Tetrahydrofurfuryl acetate

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  • Identifiers

    CAS number
    637-64-9

    Molecular formula
    C7H12O3

    SMILES
    CC(=O)OCC1CCCO1

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fruity 93.61%
    Sweet 85.41%
    Ethereal 65.96%
    Caramellic 52.24%
    Banana 47.39%
    Rummy 46.09%
    Nutty 44.61%
    Solvent 42.75%
    Fermented 42.61%
    Winey 42.05%

    Scent© AI

  • Properties

    XLogP3-AA
    0.5

    Molecular weight
    144.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point

    • 194.00 to 195.00 °C. @ 753.00 mm Hg

    Flash point est.
    84.1 ˚C

    Solubility expt.

    • Soluble in water, ether, chloroform
    • Soluble (in ethanol)

  • Synonyms

    • TETRAHYDROFURFURYL ACETATE
    • 637-64-9
    • 2-Acetoxymethyloxolane
    • oxolan-2-ylmethyl acetate
    • (Tetrahydrofuran-2-yl)methyl acetate
    • 2-Furanmethanol, tetrahydro-, acetate
    • 2-(Acetoxymethyl)tetrahydrofuran
    • Tetrahydro-2-furanmethyl acetate
    • Furfuryl alcohol, tetrahydro-, acetate
    • Tetrahydro-2-furanmethanol acetate
    • FEMA No. 3055
    • I1PIW4REZU
    • 2-Furanmethanol, tetrahydro-, 2-acetate
    • NSC 4872
    • EINECS 211-296-8
    • (oxolan-2-yl)methyl acetate
    • Tetrahydro-2-furylmethyl acetate
    • AI3-21209
    • NSC-4872
    • MFCD00022478
    • 2-(ACETOXYMETHYL)OXOLANE
    • DTXSID30862335
    • (+/-)-TETRAHYDROFURFURYL ACETATE
    • TETRAHYDROFURFURYL ACETATE, [FHFI]
    • TETRAHYDROFURFURYL ACETATE, (+/-)-
    • Furfuryl alcohol, tetrahydro-, acetate (8CI)
    • UNII-I1PIW4REZU
    • 2Acetoxymethyloxolane
    • 2(Acetoxymethyl)oxolane
    • Tetrahydro2furanmethyl acetate
    • SCHEMBL118897
    • 2(Acetoxymethyl)tetrahydrofuran
    • Tetrahydro2furanmethanol acetate
    • CHEMBL2287522
    • AAQDYYFAFXGBFZ-UHFFFAOYSA-
    • FEMA 3055
    • Tetrahydrofurfuryl acetate, 97%
    • DTXCID80811116
    • NSC4872
    • CHEBI:169190
    • TETRAHYDROFURFURYL ACETATE,
    • Tetrahydro-2-furanylmethyl acetate
    • 2Furanmethanol, tetrahydro, acetate
    • 2Furanmethanol, tetrahydro, 2acetate
    • Tetrahydro-2-furanylmethyl acetate #
    • Furfuryl alcohol, tetrahydro, acetate
    • AKOS005206826
    • TETRAHYDROFURFURYL ACETATE [INCI]
    • Tetrahydrofurfuryl acetate, >=97%, FG
    • AS-62668
    • SY036811
    • CS-0155423
    • NS00014151
    • T0105
    • F16574
    • Q27280260
    • InChI=1/C7H12O3/c1-6(8)10-5-7-3-2-4-9-7/h7H,2-5H2,1H3
    • 211-296-8

  • Applications

    Tetrahydrofurfuryl acetate (THFAc, CAS 637-64-9) is a mild-odor ester widely applied as a slow-evaporating, high-solvency solvent in wood coatings, varnishes, water-borne inks, adhesives, industrial cleaners and metal degreasing formulations; it also functions as a fragrance carrier in cosmetics, a leather-finishing additive, an eco-friendly plasticizer, and an intermediate in the synthesis of pharmaceuticals, agrochemicals and high-performance epoxy resins.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 825.5
    methanol 1501.53
    isopropanol 503.87
    water 110.88
    ethyl acetate 167.63
    n-propanol 417.17
    acetone 322.02
    n-butanol 324.14
    acetonitrile 528.47
    DMF 665.29
    toluene 99.41
    isobutanol 259.27
    1,4-dioxane 583.43
    methyl acetate 235.95
    THF 433.61
    2-butanone 184.48
    n-pentanol 187.1
    sec-butanol 289.63
    n-hexane 9.23
    ethylene glycol 427.09
    NMP 437.03
    cyclohexane 36.03
    DMSO 736.1
    n-butyl acetate 64.84
    n-octanol 93.85
    chloroform 1119.69
    n-propyl acetate 78.85
    acetic acid 998.79
    dichloromethane 1017.64
    cyclohexanone 285.02
    propylene glycol 427.64
    isopropyl acetate 81.49
    DMAc 593.07
    2-ethoxyethanol 395.42
    isopentanol 213.86
    n-heptane 9.7
    ethyl formate 252.35
    1,2-dichloroethane 321.42
    n-hexanol 117.41
    2-methoxyethanol 797.54
    isobutyl acetate 51.49
    tetrachloromethane 103.24
    n-pentyl acetate 54.97
    transcutol 621.05
    n-heptanol 68.71
    ethylbenzene 54.95
    MIBK 72.46
    2-propoxyethanol 237.76
    tert-butanol 399.37
    MTBE 120.62
    2-butoxyethanol 149.18
    propionic acid 456.19
    o-xylene 85.91
    formic acid 743.29
    diethyl ether 124.34
    m-xylene 70.47
    p-xylene 88.8
    chlorobenzene 175.25
    dimethyl carbonate 86.73
    n-octane 5.35
    formamide 777.01
    cyclopentanone 280.52
    2-pentanone 116.27
    anisole 161.1
    cyclopentyl methyl ether 138.04
    gamma-butyrolactone 395.02
    1-methoxy-2-propanol 432.36
    pyridine 447.73
    3-pentanone 87.61
    furfural 562.18
    n-dodecane 7.23
    diethylene glycol 309.99
    diisopropyl ether 28.31
    tert-amyl alcohol 243.62
    acetylacetone 153.01
    n-hexadecane 7.9
    acetophenone 152.27
    methyl propionate 145.41
    isopentyl acetate 62.97
    trichloroethylene 690.14
    n-nonanol 80.5
    cyclohexanol 259.26
    benzyl alcohol 210.08
    2-ethylhexanol 63.33
    isooctanol 54.09
    dipropyl ether 50.79
    1,2-dichlorobenzene 169.93
    ethyl lactate 94.99
    propylene carbonate 226.12
    n-methylformamide 564.45
    2-pentanol 144.37
    n-pentane 13.21
    1-propoxy-2-propanol 143.85
    1-methoxy-2-propyl acetate 89.5
    2-(2-methoxypropoxy) propanol 165.1
    mesitylene 43.11
    ε-caprolactone 248.63
    p-cymene 36.82
    epichlorohydrin 391.25
    1,1,1-trichloroethane 265.76
    2-aminoethanol 598.88
    morpholine-4-carbaldehyde 587.52
    sulfolane 390.64
    2,2,4-trimethylpentane 9.35
    2-methyltetrahydrofuran 248.1
    n-hexyl acetate 101.44
    isooctane 6.1
    2-(2-butoxyethoxy)ethanol 229.31
    sec-butyl acetate 51.73
    tert-butyl acetate 74.34
    decalin 14.53
    glycerin 503.64
    diglyme 394.89
    acrylic acid 466.36
    isopropyl myristate 45.25
    n-butyric acid 392.97
    acetyl acetate 150.78
    di(2-ethylhexyl) phthalate 65.4
    ethyl propionate 79.43
    nitromethane 874.28
    1,2-diethoxyethane 108.74
    benzonitrile 268.64
    trioctyl phosphate 42.36
    1-bromopropane 150.67
    gamma-valerolactone 477.02
    n-decanol 59.91
    triethyl phosphate 54.32
    4-methyl-2-pentanol 77.53
    propionitrile 293.13
    vinylene carbonate 276.74
    1,1,2-trichlorotrifluoroethane 477.83
    DMS 96.88
    cumene 44.45
    2-octanol 47.7
    2-hexanone 78.35
    octyl acetate 60.62
    limonene 49.0
    1,2-dimethoxyethane 430.34
    ethyl orthosilicate 49.44
    tributyl phosphate 51.04
    diacetone alcohol 141.77
    N,N-dimethylaniline 116.68
    acrylonitrile 441.59
    aniline 244.95
    1,3-propanediol 543.13
    bromobenzene 159.66
    dibromomethane 514.97
    1,1,2,2-tetrachloroethane 507.63
    2-methyl-cyclohexyl acetate 73.2
    tetrabutyl urea 71.2
    diisobutyl methanol 40.35
    2-phenylethanol 129.56
    styrene 77.94
    dioctyl adipate 81.74
    dimethyl sulfate 154.7
    ethyl butyrate 69.18
    methyl lactate 153.66
    butyl lactate 73.33
    diethyl carbonate 66.51
    propanediol butyl ether 186.01
    triethyl orthoformate 60.53
    p-tert-butyltoluene 33.15
    methyl 4-tert-butylbenzoate 120.47
    morpholine 631.01
    tert-butylamine 224.27
    n-dodecanol 46.64
    dimethoxymethane 272.84
    ethylene carbonate 206.22
    cyrene 165.65
    2-ethoxyethyl acetate 89.81
    2-ethylhexyl acetate 47.83
    1,2,4-trichlorobenzene 206.96
    4-methylpyridine 363.87
    dibutyl ether 60.65
    2,6-dimethyl-4-heptanol 40.35
    DEF 225.22
    dimethyl isosorbide 203.22
    tetrachloroethylene 325.63
    eugenol 144.82
    triacetin 137.74
    span 80 152.36
    1,4-butanediol 249.58
    1,1-dichloroethane 358.75
    2-methyl-1-pentanol 134.94
    methyl formate 354.99
    2-methyl-1-butanol 197.36
    n-decane 10.47
    butyronitrile 282.64
    3,7-dimethyl-1-octanol 83.16
    1-chlorooctane 39.05
    1-chlorotetradecane 20.0
    n-nonane 9.28
    undecane 8.33
    tert-butylcyclohexane 12.08
    cyclooctane 9.53
    cyclopentanol 283.42
    tetrahydropyran 313.4
    tert-amyl methyl ether 87.45
    2,5,8-trioxanonane 299.5
    1-hexene 41.22
    2-isopropoxyethanol 193.09
    2,2,2-trifluoroethanol 362.18
    methyl butyrate 122.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction