% (HPLC)
    • Tox21_111560
    • EBC-29026
    • HG1139
    • s4803
    • SBB003204
    • AKOS015895360
    • STAVUDINE IMPURITY C [WHO-IP]
    • thymine-1 2-deoxy-b-D-Ribofuranoside
    • AC-1475
    • CCG-266886
    • CS-W019644
    • DB04485
    • NT02592
    • 2'-DEOXY-3,4-DIHYDROTHYMIDINE
    • CAS-50-89-5
    • DEOXYTHYMIDINE; 2'-DEOXYTHYMIDINE
    • NCGC00142484-01
    • 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-furan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
    • BP-58693
    • ST056941
    • SY005232
    • STAVUDINE IMPURITY C [EP IMPURITY]
    • Thymidine, Vetec(TM) reagent grade, 99%
    • DB-030432
    • ZIDOVUDINE IMPURITY E [EP IMPURITY]
    • NS00068173
    • 50-89-5

  • Applications

    Thymidine (CAS 50-89-5) is a deoxyribonucleoside that serves as a building block for DNA and oligonucleotide synthesis in molecular biology and biotechnology, is used as a substrate and analytical standard in nucleotide-focused assays (e.g., HPLC/LC-MS) to support method development and quality control, and functions as a common reagent in nucleoside chemistry and enzymology studies within pharmaceutical and biotech R&D; it is also utilized in nucleotide metabolism and cell biology research workflows.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.7
    methanol 18.77
    isopropanol 4.16
    water 97.11
    ethyl acetate 0.83
    n-propanol 3.79
    acetone 2.47
    n-butanol 3.72
    acetonitrile 2.98
    DMF 283.53
    toluene 0.32
    isobutanol 2.9
    1,4-dioxane 3.95
    methyl acetate 1.36
    THF 11.29
    2-butanone 2.68
    n-pentanol 2.21
    sec-butanol 3.19
    n-hexane 0.07
    ethylene glycol 29.29
    NMP 194.95
    cyclohexane 0.1
    DMSO 271.34
    n-butyl acetate 1.46
    n-octanol 0.79
    chloroform 1.06
    n-propyl acetate 1.35
    acetic acid 44.32
    dichloromethane 1.38
    cyclohexanone 10.81
    propylene glycol 28.48
    isopropyl acetate 0.85
    DMAc 197.49
    2-ethoxyethanol 24.13
    isopentanol 3.91
    n-heptane 0.09
    ethyl formate 4.25
    1,2-dichloroethane 1.17
    n-hexanol 1.62
    2-methoxyethanol 64.29
    isobutyl acetate 0.81
    tetrachloromethane 0.4
    n-pentyl acetate 1.1
    transcutol 17.61
    n-heptanol 1.34
    ethylbenzene 0.3
    MIBK 2.34
    2-propoxyethanol 14.74
    tert-butanol 4.8
    MTBE 0.63
    2-butoxyethanol 8.27
    propionic acid 9.56
    o-xylene 0.58
    formic acid 260.93
    diethyl ether 0.56
    m-xylene 0.53
    p-xylene 0.58
    chlorobenzene 0.37
    dimethyl carbonate 4.47
    n-octane 0.05
    formamide 253.82
    cyclopentanone 17.07
    2-pentanone 2.42
    anisole 0.98
    cyclopentyl methyl ether 2.74
    gamma-butyrolactone 28.39
    1-methoxy-2-propanol 33.2
    pyridine 4.38
    3-pentanone 1.85
    furfural 34.21
    n-dodecane 0.04
    diethylene glycol 34.48
    diisopropyl ether 0.22
    tert-amyl alcohol 4.03
    acetylacetone 3.87
    n-hexadecane 0.05
    acetophenone 3.19
    methyl propionate 2.85
    isopentyl acetate 1.9
    trichloroethylene 2.58
    n-nonanol 0.87
    cyclohexanol 3.38
    benzyl alcohol 3.78
    2-ethylhexanol 1.09
    isooctanol 1.16
    dipropyl ether 0.86
    1,2-dichlorobenzene 0.63
    ethyl lactate 6.93
    propylene carbonate 12.02
    n-methylformamide 93.62
    2-pentanol 1.84
    n-pentane 0.06
    1-propoxy-2-propanol 8.27
    1-methoxy-2-propyl acetate 4.22
    2-(2-methoxypropoxy) propanol 10.01
    mesitylene 0.45
    ε-caprolactone 10.99
    p-cymene 0.5
    epichlorohydrin 12.56
    1,1,1-trichloroethane 0.56
    2-aminoethanol 28.97
    morpholine-4-carbaldehyde 81.15
    sulfolane 77.81
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 3.44
    n-hexyl acetate 1.27
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 10.42
    sec-butyl acetate 0.79
    tert-butyl acetate 1.53
    decalin 0.07
    glycerin 94.63
    diglyme 17.85
    acrylic acid 18.66
    isopropyl myristate 0.58
    n-butyric acid 9.2
    acetyl acetate 1.08
    di(2-ethylhexyl) phthalate 2.25
    ethyl propionate 1.35
    nitromethane 48.1
    1,2-diethoxyethane 1.41
    benzonitrile 2.74
    trioctyl phosphate 1.47
    1-bromopropane 0.45
    gamma-valerolactone 48.15
    n-decanol 0.66
    triethyl phosphate 2.28
    4-methyl-2-pentanol 1.42
    propionitrile 2.24
    vinylene carbonate 11.43
    1,1,2-trichlorotrifluoroethane 44.25
    DMS 2.17
    cumene 0.33
    2-octanol 0.72
    2-hexanone 1.76
    octyl acetate 0.88
    limonene 0.63
    1,2-dimethoxyethane 15.94
    ethyl orthosilicate 1.72
    tributyl phosphate 1.69
    diacetone alcohol 10.28
    N,N-dimethylaniline 1.56
    acrylonitrile 5.46
    aniline 1.78
    1,3-propanediol 27.17
    bromobenzene 0.26
    dibromomethane 0.72
    1,1,2,2-tetrachloroethane 2.51
    2-methyl-cyclohexyl acetate 2.06
    tetrabutyl urea 3.29
    diisobutyl methanol 0.82
    2-phenylethanol 2.85
    styrene 0.26
    dioctyl adipate 1.59
    dimethyl sulfate 20.18
    ethyl butyrate 1.65
    methyl lactate 18.34
    butyl lactate 4.63
    diethyl carbonate 1.47
    propanediol butyl ether 10.59
    triethyl orthoformate 1.88
    p-tert-butyltoluene 0.45
    methyl 4-tert-butylbenzoate 5.06
    morpholine 10.75
    tert-butylamine 1.11
    n-dodecanol 0.49
    dimethoxymethane 18.38
    ethylene carbonate 7.5
    cyrene 25.84
    2-ethoxyethyl acetate 1.88
    2-ethylhexyl acetate 1.35
    1,2,4-trichlorobenzene 1.09
    4-methylpyridine 3.72
    dibutyl ether 0.48
    2,6-dimethyl-4-heptanol 0.82
    DEF 13.28
    dimethyl isosorbide 15.23
    tetrachloroethylene 1.83
    eugenol 7.27
    triacetin 3.37
    span 80 6.87
    1,4-butanediol 13.44
    1,1-dichloroethane 0.48
    2-methyl-1-pentanol 2.25
    methyl formate 38.09
    2-methyl-1-butanol 3.5
    n-decane 0.06
    butyronitrile 2.26
    3,7-dimethyl-1-octanol 0.94
    1-chlorooctane 0.18
    1-chlorotetradecane 0.1
    n-nonane 0.06
    undecane 0.05
    tert-butylcyclohexane 0.05
    cyclooctane 0.05
    cyclopentanol 5.48
    tetrahydropyran 1.85
    tert-amyl methyl ether 1.03
    2,5,8-trioxanonane 14.84
    1-hexene 0.22
    2-isopropoxyethanol 8.84
    2,2,2-trifluoroethanol 37.01
    methyl butyrate 2.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction