Tetrasodium Glutamate Diacetate

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  • Identifiers

    CAS number
    51981-21-6

    Molecular formula
    C9H9NNa4O8

    SMILES
    C(CC(=O)[O-])[C@@H](C(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+]

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 63.75%
    Sweet 46.6%
    Savory 25.01%
    Alcoholic 16.47%
    Buttery 16.29%
    Milky 16.1%
    Clean 15.73%
    Creamy 15.15%
    Oily 14.7%
    Winey 14.41%

     

    Flavor
    Odorless 60.77%
    Bitter 36.47%
    Bland 28.49%
    Mild 28.34%
    Very mild 27.23%
    Sweet-like 21.48%
    Yeast 21.43%
    Bread crust 19.21%
    Nitrile 18.86%
    Taco 18.63%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    -2.66 (strong acid)

    Molecular weight
    351.13 g/mol

    Flash point

    • 242.83 ˚C est.

  • Synonyms

    • 51981-21-6
    • tetrasodium glutamate diacetate
    • UNII-5EHL50I4MY
    • Tetrasodium N,N-Bis(carboxymethyl)-L-glutamate
    • 5EHL50I4MY
    • Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate
    • EINECS 257-573-7
    • DISSOLVINE GL
    • CHELEST CMG-40
    • EC 257-573-7
    • L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)
    • DTXSID2052158
    • L-Glutamic acid, N,N-bis(carboxymethyl)-, tetrasodium salt
    • GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT
    • N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT
    • L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT
    • RefChem:188887
    • DTXCID7030727
    • TETRASODIUM GLUTAMATE DIACETATE [INCI]
    • MFCD01862262
    • N,N-Bis(carboxymethyl)-L-glutamic Acid Tetrasodium Salt
    • tetrasodium;(2S)-2-[bis(carboxylatomethyl)amino]pentanedioate
    • Sodium (S)-2-(bis(carboxylatomethyl)amino)pentanedioate
    • GLDA
    • N,N-BIS-(CARBOXYMETHYL)-L-GLUTAMIC ACID TETRASODIUMN SALT
    • TETRASODIUM (2S)-2-[BIS(CARBOXYLATOMETHYL)AMINO]PENTANEDIOATE
    • N,N-Bis(carboxymethyl)-L-glutamic acid tetrasodium salt (ca. 40% in Water)
    • N,N-bis-(Carboxymethyl)-L-glutamic Acid Tetrasodiumn Salt (40% in water)
    • C9H9NNa4O8
    • SCHEMBL169001
    • orb1705734
    • FC36385
    • SY060096
    • B2135
    • F555025
    • Q25393000
    • tetrasodium mono((S)-2-(bis(carboxymethyl)amino)-4-carboxybutanoate)
    • N, N-Bis(Carboxymethyl)-L -glutamic acid tetrasodium salt - ca. 40% in water
    • 51981-21-6

  • Applications

    Tetrasodium Glutamate Diacetate (CAS 51981-21-6) is primarily used as a biodegradable chelating agent to sequester metal ions in cleaning and formulation systems. In household and industrial detergents, it helps soften water and boost cleaning performance by binding calcium, magnesium, and other trace metals. It is commonly evaluated for cosmetics and personal care formulations as a chelating/stabilizing additive that maintains product stability and ingredient compatibility. In polymer and plastics processing, it can act as a processing aid to control metal-catalyzed reactions and reduce unwanted side reactions. In coatings and inks, it serves as a stabilizing/chelating additive to improve formulation stability and film formation. It also finds use in specialty cleaners and metalworking fluids where metal ions must be controlled to prevent corrosion or degradation.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 126.24
    methanol 382.13
    isopropanol 41.15
    water 216.86
    ethyl acetate 65.56
    n-propanol 71.79
    acetone 151.67
    n-butanol 33.38
    acetonitrile 80.96
    DMF 1159.71
    toluene 37.8
    isobutanol 28.35
    1,4-dioxane 124.8
    methyl acetate 90.36
    THF 191.09
    2-butanone 76.38
    n-pentanol 24.47
    sec-butanol 27.01
    n-hexane 1.84
    ethylene glycol 252.14
    NMP 1490.02
    cyclohexane 1.52
    DMSO 1074.36
    n-butyl acetate 28.9
    n-octanol 20.66
    chloroform 13.34
    n-propyl acetate 37.15
    acetic acid 140.87
    dichloromethane 48.89
    cyclohexanone 103.73
    propylene glycol 150.06
    isopropyl acetate 27.0
    DMAc 826.93
    2-ethoxyethanol 206.11
    isopentanol 16.08
    n-heptane 2.96
    ethyl formate 83.15
    1,2-dichloroethane 55.03
    n-hexanol 17.43
    2-methoxyethanol 461.85
    isobutyl acetate 12.27
    tetrachloromethane 1.43
    n-pentyl acetate 29.51
    transcutol 402.02
    n-heptanol 16.91
    ethylbenzene 13.28
    MIBK 18.55
    2-propoxyethanol 164.9
    tert-butanol 26.55
    MTBE 13.39
    2-butoxyethanol 91.34
    propionic acid 128.35
    o-xylene 31.46
    formic acid 568.57
    diethyl ether 27.63
    m-xylene 26.54
    p-xylene 15.39
    chlorobenzene 20.72
    dimethyl carbonate 173.47
    n-octane 1.84
    formamide 834.28
    cyclopentanone 212.27
    2-pentanone 51.12
    anisole 45.22
    cyclopentyl methyl ether 69.86
    gamma-butyrolactone 556.32
    1-methoxy-2-propanol 255.99
    pyridine 157.02
    3-pentanone 55.15
    furfural 495.34
    n-dodecane 1.63
    diethylene glycol 225.26
    diisopropyl ether 5.73
    tert-amyl alcohol 19.76
    acetylacetone 98.7
    n-hexadecane 1.72
    acetophenone 69.61
    methyl propionate 153.22
    isopentyl acetate 15.82
    trichloroethylene 59.77
    n-nonanol 20.83
    cyclohexanol 26.22
    benzyl alcohol 70.58
    2-ethylhexanol 9.78
    isooctanol 10.17
    dipropyl ether 27.61
    1,2-dichlorobenzene 20.12
    ethyl lactate 66.03
    propylene carbonate 146.23
    n-methylformamide 698.91
    2-pentanol 14.91
    n-pentane 2.15
    1-propoxy-2-propanol 94.7
    1-methoxy-2-propyl acetate 72.12
    2-(2-methoxypropoxy) propanol 104.72
    mesitylene 12.73
    ε-caprolactone 153.77
    p-cymene 10.22
    epichlorohydrin 275.19
    1,1,1-trichloroethane 7.95
    2-aminoethanol 254.35
    morpholine-4-carbaldehyde 875.5
    sulfolane 684.14
    2,2,4-trimethylpentane 0.7
    2-methyltetrahydrofuran 70.7
    n-hexyl acetate 36.98
    isooctane 0.39
    2-(2-butoxyethoxy)ethanol 169.53
    sec-butyl acetate 14.91
    tert-butyl acetate 21.55
    decalin 1.41
    glycerin 312.22
    diglyme 230.31
    acrylic acid 226.55
    isopropyl myristate 14.15
    n-butyric acid 64.33
    acetyl acetate 34.43
    di(2-ethylhexyl) phthalate 24.19
    ethyl propionate 49.86
    nitromethane 452.81
    1,2-diethoxyethane 59.14
    benzonitrile 48.83
    trioctyl phosphate 18.85
    1-bromopropane 16.47
    gamma-valerolactone 558.33
    n-decanol 16.86
    triethyl phosphate 19.44
    4-methyl-2-pentanol 6.36
    propionitrile 47.02
    vinylene carbonate 189.14
    1,1,2-trichlorotrifluoroethane 196.02
    DMS 88.17
    cumene 8.53
    2-octanol 11.12
    2-hexanone 26.07
    octyl acetate 24.65
    limonene 10.81
    1,2-dimethoxyethane 187.55
    ethyl orthosilicate 15.85
    tributyl phosphate 21.23
    diacetone alcohol 52.5
    N,N-dimethylaniline 46.69
    acrylonitrile 127.72
    aniline 69.92
    1,3-propanediol 145.68
    bromobenzene 15.78
    dibromomethane 22.42
    1,1,2,2-tetrachloroethane 40.16
    2-methyl-cyclohexyl acetate 19.17
    tetrabutyl urea 47.8
    diisobutyl methanol 5.45
    2-phenylethanol 38.37
    styrene 15.71
    dioctyl adipate 30.78
    dimethyl sulfate 365.06
    ethyl butyrate 29.95
    methyl lactate 211.95
    butyl lactate 55.19
    diethyl carbonate 21.2
    propanediol butyl ether 105.03
    triethyl orthoformate 24.21
    p-tert-butyltoluene 9.13
    methyl 4-tert-butylbenzoate 73.43
    morpholine 203.72
    tert-butylamine 10.81
    n-dodecanol 12.51
    dimethoxymethane 428.44
    ethylene carbonate 115.62
    cyrene 168.98
    2-ethoxyethyl acetate 72.42
    2-ethylhexyl acetate 13.4
    1,2,4-trichlorobenzene 27.74
    4-methylpyridine 138.65
    dibutyl ether 17.62
    2,6-dimethyl-4-heptanol 5.45
    DEF 172.66
    dimethyl isosorbide 180.66
    tetrachloroethylene 24.28
    eugenol 87.93
    triacetin 82.06
    span 80 84.26
    1,4-butanediol 73.13
    1,1-dichloroethane 17.28
    2-methyl-1-pentanol 12.1
    methyl formate 494.78
    2-methyl-1-butanol 19.07
    n-decane 2.6
    butyronitrile 28.15
    3,7-dimethyl-1-octanol 11.16
    1-chlorooctane 8.04
    1-chlorotetradecane 3.85
    n-nonane 2.44
    undecane 2.08
    tert-butylcyclohexane 1.0
    cyclooctane 1.16
    cyclopentanol 45.76
    tetrahydropyran 42.16
    tert-amyl methyl ether 17.29
    2,5,8-trioxanonane 196.83
    1-hexene 6.34
    2-isopropoxyethanol 78.38
    2,2,2-trifluoroethanol 101.79
    methyl butyrate 57.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction