Tetraglyme

Overview IFRA Request a quote

  • Identifiers

    CAS number
    143-24-8

    Molecular formula
    C10H22O5

    SMILES
    COCCOCCOCCOCCOC

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Ethereal 46.8%
    Alcoholic 42.84%
    Odorless 32.17%
    Sweet 23.72%
    Solvent 23.56%
    Fresh 18.86%
    Fruity 17.48%
    Musty 16.5%
    Fermented 16.17%
    Fishy 15.61%

     

    Flavor
    Sweet 40.31%
    Vegetable 34.99%
    Alcoholic 34.35%
    Bitter 33.62%
    Musty 32.96%
    Earthy 29.98%
    Green 29.25%
    Fruit 24.56%
    Fatty 24.05%
    Oily 22.34%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    4.01 (weak acid)

    Molecular weight
    222.28 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    281°C

    Flash point

    • 120.97 ˚C est.

  • Synonyms

    • Tetraglyme
    • 143-24-8
    • Tetraethylene glycol dimethyl ether
    • 2,5,8,11,14-PENTAOXAPENTADECANE
    • Glyme 5
    • Dimethoxytetraethylene glycol
    • Dimethoxytetraglycol
    • Ansul ether 181AT
    • Bis[2-(2-methoxyethoxy)ethyl] ether
    • Nissan uniox MM 200
    • Methyltetraglyme200
    • E181 (Ether)
    • DTXSID7044396
    • Bis(2-(2-methoxyethoxy)ethyl) ether
    • 78L136FLZ9
    • NSC-65624
    • DTXCID5024396
    • CHEBI:46785
    • RefChem:188598
    • 205-594-7
    • Me-PEG4-Me
    • 1-methoxy-2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethane
    • NSC 65624
    • C10H22O5
    • MFCD00008505
    • Glyme-5
    • CH3O[CH2CH2O]4CH3
    • Ether, bis(2-(2-methoxyethoxy)ethyl)
    • tetraethyleneglycol dimethyl ether
    • Ether, bis[2-(2-methoxyethoxy)ethyl]
    • Tetraethylene glycol dimethyl ether, >=99%
    • EINECS 205-594-7
    • BRN 1760005
    • 2-(2-methoxyethoxy)-1-[2-(2-methoxyethoxy)ethoxy]ethane
    • UNII-78L136FLZ9
    • AI3-01596
    • Methyl-PEG4-methyl
    • TETRAGLYME [MI]
    • E 181 (ether)
    • Me-PEG4-Me (Standard)
    • EC 205-594-7
    • SCHEMBL14920
    • PEG-4 DIMETHYL ETHER
    • tetraethyleneglycol dimethylether
    • CHEMBL3182543
    • WLN: 1O2O2O2O2O1
    • tetraethylene glycol dimethylether
    • 2,8,11,14-Pentaoxapentadecane
    • HY-W013522R
    • NSC65624
    • RYB62815
    • Tox21_302147
    • SBB060898
    • STL280528
    • AKOS015950630
    • CS-W014238
    • DB14000
    • HY-W013522
    • MSK157657-100M
    • NCGC00255794-01
    • AS-60434
    • CAS-143-24-8
    • DB-234024
    • B0497
    • NS00010103
    • ST51046994
    • D70429
    • Tetraethylene glycol dimethyl ether (Tetraglyme)
    • F463249
    • Q3788669
    • F0001-0510
    • Tetraethylene glycol dimethyl ether, analytical standard
    • Tetraethylene glycol dimethyl ether Solution in Methanol, 100ug/mL
    • 2,5,8,11,14-pentaoxapentadecane;bis(2-(2-methoxyethoxy)ethyl) ether;2,5,8,11,14-pentaoxapentadecane bis(2-(2-methoxyethoxy)ethyl) ether
    • 143-24-8

  • Applications

    Tetraglyme (CAS 143-24-8) is a high-boiling, polar aprotic ether solvent used in several specialized processes across chemicals and electronics. It is commonly used as a solvent in chemical synthesis and catalytic systems due to its strong solvating power for polar substrates; as a medium for dissolving lithium salts in battery electrolytes; in electroplating baths as a solvent component for metal deposition; as a processing solvent in polymerization and in formulations for specialty coatings and inks; and as a high-temperature solvent for purification and formulation steps in research settings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 43.71
    methanol 91.47
    isopropanol 25.11
    water 8.79
    ethyl acetate 55.19
    n-propanol 36.76
    acetone 58.81
    n-butanol 23.34
    acetonitrile 65.42
    DMF 186.07
    toluene 20.69
    isobutanol 23.55
    1,4-dioxane 127.02
    methyl acetate 70.87
    THF 155.15
    2-butanone 47.5
    n-pentanol 16.62
    sec-butanol 26.24
    n-hexane 5.38
    ethylene glycol 40.2
    NMP 299.8
    cyclohexane 33.1
    DMSO 405.09
    n-butyl acetate 36.29
    n-octanol 12.68
    chloroform 425.93
    n-propyl acetate 39.08
    acetic acid 280.13
    dichloromethane 433.95
    cyclohexanone 117.2
    propylene glycol 29.54
    isopropyl acetate 24.57
    DMAc 205.1
    2-ethoxyethanol 72.92
    isopentanol 15.71
    n-heptane 9.97
    ethyl formate 62.64
    1,2-dichloroethane 200.76
    n-hexanol 17.19
    2-methoxyethanol 116.49
    isobutyl acetate 19.27
    tetrachloromethane 84.04
    n-pentyl acetate 23.66
    transcutol 151.19
    n-heptanol 11.06
    ethylbenzene 12.09
    MIBK 12.89
    2-propoxyethanol 53.31
    tert-butanol 31.83
    MTBE 20.89
    2-butoxyethanol 32.95
    propionic acid 114.25
    o-xylene 23.79
    formic acid 196.1
    diethyl ether 28.36
    m-xylene 12.72
    p-xylene 20.14
    chlorobenzene 55.3
    dimethyl carbonate 30.5
    n-octane 3.62
    formamide 231.61
    cyclopentanone 144.72
    2-pentanone 25.07
    anisole 32.16
    cyclopentyl methyl ether 56.54
    gamma-butyrolactone 226.76
    1-methoxy-2-propanol 57.85
    pyridine 138.93
    3-pentanone 36.27
    furfural 267.04
    n-dodecane 2.38
    diethylene glycol 60.98
    diisopropyl ether 7.06
    tert-amyl alcohol 31.79
    acetylacetone 49.47
    n-hexadecane 2.75
    acetophenone 50.19
    methyl propionate 51.64
    isopentyl acetate 26.29
    trichloroethylene 406.94
    n-nonanol 13.17
    cyclohexanol 52.46
    benzyl alcohol 37.41
    2-ethylhexanol 15.75
    isooctanol 9.78
    dipropyl ether 29.09
    1,2-dichlorobenzene 74.73
    ethyl lactate 38.67
    propylene carbonate 109.7
    n-methylformamide 126.94
    2-pentanol 13.6
    n-pentane 5.9
    1-propoxy-2-propanol 40.37
    1-methoxy-2-propyl acetate 38.67
    2-(2-methoxypropoxy) propanol 48.78
    mesitylene 9.98
    ε-caprolactone 118.18
    p-cymene 15.22
    epichlorohydrin 181.22
    1,1,1-trichloroethane 140.25
    2-aminoethanol 54.37
    morpholine-4-carbaldehyde 193.71
    sulfolane 388.3
    2,2,4-trimethylpentane 4.08
    2-methyltetrahydrofuran 86.25
    n-hexyl acetate 29.49
    isooctane 1.4
    2-(2-butoxyethoxy)ethanol 50.91
    sec-butyl acetate 21.34
    tert-butyl acetate 24.52
    decalin 8.99
    glycerin 75.12
    diglyme 123.12
    acrylic acid 150.71
    isopropyl myristate 13.87
    n-butyric acid 86.11
    acetyl acetate 63.04
    di(2-ethylhexyl) phthalate 20.03
    ethyl propionate 39.66
    nitromethane 327.36
    1,2-diethoxyethane 40.23
    benzonitrile 52.22
    trioctyl phosphate 13.24
    1-bromopropane 62.78
    gamma-valerolactone 187.65
    n-decanol 9.52
    triethyl phosphate 47.59
    4-methyl-2-pentanol 6.57
    propionitrile 44.91
    vinylene carbonate 128.99
    1,1,2-trichlorotrifluoroethane 322.7
    DMS 45.82
    cumene 10.73
    2-octanol 7.61
    2-hexanone 23.98
    octyl acetate 18.43
    limonene 24.24
    1,2-dimethoxyethane 107.44
    ethyl orthosilicate 39.86
    tributyl phosphate 20.36
    diacetone alcohol 31.66
    N,N-dimethylaniline 30.41
    acrylonitrile 79.02
    aniline 52.53
    1,3-propanediol 48.97
    bromobenzene 55.51
    dibromomethane 238.88
    1,1,2,2-tetrachloroethane 355.6
    2-methyl-cyclohexyl acetate 41.45
    tetrabutyl urea 28.89
    diisobutyl methanol 10.37
    2-phenylethanol 26.58
    styrene 18.21
    dioctyl adipate 34.03
    dimethyl sulfate 92.79
    ethyl butyrate 47.1
    methyl lactate 48.97
    butyl lactate 28.62
    diethyl carbonate 44.64
    propanediol butyl ether 30.83
    triethyl orthoformate 46.51
    p-tert-butyltoluene 14.04
    methyl 4-tert-butylbenzoate 48.43
    morpholine 146.64
    tert-butylamine 20.83
    n-dodecanol 7.53
    dimethoxymethane 57.66
    ethylene carbonate 94.09
    cyrene 72.59
    2-ethoxyethyl acetate 36.58
    2-ethylhexyl acetate 25.04
    1,2,4-trichlorobenzene 101.92
    4-methylpyridine 72.88
    dibutyl ether 21.7
    2,6-dimethyl-4-heptanol 10.37
    DEF 68.69
    dimethyl isosorbide 100.62
    tetrachloroethylene 288.81
    eugenol 43.73
    triacetin 68.96
    span 80 42.36
    1,4-butanediol 23.2
    1,1-dichloroethane 112.82
    2-methyl-1-pentanol 13.88
    methyl formate 98.28
    2-methyl-1-butanol 19.64
    n-decane 4.55
    butyronitrile 31.72
    3,7-dimethyl-1-octanol 12.71
    1-chlorooctane 14.79
    1-chlorotetradecane 6.4
    n-nonane 4.53
    undecane 3.1
    tert-butylcyclohexane 5.34
    cyclooctane 9.08
    cyclopentanol 68.09
    tetrahydropyran 89.92
    tert-amyl methyl ether 22.85
    2,5,8-trioxanonane 95.4
    1-hexene 11.05
    2-isopropoxyethanol 37.84
    2,2,2-trifluoroethanol 172.6
    methyl butyrate 53.37

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction