Thionyl chloride

Overview IFRA Request a quote

  • Identifiers

    CAS number
    7719-09-7

    Molecular formula
    Cl2OS

    SMILES
    O=S(Cl)Cl

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 59.29%
    Sulfurous 40.73%
    Onion 27.92%
    Savory 26.36%
    Meaty 26.36%
    Roasted 26.0%
    Cooked 25.47%
    Pungent 25.26%
    Garlic 24.38%
    Alliaceous 22.71%

     

    Flavor
    Odorless 40.38%
    Sulfur 22.98%
    Bitter 22.77%
    Mustard 22.04%
    Mousy 21.01%
    Formyl 20.46%
    Pungent 20.07%
    Nitrile 19.79%
    Rotten 19.73%
    Garlic 19.47%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    -2.35 (strong acid)

    Molecular weight
    118.97 g/mol

    Melting point expt.

    • -156 °F (NIOSH, 2024)
    • -104.5 °C
    • -156 °F

    Boiling point

    • 169 °F at 760 mmHg (NIOSH, 2024)
    • 76 °C at 760 mm Hg
    • 76 °C
    • 169 °F

    Flash point

    • 52.47 ˚C est.

    Solubility expt.

    • Reacts with water (NIOSH, 2024)
    • Decomposes (fumes) in water
    • Decomp in acids, alc, alkalies; in cold and hot water
    • Miscible with benzene, chloroform, carbon tetrachloride
    • Solubility in water: reaction
    • Reacts

  • Synonyms

    • THIONYL CHLORIDE
    • Thionyl dichloride
    • 7719-09-7
    • Sulfinyl chloride
    • Sulfurous dichloride
    • Sulfurous oxychloride
    • Sulfinyl dichloride
    • Sulfur oxychloride
    • Thionylchloride
    • SOCl2
    • Sulfur chloride oxide
    • Sulfur chloride oxide (Cl2SO)
    • dichloridooxidosulfur
    • 4A8YJA13N4
    • CCRIS 1280
    • HSDB 859
    • sulfur dichloride oxide
    • EINECS 231-748-8
    • Thionyl chloride (socl2)
    • Sulfur oxychloride (socl2)
    • UNII-4A8YJA13N4
    • AI3-10628
    • DTXSID3064778
    • CHEBI:29290
    • (SCl2O)
    • [SCl2O]
    • EC 231-748-8
    • Dichlorosulfoxide
    • MFCD00011449
    • Thionyl chloride, ReagentPlus(R), >=99%
    • thionylchioride
    • thionylchoride
    • Thionyichloride
    • Thionylchlorid
    • thiony-chloride
    • thionyl chlorie
    • thionyl choride
    • Thionyl cloride
    • thionyl-chloride
    • thionyldichloride
    • sulphinyl chloride
    • thionyl -chloride
    • thionyl chloride-
    • UN1836
    • SULFOXIDE CHLORIDE
    • Thionyl chloride, >=98%
    • THIONYL CHLORIDE [MI]
    • Sulfur chloride oxide (scl2o)
    • THIONYL CHLORIDE [HSDB]
    • DTXCID0047953
    • Thionyl chloride, technical grade
    • Thionyl chloride, LR, >=99.5%
    • AKOS016016202
    • Thionyl chloride, reagent grade, 97%
    • UN 1836
    • Thionyl chloride, puriss., >=99.0%
    • Thionyl chloride [UN1836] [Corrosive]
    • NS00001820
    • T2040
    • T2048
    • Thionyl chloride, ReagentPlus(R), >=99.0%
    • Thionyl chloride, SAJ first grade, >=90.0%
    • Thionyl chloride, SAJ special grade, >=95.0%
    • Q409171
    • Thionyl chloride, ReagentPlus(R), 99.5%, low iron
    • 231-748-8

  • Applications

    Thionyl chloride (CAS 7719-09-7) is widely used in industrial synthesis as a chlorinating and dehydrating reagent. The principal application is the conversion of carboxylic acids to acid chlorides, enabling subsequent formation of esters and amides used in pharmaceutical, agrochemical, and polymer manufacturing. It is also employed to transform alcohols into alkyl chlorides, providing reactive intermediates for coatings, inks, and adhesives. Additionally, acid chlorides derived from thionyl chloride serve as key intermediates in the production of polyamides and other polymers, and the reagent supports activation of carboxyl groups in diverse synthetic routes. All uses are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 264.79
    methanol 420.15
    isopropanol 203.16
    water 76.01
    ethyl acetate 175.63
    n-propanol 175.65
    acetone 524.35
    n-butanol 156.38
    acetonitrile 299.05
    DMF 1311.04
    toluene 111.98
    isobutanol 125.3
    1,4-dioxane 388.77
    methyl acetate 241.25
    THF 494.24
    2-butanone 268.15
    n-pentanol 115.67
    sec-butanol 160.46
    n-hexane 37.36
    ethylene glycol 174.48
    NMP 847.83
    cyclohexane 71.82
    DMSO 1089.9
    n-butyl acetate 108.44
    n-octanol 96.27
    chloroform 313.81
    n-propyl acetate 130.22
    acetic acid 365.25
    dichloromethane 350.58
    cyclohexanone 308.92
    propylene glycol 104.59
    isopropyl acetate 118.42
    DMAc 926.23
    2-ethoxyethanol 259.04
    isopentanol 119.74
    n-heptane 48.07
    ethyl formate 171.41
    1,2-dichloroethane 257.93
    n-hexanol 98.61
    2-methoxyethanol 449.91
    isobutyl acetate 76.44
    tetrachloromethane 92.89
    n-pentyl acetate 102.75
    transcutol 408.06
    n-heptanol 82.86
    ethylbenzene 61.49
    MIBK 128.78
    2-propoxyethanol 205.85
    tert-butanol 215.39
    MTBE 185.58
    2-butoxyethanol 153.89
    propionic acid 162.36
    o-xylene 107.37
    formic acid 294.49
    diethyl ether 239.26
    m-xylene 87.81
    p-xylene 80.94
    chlorobenzene 119.4
    dimethyl carbonate 163.23
    n-octane 23.82
    formamide 480.54
    cyclopentanone 411.81
    2-pentanone 219.8
    anisole 157.94
    cyclopentyl methyl ether 234.28
    gamma-butyrolactone 355.99
    1-methoxy-2-propanol 300.11
    pyridine 349.64
    3-pentanone 203.26
    furfural 436.55
    n-dodecane 18.58
    diethylene glycol 242.55
    diisopropyl ether 87.79
    tert-amyl alcohol 168.15
    acetylacetone 256.94
    n-hexadecane 20.36
    acetophenone 174.67
    methyl propionate 197.07
    isopentyl acetate 87.57
    trichloroethylene 389.44
    n-nonanol 85.86
    cyclohexanol 171.4
    benzyl alcohol 140.29
    2-ethylhexanol 74.09
    isooctanol 68.9
    dipropyl ether 135.28
    1,2-dichlorobenzene 117.01
    ethyl lactate 91.48
    propylene carbonate 160.12
    n-methylformamide 485.52
    2-pentanol 121.83
    n-pentane 58.63
    1-propoxy-2-propanol 156.34
    1-methoxy-2-propyl acetate 124.3
    2-(2-methoxypropoxy) propanol 144.45
    mesitylene 68.41
    ε-caprolactone 217.3
    p-cymene 60.35
    epichlorohydrin 323.3
    1,1,1-trichloroethane 196.05
    2-aminoethanol 196.1
    morpholine-4-carbaldehyde 638.84
    sulfolane 489.59
    2,2,4-trimethylpentane 27.31
    2-methyltetrahydrofuran 297.64
    n-hexyl acetate 113.28
    isooctane 20.4
    2-(2-butoxyethoxy)ethanol 180.77
    sec-butyl acetate 86.43
    tert-butyl acetate 128.14
    decalin 26.77
    glycerin 189.49
    diglyme 380.09
    acrylic acid 199.01
    isopropyl myristate 69.31
    n-butyric acid 165.05
    acetyl acetate 129.87
    di(2-ethylhexyl) phthalate 63.3
    ethyl propionate 119.88
    nitromethane 582.49
    1,2-diethoxyethane 170.85
    benzonitrile 156.1
    trioctyl phosphate 54.85
    1-bromopropane 152.93
    gamma-valerolactone 431.41
    n-decanol 70.07
    triethyl phosphate 72.07
    4-methyl-2-pentanol 74.15
    propionitrile 169.39
    vinylene carbonate 166.39
    1,1,2-trichlorotrifluoroethane 354.5
    DMS 113.48
    cumene 48.98
    2-octanol 68.51
    2-hexanone 151.31
    octyl acetate 80.42
    limonene 91.27
    1,2-dimethoxyethane 446.45
    ethyl orthosilicate 74.03
    tributyl phosphate 57.92
    diacetone alcohol 168.09
    N,N-dimethylaniline 172.4
    acrylonitrile 253.32
    aniline 163.23
    1,3-propanediol 199.63
    bromobenzene 106.43
    dibromomethane 246.04
    1,1,2,2-tetrachloroethane 296.39
    2-methyl-cyclohexyl acetate 85.86
    tetrabutyl urea 104.18
    diisobutyl methanol 65.01
    2-phenylethanol 104.64
    styrene 85.83
    dioctyl adipate 91.93
    dimethyl sulfate 299.38
    ethyl butyrate 110.41
    methyl lactate 152.45
    butyl lactate 88.2
    diethyl carbonate 79.66
    propanediol butyl ether 137.65
    triethyl orthoformate 93.64
    p-tert-butyltoluene 62.96
    methyl 4-tert-butylbenzoate 157.44
    morpholine 428.23
    tert-butylamine 158.98
    n-dodecanol 61.03
    dimethoxymethane 496.08
    ethylene carbonate 133.05
    cyrene 166.34
    2-ethoxyethyl acetate 126.43
    2-ethylhexyl acetate 76.03
    1,2,4-trichlorobenzene 141.46
    4-methylpyridine 295.95
    dibutyl ether 100.61
    2,6-dimethyl-4-heptanol 65.01
    DEF 408.43
    dimethyl isosorbide 210.58
    tetrachloroethylene 255.94
    eugenol 158.43
    triacetin 136.48
    span 80 137.57
    1,4-butanediol 108.38
    1,1-dichloroethane 217.27
    2-methyl-1-pentanol 92.88
    methyl formate 355.99
    2-methyl-1-butanol 116.5
    n-decane 27.84
    butyronitrile 154.41
    3,7-dimethyl-1-octanol 82.02
    1-chlorooctane 69.52
    1-chlorotetradecane 36.67
    n-nonane 29.04
    undecane 21.7
    tert-butylcyclohexane 23.45
    cyclooctane 33.24
    cyclopentanol 208.32
    tetrahydropyran 280.88
    tert-amyl methyl ether 176.63
    2,5,8-trioxanonane 279.98
    1-hexene 75.87
    2-isopropoxyethanol 173.14
    2,2,2-trifluoroethanol 235.19
    methyl butyrate 159.57

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction