Tetrahydrofuran

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  • Identifiers

    CAS number
    109-99-9

    Molecular formula
    C4H8O

    SMILES
    C1CCOC1

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Sweet 89.19%
    Ethereal 75.06%
    Solvent 58.26%
    Pungent 38.61%
    Musty 32.9%
    Fermented 30.82%
    Alcoholic 30.31%
    Rummy 28.85%
    Oily 25.35%
    Fruity 24.28%

    Scent© AI

    Odor threshold>

    • Odor Threshold Low: 0.09 [mmHg]. Odor Threshold High: 61.0 [mmHg]. Detection odor threshold from AIHA (mean = 31 ppm)
    • 20-50 ppm @3.8 M
    • 7.3-10.2 mg/cu m (recognition in air)
    • Low: 7.37 mg/cu m; High: 177.0 mg/cu m /From table/

  • Properties

    XLogP3-AA
    0.5

    Molecular weight
    72.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -163.3 °F (NTP, 1992)
    • -108.44 °C
    • -108.3 °C
    • -108.5 °C
    • -163.3 °F
    • -163 °F

    Boiling point

    • 151 °F at 760 mmHg (NTP, 1992)
    • 65 °C
    • 65.00 °C. @ 760.00 mm Hg
    • 66 °C
    • 151 °F

    Flash point est.
    -19.43 ˚C

    Flash point expt.

    • 6 °F (NTP, 1992)
    • -14 °C
    • 6 °F (closed cup); -4 °F (open cup)
    • -14.5 °C (closed cup)
    • -14.5 °C c.c.
    • 6 °F

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • Miscible with alcohols, ketones, esters, hydrocarbons, and ethers.
    • Very soluble in acetone, benzene, ether, ethanol, and chloroform
    • 30% IN WATER AT 25 °C
    • Miscible in water at 25 °C
    • 1000.0 mg/mL
    • Solubility in water: freely soluble
    • Miscible

  • Synonyms

    • TETRAHYDROFURAN
    • 109-99-9
    • Oxolane
    • Furan, tetrahydro-
    • Furanidine
    • Hydrofuran
    • Tetramethylene oxide
    • Oxacyclopentane
    • 1,4-Epoxybutane
    • Tetrahydrofuranne
    • Tetraidrofurano
    • Tetrahydrofuraan
    • Tetrahydrofurane
    • Cyclotetramethylene oxide
    • THF
    • tetrahydro-furan
    • Butane, 1,4-epoxy-
    • Cyclotetramethylene
    • RCRA waste number U213
    • 24979-97-3
    • NCI-C60560
    • NSC 57858
    • Butane .alpha.,.delta.-oxide
    • Butane alpha,delta-oxide
    • MFCD00005356
    • 3N8FZZ6PY4
    • DTXSID1021328
    • CHEBI:26911
    • NSC-57858
    • Tetrahydrofuran, anhydrous
    • Agrisynth THF
    • tetrahydofurane
    • Tetrahydrofuraan [Dutch]
    • Tetraidrofurano [Italian]
    • Butane, alpha,delta-oxide
    • Tetrahydrofuranne [French]
    • Tetrahydrofuran, Spectrophotometric Grade
    • CCRIS 6276
    • HSDB 125
    • EINECS 203-726-8
    • UN2056
    • RCRA waste no. U213
    • Tetrahydrofuran(Stabilized)
    • UNII-3N8FZZ6PY4
    • terahydrofuran
    • terahydrofurane
    • terahyrofuran
    • tetrahydofuran
    • tetrahydorfuran
    • tetrahyrdofuran
    • tetrahyrofuran
    • tetraliydrofuran
    • tetra hydrofuran
    • tetra-hydrofuran
    • tetrahy-drofuran
    • tetrahydro furan
    • tetrahydrof uran
    • tetrahydrofu ran
    • tetrahydrofura n
    • tetrahydrofuran-
    • AI3-07570
    • tet-rahydrofurane
    • tetra-hydrofurane
    • tetrahydro furane
    • tetrahydro-furane
    • tetrahydrofurane-
    • Tetrahydrofuran, contains 250 ppm BHT as inhibitor, ACS reagent, >=99.0%
    • tetra hydro-furan
    • tetra- hydrofuran
    • tetrahydro- furan
    • Butane a,d-oxide
    • Butane,4-epoxy-
    • Dynasolve 150
    • Tetrahydrofuran ACS
    • 1,4-epoxy-Butane
    • c0019
    • tetrahydrofuran solvent
    • THF (tetrahydrofuran)
    • Tetrahydrofuran, 99%
    • Tetrahydrofuran, Biograde
    • WLN: T5OTJ
    • EC 203-726-8
    • TETRAHYDROFURAN [MI]
    • Tetrahydrofuran Ultra LC-MS
    • Tetrahydrofuran, ACS reagent
    • Tetrahydrofuran, >=99.5%
    • TETRAHYDROFURAN [HSDB]
    • TETRAHYDROFURAN [IARC]
    • Tetrahydrofuran, p.a., 99%
    • CHEMBL276521
    • DTXCID501328
    • TETRAHYDROFURAN [USP-RS]
    • Diethylene oxide 1,4-Epoxybutane
    • Tetrahydrofuran, UV, HPLC Grade
    • NSC57858
    • Tetrahydrofuran, analytical standard
    • Tox21_201026
    • MSK001504
    • STL264218
    • AKOS000119982
    • UN 2056
    • Tetrahydrofuran, for HPLC, >=99.9%
    • NCGC00090740-01
    • NCGC00090740-02
    • NCGC00258579-01
    • BP-30232
    • CAS-109-99-9
    • Tetrahydrofuran, anhydrous, inhibitor free
    • Tetrahydrofuran, purum, >=99.0% (GC)
    • DB-038044
    • NS00009145
    • T0104
    • T0856
    • T2394
    • EN300-21322
    • Tetrahydrofuran, SAJ first grade, >=99.0%
    • Tetrahydrofuran, Selectophore(TM), >=99.5%
    • Tetrahydrofuran [UN2056] [Flammable liquid]
    • Tetrahydrofuran HPLC grade stabilized with BHT
    • Tetrahydrofuran, JIS special grade, >=99.5%
    • Tetrahydrofuran, HPLC grade stabilized with BHT
    • A802124
    • InChI=1/C4H8O/c1-2-4-5-3-1/h1-4H
    • Q278332
    • Tetrahydrofuran, for HPLC, contains No stabilizer
    • Tetrahydrofuran, inhibitor-free, purification grade
    • Tetrahydrofuran, puriss. p.a., >=99.9% (GC)
    • Tetrahydrofuran, for luminescence, >=99.5% (GC)

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1016.87
    methanol 1139.06
    isopropanol 676.01
    water 23.68
    ethyl acetate 264.05
    n-propanol 648.87
    acetone 481.59
    n-butanol 508.88
    acetonitrile 442.88
    DMF 551.38
    toluene 102.26
    isobutanol 381.82
    1,4-dioxane 474.23
    methyl acetate 307.89
    THF 654.5
    2-butanone 318.43
    n-pentanol 272.84
    sec-butanol 467.53
    n-hexane 81.2
    ethylene glycol 489.9
    NMP 443.72
    cyclohexane 126.62
    DMSO 541.84
    n-butyl acetate 212.33
    n-octanol 159.92
    chloroform 1263.27
    n-propyl acetate 151.93
    acetic acid 1570.45
    dichloromethane 797.91
    cyclohexanone 321.93
    propylene glycol 574.94
    isopropyl acetate 132.91
    DMAc 361.15
    2-ethoxyethanol 403.39
    isopentanol 293.79
    n-heptane 105.15
    ethyl formate 188.44
    1,2-dichloroethane 346.45
    n-hexanol 346.01
    2-methoxyethanol 738.16
    isobutyl acetate 89.76
    tetrachloromethane 248.59
    n-pentyl acetate 111.13
    transcutol 911.9
    n-heptanol 151.41
    ethylbenzene 52.87
    MIBK 101.5
    2-propoxyethanol 506.15
    tert-butanol 504.38
    MTBE 219.28
    2-butoxyethanol 275.21
    propionic acid 690.13
    o-xylene 70.53
    formic acid 582.8
    diethyl ether 316.14
    m-xylene 64.79
    p-xylene 68.95
    chlorobenzene 155.62
    dimethyl carbonate 96.18
    n-octane 28.71
    formamide 468.38
    cyclopentanone 439.6
    2-pentanone 212.9
    anisole 126.89
    cyclopentyl methyl ether 266.86
    gamma-butyrolactone 478.2
    1-methoxy-2-propanol 493.15
    pyridine 410.74
    3-pentanone 180.85
    furfural 410.22
    n-dodecane 22.04
    diethylene glycol 490.88
    diisopropyl ether 72.62
    tert-amyl alcohol 344.73
    acetylacetone 192.18
    n-hexadecane 23.31
    acetophenone 115.43
    methyl propionate 221.96
    isopentyl acetate 144.04
    trichloroethylene 664.33
    n-nonanol 139.81
    cyclohexanol 350.91
    benzyl alcohol 149.58
    2-ethylhexanol 174.38
    isooctanol 104.45
    dipropyl ether 239.45
    1,2-dichlorobenzene 134.52
    ethyl lactate 116.87
    propylene carbonate 240.94
    n-methylformamide 405.32
    2-pentanol 314.9
    n-pentane 106.99
    1-propoxy-2-propanol 396.12
    1-methoxy-2-propyl acetate 180.65
    2-(2-methoxypropoxy) propanol 223.87
    mesitylene 41.83
    ε-caprolactone 277.69
    p-cymene 61.98
    epichlorohydrin 418.66
    1,1,1-trichloroethane 400.8
    2-aminoethanol 711.68
    morpholine-4-carbaldehyde 439.07
    sulfolane 482.7
    2,2,4-trimethylpentane 35.29
    2-methyltetrahydrofuran 427.28
    n-hexyl acetate 169.2
    isooctane 23.2
    2-(2-butoxyethoxy)ethanol 335.95
    sec-butyl acetate 89.18
    tert-butyl acetate 120.12
    decalin 33.74
    glycerin 626.11
    diglyme 464.05
    acrylic acid 710.9
    isopropyl myristate 70.96
    n-butyric acid 555.85
    acetyl acetate 185.46
    di(2-ethylhexyl) phthalate 77.17
    ethyl propionate 131.75
    nitromethane 794.53
    1,2-diethoxyethane 231.2
    benzonitrile 156.0
    trioctyl phosphate 59.48
    1-bromopropane 272.64
    gamma-valerolactone 448.29
    n-decanol 103.67
    triethyl phosphate 70.29
    4-methyl-2-pentanol 123.02
    propionitrile 323.37
    vinylene carbonate 216.12
    1,1,2-trichlorotrifluoroethane 619.05
    DMS 122.71
    cumene 43.72
    2-octanol 90.13
    2-hexanone 142.27
    octyl acetate 97.98
    limonene 105.62
    1,2-dimethoxyethane 368.27
    ethyl orthosilicate 75.23
    tributyl phosphate 70.33
    diacetone alcohol 198.01
    N,N-dimethylaniline 92.85
    acrylonitrile 376.99
    aniline 214.79
    1,3-propanediol 605.06
    bromobenzene 139.73
    dibromomethane 569.39
    1,1,2,2-tetrachloroethane 584.6
    2-methyl-cyclohexyl acetate 113.81
    tetrabutyl urea 84.75
    diisobutyl methanol 89.75
    2-phenylethanol 158.93
    styrene 78.78
    dioctyl adipate 113.53
    dimethyl sulfate 131.97
    ethyl butyrate 147.37
    methyl lactate 193.27
    butyl lactate 131.08
    diethyl carbonate 93.68
    propanediol butyl ether 304.52
    triethyl orthoformate 108.89
    p-tert-butyltoluene 60.67
    methyl 4-tert-butylbenzoate 127.3
    morpholine 620.5
    tert-butylamine 343.38
    n-dodecanol 81.32
    dimethoxymethane 253.8
    ethylene carbonate 175.83
    cyrene 149.6
    2-ethoxyethyl acetate 155.56
    2-ethylhexyl acetate 116.03
    1,2,4-trichlorobenzene 174.29
    4-methylpyridine 248.39
    dibutyl ether 142.08
    2,6-dimethyl-4-heptanol 89.75
    DEF 252.29
    dimethyl isosorbide 229.12
    tetrachloroethylene 441.14
    eugenol 138.16
    triacetin 185.51
    span 80 255.24
    1,4-butanediol 266.31
    1,1-dichloroethane 448.79
    2-methyl-1-pentanol 166.73
    methyl formate 246.07
    2-methyl-1-butanol 294.58
    n-decane 36.45
    butyronitrile 276.75
    3,7-dimethyl-1-octanol 137.95
    1-chlorooctane 90.1
    1-chlorotetradecane 40.2
    n-nonane 38.27
    undecane 26.83
    tert-butylcyclohexane 34.56
    cyclooctane 39.24
    cyclopentanol 437.74
    tetrahydropyran 455.89
    tert-amyl methyl ether 172.74
    2,5,8-trioxanonane 348.04
    1-hexene 171.13
    2-isopropoxyethanol 247.74
    2,2,2-trifluoroethanol 480.8
    methyl butyrate 156.08

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction