Thiazole, 2-(ethylthio)-

Overview IFRA Request a quote

  • Identifiers

    CAS number
    14527-48-1

    Molecular formula
    C5H7NS2

    SMILES
    CCSC1=NC=CS1

    Safety labels

  • Odor profile

    Fragrance
    Meaty 71.34%
    Sulfurous 67.4%
    Roasted 66.64%
    Nutty 60.37%
    Coffee 54.43%
    Burnt 48.95%
    Vegetable 44.1%
    Savory 42.07%
    Beefy 40.07%
    Alliaceous 39.62%

     

    Flavor
    Green 54.2%
    Roasted 50.93%
    Nutty 49.56%
    Vegetable 46.94%
    Meaty 46.51%
    Sulfury 43.6%
    Coffee 39.76%
    Onion 34.74%
    Earthy 32.82%
    Tomato 31.68%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    4.61 (weak acid)

    Molecular weight
    145.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    234°C

    Flash point

    • 86.01 ˚C est.

  • Synonyms

    • Thiazole, 2-(ethylthio)-
    • 14527-48-1
    • 2-ethylsulfanyl-1,3-thiazole
    • 2-(Ethylsulfanyl)-1,3-thiazole
    • SCHEMBL318897
    • SCHEMBL5248422
    • SCHEMBL5248427
    • SCHEMBL9885798
    • DTXSID40499050
    • AKOS006237857
    • 14527-48-1

  • Applications

    Thiazole, 2-(ethylthio)-, CAS number: 14527-48-1, is used as a building block and aroma-related ingredient across several sectors: in perfumery and cosmetics/personal care as an odorant/fragrance component; in the flavor/aroma field as a limited-use flavor intermediate; in pharmaceutical and agrochemical synthesis as a heterocyclic building block for intermediate compounds; and in coatings, inks, and specialty polymers as a structural motif for formulation ingredients.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 386.04
    methanol 438.73
    isopropanol 305.16
    water 1.88
    ethyl acetate 705.79
    n-propanol 325.44
    acetone 1448.37
    n-butanol 327.99
    acetonitrile 688.95
    DMF 2732.2
    toluene 675.51
    isobutanol 290.31
    1,4-dioxane 1515.41
    methyl acetate 733.17
    THF 1961.31
    2-butanone 922.14
    n-pentanol 289.58
    sec-butanol 288.82
    n-hexane 81.51
    ethylene glycol 170.6
    NMP 2737.07
    cyclohexane 168.8
    DMSO 2656.04
    n-butyl acetate 715.54
    n-octanol 283.37
    chloroform 2102.93
    n-propyl acetate 623.32
    acetic acid 653.55
    dichloromethane 2048.39
    cyclohexanone 1891.34
    propylene glycol 176.77
    isopropyl acetate 512.18
    DMAc 1512.45
    2-ethoxyethanol 589.48
    isopentanol 302.98
    n-heptane 99.28
    ethyl formate 571.37
    1,2-dichloroethane 1377.29
    n-hexanol 360.26
    2-methoxyethanol 821.47
    isobutyl acetate 449.92
    tetrachloromethane 532.02
    n-pentyl acetate 567.33
    transcutol 1295.67
    n-heptanol 246.33
    ethylbenzene 317.52
    MIBK 557.62
    2-propoxyethanol 694.95
    tert-butanol 393.29
    MTBE 465.21
    2-butoxyethanol 467.41
    propionic acid 448.94
    o-xylene 409.89
    formic acid 181.9
    diethyl ether 526.93
    m-xylene 475.05
    p-xylene 448.9
    chlorobenzene 1235.64
    dimethyl carbonate 538.52
    n-octane 62.03
    formamide 325.37
    cyclopentanone 2335.05
    2-pentanone 822.1
    anisole 754.45
    cyclopentyl methyl ether 952.05
    gamma-butyrolactone 2178.72
    1-methoxy-2-propanol 634.45
    pyridine 1615.24
    3-pentanone 678.96
    furfural 2301.4
    n-dodecane 58.45
    diethylene glycol 594.08
    diisopropyl ether 236.34
    tert-amyl alcohol 346.46
    acetylacetone 1290.95
    n-hexadecane 68.86
    acetophenone 815.89
    methyl propionate 667.34
    isopentyl acetate 600.4
    trichloroethylene 2804.99
    n-nonanol 244.9
    cyclohexanol 482.38
    benzyl alcohol 563.89
    2-ethylhexanol 291.58
    isooctanol 221.47
    dipropyl ether 414.6
    1,2-dichlorobenzene 1144.21
    ethyl lactate 315.95
    propylene carbonate 1117.65
    n-methylformamide 850.14
    2-pentanol 252.35
    n-pentane 77.68
    1-propoxy-2-propanol 521.01
    1-methoxy-2-propyl acetate 709.59
    2-(2-methoxypropoxy) propanol 449.8
    mesitylene 349.65
    ε-caprolactone 1330.44
    p-cymene 258.21
    epichlorohydrin 1881.07
    1,1,1-trichloroethane 1508.03
    2-aminoethanol 234.64
    morpholine-4-carbaldehyde 2369.09
    sulfolane 3285.96
    2,2,4-trimethylpentane 66.42
    2-methyltetrahydrofuran 1172.88
    n-hexyl acetate 694.04
    isooctane 61.24
    2-(2-butoxyethoxy)ethanol 594.85
    sec-butyl acetate 402.04
    tert-butyl acetate 637.38
    decalin 120.71
    glycerin 321.07
    diglyme 1209.96
    acrylic acid 535.06
    isopropyl myristate 305.29
    n-butyric acid 606.71
    acetyl acetate 645.7
    di(2-ethylhexyl) phthalate 304.06
    ethyl propionate 495.45
    nitromethane 1671.64
    1,2-diethoxyethane 695.84
    benzonitrile 1060.98
    trioctyl phosphate 231.58
    1-bromopropane 679.14
    gamma-valerolactone 2536.33
    n-decanol 196.48
    triethyl phosphate 291.95
    4-methyl-2-pentanol 183.07
    propionitrile 566.14
    vinylene carbonate 1228.9
    1,1,2-trichlorotrifluoroethane 1283.8
    DMS 665.61
    cumene 227.14
    2-octanol 223.09
    2-hexanone 649.95
    octyl acetate 363.26
    limonene 368.91
    1,2-dimethoxyethane 1143.17
    ethyl orthosilicate 278.51
    tributyl phosphate 277.25
    diacetone alcohol 625.37
    N,N-dimethylaniline 530.71
    acrylonitrile 841.02
    aniline 667.04
    1,3-propanediol 353.98
    bromobenzene 1453.91
    dibromomethane 1291.56
    1,1,2,2-tetrachloroethane 1964.7
    2-methyl-cyclohexyl acetate 455.65
    tetrabutyl urea 413.37
    diisobutyl methanol 218.0
    2-phenylethanol 563.78
    styrene 495.24
    dioctyl adipate 409.99
    dimethyl sulfate 1117.95
    ethyl butyrate 508.37
    methyl lactate 413.45
    butyl lactate 404.65
    diethyl carbonate 359.14
    propanediol butyl ether 468.07
    triethyl orthoformate 374.07
    p-tert-butyltoluene 264.41
    methyl 4-tert-butylbenzoate 593.91
    morpholine 1303.64
    tert-butylamine 248.23
    n-dodecanol 166.8
    dimethoxymethane 1081.22
    ethylene carbonate 944.0
    cyrene 677.19
    2-ethoxyethyl acetate 722.32
    2-ethylhexyl acetate 542.75
    1,2,4-trichlorobenzene 1312.24
    4-methylpyridine 1561.03
    dibutyl ether 411.65
    2,6-dimethyl-4-heptanol 218.0
    DEF 1055.69
    dimethyl isosorbide 1001.19
    tetrachloroethylene 1287.67
    eugenol 642.18
    triacetin 644.67
    span 80 480.0
    1,4-butanediol 217.7
    1,1-dichloroethane 1216.25
    2-methyl-1-pentanol 275.29
    methyl formate 803.16
    2-methyl-1-butanol 296.27
    n-decane 83.74
    butyronitrile 601.95
    3,7-dimethyl-1-octanol 261.81
    1-chlorooctane 295.4
    1-chlorotetradecane 145.43
    n-nonane 83.72
    undecane 67.89
    tert-butylcyclohexane 110.41
    cyclooctane 83.0
    cyclopentanol 561.02
    tetrahydropyran 1110.91
    tert-amyl methyl ether 403.03
    2,5,8-trioxanonane 837.4
    1-hexene 248.94
    2-isopropoxyethanol 440.92
    2,2,2-trifluoroethanol 312.95
    methyl butyrate 685.39

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction