Tetrabutylammonium Bromide

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  • Identifiers

    CAS number
    1643-19-2

    Molecular formula
    C16H36BrN

    SMILES
    CCCC[N+](CCCC)(CCCC)CCCC.[Br-]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Waxy 41.27%
    Oily 39.13%
    Sweet 32.68%
    Fresh 30.37%
    Fatty 29.69%
    Fishy 25.36%
    Floral 23.58%
    Fruity 23.03%
    Herbal 21.59%
    Gassy 21.36%

     

    Flavor
    Waxy 26.91%
    Alkane 24.55%
    Bland 23.03%
    Mild 21.91%
    Delicate 21.13%
    Slightly waxy 20.58%
    Diterpene 20.39%
    Skunky 20.22%
    Violet-leaf 20.08%
    Leathery 19.97%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    7.97 (neutral)

    Molecular weight
    322.37 g/mol

    Flash point

    • 198.49 ˚C est.

  • Synonyms

    • Tetrabutylammonium bromide
    • 1643-19-2
    • 1-Butanaminium, N,N,N-tributyl-, bromide (1:1)
    • N,N,N-tributylbutan-1-aminium bromide
    • VJZ168I98R
    • DTXSID4044400
    • 1-Butanaminium, N,N,N-tributyl-, bromide
    • TBAB SUMQUAT 6065
    • DTXCID2024400
    • CHEBI:51993
    • RefChem:6293
    • Bu(4)NBr
    • 216-699-2
    • Tetra-N-butylammonium bromide
    • Tetrabutyl ammonium bromide
    • TBAB
    • Tetrabutyl-ammonium bromide
    • tetrabutylazanium bromide
    • Tetrabutylammoniumbromide
    • MFCD00011633
    • N,N,N-Tributyl-1-butanaminium bromide
    • ALIQUAT 100
    • C16H36BrN
    • TBABR
    • tetrabutylammomium bromide
    • tetra-n-butyl ammonium bromide
    • BR1208
    • tetrabutylamine, bromide
    • IPC-TBA-Br
    • UNII-VJZ168I98R
    • nBu4NBr
    • EINECS 216-699-2
    • Bu4NBr
    • n-Bu4NBr
    • (nBu)4NBr
    • tetrabutyammonium bromide
    • tetrabutylamonium bromide
    • (n-Bu)4NBr
    • Tetrabuylammonium Bromide
    • bromide tetrabutylammonium
    • tetrabutyl-ammoniumbromide
    • tetrabutylammonium;bromide
    • tetrabuthylammonium bromide
    • tetra-butylammonium bromide
    • EC 216-699-2
    • tetra-n-butylammoniumbromide
    • tetran-butylammonium bromide
    • SCHEMBL1891
    • tetra butyl ammonium bromide
    • tetra-butyl ammonium bromide
    • (n-C4H9)4NBr
    • Tetrabutylammonium (bromide)
    • tetra n-butylammonium bromide
    • tetra-n-butyl-ammoniumbromide
    • tetran- butylammonium bromide
    • CHEMBL60696
    • tetra n-butyl ammonium bromide
    • tetra(n-butyl)ammonium bromide
    • tetra-n-butyl-ammonium bromide
    • orb2939158
    • tetra(n-butyl) ammonium bromide
    • tetra(n-butyl)-ammonium bromide
    • tetra (n-butyl) ammonium bromide
    • N,N,N,N-tetrabutylammoniumbromide
    • N,N,N,N-tetrabutylammonium bromide
    • tetra-normal-butyl ammonium bromide
    • HY-D0172
    • STR00258
    • Tox21_302149
    • SBB060660
    • AKOS015899557
    • FT07883
    • NCGC00255885-01
    • BP-31079
    • CAS-1643-19-2
    • DB-004100
    • Tetrabutylammonium bromide ACS reagent grade
    • CS-0010099
    • I0365
    • NS00099594
    • ST51046797
    • T0054
    • EN300-36588
    • D72482
    • T-1950
    • doi:10.14272/JRMUNVKIHCOMHV-UHFFFAOYSA-M.1
    • Q6296780
    • F0001-0598
    • 1643-19-2

  • Applications

    Tetrabutylammonium bromide (CAS 1643-19-2) is widely used as a phase-transfer catalyst in biphasic organic syntheses, enabling alkylations, cyclizations, and other nucleophilic substitutions by shuttling ionic species between aqueous and organic phases. It also serves as an ion-pairing reagent in analytical chromatography, improving the separation of polar compounds in liquid chromatography. In electrochemical contexts, it functions as a supporting electrolyte or salt additive to enhance conductivity in organic solvent systems and to facilitate sensor or cell performance. Additionally, it can be employed as a precursor or component for preparing ionic liquids or specialized quaternary ammonium salts used in polymer and coating formulations. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1579.51
    methanol 555.31
    isopropanol 3002.26
    water 0.1
    ethyl acetate 9993.97
    n-propanol 3236.09
    acetone 7231.06
    n-butanol 4662.7
    acetonitrile 2563.67
    DMF 4855.02
    toluene 10765.58
    isobutanol 4337.41
    1,4-dioxane 13051.73
    methyl acetate 6154.05
    THF 20003.16
    2-butanone 8681.22
    n-pentanol 3643.22
    sec-butanol 5180.42
    n-hexane 16628.79
    ethylene glycol 137.26
    NMP 8665.52
    cyclohexane 41175.62
    DMSO 3950.27
    n-butyl acetate 19774.94
    n-octanol 5734.15
    chloroform 26107.59
    n-propyl acetate 9262.02
    acetic acid 1999.94
    dichloromethane 19413.25
    cyclohexanone 24600.66
    propylene glycol 438.88
    isopropyl acetate 10588.58
    DMAc 5702.39
    2-ethoxyethanol 2915.97
    isopentanol 6241.25
    n-heptane 26565.23
    ethyl formate 4074.69
    1,2-dichloroethane 15681.13
    n-hexanol 8154.41
    2-methoxyethanol 2639.97
    isobutyl acetate 8072.26
    tetrachloromethane 10942.99
    n-pentyl acetate 12535.34
    transcutol 9691.2
    n-heptanol 5461.16
    ethylbenzene 7040.83
    MIBK 8569.12
    2-propoxyethanol 5342.9
    tert-butanol 6981.47
    MTBE 16373.32
    2-butoxyethanol 5180.15
    propionic acid 3090.11
    o-xylene 7904.15
    formic acid 147.64
    diethyl ether 13881.4
    m-xylene 7457.85
    p-xylene 9848.21
    chlorobenzene 10717.55
    dimethyl carbonate 2153.15
    n-octane 7789.83
    formamide 291.79
    cyclopentanone 16532.38
    2-pentanone 10635.44
    anisole 6168.9
    cyclopentyl methyl ether 19284.13
    gamma-butyrolactone 12138.95
    1-methoxy-2-propanol 3495.62
    pyridine 10960.99
    3-pentanone 9842.79
    furfural 7242.23
    n-dodecane 3091.01
    diethylene glycol 1329.05
    diisopropyl ether 10707.23
    tert-amyl alcohol 8539.26
    acetylacetone 8441.88
    n-hexadecane 3721.7
    acetophenone 5441.62
    methyl propionate 6186.34
    isopentyl acetate 18363.91
    trichloroethylene 21842.59
    n-nonanol 5638.86
    cyclohexanol 13139.16
    benzyl alcohol 3127.88
    2-ethylhexanol 12184.32
    isooctanol 6214.89
    dipropyl ether 23340.32
    1,2-dichlorobenzene 10202.49
    ethyl lactate 2541.2
    propylene carbonate 8863.53
    n-methylformamide 1452.36
    2-pentanol 6165.27
    n-pentane 10943.98
    1-propoxy-2-propanol 8383.63
    1-methoxy-2-propyl acetate 8862.63
    2-(2-methoxypropoxy) propanol 3318.88
    mesitylene 6826.4
    ε-caprolactone 17217.98
    p-cymene 8228.41
    epichlorohydrin 13018.85
    1,1,1-trichloroethane 25614.92
    2-aminoethanol 504.03
    morpholine-4-carbaldehyde 6698.36
    sulfolane 13965.3
    2,2,4-trimethylpentane 6199.93
    2-methyltetrahydrofuran 22247.42
    n-hexyl acetate 13760.42
    isooctane 4767.57
    2-(2-butoxyethoxy)ethanol 4624.36
    sec-butyl acetate 9058.19
    tert-butyl acetate 13076.22
    decalin 10697.15
    glycerin 479.57
    diglyme 10895.02
    acrylic acid 1894.64
    isopropyl myristate 6658.9
    n-butyric acid 7503.34
    acetyl acetate 6180.85
    di(2-ethylhexyl) phthalate 2740.78
    ethyl propionate 8565.47
    nitromethane 3366.49
    1,2-diethoxyethane 12432.41
    benzonitrile 5822.4
    trioctyl phosphate 3297.97
    1-bromopropane 18596.33
    gamma-valerolactone 13031.03
    n-decanol 4153.24
    triethyl phosphate 5782.26
    4-methyl-2-pentanol 4704.28
    propionitrile 4839.8
    vinylene carbonate 5993.9
    1,1,2-trichlorotrifluoroethane 6492.33
    DMS 5519.67
    cumene 5229.42
    2-octanol 5902.33
    2-hexanone 9064.24
    octyl acetate 6884.84
    limonene 16948.14
    1,2-dimethoxyethane 9947.72
    ethyl orthosilicate 6698.95
    tributyl phosphate 4196.86
    diacetone alcohol 6535.02
    N,N-dimethylaniline 5363.36
    acrylonitrile 3358.98
    aniline 5711.37
    1,3-propanediol 1178.77
    bromobenzene 14935.29
    dibromomethane 18555.61
    1,1,2,2-tetrachloroethane 23968.1
    2-methyl-cyclohexyl acetate 10402.44
    tetrabutyl urea 5207.35
    diisobutyl methanol 9379.49
    2-phenylethanol 4249.11
    styrene 7572.04
    dioctyl adipate 6439.79
    dimethyl sulfate 2960.13
    ethyl butyrate 15252.69
    methyl lactate 1832.62
    butyl lactate 5759.34
    diethyl carbonate 7946.54
    propanediol butyl ether 2835.87
    triethyl orthoformate 12684.73
    p-tert-butyltoluene 8052.61
    methyl 4-tert-butylbenzoate 5784.49
    morpholine 12484.24
    tert-butylamine 7882.37
    n-dodecanol 3456.38
    dimethoxymethane 4646.63
    ethylene carbonate 7319.74
    cyrene 2517.42
    2-ethoxyethyl acetate 7908.94
    2-ethylhexyl acetate 18020.97
    1,2,4-trichlorobenzene 10352.9
    4-methylpyridine 11942.65
    dibutyl ether 20504.4
    2,6-dimethyl-4-heptanol 9379.49
    DEF 10568.0
    dimethyl isosorbide 6497.28
    tetrachloroethylene 15582.94
    eugenol 3480.39
    triacetin 6903.68
    span 80 4495.02
    1,4-butanediol 646.34
    1,1-dichloroethane 17502.82
    2-methyl-1-pentanol 5237.65
    methyl formate 1363.48
    2-methyl-1-butanol 5971.42
    n-decane 6492.79
    butyronitrile 7356.46
    3,7-dimethyl-1-octanol 7539.84
    1-chlorooctane 11634.61
    1-chlorotetradecane 4489.62
    n-nonane 7943.34
    undecane 4152.78
    tert-butylcyclohexane 8815.14
    cyclooctane 15998.77
    cyclopentanol 8885.18
    tetrahydropyran 28238.17
    tert-amyl methyl ether 13503.6
    2,5,8-trioxanonane 5261.09
    1-hexene 15887.21
    2-isopropoxyethanol 3396.78
    2,2,2-trifluoroethanol 803.69
    methyl butyrate 11467.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction