Tetradecyl 5-oxo-L-prolinate

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  • Identifiers

    CAS number
    37673-27-1

    Molecular formula
    C19H35NO3

    SMILES
    CCCCCCCCCCCCCCOC(=O)[C@@H]1CCC(=O)N1

    Safety labels

  • Odor profile

    Fragrance
    Waxy 41.4%
    Fatty 39.63%
    Oily 36.55%
    Lactonic 35.11%
    Peach 32.67%
    Odorless 30.17%
    Milky 29.83%
    Fresh 28.31%
    Buttery 26.79%
    Citrus 26.2%

     

    Flavor
    Waxy 41.38%
    Fatty 39.05%
    Oily 36.17%
    Mild 31.14%
    Bland 30.82%
    Odorless 25.52%
    Creamy 23.18%
    Faint 22.75%
    Slightly waxy 22.74%
    Bay oil 21.69%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.2

    pKa est.
    7.45 (neutral)

    Molecular weight
    325.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    484°C

    Flash point

    • 199.12 ˚C est.

  • Synonyms

    • Tetradecyl 5-oxo-L-prolinate
    • Myristyl PCA
    • 37673-27-1
    • myristyl pidolate
    • UNII-1B5HPD00PP
    • 1B5HPD00PP
    • EINECS 253-595-6
    • MYRISTIDONE
    • MYRISTYL PYROGLUTAMATE
    • SCHEMBL8754822
    • DTXSID50191093
    • PMWMXMYOKCFDIB-KRWDZBQOSA-N
    • L-PROLINE, 4-OXO-, TETRADECYL ESTER
    • NS00030244
    • Q27252185
    • 37673-27-1

  • Applications

    Tetradecyl 5-oxo-L-prolinate (CAS 37673-27-1) is an ester of proline with a tetradecyl group; in practice it is considered a surfactant/emulsifier that can be used in cosmetics and personal care products, and is also evaluated as a surfactant for household and industrial cleaning formulations. It may act as a plasticizer or processing aid in polymer, coatings, and ink systems to improve flexibility and processability. It can serve as an intermediate in the synthesis of specialty chemicals based on amino acids, including proline-derived building blocks, supporting formulation and materials development in the chemical industry. Its use is typically governed by formulation requirements and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 222.38
    methanol 353.88
    isopropanol 196.49
    water 0.49
    ethyl acetate 668.19
    n-propanol 205.84
    acetone 660.53
    n-butanol 206.9
    acetonitrile 313.53
    DMF 884.22
    toluene 152.48
    isobutanol 179.81
    1,4-dioxane 422.03
    methyl acetate 475.78
    THF 1076.75
    2-butanone 569.58
    n-pentanol 155.79
    sec-butanol 205.02
    n-hexane 12.59
    ethylene glycol 19.0
    NMP 1149.63
    cyclohexane 44.43
    DMSO 936.2
    n-butyl acetate 513.75
    n-octanol 102.2
    chloroform 1274.97
    n-propyl acetate 693.84
    acetic acid 429.97
    dichloromethane 1494.67
    cyclohexanone 1279.04
    propylene glycol 44.8
    isopropyl acetate 571.32
    DMAc 1278.02
    2-ethoxyethanol 390.61
    isopentanol 237.31
    n-heptane 8.44
    ethyl formate 401.57
    1,2-dichloroethane 907.29
    n-hexanol 105.22
    2-methoxyethanol 438.52
    isobutyl acetate 429.32
    tetrachloromethane 199.82
    n-pentyl acetate 612.97
    transcutol 1163.45
    n-heptanol 103.01
    ethylbenzene 99.62
    MIBK 433.03
    2-propoxyethanol 288.94
    tert-butanol 257.5
    MTBE 363.51
    2-butoxyethanol 331.05
    propionic acid 308.87
    o-xylene 130.41
    formic acid 123.73
    diethyl ether 238.11
    m-xylene 114.12
    p-xylene 162.02
    chlorobenzene 372.55
    dimethyl carbonate 174.33
    n-octane 6.9
    formamide 276.49
    cyclopentanone 1242.2
    2-pentanone 576.8
    anisole 263.64
    cyclopentyl methyl ether 469.19
    gamma-butyrolactone 1425.6
    1-methoxy-2-propanol 385.28
    pyridine 615.89
    3-pentanone 377.25
    furfural 954.27
    n-dodecane 5.81
    diethylene glycol 146.93
    diisopropyl ether 92.22
    tert-amyl alcohol 261.48
    acetylacetone 804.8
    n-hexadecane 7.12
    acetophenone 404.33
    methyl propionate 434.01
    isopentyl acetate 506.29
    trichloroethylene 1582.84
    n-nonanol 99.03
    cyclohexanol 301.64
    benzyl alcohol 224.08
    2-ethylhexanol 95.94
    isooctanol 107.37
    dipropyl ether 134.26
    1,2-dichlorobenzene 411.04
    ethyl lactate 240.23
    propylene carbonate 875.68
    n-methylformamide 393.42
    2-pentanol 156.36
    n-pentane 9.88
    1-propoxy-2-propanol 253.77
    1-methoxy-2-propyl acetate 463.94
    2-(2-methoxypropoxy) propanol 254.08
    mesitylene 79.21
    ε-caprolactone 1182.17
    p-cymene 66.22
    epichlorohydrin 1241.0
    1,1,1-trichloroethane 846.91
    2-aminoethanol 76.83
    morpholine-4-carbaldehyde 883.23
    sulfolane 1496.1
    2,2,4-trimethylpentane 15.51
    2-methyltetrahydrofuran 766.05
    n-hexyl acetate 510.34
    isooctane 7.82
    2-(2-butoxyethoxy)ethanol 358.63
    sec-butyl acetate 475.76
    tert-butyl acetate 564.05
    decalin 25.85
    glycerin 80.42
    diglyme 902.18
    acrylic acid 229.79
    isopropyl myristate 127.47
    n-butyric acid 727.68
    acetyl acetate 474.1
    di(2-ethylhexyl) phthalate 133.07
    ethyl propionate 500.15
    nitromethane 1029.73
    1,2-diethoxyethane 440.18
    benzonitrile 378.32
    trioctyl phosphate 90.6
    1-bromopropane 390.79
    gamma-valerolactone 1686.53
    n-decanol 59.97
    triethyl phosphate 187.32
    4-methyl-2-pentanol 111.72
    propionitrile 285.57
    vinylene carbonate 667.3
    1,1,2-trichlorotrifluoroethane 759.19
    DMS 336.31
    cumene 74.81
    2-octanol 89.94
    2-hexanone 483.16
    octyl acetate 177.03
    limonene 106.82
    1,2-dimethoxyethane 805.01
    ethyl orthosilicate 176.0
    tributyl phosphate 137.35
    diacetone alcohol 469.04
    N,N-dimethylaniline 174.0
    acrylonitrile 341.35
    aniline 218.31
    1,3-propanediol 172.24
    bromobenzene 402.39
    dibromomethane 812.94
    1,1,2,2-tetrachloroethane 1321.73
    2-methyl-cyclohexyl acetate 294.65
    tetrabutyl urea 182.56
    diisobutyl methanol 64.8
    2-phenylethanol 170.51
    styrene 138.47
    dioctyl adipate 224.15
    dimethyl sulfate 384.45
    ethyl butyrate 398.97
    methyl lactate 199.59
    butyl lactate 357.98
    diethyl carbonate 244.08
    propanediol butyl ether 247.49
    triethyl orthoformate 269.05
    p-tert-butyltoluene 60.51
    methyl 4-tert-butylbenzoate 342.59
    morpholine 653.89
    tert-butylamine 135.0
    n-dodecanol 40.97
    dimethoxymethane 432.19
    ethylene carbonate 642.46
    cyrene 289.02
    2-ethoxyethyl acetate 663.55
    2-ethylhexyl acetate 376.94
    1,2,4-trichlorobenzene 485.84
    4-methylpyridine 664.14
    dibutyl ether 187.47
    2,6-dimethyl-4-heptanol 64.8
    DEF 792.04
    dimethyl isosorbide 480.9
    tetrachloroethylene 851.49
    eugenol 295.06
    triacetin 520.35
    span 80 215.54
    1,4-butanediol 79.15
    1,1-dichloroethane 769.24
    2-methyl-1-pentanol 185.8
    methyl formate 252.34
    2-methyl-1-butanol 213.59
    n-decane 12.19
    butyronitrile 351.52
    3,7-dimethyl-1-octanol 108.84
    1-chlorooctane 91.95
    1-chlorotetradecane 26.39
    n-nonane 10.59
    undecane 7.81
    tert-butylcyclohexane 18.68
    cyclooctane 10.51
    cyclopentanol 323.1
    tetrahydropyran 597.33
    tert-amyl methyl ether 277.1
    2,5,8-trioxanonane 449.3
    1-hexene 73.14
    2-isopropoxyethanol 305.46
    2,2,2-trifluoroethanol 237.29
    methyl butyrate 820.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction