Tetrahydropiperine

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  • Identifiers

    CAS number
    23434-88-0

    Molecular formula
    C17H23NO3

    SMILES
    C1CCN(CC1)C(=O)CCCCC2=CC3=C(C=C2)OCO3

    Safety labels

  • Odor profile

    Fragrance
    Animal 33.62%
    Spicy 29.88%
    Odorless 27.07%
    Fresh 25.19%
    Savory 24.5%
    Herbal 24.42%
    Jasmin 23.8%
    Cooling 23.58%
    Floral 22.98%
    Sweet 21.2%

     

    Flavor
    Bitter 40.17%
    Herbal 22.84%
    Bland 21.64%
    Lovage 21.46%
    Odorless 21.2%
    Cedarleaf 20.94%
    Animal 20.81%
    Outdoor 20.61%
    Parsley 20.54%
    Floral 19.99%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    7.49 (neutral)

    Molecular weight
    289.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    443°C

    Flash point

    • 179.88 ˚C est.

  • Synonyms

    • Tetrahydropiperine
    • 23434-88-0
    • Tetrahydropiperidine
    • Cosmoperine
    • 1-Pentanone, 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-
    • 5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpentan-1-one
    • UNII-8904DO502T
    • 8904DO502T
    • Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxopentyl)-
    • Piperidine, 1-(5-(3,4-(methylenedioxy)phenyl)valeryl)-
    • DTXSID00177988
    • Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxopentyl]-
    • 5-(3,4-Methylenedioxyphenyl) Pentanoicacid Piperidine Amide
    • RefChem:188697
    • TETRAHYDROPIPERINE [INCI]
    • DTXCID60100479
    • 927-574-3
    • Tetrahydropiperin
    • 5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)pentan-1-one
    • CHEMBL332479
    • MFCD17167032
    • 5-(2H-1,3-BENZODIOXOL-5-YL)-1-(PIPERIDIN-1-YL)PENTAN-1-ONE
    • 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-1-pentanone
    • orb1301491
    • SCHEMBL4898699
    • SCHEMBL29392462
    • CHEBI:184110
    • HMS3886A15
    • HY-N4205
    • YAA43488
    • BDBM50381233
    • MSK175423
    • s5154
    • XH1542
    • AKOS030631903
    • CCG-267372
    • EBC-615936
    • AC-34775
    • BS-51886
    • DA-78353
    • CS-0032425
    • NS00027417
    • E77130
    • 5-(3,4-methylenedioxyphenyl)-pentanoylpiperidine
    • 1-[5-(1,3-Benzodioxol-5-yl)pentanoyl]piperidine #
    • Q27269974
    • TetrahydropiperinTetrahydropiperidine; Tetrahydropiperin
    • 5-(1,3-benzodioxol-5-yl)-1-(1-piperidyl)pentan-1-one
    • 5-(1,3-dioxaindan-5-yl)-1-(piperidin-1-yl)pentan-1-one
    • 23434-88-0

  • Applications

    Tetrahydropiperine (CAS 23434-88-0) is primarily regarded as an intermediate in chemical synthesis, serving as a building block for piperidine-containing and related heterocyclic compounds. In practice, it is used as a precursor to prepare drug-like and biologically active derivatives and is considered a scaffold for pharmaceutical and agrochemical R&D. It is also employed as a starting material for chemical transformations to generate diverse piperidine-containing products, supporting in-house and contract research in organic chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 77.49
    methanol 106.09
    isopropanol 50.88
    water 0.33
    ethyl acetate 83.05
    n-propanol 61.91
    acetone 81.32
    n-butanol 62.15
    acetonitrile 90.52
    DMF 91.53
    toluene 44.21
    isobutanol 45.38
    1,4-dioxane 158.44
    methyl acetate 78.38
    THF 134.56
    2-butanone 89.48
    n-pentanol 52.1
    sec-butanol 46.76
    n-hexane 0.62
    ethylene glycol 27.59
    NMP 59.98
    cyclohexane 2.47
    DMSO 166.36
    n-butyl acetate 52.68
    n-octanol 17.5
    chloroform 509.22
    n-propyl acetate 68.27
    acetic acid 167.74
    dichloromethane 519.02
    cyclohexanone 141.87
    propylene glycol 33.73
    isopropyl acetate 51.48
    DMAc 140.2
    2-ethoxyethanol 145.25
    isopentanol 57.56
    n-heptane 0.69
    ethyl formate 94.85
    1,2-dichloroethane 221.29
    n-hexanol 30.74
    2-methoxyethanol 172.06
    isobutyl acetate 47.19
    tetrachloromethane 25.0
    n-pentyl acetate 39.66
    transcutol 374.72
    n-heptanol 20.16
    ethylbenzene 18.62
    MIBK 48.55
    2-propoxyethanol 94.2
    tert-butanol 40.45
    MTBE 22.37
    2-butoxyethanol 68.22
    propionic acid 73.74
    o-xylene 23.07
    formic acid 97.38
    diethyl ether 32.16
    m-xylene 23.07
    p-xylene 26.14
    chlorobenzene 86.06
    dimethyl carbonate 39.61
    n-octane 0.78
    formamide 148.05
    cyclopentanone 122.98
    2-pentanone 66.53
    anisole 50.0
    cyclopentyl methyl ether 38.9
    gamma-butyrolactone 147.54
    1-methoxy-2-propanol 102.35
    pyridine 183.85
    3-pentanone 49.26
    furfural 196.39
    n-dodecane 1.19
    diethylene glycol 110.86
    diisopropyl ether 8.26
    tert-amyl alcohol 36.84
    acetylacetone 96.92
    n-hexadecane 1.37
    acetophenone 69.2
    methyl propionate 57.51
    isopentyl acetate 52.99
    trichloroethylene 418.39
    n-nonanol 19.66
    cyclohexanol 50.98
    benzyl alcohol 72.18
    2-ethylhexanol 20.32
    isooctanol 20.11
    dipropyl ether 13.09
    1,2-dichlorobenzene 84.3
    ethyl lactate 52.07
    propylene carbonate 108.21
    n-methylformamide 85.46
    2-pentanol 30.34
    n-pentane 0.72
    1-propoxy-2-propanol 57.01
    1-methoxy-2-propyl acetate 67.27
    2-(2-methoxypropoxy) propanol 76.74
    mesitylene 12.87
    ε-caprolactone 125.3
    p-cymene 12.94
    epichlorohydrin 244.85
    1,1,1-trichloroethane 108.8
    2-aminoethanol 52.98
    morpholine-4-carbaldehyde 123.29
    sulfolane 123.76
    2,2,4-trimethylpentane 1.12
    2-methyltetrahydrofuran 72.6
    n-hexyl acetate 48.23
    isooctane 0.76
    2-(2-butoxyethoxy)ethanol 108.73
    sec-butyl acetate 44.99
    tert-butyl acetate 44.63
    decalin 1.99
    glycerin 65.91
    diglyme 192.74
    acrylic acid 78.28
    isopropyl myristate 21.26
    n-butyric acid 124.48
    acetyl acetate 71.02
    di(2-ethylhexyl) phthalate 34.13
    ethyl propionate 49.4
    nitromethane 200.96
    1,2-diethoxyethane 78.69
    benzonitrile 99.21
    trioctyl phosphate 20.05
    1-bromopropane 61.34
    gamma-valerolactone 194.15
    n-decanol 15.29
    triethyl phosphate 29.89
    4-methyl-2-pentanol 22.02
    propionitrile 74.66
    vinylene carbonate 120.49
    1,1,2-trichlorotrifluoroethane 178.66
    DMS 54.24
    cumene 12.95
    2-octanol 13.56
    2-hexanone 55.54
    octyl acetate 27.26
    limonene 13.29
    1,2-dimethoxyethane 145.66
    ethyl orthosilicate 27.15
    tributyl phosphate 27.28
    diacetone alcohol 61.23
    N,N-dimethylaniline 28.84
    acrylonitrile 107.84
    aniline 69.03
    1,3-propanediol 97.84
    bromobenzene 82.03
    dibromomethane 232.09
    1,1,2,2-tetrachloroethane 275.39
    2-methyl-cyclohexyl acetate 42.21
    tetrabutyl urea 34.61
    diisobutyl methanol 12.18
    2-phenylethanol 56.02
    styrene 25.5
    dioctyl adipate 39.1
    dimethyl sulfate 54.58
    ethyl butyrate 44.67
    methyl lactate 50.75
    butyl lactate 46.66
    diethyl carbonate 39.31
    propanediol butyl ether 60.81
    triethyl orthoformate 36.26
    p-tert-butyltoluene 10.22
    methyl 4-tert-butylbenzoate 56.0
    morpholine 158.6
    tert-butylamine 17.23
    n-dodecanol 12.0
    dimethoxymethane 84.79
    ethylene carbonate 106.28
    cyrene 73.31
    2-ethoxyethyl acetate 76.91
    2-ethylhexyl acetate 41.45
    1,2,4-trichlorobenzene 90.31
    4-methylpyridine 120.72
    dibutyl ether 21.62
    2,6-dimethyl-4-heptanol 12.18
    DEF 68.59
    dimethyl isosorbide 98.24
    tetrachloroethylene 176.5
    eugenol 65.9
    triacetin 70.02
    span 80 53.94
    1,4-butanediol 57.4
    1,1-dichloroethane 151.19
    2-methyl-1-pentanol 49.47
    methyl formate 71.33
    2-methyl-1-butanol 50.23
    n-decane 1.69
    butyronitrile 83.13
    3,7-dimethyl-1-octanol 21.59
    1-chlorooctane 10.33
    1-chlorotetradecane 5.19
    n-nonane 1.25
    undecane 1.36
    tert-butylcyclohexane 1.45
    cyclooctane 0.91
    cyclopentanol 43.35
    tetrahydropyran 87.89
    tert-amyl methyl ether 19.77
    2,5,8-trioxanonane 141.25
    1-hexene 5.24
    2-isopropoxyethanol 89.27
    2,2,2-trifluoroethanol 74.36
    methyl butyrate 72.55

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction