Tetracaine Hydrochloride

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  • Identifiers

    CAS number
    136-47-0

    Molecular formula
    C15H25ClN2O2

    SMILES
    CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Grape 32.75%
    Odorless 31.05%
    Cheesy 30.62%
    Fishy 29.88%
    Savory 29.29%
    Cooling 28.4%
    Animal 27.09%
    Meaty 27.0%
    Citrus 25.84%
    Roasted 24.97%

     

    Flavor
    Fruity 48.57%
    Mild 31.95%
    Herbal 30.56%
    Odorless 27.57%
    Floral 25.47%
    Bitter 23.92%
    Bland 22.36%
    Oily 20.82%
    Petitgrain 20.76%
    Grape 20.62%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.53 (neutral)

    Molecular weight
    300.82 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    396°C

    Flash point

    • 173.71 ˚C est.

    Solubility expt.

    • >45.1 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • Tetracaine hydrochloride
    • 136-47-0
    • Tetracaine HCl
    • Butethanol
    • Curtacain
    • Menonasal
    • Pantocaine
    • Anethaine
    • Dicainum
    • Amethocaine hydrochloride
    • Tetocaine
    • Tetraca
    • 5NF5D4OPCI
    • NSC-757337
    • DTXSID6042448
    • Pontocaine Hydrochloride
    • Tetracaini hydrochloridum
    • Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride
    • DTXCID4022448
    • KOVANAZE COMPONENT TETRACAINE HYDROCHLORIDE
    • Locan
    • Comfortox Tetracaine
    • RefChem:56113
    • NeuroMed Topical Analgesic
    • Eclipse Topical Analgesic LL
    • NeuroMed Topical Analgesic LA
    • 2-(Dimethylamino)ethyl 4-(butylamino)benzoate monohydrochloride
    • 205-248-5
    • Butylocaine
    • 2-(dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride
    • Tetracaine (hydrochloride)
    • Tetracaine, HCl
    • MFCD00038912
    • 4-(Butylamino)benzoic Acid 2-(Dimethylamino)ethyl Ester Hydrochloride
    • Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester,monohydrochloride
    • MLS000069780
    • 2-Dimethylaminoethanol 4-N-butylaminobenzoate hydrochloride
    • 2-(Dimethylamino)ethyl p-(butylamino)benzoate monohydrochloride
    • Tetracaine hydrochloride (Pontocaine)
    • 2-(dimethylamino)ethyl 4-(butylamino)benzoate;hydrochloride
    • Anethain
    • Decicain
    • Decicaine
    • Dessicain
    • Intercaine
    • Leocaine
    • Pantocain
    • SMR000058522
    • Tonexol
    • Anacel
    • Gingicain M
    • 53762-93-9
    • Tetracainium chloridum
    • Tetracaine chlorhydrate
    • Viractin
    • Tetracaine monohydrochloride
    • Amethocaine monohydrochloride
    • SR-01000075240
    • NCGC00016049-02
    • CAS-136-47-0
    • EINECS 205-248-5
    • UNII-5NF5D4OPCI
    • Exactacain
    • Tetracaine hydrochloride [USP:JAN]
    • p-Butylaminobenzoyl-2-dimethylaminoethanol hydrochloride
    • 2-(Dimethylamino)ethyl p-(butylamino)benzoate hydrochloride
    • Opera_ID_1220
    • Am ethocaine hydrochloride
    • p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester, hydrochloride
    • DICAINUM [WHO-IP]
    • Tetracaine hydrochloride CRS
    • SCHEMBL24370
    • MLS002222164
    • SPECTRUM1500564
    • 4-butylaminobenzoic acid dimethylaminoethyl ester hcl
    • CHEBI:9469
    • orb1309441
    • orb3025038
    • CHEMBL1255654
    • Tetracaine for system suitability
    • Tetracaine hydrochloride, >=99%
    • HMS1569D04
    • HMS1921C17
    • HMS5081J05
    • Pharmakon1600-01500564
    • HY-B0473
    • Tox21_110290
    • Tox21_501211
    • AC-774
    • CCG-39266
    • EBC-28048
    • NSC757337
    • s2573
    • TETRACAINE HYDROCHLORIDE [MI]
    • Tetracaine for system suitability CRS
    • Tetracaine hydrochloride (JP18/USP)
    • TETRACAINE HYDROCHLORIDE [JAN]
    • AKOS015888160
    • Tox21_110290_1
    • FT28067
    • KS-5059
    • LP01211
    • NSC 757337
    • BENZOIC ACID, p-(BUTYLAMINO)-, 2-(DIMETHYLAMINO)ETHYL ESTER, MONOHYDROCHLORIDE
    • TETRACAINE HYDROCHLORIDE [MART.]
    • TETRACAINE HYDROCHLORIDE [VANDF]
    • NCGC00016049-07
    • NCGC00094458-01
    • NCGC00094458-02
    • NCGC00094458-03
    • NCGC00094458-04
    • NCGC00094458-05
    • NCGC00261896-01
    • TETRACAINE HYDROCHLORIDE [USP-RS]
    • TETRACAINE HYDROCHLORIDE [WHO-DD]
    • TETRACAINE HYDROCHLORIDE [WHO-IP]
    • AMETHOCAINE HYDROCHLORIDE [WHO-IP]
    • DB-042341
    • EU-0101211
    • NS00079216
    • SW196411-3
    • T1688
    • TETRACAINE HYDROCHLORIDE [GREEN BOOK]
    • TETRACAINE HYDROCHLORIDE [ORANGE BOOK]
    • D00741
    • T 7508
    • TETRACAINE HYDROCHLORIDE [EP MONOGRAPH]
    • 136-47-0

  • Applications

    Tetracaine Hydrochloride (CAS 136-47-0) is a long-acting local anesthetic of the ester class, used in pharmaceutical formulations to provide local and regional anesthesia. In ophthalmology, it is used in topical eye drops to achieve corneal anesthesia for procedures or examinations. In regional anesthesia, it is employed for spinal or epidural anesthesia due to its long duration of action. For mucosal surfaces, it is used to numb the oral, throat, or ENT-related mucosa during procedures such as dental or endoscopic interventions. In dermatology and minor procedures, it is used in topical formulations to numb the skin before procedures. In pharmaceutical manufacturing, it is used as an active local anesthetic component in various dosage forms.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 262.66
    methanol 672.82
    isopropanol 74.65
    water 13.46
    ethyl acetate 144.32
    n-propanol 163.56
    acetone 155.13
    n-butanol 119.69
    acetonitrile 68.58
    DMF 345.07
    toluene 20.91
    isobutanol 102.11
    1,4-dioxane 83.22
    methyl acetate 102.87
    THF 97.95
    2-butanone 90.06
    n-pentanol 79.05
    sec-butanol 78.27
    n-hexane 2.06
    ethylene glycol 201.98
    NMP 433.44
    cyclohexane 5.23
    DMSO 653.24
    n-butyl acetate 86.02
    n-octanol 20.82
    chloroform 443.58
    n-propyl acetate 82.92
    acetic acid 1165.15
    dichloromethane 444.67
    cyclohexanone 214.72
    propylene glycol 200.29
    isopropyl acetate 85.06
    DMAc 431.91
    2-ethoxyethanol 223.74
    isopentanol 90.88
    n-heptane 1.39
    ethyl formate 133.8
    1,2-dichloroethane 276.46
    n-hexanol 61.65
    2-methoxyethanol 426.02
    isobutyl acetate 54.83
    tetrachloromethane 45.39
    n-pentyl acetate 47.73
    transcutol 708.29
    n-heptanol 34.16
    ethylbenzene 12.55
    MIBK 59.25
    2-propoxyethanol 166.76
    tert-butanol 99.28
    MTBE 37.9
    2-butoxyethanol 108.98
    propionic acid 344.85
    o-xylene 26.77
    formic acid 860.61
    diethyl ether 27.27
    m-xylene 26.55
    p-xylene 22.12
    chlorobenzene 71.92
    dimethyl carbonate 75.3
    n-octane 0.85
    formamide 884.53
    cyclopentanone 226.45
    2-pentanone 82.9
    anisole 36.71
    cyclopentyl methyl ether 65.1
    gamma-butyrolactone 354.34
    1-methoxy-2-propanol 213.92
    pyridine 115.92
    3-pentanone 70.29
    furfural 360.94
    n-dodecane 0.83
    diethylene glycol 234.5
    diisopropyl ether 11.65
    tert-amyl alcohol 102.82
    acetylacetone 170.62
    n-hexadecane 0.93
    acetophenone 78.85
    methyl propionate 122.78
    isopentyl acetate 79.39
    trichloroethylene 619.59
    n-nonanol 20.54
    cyclohexanol 113.81
    benzyl alcohol 82.58
    2-ethylhexanol 33.15
    isooctanol 30.19
    dipropyl ether 17.69
    1,2-dichlorobenzene 92.75
    ethyl lactate 84.26
    propylene carbonate 228.74
    n-methylformamide 317.59
    2-pentanol 51.25
    n-pentane 1.8
    1-propoxy-2-propanol 102.23
    1-methoxy-2-propyl acetate 119.21
    2-(2-methoxypropoxy) propanol 109.7
    mesitylene 18.76
    ε-caprolactone 228.72
    p-cymene 14.93
    epichlorohydrin 317.24
    1,1,1-trichloroethane 163.8
    2-aminoethanol 329.41
    morpholine-4-carbaldehyde 318.65
    sulfolane 539.89
    2,2,4-trimethylpentane 3.36
    2-methyltetrahydrofuran 83.16
    n-hexyl acetate 58.71
    isooctane 1.88
    2-(2-butoxyethoxy)ethanol 156.84
    sec-butyl acetate 51.69
    tert-butyl acetate 86.7
    decalin 3.54
    glycerin 354.55
    diglyme 264.48
    acrylic acid 391.35
    isopropyl myristate 19.61
    n-butyric acid 407.66
    acetyl acetate 155.9
    di(2-ethylhexyl) phthalate 43.67
    ethyl propionate 64.22
    nitromethane 930.76
    1,2-diethoxyethane 72.51
    benzonitrile 66.79
    trioctyl phosphate 28.59
    1-bromopropane 53.31
    gamma-valerolactone 337.7
    n-decanol 15.02
    triethyl phosphate 46.83
    4-methyl-2-pentanol 34.37
    propionitrile 54.64
    vinylene carbonate 217.34
    1,1,2-trichlorotrifluoroethane 612.63
    DMS 92.39
    cumene 13.81
    2-octanol 16.87
    2-hexanone 54.29
    octyl acetate 28.8
    limonene 20.48
    1,2-dimethoxyethane 143.81
    ethyl orthosilicate 43.28
    tributyl phosphate 38.6
    diacetone alcohol 139.39
    N,N-dimethylaniline 37.6
    acrylonitrile 107.24
    aniline 80.97
    1,3-propanediol 321.3
    bromobenzene 60.85
    dibromomethane 204.57
    1,1,2,2-tetrachloroethane 517.92
    2-methyl-cyclohexyl acetate 64.7
    tetrabutyl urea 46.91
    diisobutyl methanol 19.14
    2-phenylethanol 73.63
    styrene 14.57
    dioctyl adipate 47.99
    dimethyl sulfate 177.5
    ethyl butyrate 57.86
    methyl lactate 145.24
    butyl lactate 81.2
    diethyl carbonate 50.21
    propanediol butyl ether 123.38
    triethyl orthoformate 47.78
    p-tert-butyltoluene 14.57
    methyl 4-tert-butylbenzoate 83.65
    morpholine 144.76
    tert-butylamine 38.41
    n-dodecanol 11.4
    dimethoxymethane 118.67
    ethylene carbonate 176.46
    cyrene 141.14
    2-ethoxyethyl acetate 99.89
    2-ethylhexyl acetate 58.53
    1,2,4-trichlorobenzene 132.9
    4-methylpyridine 88.29
    dibutyl ether 15.23
    2,6-dimethyl-4-heptanol 19.14
    DEF 152.56
    dimethyl isosorbide 170.87
    tetrachloroethylene 343.97
    eugenol 96.37
    triacetin 108.82
    span 80 97.43
    1,4-butanediol 130.39
    1,1-dichloroethane 153.66
    2-methyl-1-pentanol 74.76
    methyl formate 210.29
    2-methyl-1-butanol 101.38
    n-decane 1.24
    butyronitrile 50.03
    3,7-dimethyl-1-octanol 26.36
    1-chlorooctane 8.92
    1-chlorotetradecane 3.8
    n-nonane 1.05
    undecane 0.96
    tert-butylcyclohexane 2.97
    cyclooctane 1.84
    cyclopentanol 108.12
    tetrahydropyran 58.33
    tert-amyl methyl ether 38.67
    2,5,8-trioxanonane 180.7
    1-hexene 8.92
    2-isopropoxyethanol 121.14
    2,2,2-trifluoroethanol 453.61
    methyl butyrate 98.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction