Tetrasodium Etidronate

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  • Identifiers

    CAS number
    3794-83-0

    Molecular formula
    C2H4Na4O7P2

    SMILES
    CC(O)(P(=O)([O-])[O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 78.82%
    Sweet 27.53%
    Savory 16.03%
    Clean 15.73%
    Bitter 14.61%
    Cooling 13.91%
    Milky 12.27%
    Dry 11.85%
    Buttery 11.12%
    Balsamic 11.08%

     

    Flavor
    Odorless 62.89%
    Bland 26.62%
    Very mild 24.44%
    Mild 22.58%
    Sweet-like 20.23%
    Yeast 18.96%
    Mousy 18.21%
    Very slight 17.88%
    Soy 17.57%
    Sour 17.54%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    2.87 (strong acid)

    Molecular weight
    293.96 g/mol

    Flash point

    • 208.21 ˚C est.

  • Synonyms

    • 3794-83-0
    • Tetrasodium etidronate
    • Tarpinel 4NL
    • Turpinal 4NL
    • Sequion 10Na4
    • etidronate tetrasodium
    • Defloc EN 43
    • Dequest 2016
    • UNII-CZZ9T1T1X4
    • EINECS 223-267-7
    • CZZ9T1T1X4
    • Tetrasodium 1-hydroxyethylidene-1,1-diphosphonate
    • (1-Hydroxyethylidene)diphosphonic acid, tetrasodium salt
    • Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt
    • 1-Hydroxyethylidene-1,1-diphosphonic acid, tetrasodium salt
    • DTXSID7029663
    • Tetrasodium 1-hydroxyethane-1, 1-diphosphonate
    • EC 223-267-7
    • ETIDRONATE TETRASODIUM [WHO-DD]
    • (1-Hydroxyethylidene)bisphosphonic acid, tetrasodium salt
    • DIPHOSPHONIC ACID, (1-HYDROXYETHYLIDENE)-, TETRASODIUM SALT
    • RefChem:188886
    • DTXCID109663
    • TETRASODIUM ETIDRONATE [INCI]
    • 223-267-7
    • (1-Hydroxyethylidene)bis-phosphonic acid tetrasodium salt
    • Phosphonic acid, (1-hydroxyethylidene)bis-, tetrasodium salt
    • tetrasodium;1,1-diphosphonatoethanol
    • MFCD01729922
    • Phosphonic acid, (1-hydroxyethylidene)bis-, sodium salt
    • (1-Hydroxyethylidene)bis-phosphonicacidtetrasodiumsalt
    • 29329-71-3
    • Tetrasodium (1-hydroxyethylidene)bisphosphonate
    • C2H4Na4O7P2
    • SCHEMBL157065
    • KWXLCDNSEHTOCB-UHFFFAOYSA-J
    • AKOS015899696
    • AS-15257
    • sodium-1-hydroxyethane-1,1-diphosphonate
    • Tetrasodium 1-hydroxyethylidenediphosphonate
    • NS00078309
    • F71280
    • 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt
    • Q27275911
    • tetrasodium (1-hydroxyethane-1,1-diyl)bis(phosphonate)
    • Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:4)
    • 3794-83-0

  • Applications

    Tetrasodium etidronate functions as a chelating agent and a scale and corrosion inhibitor in water treatment, where it sequesters Ca2+/Mg2+ to prevent scale formation in boiler feedwater, cooling systems, and desalination processes, and is also used in oilfield water treatment. It is commonly used as a builder/chelating additive in detergents and cleaners to improve performance in hard water. In cosmetics and personal care, it acts as a chelating agent and stabilizer to improve formulation stability and preserve product integrity. In plastics and polymer processing, it serves as a processing aid and stabilizer to control metal ions and minimize deposit formation during manufacturing. In metalworking fluids and industrial cutting fluids, it functions as a corrosion inhibitor and chelating agent to protect metal surfaces. In textiles and papermaking, it can be used to control metal ions and reduce deposits that affect process efficiency and end-product quality.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 402.31
    methanol 959.15
    isopropanol 260.07
    water 1515.14
    ethyl acetate 27.5
    n-propanol 178.56
    acetone 190.94
    n-butanol 143.41
    acetonitrile 54.08
    DMF 851.26
    toluene 12.59
    isobutanol 88.87
    1,4-dioxane 83.79
    methyl acetate 31.17
    THF 187.87
    2-butanone 61.3
    n-pentanol 78.16
    sec-butanol 122.71
    n-hexane 7.3
    ethylene glycol 463.04
    NMP 241.11
    cyclohexane 14.39
    DMSO 945.74
    n-butyl acetate 13.21
    n-octanol 44.57
    chloroform 16.19
    n-propyl acetate 16.97
    acetic acid 70.13
    dichloromethane 26.29
    cyclohexanone 46.79
    propylene glycol 245.04
    isopropyl acetate 26.04
    DMAc 321.96
    2-ethoxyethanol 307.66
    isopentanol 90.62
    n-heptane 14.05
    ethyl formate 44.85
    1,2-dichloroethane 29.11
    n-hexanol 60.22
    2-methoxyethanol 701.99
    isobutyl acetate 6.01
    tetrachloromethane 8.67
    n-pentyl acetate 15.41
    transcutol 126.53
    n-heptanol 50.29
    ethylbenzene 7.17
    MIBK 50.42
    2-propoxyethanol 181.72
    tert-butanol 234.99
    MTBE 55.68
    2-butoxyethanol 105.9
    propionic acid 40.5
    o-xylene 16.76
    formic acid 340.73
    diethyl ether 89.94
    m-xylene 14.74
    p-xylene 7.45
    chlorobenzene 4.3
    dimethyl carbonate 51.21
    n-octane 7.43
    formamide 575.43
    cyclopentanone 87.32
    2-pentanone 82.17
    anisole 20.44
    cyclopentyl methyl ether 65.5
    gamma-butyrolactone 67.66
    1-methoxy-2-propanol 488.56
    pyridine 30.89
    3-pentanone 45.62
    furfural 61.73
    n-dodecane 3.86
    diethylene glycol 263.98
    diisopropyl ether 25.2
    tert-amyl alcohol 119.63
    acetylacetone 71.24
    n-hexadecane 3.91
    acetophenone 22.83
    methyl propionate 45.66
    isopentyl acetate 9.76
    trichloroethylene 17.88
    n-nonanol 39.92
    cyclohexanol 60.44
    benzyl alcohol 31.53
    2-ethylhexanol 22.13
    isooctanol 30.5
    dipropyl ether 35.63
    1,2-dichlorobenzene 5.2
    ethyl lactate 38.23
    propylene carbonate 23.53
    n-methylformamide 369.82
    2-pentanol 105.01
    n-pentane 20.94
    1-propoxy-2-propanol 100.67
    1-methoxy-2-propyl acetate 29.57
    2-(2-methoxypropoxy) propanol 57.06
    mesitylene 14.8
    ε-caprolactone 28.85
    p-cymene 9.23
    epichlorohydrin 61.36
    1,1,1-trichloroethane 8.12
    2-aminoethanol 415.29
    morpholine-4-carbaldehyde 198.77
    sulfolane 143.23
    2,2,4-trimethylpentane 4.83
    2-methyltetrahydrofuran 64.19
    n-hexyl acetate 19.24
    isooctane 4.51
    2-(2-butoxyethoxy)ethanol 84.15
    sec-butyl acetate 9.97
    tert-butyl acetate 33.85
    decalin 3.12
    glycerin 388.76
    diglyme 147.29
    acrylic acid 42.46
    isopropyl myristate 10.76
    n-butyric acid 43.84
    acetyl acetate 12.72
    di(2-ethylhexyl) phthalate 10.54
    ethyl propionate 18.38
    nitromethane 126.42
    1,2-diethoxyethane 33.14
    benzonitrile 10.75
    trioctyl phosphate 12.01
    1-bromopropane 20.04
    gamma-valerolactone 103.97
    n-decanol 29.99
    triethyl phosphate 10.05
    4-methyl-2-pentanol 52.13
    propionitrile 34.77
    vinylene carbonate 17.73
    1,1,2-trichlorotrifluoroethane 68.07
    DMS 12.24
    cumene 6.51
    2-octanol 33.91
    2-hexanone 29.04
    octyl acetate 15.06
    limonene 13.61
    1,2-dimethoxyethane 244.76
    ethyl orthosilicate 10.66
    tributyl phosphate 8.25
    diacetone alcohol 108.28
    N,N-dimethylaniline 33.32
    acrylonitrile 43.1
    aniline 26.6
    1,3-propanediol 348.65
    bromobenzene 3.41
    dibromomethane 20.93
    1,1,2,2-tetrachloroethane 24.6
    2-methyl-cyclohexyl acetate 11.23
    tetrabutyl urea 22.99
    diisobutyl methanol 21.8
    2-phenylethanol 26.42
    styrene 6.54
    dioctyl adipate 11.92
    dimethyl sulfate 87.29
    ethyl butyrate 14.73
    methyl lactate 96.36
    butyl lactate 24.69
    diethyl carbonate 8.38
    propanediol butyl ether 87.14
    triethyl orthoformate 13.25
    p-tert-butyltoluene 11.02
    methyl 4-tert-butylbenzoate 34.31
    morpholine 133.32
    tert-butylamine 120.78
    n-dodecanol 21.48
    dimethoxymethane 496.47
    ethylene carbonate 16.27
    cyrene 69.91
    2-ethoxyethyl acetate 20.33
    2-ethylhexyl acetate 6.89
    1,2,4-trichlorobenzene 5.64
    4-methylpyridine 26.82
    dibutyl ether 17.49
    2,6-dimethyl-4-heptanol 21.8
    DEF 118.9
    dimethyl isosorbide 62.58
    tetrachloroethylene 22.86
    eugenol 42.41
    triacetin 17.81
    span 80 39.74
    1,4-butanediol 165.08
    1,1-dichloroethane 15.62
    2-methyl-1-pentanol 41.63
    methyl formate 204.53
    2-methyl-1-butanol 70.51
    n-decane 6.75
    butyronitrile 38.34
    3,7-dimethyl-1-octanol 24.73
    1-chlorooctane 11.35
    1-chlorotetradecane 5.24
    n-nonane 7.28
    undecane 5.0
    tert-butylcyclohexane 2.65
    cyclooctane 9.86
    cyclopentanol 86.44
    tetrahydropyran 50.87
    tert-amyl methyl ether 49.56
    2,5,8-trioxanonane 103.08
    1-hexene 12.24
    2-isopropoxyethanol 131.22
    2,2,2-trifluoroethanol 69.01
    methyl butyrate 26.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction