Tetrahydro-2-hydroxyfuran

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  • Identifiers

    CAS number
    5371-52-8

    Molecular formula
    C4H8O2

    SMILES
    C1CC(OC1)O

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Fruity 53.72%
    Ethereal 50.88%
    Sweet 45.25%
    Green 39.7%
    Alcoholic 37.79%
    Fermented 32.93%
    Solvent 28.7%
    Pungent 26.92%
    Musty 26.6%
    Oily 24.83%

     

    Flavor
    Sweet 58.03%
    Bitter 40.11%
    Caramel 39.83%
    Oily 33.9%
    Warm 29.71%
    Fatty 29.13%
    Vegetable 27.02%
    Cauliflower 26.95%
    Coconut 25.96%
    Odorless 23.43%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    8.28 (weak base)

    Molecular weight
    88.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    151°C

    Flash point

    • 67.4 ˚C est.

  • Synonyms

    • 2-Hydroxytetrahydrofuran
    • 5371-52-8
    • Tetrahydro-2-furanol
    • 2-Furanol, tetrahydro-
    • Tetrahydro-2-hydroxyfuran
    • V8YVV52DLW
    • CHEBI:19662
    • RefChem:87621
    • GlyTouCan:G19261TG
    • G19261TG
    • 236-569-9
    • tetrahydrofuran-2-ol
    • oxolan-2-ol
    • MFCD07369457
    • 2-hydroxy-tetrahydrofuran
    • alpha-Hydroxytetrahydrofuran
    • tetrahydrofuryl alcohol
    • tetrahydrofuranol
    • a-hydroxytetrahydrofuran
    • SCHEMBL7390
    • SCHEMBL26770
    • .alpha.-Hydroxytetrahydrofuran
    • SCHEMBL497971
    • SCHEMBL5729790
    • SCHEMBL9778096
    • SCHEMBL22362306
    • DTXSID50968469
    • 2-hydroxytetrahydrofuran, AldrichCPR
    • AKOS006286535
    • FH24509
    • AS-57322
    • SY016132
    • CS-0197674
    • NS00054347
    • Q27109240
    • 5371-52-8

  • Applications

    Chemical name: Tetrahydro-2-hydroxyfuran; CAS number: 5371-52-8 is a versatile chemical used as an intermediate and building block in organic synthesis and medicinal chemistry. It serves as a precursor to hydroxy-functionalized tetrahydrofuran derivatives. It can function as a solvent or co-solvent for specialized reactions. In polymer chemistry, it is used as a starting material for polyol and polyether architectures. In research and development, it serves as a reagent for method development and exploratory syntheses.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1207.28
    methanol 2268.68
    isopropanol 643.59
    water 1239.68
    ethyl acetate 163.92
    n-propanol 585.68
    acetone 373.19
    n-butanol 464.11
    acetonitrile 429.98
    DMF 1053.54
    toluene 24.5
    isobutanol 349.17
    1,4-dioxane 279.33
    methyl acetate 194.24
    THF 398.43
    2-butanone 174.84
    n-pentanol 257.42
    sec-butanol 371.56
    n-hexane 7.73
    ethylene glycol 822.97
    NMP 463.69
    cyclohexane 9.04
    DMSO 660.55
    n-butyl acetate 60.61
    n-octanol 83.35
    chloroform 355.64
    n-propyl acetate 81.51
    acetic acid 1952.67
    dichloromethane 295.57
    cyclohexanone 168.16
    propylene glycol 789.27
    isopropyl acetate 86.79
    DMAc 593.62
    2-ethoxyethanol 523.2
    isopentanol 307.01
    n-heptane 8.1
    ethyl formate 259.71
    1,2-dichloroethane 109.7
    n-hexanol 151.88
    2-methoxyethanol 1123.51
    isobutyl acetate 46.67
    tetrachloromethane 76.63
    n-pentyl acetate 61.77
    transcutol 681.34
    n-heptanol 99.05
    ethylbenzene 11.51
    MIBK 84.97
    2-propoxyethanol 332.0
    tert-butanol 488.42
    MTBE 105.6
    2-butoxyethanol 240.07
    propionic acid 649.45
    o-xylene 22.53
    formic acid 2103.92
    diethyl ether 102.42
    m-xylene 24.46
    p-xylene 18.89
    chlorobenzene 50.92
    dimethyl carbonate 91.72
    n-octane 3.88
    formamide 1842.63
    cyclopentanone 290.51
    2-pentanone 146.31
    anisole 61.37
    cyclopentyl methyl ether 112.7
    gamma-butyrolactone 391.62
    1-methoxy-2-propanol 624.64
    pyridine 206.41
    3-pentanone 73.68
    furfural 398.16
    n-dodecane 3.55
    diethylene glycol 466.28
    diisopropyl ether 24.67
    tert-amyl alcohol 309.57
    acetylacetone 150.8
    n-hexadecane 3.52
    acetophenone 65.03
    methyl propionate 148.87
    isopentyl acetate 50.34
    trichloroethylene 251.87
    n-nonanol 69.37
    cyclohexanol 177.97
    benzyl alcohol 124.83
    2-ethylhexanol 62.05
    isooctanol 72.94
    dipropyl ether 43.5
    1,2-dichlorobenzene 47.07
    ethyl lactate 94.3
    propylene carbonate 198.6
    n-methylformamide 939.83
    2-pentanol 211.14
    n-pentane 11.63
    1-propoxy-2-propanol 188.06
    1-methoxy-2-propyl acetate 79.7
    2-(2-methoxypropoxy) propanol 146.08
    mesitylene 16.87
    ε-caprolactone 171.64
    p-cymene 14.49
    epichlorohydrin 294.68
    1,1,1-trichloroethane 103.15
    2-aminoethanol 1189.17
    morpholine-4-carbaldehyde 477.17
    sulfolane 320.97
    2,2,4-trimethylpentane 8.13
    2-methyltetrahydrofuran 208.7
    n-hexyl acetate 75.42
    isooctane 5.91
    2-(2-butoxyethoxy)ethanol 233.59
    sec-butyl acetate 44.63
    tert-butyl acetate 74.53
    decalin 4.91
    glycerin 965.39
    diglyme 353.38
    acrylic acid 680.44
    isopropyl myristate 24.9
    n-butyric acid 664.72
    acetyl acetate 108.37
    di(2-ethylhexyl) phthalate 41.77
    ethyl propionate 62.22
    nitromethane 1215.12
    1,2-diethoxyethane 92.63
    benzonitrile 107.07
    trioctyl phosphate 30.98
    1-bromopropane 55.78
    gamma-valerolactone 389.83
    n-decanol 47.5
    triethyl phosphate 29.36
    4-methyl-2-pentanol 106.64
    propionitrile 218.61
    vinylene carbonate 195.23
    1,1,2-trichlorotrifluoroethane 464.63
    DMS 51.39
    cumene 12.19
    2-octanol 53.95
    2-hexanone 73.39
    octyl acetate 40.15
    limonene 21.25
    1,2-dimethoxyethane 330.3
    ethyl orthosilicate 30.23
    tributyl phosphate 32.55
    diacetone alcohol 187.77
    N,N-dimethylaniline 51.71
    acrylonitrile 323.12
    aniline 138.26
    1,3-propanediol 959.19
    bromobenzene 35.03
    dibromomethane 151.07
    1,1,2,2-tetrachloroethane 191.28
    2-methyl-cyclohexyl acetate 40.08
    tetrabutyl urea 45.01
    diisobutyl methanol 32.53
    2-phenylethanol 85.62
    styrene 17.12
    dioctyl adipate 44.1
    dimethyl sulfate 139.41
    ethyl butyrate 49.98
    methyl lactate 199.78
    butyl lactate 79.79
    diethyl carbonate 35.14
    propanediol butyl ether 253.85
    triethyl orthoformate 40.69
    p-tert-butyltoluene 15.01
    methyl 4-tert-butylbenzoate 80.92
    morpholine 433.2
    tert-butylamine 222.1
    n-dodecanol 34.0
    dimethoxymethane 300.49
    ethylene carbonate 150.81
    cyrene 131.52
    2-ethoxyethyl acetate 81.5
    2-ethylhexyl acetate 35.05
    1,2,4-trichlorobenzene 57.59
    4-methylpyridine 159.25
    dibutyl ether 37.81
    2,6-dimethyl-4-heptanol 32.53
    DEF 211.56
    dimethyl isosorbide 142.79
    tetrachloroethylene 168.36
    eugenol 108.89
    triacetin 84.84
    span 80 138.52
    1,4-butanediol 405.85
    1,1-dichloroethane 127.98
    2-methyl-1-pentanol 167.99
    methyl formate 460.04
    2-methyl-1-butanol 274.35
    n-decane 5.53
    butyronitrile 227.85
    3,7-dimethyl-1-octanol 66.76
    1-chlorooctane 19.99
    1-chlorotetradecane 8.29
    n-nonane 5.21
    undecane 4.21
    tert-butylcyclohexane 5.88
    cyclooctane 3.7
    cyclopentanol 282.9
    tetrahydropyran 158.41
    tert-amyl methyl ether 78.12
    2,5,8-trioxanonane 228.28
    1-hexene 25.74
    2-isopropoxyethanol 264.41
    2,2,2-trifluoroethanol 812.26
    methyl butyrate 100.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction