Tetraglycerol

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  • Identifiers

    CAS number
    56491-53-3

    Molecular formula
    C12H32O12

    SMILES
    C(C(CO)O)O.C(C(CO)O)O.C(C(CO)O)O.C(C(CO)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 70.84%
    Alcoholic 32.16%
    Sweet 26.98%
    Ethereal 23.23%
    Caramellic 20.92%
    Fishy 19.48%
    Solvent 19.41%
    Buttery 17.99%
    Oily 17.59%
    Sharp 16.57%

     

    Flavor
    Odorless 75.67%
    Sweet 69.48%
    Sweet-like 32.0%
    Alcoholic 29.57%
    Very slight 25.23%
    Bitter 24.22%
    Cauliflower 21.33%
    Very mild 21.16%
    Buttery 21.03%
    Musty 20.77%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.45 (neutral)

    Molecular weight
    368.38 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    293°C

    Flash point

    • 163.65 ˚C est.

  • Synonyms

    • Tetraglycerol
    • 56491-53-3
    • SCHEMBL6753203
    • 56491-53-3

  • Applications

    Tetraglycerol, CAS 56491-53-3, is a multi-hydroxy polyol used as a feedstock and intermediate in polymer synthesis, often serving as the polyol component in polyurethane and polyester formulations to tailor crosslinking and mechanical properties. It can function as a crosslinking agent in coatings, inks, and adhesives to enhance film integrity and adhesion. In cosmetics and personal care, tetraglycerol is used as a humectant and emollient to help retain moisture and improve texture. In industrial manufacturing, it may act as a processing aid or solvent and serves as a precursor for polyglycerol esters used as emulsifiers or surfactant-like additives, depending on formulation and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 60.86
    methanol 210.33
    isopropanol 21.05
    water 2105.47
    ethyl acetate 2.84
    n-propanol 40.88
    acetone 8.4
    n-butanol 23.37
    acetonitrile 6.39
    DMF 212.76
    toluene 0.23
    isobutanol 16.8
    1,4-dioxane 13.13
    methyl acetate 4.2
    THF 16.17
    2-butanone 5.09
    n-pentanol 7.17
    sec-butanol 16.07
    n-hexane 0.31
    ethylene glycol 357.66
    NMP 139.89
    cyclohexane 1.22
    DMSO 279.46
    n-butyl acetate 1.92
    n-octanol 3.32
    chloroform 1.56
    n-propyl acetate 1.9
    acetic acid 206.68
    dichloromethane 1.95
    cyclohexanone 9.43
    propylene glycol 161.35
    isopropyl acetate 1.65
    DMAc 82.28
    2-ethoxyethanol 45.01
    isopentanol 9.37
    n-heptane 1.11
    ethyl formate 8.21
    1,2-dichloroethane 2.0
    n-hexanol 6.13
    2-methoxyethanol 137.87
    isobutyl acetate 0.9
    tetrachloromethane 1.15
    n-pentyl acetate 1.81
    transcutol 43.92
    n-heptanol 5.02
    ethylbenzene 0.18
    MIBK 2.09
    2-propoxyethanol 23.86
    tert-butanol 15.56
    MTBE 2.18
    2-butoxyethanol 17.37
    propionic acid 60.48
    o-xylene 0.51
    formic acid 884.99
    diethyl ether 2.62
    m-xylene 0.36
    p-xylene 0.28
    chlorobenzene 0.36
    dimethyl carbonate 4.04
    n-octane 0.39
    formamide 578.54
    cyclopentanone 16.07
    2-pentanone 3.7
    anisole 0.83
    cyclopentyl methyl ether 5.39
    gamma-butyrolactone 24.08
    1-methoxy-2-propanol 50.22
    pyridine 4.24
    3-pentanone 3.22
    furfural 25.05
    n-dodecane 0.22
    diethylene glycol 68.93
    diisopropyl ether 0.82
    tert-amyl alcohol 12.83
    acetylacetone 4.64
    n-hexadecane 0.22
    acetophenone 1.7
    methyl propionate 5.41
    isopentyl acetate 1.47
    trichloroethylene 2.46
    n-nonanol 2.88
    cyclohexanol 14.25
    benzyl alcohol 3.19
    2-ethylhexanol 2.76
    isooctanol 3.37
    dipropyl ether 3.07
    1,2-dichlorobenzene 0.48
    ethyl lactate 6.43
    propylene carbonate 7.88
    n-methylformamide 141.34
    2-pentanol 7.6
    n-pentane 0.65
    1-propoxy-2-propanol 14.59
    1-methoxy-2-propyl acetate 3.89
    2-(2-methoxypropoxy) propanol 10.94
    mesitylene 0.43
    ε-caprolactone 10.82
    p-cymene 0.64
    epichlorohydrin 8.58
    1,1,1-trichloroethane 0.73
    2-aminoethanol 270.74
    morpholine-4-carbaldehyde 84.61
    sulfolane 76.33
    2,2,4-trimethylpentane 0.36
    2-methyltetrahydrofuran 7.46
    n-hexyl acetate 2.16
    isooctane 0.21
    2-(2-butoxyethoxy)ethanol 17.29
    sec-butyl acetate 0.96
    tert-butyl acetate 1.99
    decalin 0.25
    glycerin 338.98
    diglyme 28.4
    acrylic acid 86.65
    isopropyl myristate 0.94
    n-butyric acid 31.86
    acetyl acetate 2.13
    di(2-ethylhexyl) phthalate 2.0
    ethyl propionate 1.77
    nitromethane 78.2
    1,2-diethoxyethane 3.42
    benzonitrile 1.3
    trioctyl phosphate 1.99
    1-bromopropane 0.83
    gamma-valerolactone 35.01
    n-decanol 2.01
    triethyl phosphate 2.3
    4-methyl-2-pentanol 3.0
    propionitrile 4.53
    vinylene carbonate 7.63
    1,1,2-trichlorotrifluoroethane 46.67
    DMS 2.03
    cumene 0.26
    2-octanol 2.25
    2-hexanone 1.66
    octyl acetate 1.43
    limonene 1.17
    1,2-dimethoxyethane 18.65
    ethyl orthosilicate 2.24
    tributyl phosphate 1.9
    diacetone alcohol 9.41
    N,N-dimethylaniline 1.44
    acrylonitrile 7.93
    aniline 2.68
    1,3-propanediol 167.6
    bromobenzene 0.19
    dibromomethane 1.19
    1,1,2,2-tetrachloroethane 2.78
    2-methyl-cyclohexyl acetate 1.87
    tetrabutyl urea 3.61
    diisobutyl methanol 2.03
    2-phenylethanol 2.37
    styrene 0.2
    dioctyl adipate 2.1
    dimethyl sulfate 12.62
    ethyl butyrate 2.3
    methyl lactate 20.05
    butyl lactate 5.76
    diethyl carbonate 1.39
    propanediol butyl ether 21.04
    triethyl orthoformate 2.64
    p-tert-butyltoluene 0.7
    methyl 4-tert-butylbenzoate 4.75
    morpholine 29.61
    tert-butylamine 6.21
    n-dodecanol 1.55
    dimethoxymethane 20.71
    ethylene carbonate 6.0
    cyrene 19.7
    2-ethoxyethyl acetate 2.73
    2-ethylhexyl acetate 1.15
    1,2,4-trichlorobenzene 0.75
    4-methylpyridine 2.02
    dibutyl ether 1.48
    2,6-dimethyl-4-heptanol 2.03
    DEF 17.17
    dimethyl isosorbide 13.67
    tetrachloroethylene 3.78
    eugenol 7.3
    triacetin 3.98
    span 80 13.61
    1,4-butanediol 57.52
    1,1-dichloroethane 0.8
    2-methyl-1-pentanol 3.93
    methyl formate 48.48
    2-methyl-1-butanol 12.15
    n-decane 0.35
    butyronitrile 3.5
    3,7-dimethyl-1-octanol 2.28
    1-chlorooctane 0.66
    1-chlorotetradecane 0.33
    n-nonane 0.36
    undecane 0.26
    tert-butylcyclohexane 0.21
    cyclooctane 0.55
    cyclopentanol 25.7
    tetrahydropyran 6.06
    tert-amyl methyl ether 2.51
    2,5,8-trioxanonane 21.77
    1-hexene 0.49
    2-isopropoxyethanol 14.67
    2,2,2-trifluoroethanol 132.71
    methyl butyrate 3.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction