Tetrahydrofurfuryl salicylate

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  • Identifiers

    CAS number
    2217-35-8

    Molecular formula
    C12H14O4

    SMILES
    C1CC(OC1)COC(=O)C2=CC=CC=C2O

    Safety labels

  • Odor profile

    Fragrance
    Sweet 79.14%
    Floral 70.63%
    Balsamic 51.5%
    Green 45.53%
    Herbal 45.2%
    Spicy 32.91%
    Fruity 32.14%
    Vanilla 31.68%
    Aromatic 31.63%
    Hay 28.72%

     

    Flavor
    Bitter 41.06%
    Sweet 34.76%
    Floral 30.79%
    Fruity 26.3%
    Balsam 25.25%
    Herbal 25.11%
    Faint 23.88%
    Ethyl benzoate 22.65%
    Powdery 22.05%
    Odorless 21.89%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    6.84 (neutral)

    Molecular weight
    222.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    316°C

    Flash point

    • 160.77 ˚C est.

  • Synonyms

    • Tetrahydrofurfuryl salicylate
    • Thurfyl salicylate
    • 4KUH7HZ54V
    • EINECS 218-711-1
    • NSC-68484
    • Salicylic acid, tetrahydrofurfuryl ester
    • DTXSID501043224
    • THURFYL SALICYLATE [WHO-DD]
    • NSC 68484
    • Benzoic acid, 2-hydroxy-, (tetrahydro-2-furanyl)methyl ester
    • RefChem:897176
    • DTXCID801525922
    • 218-711-1
    • 2217-35-8
    • (Tetrahydrofuran-2-yl)methyl 2-hydroxybenzoate
    • oxolan-2-ylmethyl 2-hydroxybenzoate
    • tetrahydrofuran-2-ylmethyl salicylate
    • UNII-4KUH7HZ54V
    • orb1695060
    • SCHEMBL1605649
    • VNDLMXQTZJPTOR-UHFFFAOYSA-N
    • NSC68484
    • AKOS015899692
    • AS-86333
    • NS00050212
    • H55678
    • 217T358
    • Q27259924
    • 2217-35-8

  • Applications

    Tetrahydrofurfuryl salicylate (CAS 2217-35-8) is primarily used in perfumery as a fragrance solvent and fixative, helping to dissolve odorants and extend fragrance longevity; in cosmetics and personal care it serves as a fragrance solvent and carrier for aroma compounds in products such as creams, lotions, shampoos, and body washes; in household products it is employed as a fragrance ingredient to impart or stabilize scent in cleaners, laundry detergents, and air fresheners; in industrial manufacturing it can function as a solvent for fragrance components and other volatile ingredients in formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 315.03
    methanol 567.69
    isopropanol 210.93
    water 0.31
    ethyl acetate 239.81
    n-propanol 242.06
    acetone 431.43
    n-butanol 198.02
    acetonitrile 285.24
    DMF 500.07
    toluene 42.17
    isobutanol 146.4
    1,4-dioxane 362.38
    methyl acetate 238.61
    THF 534.82
    2-butanone 276.29
    n-pentanol 104.84
    sec-butanol 168.44
    n-hexane 0.87
    ethylene glycol 95.4
    NMP 228.6
    cyclohexane 3.8
    DMSO 1059.74
    n-butyl acetate 98.18
    n-octanol 27.21
    chloroform 423.97
    n-propyl acetate 113.46
    acetic acid 352.17
    dichloromethane 410.24
    cyclohexanone 258.78
    propylene glycol 165.74
    isopropyl acetate 120.43
    DMAc 479.7
    2-ethoxyethanol 277.0
    isopentanol 169.21
    n-heptane 1.09
    ethyl formate 120.78
    1,2-dichloroethane 357.6
    n-hexanol 74.05
    2-methoxyethanol 635.29
    isobutyl acetate 66.69
    tetrachloromethane 16.95
    n-pentyl acetate 38.81
    transcutol 891.94
    n-heptanol 29.75
    ethylbenzene 24.07
    MIBK 119.87
    2-propoxyethanol 189.07
    tert-butanol 306.28
    MTBE 117.28
    2-butoxyethanol 92.93
    propionic acid 186.05
    o-xylene 32.21
    formic acid 172.06
    diethyl ether 113.15
    m-xylene 35.19
    p-xylene 33.86
    chlorobenzene 84.53
    dimethyl carbonate 101.9
    n-octane 0.68
    formamide 415.7
    cyclopentanone 349.73
    2-pentanone 202.41
    anisole 96.03
    cyclopentyl methyl ether 135.04
    gamma-butyrolactone 379.73
    1-methoxy-2-propanol 414.45
    pyridine 233.12
    3-pentanone 122.56
    furfural 299.93
    n-dodecane 1.37
    diethylene glycol 250.42
    diisopropyl ether 22.26
    tert-amyl alcohol 177.8
    acetylacetone 252.9
    n-hexadecane 1.59
    acetophenone 105.88
    methyl propionate 188.83
    isopentyl acetate 90.48
    trichloroethylene 637.87
    n-nonanol 27.47
    cyclohexanol 143.85
    benzyl alcohol 106.27
    2-ethylhexanol 36.77
    isooctanol 28.14
    dipropyl ether 27.48
    1,2-dichlorobenzene 81.88
    ethyl lactate 82.86
    propylene carbonate 178.78
    n-methylformamide 271.41
    2-pentanol 108.13
    n-pentane 0.99
    1-propoxy-2-propanol 124.94
    1-methoxy-2-propyl acetate 132.06
    2-(2-methoxypropoxy) propanol 141.97
    mesitylene 22.05
    ε-caprolactone 200.87
    p-cymene 17.48
    epichlorohydrin 530.34
    1,1,1-trichloroethane 148.82
    2-aminoethanol 206.06
    morpholine-4-carbaldehyde 299.66
    sulfolane 415.7
    2,2,4-trimethylpentane 2.6
    2-methyltetrahydrofuran 254.49
    n-hexyl acetate 61.01
    isooctane 2.22
    2-(2-butoxyethoxy)ethanol 190.86
    sec-butyl acetate 74.68
    tert-butyl acetate 128.32
    decalin 3.53
    glycerin 244.35
    diglyme 348.8
    acrylic acid 177.54
    isopropyl myristate 29.23
    n-butyric acid 232.19
    acetyl acetate 128.34
    di(2-ethylhexyl) phthalate 36.65
    ethyl propionate 98.54
    nitromethane 658.77
    1,2-diethoxyethane 121.09
    benzonitrile 113.66
    trioctyl phosphate 24.75
    1-bromopropane 91.03
    gamma-valerolactone 378.25
    n-decanol 22.21
    triethyl phosphate 43.44
    4-methyl-2-pentanol 66.3
    propionitrile 166.81
    vinylene carbonate 162.95
    1,1,2-trichlorotrifluoroethane 354.25
    DMS 91.12
    cumene 18.56
    2-octanol 17.98
    2-hexanone 106.66
    octyl acetate 35.66
    limonene 24.28
    1,2-dimethoxyethane 325.56
    ethyl orthosilicate 37.63
    tributyl phosphate 34.51
    diacetone alcohol 214.08
    N,N-dimethylaniline 56.31
    acrylonitrile 238.88
    aniline 109.77
    1,3-propanediol 321.74
    bromobenzene 72.55
    dibromomethane 214.28
    1,1,2,2-tetrachloroethane 468.23
    2-methyl-cyclohexyl acetate 60.75
    tetrabutyl urea 46.35
    diisobutyl methanol 27.35
    2-phenylethanol 82.53
    styrene 32.29
    dioctyl adipate 53.93
    dimethyl sulfate 165.76
    ethyl butyrate 69.76
    methyl lactate 143.58
    butyl lactate 57.52
    diethyl carbonate 57.32
    propanediol butyl ether 114.53
    triethyl orthoformate 51.39
    p-tert-butyltoluene 16.69
    methyl 4-tert-butylbenzoate 79.21
    morpholine 513.85
    tert-butylamine 99.64
    n-dodecanol 17.81
    dimethoxymethane 311.73
    ethylene carbonate 139.09
    cyrene 120.75
    2-ethoxyethyl acetate 85.96
    2-ethylhexyl acetate 60.65
    1,2,4-trichlorobenzene 109.26
    4-methylpyridine 179.09
    dibutyl ether 30.75
    2,6-dimethyl-4-heptanol 27.35
    DEF 189.54
    dimethyl isosorbide 178.06
    tetrachloroethylene 207.46
    eugenol 90.53
    triacetin 98.66
    span 80 89.34
    1,4-butanediol 88.05
    1,1-dichloroethane 244.9
    2-methyl-1-pentanol 98.58
    methyl formate 194.18
    2-methyl-1-butanol 137.68
    n-decane 1.72
    butyronitrile 140.56
    3,7-dimethyl-1-octanol 41.92
    1-chlorooctane 12.85
    1-chlorotetradecane 6.66
    n-nonane 1.24
    undecane 1.52
    tert-butylcyclohexane 2.81
    cyclooctane 1.19
    cyclopentanol 148.27
    tetrahydropyran 246.92
    tert-amyl methyl ether 80.07
    2,5,8-trioxanonane 251.08
    1-hexene 9.44
    2-isopropoxyethanol 155.93
    2,2,2-trifluoroethanol 126.76
    methyl butyrate 137.23

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction