Tetrahydropyran

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  • Identifiers

    CAS number
    142-68-7

    Molecular formula
    C5H10O

    SMILES
    C1CCOCC1

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Sweet 88.42%
    Ethereal 69.37%
    Solvent 53.34%
    Pungent 37.7%
    Musty 30.47%
    Mint 28.95%
    Fermented 27.9%
    Alcoholic 26.75%
    Animal 26.59%
    Rummy 26.21%

    Scent© AI

  • Properties

    XLogP3-AA
    0.9

    Molecular weight
    86.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -45 °C
    • -49.2 °C

    Boiling point

    • 88 °C

    Flash point est.
    -5.36 ˚C

    Flash point expt.

    • -4.0 °F (-20 °C) CC

    Solubility expt.

    • 80200 mg/L (at 25 °C)
    • MISCIBLE WITH ALC, ETHER, MANY OTHER ORG SOLVENTS
    • SOL IN BENZENE
    • water solubility = 80,200 mg/l @ 25 °C

  • Synonyms

    • TETRAHYDROPYRAN
    • 142-68-7
    • Oxane
    • Tetrahydro-2H-pyran
    • Oxacyclohexane
    • 2H-Pyran, tetrahydro-
    • Pentamethylene oxide
    • Tetrahydropyrane
    • 2H-tetrahydropyran
    • Oxane (VAN)
    • UNII-V06I3ILG6B
    • EINECS 205-552-8
    • V06I3ILG6B
    • HSDB 126
    • NSC 65448
    • NSC-65448
    • TETRAHYDROPYRAN [MI]
    • TETRAHYDROPYRAN [HSDB]
    • AI3-16499
    • DTXSID3059719
    • CHEBI:46941
    • PYE
    • tetrahydro-pyran
    • Tetrahydro2Hpyran
    • pyran, tetrahydro-
    • 1,1-dioxane
    • 2HPyran, tetrahydro
    • MFCD00006585
    • Tetrahydro-4H-pyran
    • DTXCID3034612
    • Tetrahydropyran, anhydrous, 99%
    • NSC65448
    • AKOS009031627
    • DB02412
    • DB-042642
    • NS00021654
    • T0110
    • H11250
    • A807947
    • Q412815
    • F0001-0499
    • 205-552-8

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 471.29
    methanol 481.6
    isopropanol 323.86
    water 3.12
    ethyl acetate 433.21
    n-propanol 377.87
    acetone 343.53
    n-butanol 329.61
    acetonitrile 550.8
    DMF 308.43
    toluene 184.65
    isobutanol 228.17
    1,4-dioxane 538.0
    methyl acetate 346.85
    THF 698.95
    2-butanone 310.22
    n-pentanol 201.63
    sec-butanol 291.42
    n-hexane 75.32
    ethylene glycol 141.38
    NMP 296.74
    cyclohexane 125.7
    DMSO 456.36
    n-butyl acetate 257.93
    n-octanol 97.04
    chloroform 2005.47
    n-propyl acetate 185.36
    acetic acid 788.82
    dichloromethane 1420.05
    cyclohexanone 361.47
    propylene glycol 189.05
    isopropyl acetate 193.11
    DMAc 227.76
    2-ethoxyethanol 277.32
    isopentanol 213.72
    n-heptane 85.95
    ethyl formate 242.15
    1,2-dichloroethane 607.5
    n-hexanol 234.92
    2-methoxyethanol 487.92
    isobutyl acetate 94.52
    tetrachloromethane 369.61
    n-pentyl acetate 143.06
    transcutol 879.53
    n-heptanol 106.76
    ethylbenzene 77.22
    MIBK 114.94
    2-propoxyethanol 333.62
    tert-butanol 286.14
    MTBE 184.92
    2-butoxyethanol 203.49
    propionic acid 474.63
    o-xylene 97.78
    formic acid 214.57
    diethyl ether 355.57
    m-xylene 92.46
    p-xylene 97.89
    chlorobenzene 308.61
    dimethyl carbonate 73.78
    n-octane 25.64
    formamide 247.45
    cyclopentanone 445.82
    2-pentanone 239.9
    anisole 146.15
    cyclopentyl methyl ether 270.39
    gamma-butyrolactone 599.87
    1-methoxy-2-propanol 342.16
    pyridine 694.47
    3-pentanone 193.33
    furfural 572.83
    n-dodecane 15.78
    diethylene glycol 271.69
    diisopropyl ether 72.61
    tert-amyl alcohol 245.61
    acetylacetone 245.4
    n-hexadecane 17.1
    acetophenone 128.17
    methyl propionate 254.4
    isopentyl acetate 161.44
    trichloroethylene 1182.08
    n-nonanol 89.47
    cyclohexanol 247.33
    benzyl alcohol 164.09
    2-ethylhexanol 142.24
    isooctanol 78.84
    dipropyl ether 235.34
    1,2-dichlorobenzene 236.45
    ethyl lactate 91.11
    propylene carbonate 325.82
    n-methylformamide 272.76
    2-pentanol 210.88
    n-pentane 79.55
    1-propoxy-2-propanol 261.88
    1-methoxy-2-propyl acetate 181.59
    2-(2-methoxypropoxy) propanol 150.96
    mesitylene 51.32
    ε-caprolactone 366.94
    p-cymene 65.35
    epichlorohydrin 603.03
    1,1,1-trichloroethane 702.21
    2-aminoethanol 278.24
    morpholine-4-carbaldehyde 375.82
    sulfolane 470.23
    2,2,4-trimethylpentane 28.36
    2-methyltetrahydrofuran 503.68
    n-hexyl acetate 163.59
    isooctane 17.63
    2-(2-butoxyethoxy)ethanol 248.0
    sec-butyl acetate 111.78
    tert-butyl acetate 145.18
    decalin 35.07
    glycerin 235.06
    diglyme 431.81
    acrylic acid 446.08
    isopropyl myristate 63.2
    n-butyric acid 552.37
    acetyl acetate 269.01
    di(2-ethylhexyl) phthalate 62.19
    ethyl propionate 169.96
    nitromethane 700.56
    1,2-diethoxyethane 299.69
    benzonitrile 274.09
    trioctyl phosphate 44.28
    1-bromopropane 460.16
    gamma-valerolactone 482.64
    n-decanol 64.23
    triethyl phosphate 74.7
    4-methyl-2-pentanol 90.6
    propionitrile 411.68
    vinylene carbonate 295.51
    1,1,2-trichlorotrifluoroethane 576.26
    DMS 109.78
    cumene 47.9
    2-octanol 64.71
    2-hexanone 160.48
    octyl acetate 84.3
    limonene 104.77
    1,2-dimethoxyethane 338.58
    ethyl orthosilicate 76.5
    tributyl phosphate 59.49
    diacetone alcohol 169.39
    N,N-dimethylaniline 85.66
    acrylonitrile 491.58
    aniline 291.75
    1,3-propanediol 322.51
    bromobenzene 316.74
    dibromomethane 1027.19
    1,1,2,2-tetrachloroethane 915.36
    2-methyl-cyclohexyl acetate 107.08
    tetrabutyl urea 69.26
    diisobutyl methanol 78.62
    2-phenylethanol 164.08
    styrene 119.01
    dioctyl adipate 96.72
    dimethyl sulfate 103.96
    ethyl butyrate 203.08
    methyl lactate 135.19
    butyl lactate 112.79
    diethyl carbonate 117.59
    propanediol butyl ether 152.17
    triethyl orthoformate 130.99
    p-tert-butyltoluene 60.71
    methyl 4-tert-butylbenzoate 113.94
    morpholine 619.53
    tert-butylamine 233.24
    n-dodecanol 49.88
    dimethoxymethane 202.81
    ethylene carbonate 244.8
    cyrene 108.59
    2-ethoxyethyl acetate 184.04
    2-ethylhexyl acetate 137.52
    1,2,4-trichlorobenzene 281.87
    4-methylpyridine 398.5
    dibutyl ether 167.53
    2,6-dimethyl-4-heptanol 78.62
    DEF 271.01
    dimethyl isosorbide 195.4
    tetrachloroethylene 673.61
    eugenol 116.24
    triacetin 165.93
    span 80 171.68
    1,4-butanediol 113.2
    1,1-dichloroethane 688.41
    2-methyl-1-pentanol 144.09
    methyl formate 170.71
    2-methyl-1-butanol 217.24
    n-decane 29.47
    butyronitrile 377.74
    3,7-dimethyl-1-octanol 99.4
    1-chlorooctane 82.62
    1-chlorotetradecane 32.65
    n-nonane 31.41
    undecane 20.61
    tert-butylcyclohexane 30.0
    cyclooctane 42.37
    cyclopentanol 294.06
    tetrahydropyran 516.0
    tert-amyl methyl ether 149.13
    2,5,8-trioxanonane 279.14
    1-hexene 190.51
    2-isopropoxyethanol 171.74
    2,2,2-trifluoroethanol 247.53
    methyl butyrate 207.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction