Tetrahydrocurcumin

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  • Identifiers

    CAS number
    36062-04-1

    Molecular formula
    C21H24O6

    SMILES
    COC1=C(C=CC(=C1)CCC(=O)CC(=O)CCC2=CC(=C(C=C2)O)OC)O

    Safety labels

  • Odor profile

    Fragrance
    Vanilla 51.78%
    Sweet 48.04%
    Spicy 47.79%
    Balsamic 35.82%
    Creamy 32.61%
    Powdery 30.4%
    Odorless 30.06%
    Savory 29.73%
    Woody 28.56%
    Milky 27.91%

     

    Flavor
    Sweet 36.06%
    Odorless 32.14%
    Bitter 27.78%
    Mild 27.47%
    Woody 26.75%
    Bland 24.62%
    Spicy 24.03%
    Faint 23.6%
    Powdery 22.6%
    Phenolic 21.49%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.8

    pKa est.
    10.61 (weak base)

    Molecular weight
    372.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    719°C

    Melting point expt.

    • 95 - 97 °C

    Flash point

    • 221.25 ˚C est.

  • Synonyms

    • Tetrahydrocurcumin
    • 36062-04-1
    • 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
    • Sabiwhite
    • Tetrahydrodiferuloylmethane
    • 3,5-Heptanedione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
    • NSC-687845
    • DTXSID30865801
    • 00U0645U03
    • CHEBI:67263
    • RefChem:188657
    • DTXCID40814168
    • 609-201-3
    • Tetrahydro Curcumin
    • 1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione
    • Tetrahydrocucumin
    • MFCD04152347
    • NSC 687845
    • CHEMBL318743
    • HZIV 81-2
    • NSC687845
    • 1,7-bis(4-hydroxy-3-methoxy-phenyl)heptane-3,5-dione
    • SabiWhite-
    • UNII-00U0645U03
    • EC 609-201-3
    • Tetrahydrocurcumin (Standard)
    • SCHEMBL284877
    • Tetrahydro curcumin - Natural
    • Tetrahydro curcumin, Synthetic
    • orb1303824
    • SCHEMBL29370299
    • SCHEMBL29372158
    • HY-N0893R
    • 3,5-Heptamedopme. 1,7-bis(hydroxy-3methoxyphenyl)heptane
    • BP_37
    • HY-N0893
    • MSK40223
    • BDBM50059985
    • s3917
    • Tetrahydrocurcumin, >=96% (HPLC)
    • AKOS015999950
    • Tetrahydrocurcumin, analytical standard
    • CCG-268326
    • CS-3739
    • EBC-616287
    • FT28087
    • AC-24240
    • AS-13957
    • DA-58439
    • FT146193
    • SY047647
    • NS00003846
    • EN300-7372534
    • 062T041
    • AP-123/42300632
    • F078919
    • Q27135730
    • 1,7-bis-(4'-hydroxy-3'-methoxyphenyl)-3,5-heptadione
    • 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-dione
    • TetrahydrocurcuminSabiwhite; Tetrahydro Curcumin; Tetrahydrodiferuloylmethane
    • 36062-04-1

  • Applications

    Chemical name: Tetrahydrocurcumin (CAS 36062-04-1) is primarily used as an antioxidant additive in cosmetics and personal care formulations, helping stabilize active ingredients and extend product shelf life. It is also considered an antioxidant stabilizer and processing aid in polymers and coatings to improve aging resistance of materials. In chemical synthesis and pharmaceutical contexts, tetrahydrocurcumin is commonly evaluated as a synthetic intermediate or precursor to curcuminoid derivatives. In coatings and inks, it has been explored as a stabilizing additive to enhance oxidative stability of surfaces and formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.84
    methanol 9.72
    isopropanol 11.76
    water 0.01
    ethyl acetate 11.89
    n-propanol 13.09
    acetone 106.78
    n-butanol 5.27
    acetonitrile 11.64
    DMF 91.59
    toluene 2.8
    isobutanol 5.91
    1,4-dioxane 66.42
    methyl acetate 23.64
    THF 854.03
    2-butanone 48.59
    n-pentanol 6.79
    sec-butanol 10.41
    n-hexane 0.33
    ethylene glycol 3.19
    NMP 44.28
    cyclohexane 0.47
    DMSO 1743.07
    n-butyl acetate 5.36
    n-octanol 4.3
    chloroform 29.86
    n-propyl acetate 8.48
    acetic acid 23.78
    dichloromethane 36.39
    cyclohexanone 54.27
    propylene glycol 6.92
    isopropyl acetate 7.01
    DMAc 141.95
    2-ethoxyethanol 32.43
    isopentanol 4.11
    n-heptane 0.34
    ethyl formate 11.3
    1,2-dichloroethane 28.13
    n-hexanol 4.03
    2-methoxyethanol 43.86
    isobutyl acetate 4.05
    tetrachloromethane 1.97
    n-pentyl acetate 6.13
    transcutol 38.86
    n-heptanol 3.68
    ethylbenzene 2.02
    MIBK 7.88
    2-propoxyethanol 23.68
    tert-butanol 15.75
    MTBE 8.63
    2-butoxyethanol 13.41
    propionic acid 12.91
    o-xylene 1.94
    formic acid 8.6
    diethyl ether 9.06
    m-xylene 1.11
    p-xylene 2.82
    chlorobenzene 4.86
    dimethyl carbonate 11.57
    n-octane 0.31
    formamide 23.57
    cyclopentanone 167.78
    2-pentanone 19.87
    anisole 8.85
    cyclopentyl methyl ether 19.76
    gamma-butyrolactone 116.31
    1-methoxy-2-propanol 26.65
    pyridine 31.03
    3-pentanone 16.45
    furfural 38.14
    n-dodecane 0.33
    diethylene glycol 19.12
    diisopropyl ether 1.49
    tert-amyl alcohol 10.27
    acetylacetone 38.53
    n-hexadecane 0.37
    acetophenone 11.22
    methyl propionate 16.08
    isopentyl acetate 5.56
    trichloroethylene 43.89
    n-nonanol 4.99
    cyclohexanol 7.61
    benzyl alcohol 8.86
    2-ethylhexanol 2.72
    isooctanol 3.36
    dipropyl ether 5.3
    1,2-dichlorobenzene 4.75
    ethyl lactate 7.16
    propylene carbonate 17.87
    n-methylformamide 26.92
    2-pentanol 3.36
    n-pentane 0.16
    1-propoxy-2-propanol 13.92
    1-methoxy-2-propyl acetate 11.83
    2-(2-methoxypropoxy) propanol 15.87
    mesitylene 0.74
    ε-caprolactone 25.9
    p-cymene 1.35
    epichlorohydrin 129.41
    1,1,1-trichloroethane 11.57
    2-aminoethanol 7.05
    morpholine-4-carbaldehyde 46.13
    sulfolane 178.26
    2,2,4-trimethylpentane 0.2
    2-methyltetrahydrofuran 66.39
    n-hexyl acetate 7.99
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 19.58
    sec-butyl acetate 4.49
    tert-butyl acetate 9.09
    decalin 0.35
    glycerin 11.36
    diglyme 42.86
    acrylic acid 12.28
    isopropyl myristate 3.83
    n-butyric acid 9.52
    acetyl acetate 9.3
    di(2-ethylhexyl) phthalate 4.68
    ethyl propionate 7.96
    nitromethane 85.7
    1,2-diethoxyethane 14.73
    benzonitrile 7.44
    trioctyl phosphate 3.47
    1-bromopropane 7.76
    gamma-valerolactone 101.7
    n-decanol 3.67
    triethyl phosphate 5.47
    4-methyl-2-pentanol 2.04
    propionitrile 11.13
    vinylene carbonate 14.76
    1,1,2-trichlorotrifluoroethane 42.11
    DMS 9.97
    cumene 1.31
    2-octanol 2.87
    2-hexanone 13.6
    octyl acetate 5.18
    limonene 2.04
    1,2-dimethoxyethane 64.92
    ethyl orthosilicate 5.07
    tributyl phosphate 4.32
    diacetone alcohol 17.13
    N,N-dimethylaniline 5.68
    acrylonitrile 15.15
    aniline 6.32
    1,3-propanediol 11.42
    bromobenzene 4.08
    dibromomethane 17.57
    1,1,2,2-tetrachloroethane 38.06
    2-methyl-cyclohexyl acetate 6.37
    tetrabutyl urea 7.74
    diisobutyl methanol 2.06
    2-phenylethanol 6.74
    styrene 2.63
    dioctyl adipate 7.82
    dimethyl sulfate 30.62
    ethyl butyrate 5.93
    methyl lactate 11.01
    butyl lactate 6.87
    diethyl carbonate 4.76
    propanediol butyl ether 10.67
    triethyl orthoformate 6.45
    p-tert-butyltoluene 1.23
    methyl 4-tert-butylbenzoate 11.32
    morpholine 82.12
    tert-butylamine 4.06
    n-dodecanol 2.69
    dimethoxymethane 60.96
    ethylene carbonate 13.06
    cyrene 19.79
    2-ethoxyethyl acetate 12.45
    2-ethylhexyl acetate 3.94
    1,2,4-trichlorobenzene 6.91
    4-methylpyridine 15.31
    dibutyl ether 6.43
    2,6-dimethyl-4-heptanol 2.06
    DEF 19.96
    dimethyl isosorbide 27.8
    tetrachloroethylene 17.09
    eugenol 10.86
    triacetin 12.55
    span 80 10.43
    1,4-butanediol 6.51
    1,1-dichloroethane 14.88
    2-methyl-1-pentanol 5.01
    methyl formate 26.12
    2-methyl-1-butanol 4.48
    n-decane 0.62
    butyronitrile 7.41
    3,7-dimethyl-1-octanol 3.62
    1-chlorooctane 2.68
    1-chlorotetradecane 1.1
    n-nonane 0.5
    undecane 0.43
    tert-butylcyclohexane 0.27
    cyclooctane 0.16
    cyclopentanol 20.35
    tetrahydropyran 53.59
    tert-amyl methyl ether 6.67
    2,5,8-trioxanonane 32.17
    1-hexene 1.77
    2-isopropoxyethanol 18.12
    2,2,2-trifluoroethanol 10.94
    methyl butyrate 11.8

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction