Tetraaminopyrimidine sulfate

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  • Identifiers

    CAS number
    5392-28-9

    Molecular formula
    C4H10N6O4S

    SMILES
    C1(=C(N=C(N=C1N)N)N)N.OS(=O)(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 62.62%
    Fishy 26.78%
    Burnt 21.04%
    Animal 20.73%
    Cheesy 20.21%
    Ripe 20.13%
    Meaty 19.88%
    Cooked 17.23%
    Musty 17.11%
    Bitter 17.06%

     

    Flavor
    Bitter 64.73%
    Odorless 39.08%
    Mild 27.77%
    Roasted 25.83%
    Scallion 20.46%
    Bread crust 20.17%
    Sweet-like 20.16%
    Soybean 20.13%
    Rotten 19.6%
    Nitrile 19.6%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.77 (weak acid)

    Molecular weight
    238.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    455°C

    Flash point

    • 261.2 ˚C est.

  • Synonyms

    • 5392-28-9
    • tetraaminopyrimidine sulfate
    • Pyrimidinetetramine, sulfate (1:1)
    • Pyrimidinetetramine, sulfate
    • Pyrimidinetetrayltetraamine sulphate
    • NSC 3277
    • 53QQY0I99M
    • NSC-3277
    • EINECS 226-393-0
    • EINECS 256-407-0
    • 2,4,5,6-Pyrimidinetetramine, sulfate (1:1)
    • NSC-227862
    • tetra-Aminopyrimidine sulfate
    • Pyrimidine, tetraamino-, sulfate (1:1)
    • AI3-17130
    • 2,4,5,6-Pyrimidinetetramine, sulfate (1:?)
    • 2,4,5,6-TETRAAMINOPYRIMIDINE SULFATE (1:1)
    • RefChem:896685
    • TETRAAMINOPYRIMIDINE SULFATE [INCI]
    • 2,4,5,6-Tetraaminopyrimidine sulfate
    • Pyrimidinetetramine sulfate
    • 49647-58-7
    • Pyrimidine-2,4,5,6-tetraamine sulfate
    • pyrimidine-2,4,5,6-tetramine;sulfuric acid
    • pyrimidine-2,4,5,6-tetramine; sulfuric acid
    • MFCD00012786
    • C4H10N6O4S
    • 2,4,5,6-Tetraaminopyrimidine sulfate salt
    • DTXSID0037023
    • 2,4,5,6-tetraminopyrimidine sulfate
    • Pyrimidine-2,4,5,6-tetraamine xsulfate
    • 2,4,5,6-Pyrimidinetetramine sulfate (1:1)
    • Tetraaminopyrimidine sulphate
    • 2,4,5,6-TETRAAMINIOPYRIMIDINE SULFATE
    • Pyrimidinetetramine sulphate
    • UNII-53QQY0I99M
    • Pyrimidine, tetraamino-, sulfate (1:1) (8CI); Pyrimidinetetramine, sulfate (1:1) (9CI); 2,4,5,6-Tetraaminopyrimidine sulfate (1:1); NSC 227862; NSC 3277
    • Methotrexate Impurity 15
    • tetraminopyrimidine sulfate
    • Pyrimidine, sulfate (1:1)
    • SCHEMBL121743
    • CHEMBL3185354
    • DTXCID8017023
    • NIOSH/UV9738000
    • MSK15626B
    • Pyrimidine, tetraamino-, sulfate
    • NSC3277
    • 2,5,6-Tetraaminopyrimidine sulfate
    • BB_SC-05393
    • Tox21_202843
    • 2,4,5,6-tetraaminopyrimidinesulfate
    • AC8133
    • NSC227862
    • SBB070638
    • 2,4,5,6-Pyrimidinetetramine sulfate
    • AKOS009157219
    • 2,4,5,6-tetraaminopyrimidine sulphate
    • AC-2771
    • CS-W018518
    • EBC-342047
    • FT00107
    • NSC 227862
    • SB60467
    • NCGC00260389-01
    • AS-11871
    • BP-12573
    • SY002869
    • CAS-5392-28-9
    • DB-231726
    • Pyrimidine, 2,4,5,6-tetraamino-, sulfate
    • NS00080448
    • NS00089532
    • T1462
    • UV97380000
    • EN300-44261
    • 92T289
    • 2,4,5,6-Tetraaminopyrimidine sulfate salt, 97%
    • A855418
    • F078880
    • Q27261126
    • Sulfuric acid--pyrimidine-2,4,5,6-tetramine (1/1)
    • Z448164718
    • 5392-28-9

  • Applications

    Tetraaminopyrimidine sulfate (CAS 5392-28-9) serves primarily as an organic-synthesis building block, notably for the preparation of pyrimidine-based intermediates used in pharmaceutical and fine chemical manufacture. Its four amino groups enable its function as a multi-site crosslinking/curing agent in polymers, resins, and waterborne coatings or adhesives. The sulfate salt improves water solubility, supporting use in aqueous formulations. It is also evaluated as a ligand or chelating agent in coordination chemistry and as a precursor for heterocyclic compounds in research contexts, including potential agrochemical and other specialty actives. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.98
    methanol 2.3
    isopropanol 0.55
    water 2.01
    ethyl acetate 0.32
    n-propanol 0.69
    acetone 0.58
    n-butanol 0.62
    acetonitrile 0.2
    DMF 2.79
    toluene 0.07
    isobutanol 0.47
    1,4-dioxane 0.36
    methyl acetate 0.33
    THF 4.04
    2-butanone 0.59
    n-pentanol 0.42
    sec-butanol 0.52
    n-hexane 0.03
    ethylene glycol 2.09
    NMP 11.43
    cyclohexane 0.01
    DMSO 23.13
    n-butyl acetate 0.62
    n-octanol 0.25
    chloroform 0.13
    n-propyl acetate 0.18
    acetic acid 3.03
    dichloromethane 0.14
    cyclohexanone 0.86
    propylene glycol 2.04
    isopropyl acetate 0.24
    DMAc 5.18
    2-ethoxyethanol 2.49
    isopentanol 0.57
    n-heptane 0.06
    ethyl formate 0.76
    1,2-dichloroethane 0.13
    n-hexanol 0.68
    2-methoxyethanol 7.16
    isobutyl acetate 0.12
    tetrachloromethane 0.14
    n-pentyl acetate 0.52
    transcutol 1.7
    n-heptanol 0.62
    ethylbenzene 0.04
    MIBK 0.43
    2-propoxyethanol 4.05
    tert-butanol 0.81
    MTBE 0.24
    2-butoxyethanol 2.54
    propionic acid 1.07
    o-xylene 0.09
    formic acid 8.64
    diethyl ether 0.18
    m-xylene 0.09
    p-xylene 0.06
    chlorobenzene 0.07
    dimethyl carbonate 0.53
    n-octane 0.02
    formamide 6.68
    cyclopentanone 3.09
    2-pentanone 0.59
    anisole 0.13
    cyclopentyl methyl ether 0.79
    gamma-butyrolactone 4.75
    1-methoxy-2-propanol 4.0
    pyridine 0.45
    3-pentanone 0.35
    furfural 5.1
    n-dodecane 0.01
    diethylene glycol 5.64
    diisopropyl ether 0.08
    tert-amyl alcohol 0.83
    acetylacetone 0.76
    n-hexadecane 0.01
    acetophenone 0.26
    methyl propionate 0.54
    isopentyl acetate 0.69
    trichloroethylene 0.24
    n-nonanol 0.27
    cyclohexanol 0.33
    benzyl alcohol 0.3
    2-ethylhexanol 0.43
    isooctanol 0.51
    dipropyl ether 0.38
    1,2-dichlorobenzene 0.1
    ethyl lactate 0.67
    propylene carbonate 1.76
    n-methylformamide 2.41
    2-pentanol 0.35
    n-pentane 0.02
    1-propoxy-2-propanol 2.65
    1-methoxy-2-propyl acetate 1.22
    2-(2-methoxypropoxy) propanol 1.82
    mesitylene 0.07
    ε-caprolactone 1.1
    p-cymene 0.15
    epichlorohydrin 2.45
    1,1,1-trichloroethane 0.14
    2-aminoethanol 2.6
    morpholine-4-carbaldehyde 4.09
    sulfolane 15.11
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 1.22
    n-hexyl acetate 0.4
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 1.84
    sec-butyl acetate 0.12
    tert-butyl acetate 0.43
    decalin 0.01
    glycerin 7.01
    diglyme 2.95
    acrylic acid 1.42
    isopropyl myristate 0.16
    n-butyric acid 1.38
    acetyl acetate 0.23
    di(2-ethylhexyl) phthalate 0.53
    ethyl propionate 0.21
    nitromethane 2.87
    1,2-diethoxyethane 0.34
    benzonitrile 0.22
    trioctyl phosphate 0.43
    1-bromopropane 0.09
    gamma-valerolactone 5.53
    n-decanol 0.2
    triethyl phosphate 0.49
    4-methyl-2-pentanol 0.27
    propionitrile 0.2
    vinylene carbonate 1.02
    1,1,2-trichlorotrifluoroethane 5.41
    DMS 0.33
    cumene 0.05
    2-octanol 0.32
    2-hexanone 0.31
    octyl acetate 0.26
    limonene 0.18
    1,2-dimethoxyethane 1.73
    ethyl orthosilicate 0.42
    tributyl phosphate 0.4
    diacetone alcohol 1.83
    N,N-dimethylaniline 0.2
    acrylonitrile 0.33
    aniline 0.32
    1,3-propanediol 3.22
    bromobenzene 0.05
    dibromomethane 0.11
    1,1,2,2-tetrachloroethane 0.33
    2-methyl-cyclohexyl acetate 0.44
    tetrabutyl urea 0.61
    diisobutyl methanol 0.3
    2-phenylethanol 0.6
    styrene 0.03
    dioctyl adipate 0.25
    dimethyl sulfate 2.7
    ethyl butyrate 0.41
    methyl lactate 1.96
    butyl lactate 1.12
    diethyl carbonate 0.28
    propanediol butyl ether 1.8
    triethyl orthoformate 0.51
    p-tert-butyltoluene 0.17
    methyl 4-tert-butylbenzoate 1.33
    morpholine 0.92
    tert-butylamine 0.25
    n-dodecanol 0.13
    dimethoxymethane 1.94
    ethylene carbonate 0.7
    cyrene 2.99
    2-ethoxyethyl acetate 0.76
    2-ethylhexyl acetate 0.48
    1,2,4-trichlorobenzene 0.17
    4-methylpyridine 0.48
    dibutyl ether 0.14
    2,6-dimethyl-4-heptanol 0.3
    DEF 0.86
    dimethyl isosorbide 3.29
    tetrachloroethylene 0.31
    eugenol 1.45
    triacetin 0.5
    span 80 1.33
    1,4-butanediol 1.01
    1,1-dichloroethane 0.09
    2-methyl-1-pentanol 0.38
    methyl formate 1.85
    2-methyl-1-butanol 0.56
    n-decane 0.02
    butyronitrile 0.29
    3,7-dimethyl-1-octanol 0.27
    1-chlorooctane 0.07
    1-chlorotetradecane 0.03
    n-nonane 0.02
    undecane 0.01
    tert-butylcyclohexane 0.02
    cyclooctane 0.01
    cyclopentanol 0.97
    tetrahydropyran 0.24
    tert-amyl methyl ether 0.36
    2,5,8-trioxanonane 2.4
    1-hexene 0.06
    2-isopropoxyethanol 1.09
    2,2,2-trifluoroethanol 2.54
    methyl butyrate 0.33

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction