Tetrahydrofurfurylamine

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  • Identifiers

    CAS number
    4795-29-3

    Molecular formula
    C5H11NO

    SMILES
    C1CC(OC1)CN

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 61.42%
    Cheesy 45.83%
    Ripe 31.18%
    Meaty 28.94%
    Nutty 26.92%
    Roasted 26.1%
    Oily 25.38%
    Musty 21.95%
    Fermented 21.82%
    Savory 21.24%

     

    Flavor
    Sulfurous 48.57%
    Roasted 43.93%
    Vegetable 34.14%
    Fishy 33.37%
    Ammoniacal 32.15%
    Meaty 31.43%
    Onion 28.01%
    Chicken 27.99%
    Sulfury 25.98%
    Cauliflower 25.65%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    -0.3

    pKa est.
    5.9 (weak acid)

    Molecular weight
    101.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    163°C

    Flash point

    • 54.11 ˚C est.

  • Synonyms

    • Tetrahydrofurfurylamine
    • 4795-29-3
    • 2-Tetrahydrofurfurylamine
    • 2-Furanmethanamine, tetrahydro-
    • 2-(Aminomethyl)tetrahydrofuran
    • 2-Aminomethyltetrahydrofuran
    • Tetrahydro-2-furanmethanamine
    • Furfurylamine, tetrahydro-
    • USAF Q-2
    • NSC 76037
    • EINECS 225-351-9
    • BRN 0102729
    • AI3-25429
    • Tetrahydro-2-furanylmethylamine
    • (tetrahydrofuran-2-ylmethyl)amine
    • 2-tetrahydrofuranmethanamine
    • 5-18-09-00488 (Beilstein Handbook Reference)
    • (.+/-.)-Tetrahydrofurfurylamine
    • DTXSID40863454
    • UN 2943
    • RefChem:188674
    • DTXCID90812073
    • (+-)-TETRAHYDROFURFURYLAMINE
    • (.+-.)-TETRAHYDROFURFURYLAMINE
    • 225-351-9
    • YNOGYQAEJGADFJ-UHFFFAOYSA-N
    • (Tetrahydrofuran-2-yl)methanamine
    • oxolan-2-ylmethanamine
    • MFCD00005373
    • UN2943
    • (oxolan-2-yl)methanamine
    • 1-(OXOLAN-2-YL)METHANAMINE
    • tetrahydrofuran-2-ylmethanamine
    • 1-(tetrahydrofuran-2-yl)methanamine
    • C-(tetrahydrofuran-2-yl)methylamine
    • C-(Tetrahydro-furan-2-yl)methylamine
    • C-(Tetrahydro-furan-2-yl)-methylamine
    • oxolan-2-ylmethylamine
    • Tetrahydrofurfurylamine [UN2943] [Flammable liquid]
    • ST093334
    • tetrahydrofuran-2-ylmethylamine
    • (tetrahydrofuran-2-yl)methylamine
    • tetrahydofurfurylamine
    • Furosemide Impurity 6
    • tetrahydro-furfurylamine
    • tetrahydrofurfuryl amine
    • tetrahydrofurfuryl-amine
    • Furosemide Impurity 29
    • rac-tetrahydrofurfurylamine
    • 2-tetrahydrofurylmethylamine
    • WLN: T5OTJ B1Z
    • (?)-Tetrahydrofurfurylamine
    • Oprea1_644974
    • SCHEMBL31558
    • tetrahydrofuran-2-methylamine
    • Tetrahydrofurfurylamine, 97%
    • SCHEMBL1372823
    • SCHEMBL7002635
    • SCHEMBL9173177
    • SCHEMBL22093002
    • (tetrahydro-2-furanylmethyl)amine
    • NSC76037
    • STR02270
    • 1-(tetrahydro-2-furanyl)methanamine
    • NSC-76037
    • SBB028168
    • STL194280
    • 1-(tetrahydrofuran-2-yl)methaneamine
    • C-(tetrahydrofuran-2-yl)-methylamine
    • AKOS000119103
    • AKOS016039383
    • AB00408
    • PB47481
    • (+/-)-(tetrahydro-2-furanylmethyl)amine
    • BP-10719
    • DB-016187
    • DB-051488
    • NS00047165
    • T1072
    • EN300-18062
    • S10918
    • (R)-(-)-2-(AMINOMETHYL)TETRAHYDROFURANE
    • A827404
    • F094973
    • Tetrahydrofurfurylamine(Discontinued,See C4X-140229)
    • F2190-0384
    • Tetrahydrofurfurylamine;(tetrahydrofuran-2-yl)methanamine
    • 4795-29-3

  • Applications

    Tetrahydrofurfurylamine (CAS 4795-29-3) is primarily used as an intermediate in organic synthesis, supporting the production of pharmaceuticals and agrochemicals by providing a reactive amine building block for further transformations. It is employed as a curing agent or co-reactant for epoxy resin and polyurethane systems, enabling crosslinking and network formation in coatings and adhesives. It also serves as a precursor for functionalized amines, diamines, and heterocyclic compounds used in specialty polymers, coatings, and related materials. In some formulations, THFA can act as a solvent or co-solvent in specialized syntheses or process steps, subject to formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3268.59
    methanol 5705.39
    isopropanol 1280.89
    water 321.64
    ethyl acetate 704.19
    n-propanol 1578.29
    acetone 938.96
    n-butanol 1230.55
    acetonitrile 1064.29
    DMF 933.35
    toluene 95.24
    isobutanol 698.22
    1,4-dioxane 824.01
    methyl acetate 541.72
    THF 1443.17
    2-butanone 527.38
    n-pentanol 514.74
    sec-butanol 653.14
    n-hexane 12.3
    ethylene glycol 955.21
    NMP 667.11
    cyclohexane 31.11
    DMSO 1451.02
    n-butyl acetate 465.1
    n-octanol 98.9
    chloroform 1631.07
    n-propyl acetate 233.37
    acetic acid 4585.52
    dichloromethane 1336.75
    cyclohexanone 602.98
    propylene glycol 710.78
    isopropyl acetate 266.12
    DMAc 459.42
    2-ethoxyethanol 887.59
    isopentanol 562.2
    n-heptane 21.61
    ethyl formate 846.08
    1,2-dichloroethane 500.71
    n-hexanol 449.64
    2-methoxyethanol 2055.9
    isobutyl acetate 109.35
    tetrachloromethane 231.21
    n-pentyl acetate 153.41
    transcutol 1111.97
    n-heptanol 150.09
    ethylbenzene 18.14
    MIBK 153.16
    2-propoxyethanol 880.17
    tert-butanol 623.68
    MTBE 219.94
    2-butoxyethanol 374.45
    propionic acid 1382.5
    o-xylene 45.79
    formic acid 3676.52
    diethyl ether 410.4
    m-xylene 57.61
    p-xylene 29.75
    chlorobenzene 229.97
    dimethyl carbonate 99.06
    n-octane 6.46
    formamide 2306.33
    cyclopentanone 876.77
    2-pentanone 432.31
    anisole 99.39
    cyclopentyl methyl ether 404.96
    gamma-butyrolactone 1278.82
    1-methoxy-2-propanol 893.58
    pyridine 727.37
    3-pentanone 219.84
    furfural 1022.28
    n-dodecane 4.66
    diethylene glycol 846.35
    diisopropyl ether 54.1
    tert-amyl alcohol 337.56
    acetylacetone 346.81
    n-hexadecane 4.96
    acetophenone 95.97
    methyl propionate 383.79
    isopentyl acetate 222.3
    trichloroethylene 1010.58
    n-nonanol 80.15
    cyclohexanol 423.28
    benzyl alcohol 185.44
    2-ethylhexanol 144.27
    isooctanol 88.97
    dipropyl ether 164.58
    1,2-dichlorobenzene 153.3
    ethyl lactate 117.84
    propylene carbonate 535.04
    n-methylformamide 1486.95
    2-pentanol 424.91
    n-pentane 30.23
    1-propoxy-2-propanol 507.68
    1-methoxy-2-propyl acetate 287.67
    2-(2-methoxypropoxy) propanol 148.17
    mesitylene 29.05
    ε-caprolactone 535.89
    p-cymene 29.69
    epichlorohydrin 974.91
    1,1,1-trichloroethane 403.49
    2-aminoethanol 1462.36
    morpholine-4-carbaldehyde 656.24
    sulfolane 752.74
    2,2,4-trimethylpentane 11.02
    2-methyltetrahydrofuran 792.05
    n-hexyl acetate 143.4
    isooctane 8.36
    2-(2-butoxyethoxy)ethanol 261.26
    sec-butyl acetate 99.82
    tert-butyl acetate 162.96
    decalin 7.06
    glycerin 823.96
    diglyme 496.07
    acrylic acid 1206.23
    isopropyl myristate 38.78
    n-butyric acid 1906.07
    acetyl acetate 369.06
    di(2-ethylhexyl) phthalate 52.76
    ethyl propionate 134.75
    nitromethane 2720.39
    1,2-diethoxyethane 321.73
    benzonitrile 262.98
    trioctyl phosphate 38.67
    1-bromopropane 268.75
    gamma-valerolactone 1042.34
    n-decanol 53.39
    triethyl phosphate 58.83
    4-methyl-2-pentanol 137.71
    propionitrile 610.94
    vinylene carbonate 529.31
    1,1,2-trichlorotrifluoroethane 815.61
    DMS 94.28
    cumene 14.65
    2-octanol 67.21
    2-hexanone 175.28
    octyl acetate 62.08
    limonene 51.69
    1,2-dimethoxyethane 590.32
    ethyl orthosilicate 60.61
    tributyl phosphate 54.01
    diacetone alcohol 241.65
    N,N-dimethylaniline 46.96
    acrylonitrile 713.64
    aniline 373.65
    1,3-propanediol 1594.12
    bromobenzene 164.17
    dibromomethane 664.08
    1,1,2,2-tetrachloroethane 606.53
    2-methyl-cyclohexyl acetate 87.0
    tetrabutyl urea 59.36
    diisobutyl methanol 55.52
    2-phenylethanol 196.78
    styrene 33.72
    dioctyl adipate 64.1
    dimethyl sulfate 137.96
    ethyl butyrate 199.23
    methyl lactate 226.62
    butyl lactate 130.81
    diethyl carbonate 100.88
    propanediol butyl ether 229.38
    triethyl orthoformate 116.57
    p-tert-butyltoluene 28.11
    methyl 4-tert-butylbenzoate 83.12
    morpholine 1158.74
    tert-butylamine 298.43
    n-dodecanol 38.47
    dimethoxymethane 462.16
    ethylene carbonate 442.33
    cyrene 125.91
    2-ethoxyethyl acetate 227.88
    2-ethylhexyl acetate 145.04
    1,2,4-trichlorobenzene 181.12
    4-methylpyridine 470.82
    dibutyl ether 88.04
    2,6-dimethyl-4-heptanol 55.52
    DEF 427.45
    dimethyl isosorbide 209.64
    tetrachloroethylene 518.21
    eugenol 105.2
    triacetin 121.17
    span 80 149.61
    1,4-butanediol 528.64
    1,1-dichloroethane 590.19
    2-methyl-1-pentanol 231.53
    methyl formate 841.99
    2-methyl-1-butanol 491.38
    n-decane 8.41
    butyronitrile 724.79
    3,7-dimethyl-1-octanol 82.98
    1-chlorooctane 36.12
    1-chlorotetradecane 12.36
    n-nonane 8.09
    undecane 5.87
    tert-butylcyclohexane 7.1
    cyclooctane 9.4
    cyclopentanol 693.76
    tetrahydropyran 695.07
    tert-amyl methyl ether 125.58
    2,5,8-trioxanonane 280.8
    1-hexene 54.01
    2-isopropoxyethanol 364.2
    2,2,2-trifluoroethanol 1153.45
    methyl butyrate 232.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction