Tetramethyllead

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  • Identifiers

    CAS number
    75-74-1

    Molecular formula
    C4H12Pb

    SMILES
    C[Pb](C)(C)C

    Safety labels

    Flammable
    Flammable

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Camphoreous 49.05%
    Ethereal 37.35%
    Fresh 33.54%
    Mint 32.53%
    Woody 30.4%
    Gassy 28.19%
    Solvent 27.56%
    Musty 25.94%
    Fermented 24.46%
    Pungent 22.98%

     

  • Properties

    pKa est.
    -212.34 (strong acid)

    Molecular weight
    267.0 g/mol

    Melting point expt.

    • -17.5 °F (EPA, 1998)
    • -30.2 °C
    • -27.5 °C
    • -17.5 °F
    • -15 °F

    Boiling point

    • 230 °F at 10 mmHg Decomposes above 212 °F (EPA, 1998)
    • 110 °C
    • at 1.33kPa: 110 °C
    • 230 °F at 10 mmHg (decomposes above 212 °F)
    • 212 °F (Decomposes)

    Flash point

    • 5545819.85 ˚C est.
    • 100.4 °F (EPA, 1998)
    • 100 °F (open cup)
    • 100 °F (38 °C) (closed cup)
    • 37.8 °C c.c.
    • 100 °F

    Solubility expt.

    • Insoluble (NTP, 1992)
    • Slightly soluble in benzene, petroleum ether, alcohol
    • SLIGHTLY SOL IN ETHYL ETHER; MISCIBLE IN FATS & OILS
    • In water, 15 mg/L at 25 °C
    • Solubility in water: none
    • 0.002%

  • Synonyms

    • Tetramethyllead
    • Tetramethylplumbane
    • Plumbane, tetramethyl-
    • 75-74-1
    • TETRAMETHYL LEAD
    • Lead tetramethyl
    • Lead, tetramethyl-
    • Tetramethylolovo
    • Piombo tetra-metile
    • Bleitetramethyl
    • CCRIS 5940
    • HSDB 1677
    • EINECS 200-897-0
    • UNII-C7J62Z32IW
    • BRN 3902986
    • LEAD, TETRAMETHYL
    • PLUMBANE, TETRAMETHYL
    • (CH3)4Pb
    • C7J62Z32IW
    • TETRAMETHYL LEAD [HSDB]
    • DTXSID0026123
    • CHEBI:30183
    • 4-04-00-04348 (Beilstein Handbook Reference)
    • TML
    • Tetramethylblei
    • Tetramethylolovo [Czech]
    • Piombo tetra-metile [Italian]
    • Methylplumban
    • Methyl plumbane
    • Piombotetrametile
    • MOTOR FUEL ANTIKNOCK COMPOUNDS (CONTAIN LEAD) (TETRA-METHYL LEAD)
    • MOTOR FUEL ANTIKNOCK COMPOUNDS (CONTAIN LEAD) {TETRA-METHYL LEAD}
    • Tetra-methyl lead
    • PbMe4
    • Tetrametile di piombo
    • Tetramethylblei (German)
    • DTXCID606123
    • Tetramethyl lead (ACGIH:OSHA)
    • NS00078882
    • TETRAMETHYL LEAD, TOLUENE BLEND NO.2
    • G28834
    • EN300-7570031
    • Q425777

  • Applications

    Tetramethyllead (CAS 75-74-1) is an organolead compound historically used as an anti-knock additive in leaded gasoline; today its use has diminished considerably due to health, environmental concerns and regulatory controls. In organometallic chemistry, it is considered a methyl source and a precursor to other lead-containing reagents, employed in specialized laboratory syntheses. Tetramethyllead is typically used in research and development contexts for preparing organolead compounds, with uses governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 262.88
    methanol 235.05
    isopropanol 233.09
    water 3.08
    ethyl acetate 135.0
    n-propanol 247.96
    acetone 242.08
    n-butanol 259.36
    acetonitrile 95.07
    DMF 237.44
    toluene 139.16
    isobutanol 189.25
    1,4-dioxane 310.6
    methyl acetate 116.96
    THF 876.51
    2-butanone 201.95
    n-pentanol 216.33
    sec-butanol 221.09
    n-hexane 205.76
    ethylene glycol 87.12
    NMP 309.49
    cyclohexane 247.99
    DMSO 312.64
    n-butyl acetate 252.75
    n-octanol 300.0
    chloroform 259.39
    n-propyl acetate 150.91
    acetic acid 165.04
    dichloromethane 175.52
    cyclohexanone 346.7
    propylene glycol 129.94
    isopropyl acetate 135.41
    DMAc 182.5
    2-ethoxyethanol 217.78
    isopentanol 220.23
    n-heptane 336.85
    ethyl formate 97.37
    1,2-dichloroethane 157.97
    n-hexanol 382.54
    2-methoxyethanol 307.53
    isobutyl acetate 135.17
    tetrachloromethane 95.45
    n-pentyl acetate 210.3
    transcutol 521.77
    n-heptanol 311.61
    ethylbenzene 109.49
    MIBK 194.27
    2-propoxyethanol 400.96
    tert-butanol 293.68
    MTBE 222.52
    2-butoxyethanol 318.07
    propionic acid 153.11
    o-xylene 112.02
    formic acid 58.74
    diethyl ether 253.98
    m-xylene 137.5
    p-xylene 118.89
    chlorobenzene 131.07
    dimethyl carbonate 77.86
    n-octane 148.39
    formamide 73.47
    cyclopentanone 469.96
    2-pentanone 229.29
    anisole 156.03
    cyclopentyl methyl ether 430.06
    gamma-butyrolactone 359.17
    1-methoxy-2-propanol 312.82
    pyridine 217.21
    3-pentanone 170.84
    furfural 234.39
    n-dodecane 95.34
    diethylene glycol 245.39
    diisopropyl ether 161.42
    tert-amyl alcohol 244.0
    acetylacetone 206.31
    n-hexadecane 102.14
    acetophenone 144.23
    methyl propionate 133.75
    isopentyl acetate 229.72
    trichloroethylene 204.06
    n-nonanol 274.84
    cyclohexanol 293.36
    benzyl alcohol 126.15
    2-ethylhexanol 296.67
    isooctanol 253.3
    dipropyl ether 419.4
    1,2-dichlorobenzene 117.15
    ethyl lactate 108.28
    propylene carbonate 196.66
    n-methylformamide 124.52
    2-pentanol 235.5
    n-pentane 193.8
    1-propoxy-2-propanol 421.22
    1-methoxy-2-propyl acetate 217.39
    2-(2-methoxypropoxy) propanol 239.67
    mesitylene 121.6
    ε-caprolactone 251.61
    p-cymene 150.57
    epichlorohydrin 270.98
    1,1,1-trichloroethane 166.18
    2-aminoethanol 155.62
    morpholine-4-carbaldehyde 259.41
    sulfolane 474.97
    2,2,4-trimethylpentane 88.12
    2-methyltetrahydrofuran 475.05
    n-hexyl acetate 271.99
    isooctane 100.2
    2-(2-butoxyethoxy)ethanol 348.86
    sec-butyl acetate 123.23
    tert-butyl acetate 207.74
    decalin 106.29
    glycerin 158.19
    diglyme 434.34
    acrylic acid 122.64
    isopropyl myristate 173.62
    n-butyric acid 210.75
    acetyl acetate 96.38
    di(2-ethylhexyl) phthalate 124.67
    ethyl propionate 133.35
    nitromethane 143.65
    1,2-diethoxyethane 268.74
    benzonitrile 130.18
    trioctyl phosphate 130.46
    1-bromopropane 186.43
    gamma-valerolactone 369.29
    n-decanol 222.13
    triethyl phosphate 116.31
    4-methyl-2-pentanol 177.46
    propionitrile 126.23
    vinylene carbonate 140.68
    1,1,2-trichlorotrifluoroethane 204.19
    DMS 111.62
    cumene 101.08
    2-octanol 245.98
    2-hexanone 216.63
    octyl acetate 196.02
    limonene 230.85
    1,2-dimethoxyethane 289.41
    ethyl orthosilicate 135.45
    tributyl phosphate 126.71
    diacetone alcohol 247.17
    N,N-dimethylaniline 150.46
    acrylonitrile 114.3
    aniline 153.7
    1,3-propanediol 191.18
    bromobenzene 123.85
    dibromomethane 184.62
    1,1,2,2-tetrachloroethane 225.52
    2-methyl-cyclohexyl acetate 211.33
    tetrabutyl urea 173.55
    diisobutyl methanol 232.79
    2-phenylethanol 197.6
    styrene 113.74
    dioctyl adipate 186.75
    dimethyl sulfate 105.52
    ethyl butyrate 206.24
    methyl lactate 116.78
    butyl lactate 187.53
    diethyl carbonate 119.32
    propanediol butyl ether 299.79
    triethyl orthoformate 196.48
    p-tert-butyltoluene 173.92
    methyl 4-tert-butylbenzoate 227.14
    morpholine 360.84
    tert-butylamine 265.02
    n-dodecanol 190.57
    dimethoxymethane 251.05
    ethylene carbonate 131.68
    cyrene 210.73
    2-ethoxyethyl acetate 174.84
    2-ethylhexyl acetate 207.92
    1,2,4-trichlorobenzene 137.61
    4-methylpyridine 178.13
    dibutyl ether 314.22
    2,6-dimethyl-4-heptanol 232.79
    DEF 166.95
    dimethyl isosorbide 347.56
    tetrachloroethylene 171.15
    eugenol 208.93
    triacetin 190.36
    span 80 303.12
    1,4-butanediol 106.72
    1,1-dichloroethane 158.33
    2-methyl-1-pentanol 183.17
    methyl formate 97.43
    2-methyl-1-butanol 198.94
    n-decane 148.9
    butyronitrile 154.93
    3,7-dimethyl-1-octanol 260.63
    1-chlorooctane 240.1
    1-chlorotetradecane 126.73
    n-nonane 160.79
    undecane 114.33
    tert-butylcyclohexane 116.96
    cyclooctane 154.32
    cyclopentanol 340.64
    tetrahydropyran 447.89
    tert-amyl methyl ether 217.34
    2,5,8-trioxanonane 344.17
    1-hexene 249.15
    2-isopropoxyethanol 182.56
    2,2,2-trifluoroethanol 64.59
    methyl butyrate 157.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction