Tetrahydro-2-methoxyfuran

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  • Identifiers

    CAS number
    13436-45-8

    Molecular formula
    C5H10O2

    SMILES
    COC1CCCO1

    Safety labels

  • Odor profile

    Fragrance
    Ethereal 77.28%
    Fruity 57.04%
    Alcoholic 43.06%
    Green 41.4%
    Fermented 41.18%
    Sweet 39.73%
    Solvent 35.82%
    Rummy 33.11%
    Fresh 30.82%
    Pungent 28.69%

     

    Flavor
    Sweet 52.43%
    Vegetable 42.58%
    Caramel 36.35%
    Green 36.24%
    Earthy 31.59%
    Nutty 29.68%
    Musty 29.13%
    Oily 27.43%
    Bitter 25.27%
    Warm 25.03%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    6.89 (neutral)

    Molecular weight
    102.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    116°C

    Flash point

    • 21.78 ˚C est.

  • Synonyms

    • 2-Methoxytetrahydrofuran
    • 13436-45-8
    • Tetrahydro-2-methoxyfuran
    • RefChem:1099680
    • 236-568-3
    • 2-methoxyoxolane
    • Furan, tetrahydro-2-methoxy-
    • 2-methoxy-tetrahydro-furan
    • FURAN,TETRAHYDRO-2-METHOXY-
    • EINECS 236-568-3
    • 2-methoxy-tetrahydrofuran
    • SCHEMBL300796
    • SCHEMBL355207
    • SCHEMBL498085
    • 2-Methoxytetrahydrofuran, 99%
    • SCHEMBL1145721
    • SCHEMBL2043272
    • SCHEMBL2050205
    • SCHEMBL9812134
    • DTXSID50928588
    • MFCD00044271
    • AKOS006274054
    • AS-58090
    • NS00053911
    • G77627
    • 13436-45-8

  • Applications

    Tetrahydro-2-methoxyfuran (CAS 13436-45-8) is primarily used as an organic-synthesis intermediate and as a specialty solvent; it serves as a building block for functionalized heterocycles in pharmaceutical and agrochemical research, may be employed as a precursor in polymer or resin syntheses, and can function as a processing solvent in coatings and ink formulations. It is occasionally explored in fragrance chemistry as a structural motif or intermediate for novel scent components.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5310.48
    methanol 7746.14
    isopropanol 2899.2
    water 179.87
    ethyl acetate 2081.54
    n-propanol 2813.56
    acetone 2444.67
    n-butanol 2490.85
    acetonitrile 3486.69
    DMF 2038.55
    toluene 742.02
    isobutanol 1871.75
    1,4-dioxane 2569.12
    methyl acetate 1757.12
    THF 3276.32
    2-butanone 1557.62
    n-pentanol 1590.3
    sec-butanol 2034.97
    n-hexane 277.06
    ethylene glycol 1330.56
    NMP 1562.73
    cyclohexane 440.29
    DMSO 2420.93
    n-butyl acetate 1196.62
    n-octanol 557.4
    chloroform 6823.12
    n-propyl acetate 956.98
    acetic acid 7903.13
    dichloromethane 6426.93
    cyclohexanone 1646.21
    propylene glycol 1123.64
    isopropyl acetate 1029.98
    DMAc 1382.85
    2-ethoxyethanol 2372.23
    isopentanol 1744.63
    n-heptane 233.66
    ethyl formate 1587.19
    1,2-dichloroethane 2362.75
    n-hexanol 1270.76
    2-methoxyethanol 3652.56
    isobutyl acetate 523.64
    tetrachloromethane 1629.52
    n-pentyl acetate 585.63
    transcutol 3266.37
    n-heptanol 538.05
    ethylbenzene 265.74
    MIBK 699.94
    2-propoxyethanol 1989.56
    tert-butanol 2416.57
    MTBE 1494.95
    2-butoxyethanol 1019.62
    propionic acid 2464.47
    o-xylene 379.27
    formic acid 4450.55
    diethyl ether 2002.67
    m-xylene 414.77
    p-xylene 367.4
    chlorobenzene 1046.52
    dimethyl carbonate 418.18
    n-octane 85.0
    formamide 3402.22
    cyclopentanone 1801.38
    2-pentanone 1271.07
    anisole 689.35
    cyclopentyl methyl ether 1443.77
    gamma-butyrolactone 2116.69
    1-methoxy-2-propanol 2051.81
    pyridine 2302.51
    3-pentanone 868.02
    furfural 2076.58
    n-dodecane 61.61
    diethylene glycol 1745.93
    diisopropyl ether 474.99
    tert-amyl alcohol 1783.83
    acetylacetone 1165.61
    n-hexadecane 66.56
    acetophenone 537.5
    methyl propionate 1107.53
    isopentyl acetate 810.34
    trichloroethylene 4192.22
    n-nonanol 450.64
    cyclohexanol 1578.78
    benzyl alcohol 787.17
    2-ethylhexanol 632.75
    isooctanol 426.38
    dipropyl ether 834.85
    1,2-dichlorobenzene 787.76
    ethyl lactate 396.7
    propylene carbonate 1167.81
    n-methylformamide 2088.79
    2-pentanol 1510.32
    n-pentane 407.33
    1-propoxy-2-propanol 1321.25
    1-methoxy-2-propyl acetate 783.28
    2-(2-methoxypropoxy) propanol 602.6
    mesitylene 267.78
    ε-caprolactone 1487.65
    p-cymene 235.02
    epichlorohydrin 2586.87
    1,1,1-trichloroethane 2461.39
    2-aminoethanol 2239.75
    morpholine-4-carbaldehyde 1777.42
    sulfolane 1665.95
    2,2,4-trimethylpentane 171.05
    2-methyltetrahydrofuran 2544.94
    n-hexyl acetate 694.54
    isooctane 127.92
    2-(2-butoxyethoxy)ethanol 906.95
    sec-butyl acetate 581.53
    tert-butyl acetate 799.49
    decalin 140.28
    glycerin 1427.2
    diglyme 1620.15
    acrylic acid 2201.25
    isopropyl myristate 248.82
    n-butyric acid 3102.71
    acetyl acetate 1322.41
    di(2-ethylhexyl) phthalate 249.88
    ethyl propionate 695.45
    nitromethane 4614.07
    1,2-diethoxyethane 1225.04
    benzonitrile 1029.27
    trioctyl phosphate 179.89
    1-bromopropane 1787.45
    gamma-valerolactone 2024.7
    n-decanol 302.71
    triethyl phosphate 267.82
    4-methyl-2-pentanol 662.63
    propionitrile 1921.81
    vinylene carbonate 1144.77
    1,1,2-trichlorotrifluoroethane 2157.33
    DMS 398.64
    cumene 208.85
    2-octanol 354.72
    2-hexanone 823.46
    octyl acetate 339.66
    limonene 387.16
    1,2-dimethoxyethane 2172.05
    ethyl orthosilicate 295.23
    tributyl phosphate 237.68
    diacetone alcohol 865.31
    N,N-dimethylaniline 413.42
    acrylonitrile 2041.09
    aniline 1234.58
    1,3-propanediol 2624.19
    bromobenzene 1063.85
    dibromomethane 3972.46
    1,1,2,2-tetrachloroethane 2775.46
    2-methyl-cyclohexyl acetate 421.3
    tetrabutyl urea 271.73
    diisobutyl methanol 345.06
    2-phenylethanol 673.93
    styrene 402.69
    dioctyl adipate 336.39
    dimethyl sulfate 514.2
    ethyl butyrate 738.27
    methyl lactate 523.8
    butyl lactate 391.34
    diethyl carbonate 427.85
    propanediol butyl ether 713.02
    triethyl orthoformate 472.28
    p-tert-butyltoluene 227.8
    methyl 4-tert-butylbenzoate 428.38
    morpholine 3089.95
    tert-butylamine 1640.2
    n-dodecanol 226.24
    dimethoxymethane 1463.08
    ethylene carbonate 984.25
    cyrene 495.67
    2-ethoxyethyl acetate 671.04
    2-ethylhexyl acetate 591.67
    1,2,4-trichlorobenzene 918.28
    4-methylpyridine 1813.06
    dibutyl ether 578.23
    2,6-dimethyl-4-heptanol 345.06
    DEF 1406.12
    dimethyl isosorbide 811.96
    tetrachloroethylene 2421.08
    eugenol 460.03
    triacetin 532.1
    span 80 512.24
    1,4-butanediol 1173.78
    1,1-dichloroethane 2925.81
    2-methyl-1-pentanol 1169.81
    methyl formate 1397.41
    2-methyl-1-butanol 1722.48
    n-decane 105.98
    butyronitrile 2300.11
    3,7-dimethyl-1-octanol 540.21
    1-chlorooctane 337.67
    1-chlorotetradecane 132.06
    n-nonane 112.52
    undecane 75.05
    tert-butylcyclohexane 140.28
    cyclooctane 142.11
    cyclopentanol 1761.28
    tetrahydropyran 2462.77
    tert-amyl methyl ether 1027.96
    2,5,8-trioxanonane 1016.17
    1-hexene 750.2
    2-isopropoxyethanol 1384.0
    2,2,2-trifluoroethanol 1932.53
    methyl butyrate 1020.96

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction