Thioflavin T

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  • Identifiers

    CAS number
    2390-54-7

    Molecular formula
    C17H19ClN2S

    SMILES
    CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fruity 48.08%
    Floral 42.53%
    Roasted 39.68%
    Animal 39.07%
    Burnt 33.49%
    Meaty 32.71%
    Grape 30.42%
    Fatty 30.34%
    Earthy 28.12%
    Neroli 27.29%

     

    Flavor
    Bitter 53.92%
    Very strong 22.5%
    Roasted 22.37%
    Indole 22.08%
    Earthy 21.59%
    Green pepper 21.33%
    Syrup 20.75%
    Moth ball 20.53%
    Burnt almonds 20.46%
    Nitrile 20.43%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    7.13 (neutral)

    Molecular weight
    318.9 g/mol

    Flash point

    • 172.57 ˚C est.

  • Synonyms

    • Thioflavin T
    • 2390-54-7
    • Thioflavine T
    • Basic yellow 1
    • Acronol Yellow TC
    • C.I. Basic Yellow 1
    • C.I. 49005
    • CAX9SG0II0
    • Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride
    • 3,6-Dimethyl-2-dimethylaminophenylbenzothiazolium chloride
    • NSC-11235
    • CHEBI:76023
    • DTXSID10883841
    • Benzothiazolium, 2-(p-(dimethylamino)phenyl)-3,6-dimethyl-, chloride
    • Benzothiazolium, 2-(4-(dimethylamino)phenyl)-3,6-dimethyl-, chloride
    • Benzothiazolium, 2-(4-(dimethylamino)phenyl)-3,6-dimethyl-, chloride (1:1)
    • 2-(p-(dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride
    • Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride (1:1)
    • ThT (dye)
    • RefChem:189525
    • DTXCID801023326
    • 219-228-9
    • 2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo[d]thiazol-3-ium chloride
    • Setoflavine T
    • Tannoflavine T
    • Setoflavin T
    • Rhoduline Yellow
    • Thioflavin TG
    • Thioflavine TCN
    • Thioflavine TG
    • Citroflavine 8G
    • Primoflavine 8G
    • Thioflavin TCN
    • Basic Yellow T
    • Purimofurabin 8G
    • Acronol Yellow T
    • MFCD00011944
    • Thioflavine TCND
    • Methylene Yellow N
    • Brilliant Flavine T
    • Methylene Yellow NI
    • Thioflavin TCN extra
    • Acronol Lake Yellow T
    • Acronol Lake Yellow TC
    • Acronol Yellow TC180
    • Nankai Basic Flavine 8G
    • Kansai Basic Flavine 8GO
    • Methyldehydrothio-p-toluidine sulfonate
    • 4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride
    • CHEMBL224392
    • 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride
    • Thioflavine
    • 4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline;chloride
    • 2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride
    • [4-(3,6-dimethylbenzothiazol-2-yl)phenyl]dimethylamine, chloride
    • 2-[4-(Dimethylamino)phenyl]-3,6-dimethylbenzo[d]thiazol-3-ium Chloride
    • EINECS 219-228-9
    • NSC 11235
    • Thioflavin T (ThT)
    • UNII-CAX9SG0II0
    • CI BASIC YELLOW 1
    • THIOFLAVIN T CHLORIDE
    • SCHEMBL25298
    • Thioflavin S;Direct Yellow 7
    • orb1307670
    • SCHEMBL11428556
    • SCHEMBL29350189
    • MSK2449
    • ci 49005
    • JADVWWSKYZXRGX-UHFFFAOYSA-M
    • GLXC-07924
    • HY-D0218
    • NSC11235
    • CI 495
    • HB7143
    • SBB057655
    • Benzothiazolium,6-dimethyl-, chloride
    • AKOS016007447
    • CS-7552
    • CS-W009025
    • FT52680
    • Thioflavin T - CAS 2390-54-7
    • Thioflavin T, used as stain for amyloid
    • AS-72625
    • BP-30130
    • BP-41752
    • DA-68149
    • DA-78423
    • SY074376
    • NS00049463
    • ST50308406
    • T0558
    • O10470
    • F234373
    • A01-0008
    • Q2033625
    • 2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo-[d]thiazol-3-ium chloride
    • 2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo[d]thiazol-3-ium chloride (Thioflavin T)
    • 4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethyl-aniline;chloride
    • 2390-54-7

  • Applications

    Thioflavin T (CAS 2390-54-7) is a fluorescent dye primarily used in biochemical and pharmaceutical research to detect and quantify amyloid fibrils via the Thioflavin T assay, yielding enhanced fluorescence upon binding to beta-sheet rich structures; it is widely used as a histology fluorescent stain to visualize amyloid deposits in tissue samples; it also serves as a fluorogenic probe in analytical chemistry and high-throughput screening to assess protein aggregation and related processes in various systems; in materials science and polymer research, Thioflavin T is used as a fluorescent marker to study self-assembly and aggregation in peptide- or polymer-based formulations that mimic amyloid-like structures; these applications are predominantly in laboratory research and development contexts and depend on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 27.0
    methanol 24.34
    isopropanol 12.77
    water 0.1
    ethyl acetate 49.74
    n-propanol 29.18
    acetone 45.73
    n-butanol 27.21
    acetonitrile 15.07
    DMF 114.07
    toluene 25.14
    isobutanol 19.85
    1,4-dioxane 105.9
    methyl acetate 51.17
    THF 184.66
    2-butanone 64.07
    n-pentanol 26.07
    sec-butanol 18.8
    n-hexane 1.03
    ethylene glycol 6.03
    NMP 106.24
    cyclohexane 2.3
    DMSO 50.67
    n-butyl acetate 39.53
    n-octanol 6.32
    chloroform 250.55
    n-propyl acetate 40.63
    acetic acid 34.8
    dichloromethane 210.05
    cyclohexanone 96.46
    propylene glycol 8.39
    isopropyl acetate 30.77
    DMAc 149.96
    2-ethoxyethanol 72.81
    isopentanol 23.08
    n-heptane 1.09
    ethyl formate 33.37
    1,2-dichloroethane 113.41
    n-hexanol 21.98
    2-methoxyethanol 89.93
    isobutyl acetate 35.14
    tetrachloromethane 15.03
    n-pentyl acetate 26.39
    transcutol 122.0
    n-heptanol 11.39
    ethylbenzene 11.79
    MIBK 31.37
    2-propoxyethanol 74.18
    tert-butanol 13.5
    MTBE 26.0
    2-butoxyethanol 39.11
    propionic acid 25.54
    o-xylene 13.07
    formic acid 17.15
    diethyl ether 35.13
    m-xylene 13.5
    p-xylene 17.73
    chlorobenzene 54.06
    dimethyl carbonate 32.14
    n-octane 0.56
    formamide 29.65
    cyclopentanone 122.24
    2-pentanone 46.94
    anisole 44.22
    cyclopentyl methyl ether 69.13
    gamma-butyrolactone 128.79
    1-methoxy-2-propanol 50.85
    pyridine 106.29
    3-pentanone 46.99
    furfural 130.13
    n-dodecane 0.45
    diethylene glycol 49.98
    diisopropyl ether 7.86
    tert-amyl alcohol 19.09
    acetylacetone 54.63
    n-hexadecane 0.54
    acetophenone 49.35
    methyl propionate 50.99
    isopentyl acetate 42.26
    trichloroethylene 251.01
    n-nonanol 7.47
    cyclohexanol 24.8
    benzyl alcohol 42.89
    2-ethylhexanol 15.59
    isooctanol 10.9
    dipropyl ether 18.97
    1,2-dichlorobenzene 49.35
    ethyl lactate 23.8
    propylene carbonate 65.8
    n-methylformamide 39.21
    2-pentanol 14.53
    n-pentane 1.1
    1-propoxy-2-propanol 42.35
    1-methoxy-2-propyl acetate 56.5
    2-(2-methoxypropoxy) propanol 37.02
    mesitylene 6.04
    ε-caprolactone 90.1
    p-cymene 9.01
    epichlorohydrin 215.8
    1,1,1-trichloroethane 64.03
    2-aminoethanol 16.45
    morpholine-4-carbaldehyde 141.15
    sulfolane 109.59
    2,2,4-trimethylpentane 1.2
    2-methyltetrahydrofuran 102.07
    n-hexyl acetate 24.12
    isooctane 0.58
    2-(2-butoxyethoxy)ethanol 46.84
    sec-butyl acetate 31.63
    tert-butyl acetate 31.05
    decalin 1.7
    glycerin 17.01
    diglyme 96.05
    acrylic acid 26.76
    isopropyl myristate 10.5
    n-butyric acid 39.95
    acetyl acetate 30.58
    di(2-ethylhexyl) phthalate 17.29
    ethyl propionate 35.41
    nitromethane 68.09
    1,2-diethoxyethane 48.02
    benzonitrile 36.63
    trioctyl phosphate 9.75
    1-bromopropane 44.39
    gamma-valerolactone 186.52
    n-decanol 5.62
    triethyl phosphate 23.41
    4-methyl-2-pentanol 10.45
    propionitrile 22.76
    vinylene carbonate 68.47
    1,1,2-trichlorotrifluoroethane 122.04
    DMS 36.93
    cumene 9.27
    2-octanol 6.85
    2-hexanone 41.17
    octyl acetate 14.03
    limonene 12.01
    1,2-dimethoxyethane 106.25
    ethyl orthosilicate 23.44
    tributyl phosphate 13.27
    diacetone alcohol 36.29
    N,N-dimethylaniline 27.9
    acrylonitrile 28.13
    aniline 43.2
    1,3-propanediol 28.5
    bromobenzene 52.55
    dibromomethane 109.37
    1,1,2,2-tetrachloroethane 173.66
    2-methyl-cyclohexyl acetate 37.21
    tetrabutyl urea 18.16
    diisobutyl methanol 7.78
    2-phenylethanol 40.31
    styrene 16.42
    dioctyl adipate 19.91
    dimethyl sulfate 49.57
    ethyl butyrate 33.89
    methyl lactate 24.94
    butyl lactate 23.15
    diethyl carbonate 26.96
    propanediol butyl ether 20.39
    triethyl orthoformate 29.76
    p-tert-butyltoluene 7.73
    methyl 4-tert-butylbenzoate 32.8
    morpholine 133.43
    tert-butylamine 7.66
    n-dodecanol 4.23
    dimethoxymethane 90.16
    ethylene carbonate 56.36
    cyrene 60.01
    2-ethoxyethyl acetate 53.25
    2-ethylhexyl acetate 36.75
    1,2,4-trichlorobenzene 66.34
    4-methylpyridine 85.59
    dibutyl ether 10.94
    2,6-dimethyl-4-heptanol 7.78
    DEF 68.42
    dimethyl isosorbide 75.19
    tetrachloroethylene 99.52
    eugenol 41.65
    triacetin 33.14
    span 80 26.22
    1,4-butanediol 14.38
    1,1-dichloroethane 74.31
    2-methyl-1-pentanol 25.85
    methyl formate 34.27
    2-methyl-1-butanol 25.32
    n-decane 0.76
    butyronitrile 26.22
    3,7-dimethyl-1-octanol 8.91
    1-chlorooctane 5.42
    1-chlorotetradecane 2.07
    n-nonane 0.61
    undecane 0.56
    tert-butylcyclohexane 1.5
    cyclooctane 0.69
    cyclopentanol 28.17
    tetrahydropyran 88.0
    tert-amyl methyl ether 25.68
    2,5,8-trioxanonane 62.59
    1-hexene 7.61
    2-isopropoxyethanol 47.29
    2,2,2-trifluoroethanol 22.37
    methyl butyrate 44.73

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction